 Esack addressed hundreds of protest meetings, formed ties with inter-faith opponents of apartheid, and became a leading figure within the World Conference of Religions for Peace.Esack founded Call of Islam with Adli Jacobs and his cousin, Ebrahim Rasool, who later became the Premier of the Western Cape and the South African ambassador to the United States.From 1984 to 1989, Esack was the National Coordinator of Call of Islam.