 In 1904 she left school at Moscow Art Theatre and started to work in theater with her first husband Nikolai Radin.After they were divorced, Natalya Lisenko became the wife of the well known Russian actor Ivan Mosjoukine, and they appeared in multiple films together.Her film debut was in "Katyusha Maslova" (1915), directed by Pyotr Chardynin and based on Leo Tolstoy's novel "Resurrection".