 On Holy Saturday of 1389, a pogrom began in Prague that led to the burning of the Jewish quarter, the killing of many Jews, and the suicide of many Jews trapped in the main synagogue; the number of dead was estimated at 400–500 men, women and children.The brutal murders of Jews and Poles occurred during the Khmelnytsky Uprising of 1648–1657 in present-day Ukraine.Modern historians give estimates of the scale of the murders by Khmelnytsky's Cossacks ranging between 40,000 and 100,000 men, women and children, or perhaps many more.