 In "Mystery of the Urinal Deuce", it is revealed that Clyde had a colostomy at the age of five.In the episode "Quest for Ratings", after the boys resort to sensationalism to garner higher ratings for their school TV news program, Kyle reports that Clyde has only one testicle, though the truth of this is questionable.Despite his friendship with the four main characters, Clyde serves as the main antagonist of the video game "".