 In the cell cycle field, his research has shown the discovery that cyclins are direct transcriptional targets of oncogenic and tumor suppressor signals.He showed that cyclin expression is rate-limiting for oncogene-induced breast tumor growth "in vivo".He has been a pioneer of the non-canonical functions of cyclins and was the first to show that cyclins regulate diverse function including miRNA biogenesis, cellular migration, mitochondrial metabolism (the Warburg effect), angiogenesis and nuclear receptor function and hormone signaling "in vivo".