 Mertansine

Mertansine, also called DM1 (and in some of its forms emtansine), is a thiol-containing maytansinoid that for therapeutic purposes is attached to a monoclonal antibody through reaction of the thiol group with a linker structure to create an antibody-drug conjugate (ADC).ADCs with this design include trastuzumab emtansine, lorvotuzumab mertansine, and cantuzumab mertansine.