 Pezzella scored his first professional goal on 2 September 2012, netting the last in a 1–1 draw at Club Atlético Colón.He also scored the equalizer in a 1–1 Superclásico home draw against Boca Juniors, just three minutes after coming off the bench.On 10 December 2014, Pezzella scored the last in a 2014 Copa Sudamericana final 2–0 win against Atlético Nacional, as his side won its first international title after a 17-year absence.