 He was the first to suggest using the insect proteins and peptides as molecule probes for investigation of the human proteins at norm and pathology.Efetov has established a new scientific approach – monoclonal immunosystematics that makes it possible to evaluate evolutionary relationships between the biological species through studying their proteins with use of monoclonal antibodies.He has described 4 new genera and 10 subgenera of living organisms, discovered and described 25 new biological species inhabiting Japan, Korea, Indonesia, China, Taiwan, Vietnam, Myanmar (Burma), New Zealand, India, Russia, Kyrgyzstan, Turkmenistan, Afghanistan, Ukraine and Hungary.