 After crossing the Conestoga River, northbound US 222/PA 272 becomes Highland Avenue and southbound US 222/PA 272 is called South Prince Street.The southbound direction intersects PA 324 in the community of Engleside before the two routes continue into the city of Lancaster, heading into urban residential and commercial areas.A short distance after entering Lancaster, northbound US 222/PA 272 intersects the end of one-way northbound PA 324 and heads onto South Queen Street.