 Tissone featured regularly with the Balearic outfit during the 2011–12 campaign, and returned to "Samp" in June 2012.In June 2012, Sampdoria acquired Tissone outright from Udinese for an additional €100,000.Tissone made 12 appearances in 2012–13 Serie A for Sampdoria

On 29 January 2013, Tissone returned to Mallorca, on loan until June, for €100,000.