 She is the younger sister of the author Marte Huke.Huke was educated at the Heimdal Upper Secondary School between 1993 and 1996, and pursued the Jazz program at Norwegian University of Science and Technology from 1996 to 2001; in 2016, she was employed there as an assistant professor.Her own Kirsti Huke Quartet (established in 1998) also included Håvard Wiik (piano), Håkon Mjåset Johansen (drums) and Steinar Raknes (bass).