 In addition, isolation of adipocyte-containing stromal cells have shown adipocyte inhibition of the ability of HSCs to proliferate and form hematopoietic colonies.Of the many transcriptional regulators of hematopoiesis, nearly all induce leukemia when aberrant.Chromosomal translocation is a hallmark of leukemia, and "TAL1"-induced translocation deregulates expression at the locus, while "RUNX1"-induced translocation results in chimeric fusion proteins.