 US 61 and US 53 take the route through downtown La Crosse, which WIS 35 bypasses to the east, and it follows WIS 35 Business in Holmen.Finally, at Prescott, the Great River Road turns west on US 10 across the St. Croix River on the Prescott Drawbridge into Minnesota.On entering Minnesota, the east-side alignment of the Great River Road (here signed as the National Route) follows US 10 west and US 61 south across the Mississippi on the Hastings Bridge into Hastings, where it joins with the west-side alignment.