 Pestell served as chair of the Division of Endocrine-Dependent Tumor Biology at the Albert Einstein Cancer Center.In 2002 Pestell was named director of the Lombardi Cancer Center, the Francis L. and Charlotte Gragnani Endowed Chair, and chairman of the Department of Oncology at the Georgetown University Medical Center.During this tenure, he also served as associate vice president of the Georgetown University Medical Center, at the Georgetown University School of Medicine.