 SR 49 terminates at the Ohio-Michigan state line where it continues north as Michigan State Highway 49.A portion of SR 49 in Montgomery County has been designated the "Joseph G. LaPointe Jr. Memorial Highway", in honor of the United States Army medic who posthumously received the Medal of Honor for his actions during the Vietnam War.SR 49 was first designated along its current route between US 30 in Van Wert County and the Michigan state line in 1927 having replaced a discontinuous section of SR 51.