 The Lipari episcopal seat was reinstated in 1131.Though still plagued by pirate raids, the island was continually populated from this time onward.Rule of the island was passed from the Normans to the Hohenstaufen Kings, followed by the Angevins, and then the Aragonese, until Carlos I, the Aragonese King, became the Spanish King, and was then quickly crowned Holy Roman Emperor Charles V.

In 1544, Hayreddin Barbarossa, together with the French fleet of Captain Polin under a Franco-Ottoman alliance, ransacked Lipari and enslaved the entire population.