 Here, the route becomes unsigned and follow US 222 north through Lancaster along one-way city streets.North of Lancaster, US 222 splits at an interchange with US 30 and PA 272 becomes signed again, heading northeast parallel to the freeway alignment of US 222 and passing through Akron, Ephrata (where it intersects US 322), and Adamstown.The route enters Berks County and comes to its northern terminus.