 Some of the productions she appeared in are "The Man of Forty" (1900), "If I Were King" (1901) by her husband Justin Huntly McCarthy, "Hamlet" (1903) with E.H. Sothern, the Victor Herbert operetta "Dream City" (1906), "Venus" (1927) with Tyrone Power, Sr., "Three-Cornered Moon" (1933) with Ruth Gordon, Clare Boothe Luce's "Abide With Me" (1935), and "Little Dark Horse" (1941).As Cissie Loftus, she wrote lyrics and music for songs in a number of productions, including "The Belle of Bridgeport" (1900) and "The Lancers" (1907).Loftus also appeared in cinema from the 1910s to the 1940s, with roles that included "Clorinda Widairs" in "A Lady of Quality" (1913), "Mrs. Sinclair" in "Young Sinners" (1931) and “Grandmother Lovell” in The Old Maid (1939) "Granny Tyl" in "The Blue Bird" (1940).