 NY 351 begins approximately east of the hamlet of West Sand Lake at an intersection with NY 43.It initially heads northeastward through the town of Sand Lake as a two-lane highway named Reichard Lake Road, passing through a residential yet wooded area in the vicinity of Racquet Lake.The woods eventually overtake the homes as the route heads away from the lake and into the town of Poestenkill; however, NY 351 quickly enters another residential area based around the route's junction with NY 66.