 However, this requires the work of excision repair exonuclease ERCC1/XPF so inhibition of TERF2 alone may not necessarily lead to immediate shortening.Upon deletion of TERF2, there is co-localization with TERF1 with the association of DNA damage response factors.Under regular cell conditions, TERF2 is known to suppress the ATM pathway, however, the mechanisms of which, are currently unclear.