 During Holston's tenure at CSU between 2005–06 and 2008–09 (he redshirted his true freshman season), he scored a school-record 2,331 points, finished in the top five in points per game nationally for his senior season, led the NCAA in three-point field goals made per game in his final two seasons, and was the first Chicago State player to garner Division I postseason All-American honors, among others.Holston finished his collegiate career with averages of 19.6 points, 4.4 assists and 2.1 steals per game, and his 450 career three-pointers are the fourth most in NCAA Division I history.During his senior season in 2008–09, his averages of 25.9 points, 6.4 assists, 3.7 steals and three rebounds per game led CSU to a 19–13 record—its first winning season since the school transitioned to Division I—and he was named the Independent Player of the Year.