 At specific concentration of β-cellulin at 0.2, 2 and 20 ng/mL rapid repair was induced to corneal epithelial stem cells.During these concentrations β-cellulin promotes phosphorylation of erk1/2 signaling pathway in mice during cornea repair.To confirm this, the mutation of erk1/2 inhibited this pathway and slowed the repair of cornea cells in mice.