 The expressway spans a length of , passes two provinces and serves the cities of Nanjing, Jiangsu; Ma'anshan, Anhui; and Wuhu, Anhui.The north terminus of G4211 is at Tianbao Bridge in Yuhuatai District, Nanjing, and the south terminus connects to G50 and G5011 Wuhu-Hefei Expressway via a cloverleaf interchange in Wuhu.G4211 is a four-lane limited access tollway for its entire length.