 At North Prince Street, southbound US 222/PA 272 turn south while PA 72 becomes two-way heading north.Both directions of US 222/PA 272 continue north along four-lane undivided North Duke Street and the road reaches the Thaddeus Stevens Bridge over Amtrak's Keystone Corridor, where it becomes the border between Manheim Township to the west and Lancaster to the east.At Keller Avenue, the road becomes Lititz Pike and fully enters Manheim Township, running through commercial areas as a five-lane road with a center left-turn lane.