 In contrast, the Upland South was less involved with slavery from the start.In addition, the Cotton Belt of the Deep South was controlled by Indians (mainly the Five Civilized Tribes of the Cherokee, Creek (Muscogee), Chickasaw, Choctaw, and Seminole) powerful enough to keep pioneering settlers from moving into the region.The Deep South's cotton boom did not occur until after the Indians were forced west in the early 19th century.