 The maturation is finished with the emergence of a segmented nucleus that is specific for a mature granulocyte.The maturation of granulocytic precursors is tightly regulated at transcriptional level.Granulocyte lineage determination is regulated by expression of C/EBPα, which is necessary for the transition from CMPs to GMPs and levels of PU.1, that drive the differentation from GMPs to monocytes (high PU.1 levels) or to granulocytes (low PU.1 levels).