 On January 1, 1905, Wilson began working at Mayo Clinic as the chief of pathology and he initiated a new scientific way of doing things at St. Marys Hospital.He systematized the processing of surgical and autopsy specimens and increased the number of autopsies performed at the hospital.Wilson began using a frozen section technique he created in 1905 and published a paper on his method in "JAMA" at the end of that year.