 After beginning the season with the Isotopes, the Dodgers purchased his contract and called him up to make his Major League debut in the second game of a doubleheader on May 1, 2014 against the Minnesota Twins.In that game he pitched 4 2/3 innings and only allowed two hits and one run and strike out Pedro Florimon swinging for his only major league K.

Patterson spent the rest of 2014 in the minors, where he made 20 starts for the Isotopes (and 9 relief appearances).He finished with a 5-8 record and 5.79 ERA.