 Knowing that B-cells experience DNA breaks during development can give insight to the genome of lymphomas.Many types of lymphoma are caused by chromosomal translocation, which can arise from breaks in DNA, leading to incorrect joining.In Burkitt’s lymphoma, c-myc, an oncogene encoding a transcription factor, is translocated to a position after the promoter of the immunoglobulin gene, leading to dysregulation of c-myc transcription.