 Cram was a cousin of American architect Ralph Adams Cram.He married Mary Belle (Mabel) Laventure in 1892, and they had six children including parasitologist Eloise Blaine Cram (1896–1957) and aviation engineer Ralph LaVenture Cram (1906–1939) who was killed during a test flight of the first Boeing 307 Stratoliner.He died in 1952.