 No trials have been published that examine the effectiveness of antibiotics for pulmonary exacerbations is people with cystic fibrosis and Burkholderia cepacia complex.Aerosolized medications that help loosen secretions include dornase alfa and hypertonic saline.Dornase is a recombinant human deoxyribonuclease, which breaks down DNA in the sputum, thus decreasing its viscosity.