 Angiopoietin 1 has been shown to interact with TEK tyrosine kinase.Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins.Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with "Plasmodium" (the causative agent of malaria).