 (Westbound US 35 proceeds along West Third Street)

SR 49 continues north from US 35 through Trotwood along a roadway locally called the "Northwest Connector" or the "Trotwood Connector", then turns onto Salem Avenue, which crosses into Clayton.The route then briefly travels through Englewood, straddles the Englewood-Clayton line, again crosses into Clayton, then the ramps to and from Interstate 70 cross into Englewood and back into Clayton.SR 49 is then concurrent with I-70 for approximately through Clayton.