 He made his major league debut for the Phillies on August 21.Eickhoff's 2015 big league pitching totals included a 3-3 win-loss record with a 2.65 ERA, while he struck out 49 batters in 51 innings pitched.In 2016 (his first full season with the Phillies), Eickhoff was 11–14, with a 3.65 ERA, gave up 1.92 walks per 9 innings pitched (4th in the National League), had 20 quality starts (tied for 6th), struck out 167 batters in 197.1 innings (8th), and had a strikeout-to-walk ratio of 3.976 (9th).