 Kafr 'Ana actually represents a Byzantine-period expansion of a nearby and much older site –– "Kafr Juna", believed to be the ancient Ono.During early Ottoman rule in Palestine, the revenues of the village of Kafr 'Ana were in 1557 designated for the new waqf of Hasseki Sultan Imaret in Jerusalem, established by Hasseki Hurrem Sultan (Roxelana), the wife of Suleiman the Magnificent.In 1596, "Kafr 'Ana" appeared in the census located in the "Nahiya" of Ramla, part of Gaza Sanjak.