 "Portadown won 4−1 on aggregate"

The winners of the four first-round games joined the four seeded teams (Shamrock Rovers, Sligo Rovers, Crusaders and Glentoran) who received a Bye into the quarter-finals.The first legs were played on 7 March/14 March/28 March 2011 and the second legs were played on 21 March/22 March/4 April 2011.