 In the 2012 summer, he was loaned to Pescara, newly promoted in Serie A, obtaining 29 league appearances at the end of the season.On 8 January 2017, Perin tore the anterior cruciate ligament in his right knee in a 1–0 home defeat to Roma, ruling him out for the remainder of the 2016–17 season.On 8 June 2018, Perin was signed by Juventus on a four-year contract for a fee of €12 million plus €3 million in bonuses.