 The northbound direction passes to the east of Lancaster General Hospital between East James and East Frederick streets while the southbound direction passes to the east of Clipper Magazine Stadium, home of the Lancaster Barnstormers baseball team, north of the Harrisburg Avenue intersection.At the intersection with Liberty Street, northbound US 222/PA 272 shifts west a block onto four-lane undivided North Duke Street, a two-way road, while the one-way pair continues into Manheim Township.A block later, at McGovern Avenue, both directions of US 222/PA 272 rejoin along North Duke Street.