 From Yale, Jegasothy's career took him to Duke University, where he worked as a clinician, educator, administrator and researcher, receiving numerous grants from pharmaceutical companies, foundations, and the National Institutes of Health.He later joined the University of Pennsylvania, before he became chairman of the dermatology department at the University of Pittsburgh in 1987, a post he held until 1999.Throughout his career Brian V. Jegasothy was a visiting professor at countless national and international universities, including Yale University, Cambridge University, and New York University.