 He made his debut with the national team on 18 November 2014, in a 1–0 friendly win against Albania, replacing Sirigu for the last 17 minutes at his club ground of the Stadio Luigi Ferraris.On 9 April 2016, he suffered an injury with Genoa in which he tore his anterior cruciate ligament and damaged his meniscus in his right knee, which would cause his absence as Italy's third goalkeeper at the UEFA Euro 2016.Perin made his first start on his second cap on 4 June 2018, a 1–1 friendly draw against the Netherlands in Turin.