 In 1517 after a quarrel with King Manuel I, who denied his persistent demands to lead an expedition to reach the spice islands from the east (i.e., while sailing westwards, seeking to avoid the need to sail around the tip of Africa), he was allowed to leave for Spain.In Seville he befriended his countryman Diogo Barbosa and soon married the daughter of Diogo's second wife, Maria Caldera Beatriz Barbosa.They had two children