 The route runs through a mix of farms, trees, and residential and commercial development to the east of parallel Muddy Creek, curving to the northeast.PA 625 enters Brecknock Township in Berks County and becomes New Holland Road, crossing Muddy Creek and passing through forested areas with some homes.The road runs through a mix of woods, fields, and residences as it reaches a junction with PA 568 in the community of Knauers.