 Route 49 is designated as a scenic road from Route 184 (milepost 2.09) in North Stonington to milepost 12.95 (south of Route 165) in Voluntown and from the Voluntown boat launch (milepost 13.84) to the northern terminus in Sterling.In the 1920s, the road from the northeast corner of Stonington (at New England Route 17) heading north through North Stonington and Voluntown to the Sterling Hill section of Sterling was designated as State Highway 216.In the 1932 state highway renumbering, State Highway 216 was renumbered to Route 95.