 Migration and settlement patterns from colonial coastal regions into the interior had been established for many decades, but the scale grew dramatically toward the end of the 18th century.The general pattern was a westward migration from the lowcountry and Piedmont regions of Virginia, North Carolina, and Maryland, as well as a southwestern migration from Pennsylvania.Large numbers of European immigrants arrived in Philadelphia and followed the Great Wagon Road west and south into the Appalachian Highlands, via the Great Appalachian Valley.