 SR 33 was established at least as early as 1919, from Thomasville northeast and north-northwet to Sylvester.At this time, SR 35 was established from the Florida state line south-southeast of Quitman to SR 33 in Moultrie.By the end of September 1921, the northern terminus of SR 33 was proposed to be extended north-northeast to SR 7 south of Cordele.