 The first synthesis of Promin is sometimes credited to Edward Tillitson and B.F. Tuller of Parke, Davis, & Co. pharmaceuticals in August 1937.However, although Parke-Davis did in fact synthesize the compound, it seems certain that they were not the first; in cooperation with J. Wittmann, Emil Fromm synthesised various sulfone compounds in 1908, including both dapsone and some of its derivatives, such as promin.Fromm and Wittmann however were engaged on chemical rather than medical work, and no-one investigated the medical value of such compounds until some decades afterwards.