 The panel was thus one of the works commissioned by the Medici to van der Weyden, including the "Medici Madonna" now at Städel of Frankfurt, which has been also assigned to the artist's trip to Italy in 1450.Another hypothesis is that the panel was part of a lost triptych painted for Lionello d'Este of Ferrara, and mentioned in 1449, or that it was the painting described by Giorgio Vasari as Hans Memling's.The panel adopts the same scheme in Fra Angelico's "Pietà" for the predella of the San Marco Altarpiece (1438–1443), now at the Alte Pinakothek, Munich, confirming that the Flemish artist visited Florence during his pilgrimage in Italy of 1449–1450, as mentioned in "De viribus illustribus" by Bartolomeo Facio (c. 1456).