 Potentially actionable coding mutations have been identified in 67 genes, including those in CR2, HGF, FGFR4 and ESRRB.Numerous genes harbouring somatic coding mutations and copy number changes in the microsatellite stable (MSS) OGJA are also known to be altered with similar predicted functional consequence in other tumour types.TP53, SYNE1, and ARID1A are among the most frequently mutated genes.