 In the following 2014–15 Serie A campaign, Vázquez gained notoriety thanks to him forming a successful and effective striking partnership with Paulo Dybala, which saw them both finish the season as two of the top assist providers in the league, with ten assists.On 16 January 2015, he agreed a contract extension with Palermo lasting until 30 June 2019.On 15 May 2016, he scored in a 3–2 home win over Hellas Verona to help save Palermo from relegation at the conclusion of the 2015–16 Serie A season.