 His wife Amenhotep bore him three sons Djehutjmes-machet, User-pechtj, and Aa-cheper-ka-ra-nefer (who was High Priest at the Mortuary Temple of Thutmose II, lector priest) and 4 daughters Henut, Henut-nefert (a singer of Amun), Sen-seneb, and Ta-em-resefu (also a singer of Amun).Hapuseneb served as High Priest during Year 2 to Year 16 of Hatshepsut.He was buried in TT67 in Upper Egypt.