 The point at which the river flows from Tajikistan into Uzbekistan is, at above sea level, the lowest elevation in Tajikistan.When the Macedonian army of Alexander the Great reached the Jaxartes in 329 BCE, after travelling through Bactria and Sogdia without encountering any opposition, they met with the first instances of native resistance to their presence.Alexander was wounded in the fighting that ensued and the native tribes took to massacring the Macedonian garrisons stationed in their towns.