 The 2010 French Open also featured the return of four-time champion Justine Henin, who retired immediately before the 2008 French Open, where she was the 3-time defending champion.Men's Singles

Women's Singles

 Rafael Nadal defeated Robin Söderling, 6–4, 6–2, 6–4

 Francesca Schiavone defeated Samantha Stosur, 6–4, 7–6(7–2)

 Daniel Nestor / Nenad Zimonjić defeated Lukáš Dlouhý / Leander Paes, 7–5, 6–2

 Serena Williams / Venus Williams defeated Květa Peschke / Katarina Srebotnik, 6–2, 6–3

 Katarina Srebotnik / Nenad Zimonjić defeated Yaroslava Shvedova / Julian Knowle, 4–6, 7–6(7–5), [11–9]

 Agustín Velotti defeated Andrea Collarini, 6–4, 7–5

 Elina Svitolina defeated Ons Jabeur, 6–2, 7–5

 Duilio Beretta / Roberto Quiroz defeated Facundo Argüello / Agustín Velotti, 6–3, 6–2

 Tímea Babos / Sloane Stephens defeated Lara Arruabarrena / María Teresa Torró Flor, 6–2, 6–3

 Yevgeny Kafelnikov / Andriy Medvedev defeated Goran Ivanišević / Michael Stich, 6–1, 6–1

 John McEnroe / Andrés Gómez defeated Mansour Bahrami / Henri Leconte, 6–1, 6–1

 Martina Navratilova / Jana Novotná defeated Iva Majoli / Nathalie Tauziat, 6–4, 6–2

 Shingo Kunieda defeated Stefan Olsson, 6–4, 6–0

 Esther Vergeer defeated Sharon Walraven, 6–0, 6–0

 Stéphane Houdet / Shingo Kunieda defeated Robin Ammerlaan / Stefan Olsson, 6–0, 5–7, [10–8]

 Daniela Di Toro / Aniek van Koot defeated Esther Vergeer / Sharon Walraven, 3–6, 6–3, [10–4]

The following are the seeded players and notable players who withdrew from the event.Seedings based on ATP and WTA rankings as of 17 May 2010.