 Near the end of the first half, Tigres defender Hugo Ayala left the game with an ankle injury.River Plate right-back Gabriel Mercado was booked soon after for a stamp on André-Pierre Gignac, leading him to miss the second leg.At the break, River manager Marcelo Gallardo made an attacking double substitution, withdrawing Rodrigo Mora and Tabaré Viúdez for Gonzalo Martínez and Nicolás Bertolo, but was also suspended after shouting at the fourth official.