 Later on, Ortiz went back to Spain, where he founded and headed the Bioinformatics Unit at the Centro de Biología Molecular "Severo Ochoa" in Madrid, under the auspices of the Spanish National Research Council.There he applied the MAMMOTH algorithm to the study of protein structure evolution, unveiling how deeply protein topology constrains the possible evolutionary paths.The other research pillar in his group was the development and optimization of a complete suite of programs to carry out docking and virtual screening experiments aimed at the identification of drug candidates, being gCOMBINE (COMparative BINding Energy) and CRDOCK two successful examples.