 These were initiated on infertility patients of Dr. John Rock in Brookline, Massachusetts using progesterone in 1953 and then three different progestins in 1954.Puerto Rico was selected as a trial site in 1955, in part because there was an existing network of 67 birth control clinics serving low-income women on the island.Trials began there in 1956 and were supervised by Dr. Edris Rice-Wray and Celso-Ramón García.