 These organisations were especially active and important during the Austro-Prussian war, but the time Alice dedicated to them annoyed her husband, who saw them as consuming his wife's time at his expense.Alice's descendants went on to play significant roles in world history.Her fourth daughter, Alix, married Tsar Nicholas II of Russia, passing her mother's gene for haemophilia on to her only son, the Tsarevich Alexei.