 Lamwo District is bordered by South Sudan to the north, Kitgum District to the east and southeast, Pader District to the south, Gulu District to the southwest, and Amuru District to the west.The town of Lamwo is approximately , by road, northwest of Kitgum, the nearest large town.This is approximately , by road, northeast of Gulu, the largest city in the Acholi sub-region.