 With regards to its population, it is known that it was one of the most populated Mayan cities of the Tabasco Plain, because the cleric Juan Díaz, in his "Itinerary," speaks of the arrival of Juan de Grijalva's expedition in 1518, it "had more than two thousand Indians..."

For his part, Bernal Diaz del Castillo in "Historia verdadera de la conquista de la Nueva España", says that when they reached Potonchán, it had "over twelve thousand warriors ready to attack [in the main square], plus the riverbank was all full of Indians in the bushes..."

Peter Martyr says in his chronicle, that "the great city flanks the river of Tabasco, so great that it has twenty-five thousand houses..." This gives us an idea of the size of the city and of the quantity of inhabitants Potonchán would have had, as well as the natives that were living in nearby towns under control of Potonchán proper.The city was very inhabited, the houses were made mostly of adobe.Potonchán counted on intense commercial activity, in fact, this was the predominant activity.