 While in Denver, Wyer founded a Bibliographical Center for Research in 1934, the Western History Department in 1935, and the University of Denver School of Librarianship.Wyer served as Dean of the School from 1931 to 1948 as well as the Director of Libraries at the University of Denver during that same time.During his career, Wyer served as president of the Iowa Library Association, the Nebraska Library Association, the Nebraska Library Commission, the Colorado Library Association and the American Library Association as well as receiving numerous honors and honorary degrees that continued until his death in 1965.