 The common record facilitated a subsequent exploratory analysis of individual patient data by Bird and Fontaine.This suggested benefit from lower osmolarity solutions, which was then formally tested in a series of RCTs with global change to low osmolarity ORS adopted in 2001.Back in Cambridge, Bird worked with paediatrician Dr Colin Morley on the British Randomised Evaluation of ALEC Therapy (BREATHE), the first RCT to demonstrate a one-third reduced mortality in premature babies by administration at birth of artificial surfactant.