 In the 16th century, it was giving to Hernán Cortés by Charles V.

By the middle of the 18th century, interior modifications and additions made it heavily decorated with all types of religious art, including those made of silver and other costly materials.This was also the time that the main church of the monastery began to function as the parish church for the city of Cuernavaca.The buildings and grounds of the monastery/parish remained the same until the latter 19th century, when the Reform Laws closed down and expropriated many monasteries and convents in Mexico.