 His first major work there was a six-volume "Handbuch der speciellen Pathologie und Therapie (Handbook on Special Pathology and Therapeutics)" published in 1854.In 1856, he returned to Berlin to become the newly created Chair for Pathological Anatomy and Physiology at the Friedrich-Wilhelms-University, as well as Director of the newly built Institute for Pathology on the premises of the Charité.He held the latter post for the next 20 years.