 SR 49's southern terminus is west of Dayton, at the intersection of U.S. Route 35 and West Third Street in Drexel.Both Drexel (a census-designated place) and the intersection straddle the border between Trotwood and Montgomery County's Jefferson Township.The roadway carrying SR 49 continues southward (signed "east") from this intersection as US 35 (designated "C. J. McLin Jr. Parkway"), a limited-access expressway into downtown Dayton.