 In 325 CE, Eleutheropolis was the seat of Bishop Macrinus, who in that year attended the First Council of Nicaea.Epiphanius of Salamis, Bishop of Salamis in Cyprus, was born at Eleutheropolis; at Ad nearby he established a monastery which is often mentioned in the polemics of Jerome with Rufinus and John, Bishop of Jerusalem.Beit Guvrin is mentioned in the Talmud in the 3rd and 4th centuries, indicating a revival of the Jewish community around that time.