 In 1986, Efetov was among the founders of the Hybridoma Laboratory at CSMU.Since 1986, he worked as the senior, chief, and then top research scientific researcher at CSMU; since 1992, he has been working as the Head of the Laboratory of Biotechnology.In 1994, he became Doctor of Biological Sciences having defended his doctoral thesis "A Study of Immunoglobulins at Norm and Pathology with Use of Monoclonal Antibodies and Spectral Methods", in which, for the first time, he applied insect peptides for investigation of human proteins.