 These diseases swept through Yucatán in the 1520s and 1530s, with periodic recurrences throughout the 16th century.By the late 16th century, the reports of high fevers suggest the arrival of malaria in the region, and yellow fever was first reported in the mid-17th century, with a terse mention in the "Chilam Balam of Chumayel" for 1648.That particular outbreak was traced back to the island of Guadaloupe in the Caribbean, from whence it was introduced to the port city of Campeche, and from there was transmitted to Mérida.