 A son of Minamoto Mitsunaka, Minamoto Mitsusane, settled in Takai District, Mino Province in a place called "Inoue".Under the Tokugawa shogunate, the Inoue, as hereditary vassals of the Tokugawa clan, were classified as one of the "fudai" "daimyō" clans.The main branch of the Inoue clan was transferred numerous times throughout the Edo period.