 Griffith was recruited on a "cold call" to Alabama and established the Huntsville Cancer Treatment Center.As a physician, he provided discounted care to patients who lacked insurance.Griffith also conducted several clinical trials in conjunction with the University of Alabama School of Medicine, and partnered with St. Jude Children's Research Hospital in Memphis, Tennessee He retired from medicine in December 1992, though he still holds a license to practice in both Alabama and Texas.