 At UCL, the focus of his group’s research has been based on understanding the transmission and control of pain, how neuronal systems alter in pathophysiological states and how novel and licensed drugs produce their effects with the aim of translating the basic research into clinical applications.Early studies described the neuronal basis of Diffuse Noxious Inhibitory controls (DNIC).Tony’s group was also the first to show the NMDA receptor mediation of wind-up and its role in persistent pain.