 "U-331" left Salamis on 14 January 1942 for another patrol off the Egyptian coast, this time with no success, she then sailed for La Spezia, Italy, arriving on 28 February.Her next patrol was the reverse of the previous one, she left La Spezia on 4 April, patrolled the enemy coast, then returned to Salamis on 19 April.Her next four patrols were similarly uneventful, operating from Messina, Sicily, and then La Spezia again, from May to September 1942, patrolling the North African coast without success.