 Cers3 gene expression is located within germ cells, where it is massively upregulated during juvenile testicular maturation.This upregulation is correlated with increase in levels of glycosphingolipids containing very long chain (C26-C32) polyunsaturated fatty acid (LC-PUFA), which are required for spermatogenesis.CerS3 (T3l) mRNA is strongly expressed in skin, and was also found in brain, lung and kidney.