 Mizuno first worked with director Ishirō Honda in "Seniors, Juniors, Co-Workers" in 1959.She would later work with Honda in "Attack of the Mushroom People", "Frankenstein Conquers the World", "Godzilla vs. the Sea Monster", "Gorath", "Invasion of Astro-Monster" and "The War of the Gargantuas".In 1991, she played Kanako Yanagawa in Kihachi Okamoto's "Rainbow Kids".