 Perin received his first call up for the Italian senior team by head coach Cesare Prandelli, for the friendly match against England held on 15 August 2012 in Bern; seven other new faces were in the squad.He was included in Prandelli's provisional 30-man squad ahead of 2014 FIFA World Cup in Brazil, and then confirmed in the 23-man squad as the third choice goalkeeper behind Gianluigi Buffon and Salvatore Sirigu.He became the youngest player of the squad and the only one who had no previous caps.