 Some prominent corporations include Eli Lilly and Company, Nestlé, Procter & Gamble, Tempur-Pedic, Boehringer-Ingelheim, and Toys "R" Us.In 2018, April, Swift Engineering USA, an American aerospace engineering firm established their joint venture in Kobe called Swift Xi Inc.

Kobe is the site of a number of research institutes, such as the RIKEN Kobe Institute Center for developmental biology and medical imaging techniques, and Advanced Institute for Computational Science (AICS, home of the K supercomputer), the National Institute of Information and Communications Technology (NICT) Advanced ICT Research Institute, the National Research Institute for Earth Science and Disaster Prevention, and the Asian Disaster Reduction Center.International organizations include the WHO Centre for Health Development, an intergovernmental agency forming part of the World Health Organization.