 Between Onward and west of Lula, it runs nearer to the river on MS 1.The routing in the vicinity of Lula is not marked; the only state-maintained road connecting to US 61 is US 49.Historically, the National Route turned off MS 1 at Greenville and followed US 82 to the Benjamin G. Humphreys Bridge (replaced by the Greenville Bridge in 2010).