 On 26 June 2008, Tissone returned to Udinese for €4.165 million, with Rinaldi and Tiboni both returning to Atalanta for undisclosed fees (which Atalanta immediately write-down their value).On 22 July 2009, Tissone joined Sampdoria in a co-ownership from Udinese, for €2.5 million cash and 50% of the registration rights of Jonathan Rossini; Tissone signed four-year contract.He remained at the club for two seasons, appearing in 52 league matches and scoring once, against Brescia on 1 May 2011.