 One day, the Manhunters collectively changed their directives and set out on a campaign to eradicate all organic life.Starting with Sector 666, they killed the people they had been created to protect, eradicating almost all life in the entire sector before the Guardians stopped them.Most Manhunters were decommissioned after the massacre of Sector 666, but the ones that escaped became the sworn enemies of their former masters and remained so until modern times.