 The cycloruthenation activates the aromatic ring to undergo SEAr type alkylation at the position "para" to the C–Ru bond.In Gaunt's and Yu's works, some derivatives of drug molecules and biologically active compounds were successfully functionalized in their "meta"-position.For instance, "meta"-arylated derivatives of anti-inflammatory drugs ("S")-ibruprofen and ("S")-naproxen were synthesized with copper catalyzed C–H arylation.