 As the Fugue String quartet approaches its 25th anniversary, the onset of a debilitating illness to cellist Peter Mitchell (Christopher Walken), forces its members to reevaluate their relationships.After being diagnosed with Parkinson's disease, Peter announces his decision to play one final concert before he retires.Meanwhile, the second violinist, Robert (Philip Seymour Hoffman), voices his desire to alternate the first violinist role, long held by Daniel (Mark Ivanir).