 It is important to note that the ruthenium is not necessarily replacing the iron within these proteins, but that they are transported concurrently.It has been documented that transferrin-mediated ruthenium uptake is more efficient when the proteins are also saturated with iron.NAMI {Na["trans"-RuCl4](DMSO)(imida)]} and NAMI-A {H2Im["trans"-RuCl4(DMSO)HIm[imidH] are the most-stable ruthenium-based anti-cancer drugs.