 Santana debuted for Cerro Porteño in a 3–1 away victory against Club 12 de Octubre on 16 February 2014, Santana was substituted onto the field for Fidencio Oviedo in the 83rd minute of the match.In June 2007, Santana received Paraguayan citizenship (his mother is a Paraguayan citizen born in San Ignacio, Misiones Department and Argentina did not recognize dual citizenship).He played for Paraguay in the 2007 Copa América.