 The Nanning–Youyiguan Expressway begins east of the city centre of Nanning, at the San'an Interchange in Qingxiu District.At this interchange, it connects to the G72 Quanzhou–Nanning Expressway, its parent expressway, as well as the G7201 Nanning Ring Expressway, the G75 Lanzhou–Haikou Expressway, and the G80 Guangzhou–Kunming Expressway.It proceeds south, in a concurrency with the G7201 Nanning Ring Expressway and G75 Lanzhou–Haikou Expressway, to the Liangqing South interchange in Liangqing District, passing through Yongning District on the way.