 In addition, apolipoprotein AII amyloid can be induced in mice by a variety of β-sheet rich amyloid fibrils, and cerebral tauopathy can be induced by brain extracts that are rich in aggregated Aβ.There is also experimental evidence for cross-seeding between prion protein and Aβ.In general, such heterologous seeding is less efficient than is seeding by a corrupted form of the same protein.