 Williamsport has one professional baseball team, the Williamsport Crosscutters, a minor league baseball club with the New York–Penn League affiliated with the Philadelphia Phillies, and a semi-professional football team, the Williamsport Wildcats, registered with the GEFA

The Little League World Series is held annually on the south side of the West Branch Susquehanna River in South Williamsport, where Little League Baseball now has its headquarters.Each year the Susquehanna 500 Mini Indy Gokart Racing Series competes in Brandon Park.The Saturday-Sunday event is held each year, usually the third weekend of September with all proceeds going to the North Central Pennsylvania Chapter of the American Red Cross.