 The northern terminus is at an interchange with U.S. Route 222 (US 222) and PA 568 in Adamstown, where PA 568 continues east.The route heads from the Maryland border northwest through the western corner of Chester County, intersecting US 1 in Nottingham.PA 272 continues west into Lancaster County and intersects US 222 in Wakefield, where it turns north and passes through Buck before widening into a divided highway as it comes to another junction with US 222 in Willow Street.