 To avoid lipohypertrophy, persons with diabetes mellitus who inject insulin daily for an extended period of time are advised to "rotate" their injections among several areas (usually upper, outer arms, outer thighs, abdomen below and around the umbilicus, and the upper parts of the buttocks).Rotation charts are often provided as part of diabetes education to help prevent lipohypertrophy.Lipohypertrophy usually will gradually disappear over months if injections in the area are avoided.