 Pope Paul III appointed him administrator of Viterbo again (August 8, 1538 - May 25, 1548) and opted him for the deaconry of Santa Maria in Via Lata on May 31, 1540] as he became cardinal protodeacon.He was a member of a special commission of eleven cardinals for reform of the Roman Curia.On January 8, 1543 he was named Archbishop of Florence for second time and resigned again on May 25, 1548.