 The chromosomal region (locus) was named "SPCH1" (for speech-and-language-disorder-1), and it contains 70 genes.Using the known gene location of speech disorder from a boy, designated CS, of unrelated family, they discovered in 2001 that the main gene responsible for speech impediment in both KE family and CS was "FOXP2", and that this gene plays a major role in the origin and development of language.Mutations in the genes result in speech and language problems.