 She was born and raised in Cappadocia.At an unknown date, Nysa became the first wife Greek King Nicomedes III of Bithynia, who reigned between from c. 127 BC to c. 94 BC.Nysa and Nicomedes III were distantly related as they held lineage from the Seleucid dynasty, the Antipatrid dynasty and the Antigonid dynasty.