 In Purkinje cells from SCA6 patients, mutant Cav2.1 proteins form ovular intracellular inclusions, or aggregations, similar in many ways to those seen in other polyglutamine expansion disorders such as Huntington's disease.In cell culture models of the disease, this leads to early apoptotic cell death.Mutant channels that are able to traffic properly to the membrane have a negatively shifted voltage-dependence of inactivation.