 Northbound US 222 and PA 272 head northeast onto Oregon Pike, with PA 272 becoming signed again, while southbound US 222 and PA 501 continue north along Lititz Pike.The two routes continue northeast as a three-lane road with a center left-turn lane and runs past businesses and a few homes before it comes to an interchange with the US 30 freeway.Here, US 222 heads east along US 30 and PA 272 continues northeast along Oregon Pike, passing through commercial areas and narrowing to two lanes.