 On June 28, 2007, Runge was at third base when Toronto Blue Jay Frank Thomas hit his 500th career home run off Minnesota Twins pitcher Carlos Silva.Later in the game, Thomas was ejected by plate umpire Mark Wegner for arguing balls and strikes, with Toronto manager John Gibbons also getting thrown out.On Wednesday, September 3, 2008, Runge was the third-base umpire when Alex Rodriguez hit his 549th home run that bounced off a catwalk behind the left field foul pole at Tropicana Field against the Tampa Bay Rays.