 Eight months after being imprisoned for driving his car into Cuddy's living room, House has five days before he is granted parole, to which he has become eligible due to space issues and relatively good behavior.He is faced with prison bullies, mainly their leader (Jude Ciccolella), who extorts him into paying them "twenty Vicodin" as "exit tax", and meets Jessica Adams (Odette Annable), a young prison doctor who becomes fascinated with his medical skills.When a fellow prisoner collapses due to mysterious symptoms, House races against the clock and the head prison doctor to find the cure.