 Formal programs in which the opioid inverse agonist drug naloxone is distributed have been trialled and implemented.Established programs distribute naloxone, as per WHO's minimum standards, to drug users and their peers, family members, police, prisons, and others.These treatment programs and harm reduction centres operate in Afghanistan, Australia, Canada, China, Germany, Georgia, Kazakhstan, Norway, Russia, Spain, Tajikistan, the United Kingdom (UK), the United States (US), Vietnam, India, Thailand, Kyrgyzstan, Denmark and Estonia.