 The first bridge across the Iset River in the district was specially constructed in 1837 for the drive-through visit of the Grand Duke Alexander Nikolayevich (the future Alexander II of Russia).The area was part of Tobolsk Province from 1650 to 1738, but was merged into Isetsky Orenburg Province in 1738, and then in 1782 into Yalutavorsk Province until 1923.Isetsky District was officially formed in November 1923 as part of the Ishimsky district of the Ural Region.