 The next step in the history of Kisspeptin involved revealing more of its pathways and the mechanism involved.Kisspeptin was found to play a role in hypogonadotropic hypogonadism in 2003, which was supported by several independent lab groups.A mutation in GPR54 was considered responsible for this abnormality because those who held this mutation, or were missing GPR54 altogether, had problems in gonadal development during puberty.