 On 10 July 2015, Pezzella signed a five-year contract with Real Betis, newly promoted to La Liga.He made his debut for the club on 23 August, starting in a 1–1 home draw against Villarreal CF.Kelantan
After a loan spell with Serie A club Fiorentina during the 2017–18 season, Pezzella signed a five-year contract with the club that runs through the end of the 2021–22 season for an €11m transfer fee.