 Key cities in the region which are not in major metropolitan areas include Eureka on the far North Coast, Redding, at the northern end of the Central Valley, Chico, and Yuba City in the mid-north of the Central Valley, as well as Fresno and Visalia on the southern end.Though smaller in each case, with the notable exception of Fresno, than the larger cities of the general region, these smaller regional centers are often of historical and economic importance for their respective size, due to their locations, which are primarily rural or otherwise isolated.Inhabited for millennia by Native Americans, from the Shasta tribe in the north, to the Miwoks in the central coast and Sierra Nevada, to the Yokuts of the southern Central Valley, northern California was among the most densely populated areas of pre-Columbian North America.