 In January 2015, the corporate office was moved to Boca Raton, Florida, and was renamed Cancer Treatment Centers of America Global, Inc.

Cancer Treatment Centers of America® (CTCA) was founded in 1988 by Richard J. Stephenson following the death of his mother, Mary Brown Stephenson, who died from lung cancer.Stephenson purchased the American International Hospital in Zion, Illinois in 1988 and expanded the hospital to include a radiation center, the Mary Brown Stephenson Radiation Oncology Center.That center served as the CTCA's first location.