 The road widens to a four-lane divided highway and reaches a cloverleaf interchange with US 322 north of the Ephrata Cloister.Past this, the route becomes North Reading Road and runs through business areas as a three-lane road with a center left-turn lane, passing to the north of WellSpan Ephrata Community Hospital.PA 272 continues through commercial areas as it forms the border between Ephrata Township to the northwest and the borough of Ephrata to the southeast.