 After rallying with a larger conservative coalition, he served a final ministerial term in 1856, and was a minor contender in the princely election of 1859, also taking a seat in the Ad hoc Divan.While the "Caimacam" spent the remainder of his life abroad, his sons Ion and Adolf remained active in the administration of the United Principalities.Constantin was the father-in-law of General Gheorghe Manu, as well as the grandfather of microbiologist Ioan Cantacuzino and of poet Scarlat Cantacuzino.