 In recent years, ECETOC has played a key role in advising regulators during the introduction of European regulations on the production and use of chemical substances, see Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH).Of particular note are the Targeted Risk Assessment Tools developed by ECETOC which use a tiered (step by step) approach for calculating the exposure to and risks from chemicals that might reasonably be expected in defined circumstances of use.The approach addresses exposure to consumers, workers and the environment.