 She grew up in Stewart County, Georgia and married Jonathan Windsor in 1845; after Windsor's death six years later, she married John Pryor Durham, a physician, in 1854.Cassandra Durham would often accompany her second husband when he tended to patients, and together they had four children.After her husband died in 1869, she sent her children to live with relatives and moved to Macon, Georgia to attend its Reform Medical College.