 On 21 December 1507, Charles was betrothed to 11-year old Mary, the daughter of King Henry VII of England and younger sister to the future King Henry VIII of England, who was to take the throne in two years.However, the engagement was called off in 1513, on the advice of Thomas Wolsey, and Mary was instead married to King Louis XII of France in 1514.After his ascension to the Spanish thrones, negotiations for Charles's marriage began shortly after his arrival in Castile, with the Castilian nobles expressing their wishes for him to marry his first cousin Isabella of Portugal, the daughter of King Manuel I of Portugal and Charles's aunt Maria of Aragon.