 Huntzinger pitched for the Greenville Drive of the Class A South Atlantic League in 2008 and 2009.After pitching for the Portland Sea Dogs of the Class AA Eastern League in 2011, the Red Sox assigned Huntzinger to the Arizona Fall League after the season.In 2012, after beginning the season with an 0–4 record and a 9.19 earned run average (ERA) with Portland, the team transitioned Huntzinger from a starting pitcher to a relief pitcher.