 In 1857, he formed a partnership with James Parshall and opened the Finney Hotel at the southeast corner of Gratiot Avenue and Woodward Avenue in Detroit.The following year, Antisdel also became the owner of the Railroad Hotel, which was located on the site where the Detroit Opera House would later be built.Later, he sold the property on which the Railroad Hotel was located for $50,000 and bought the Blindberry Hotel at the corner of Michigan and Washington Avenues, which he renamed the Antisdel Hotel.