 Several other phenotypes related to this mutation included a smaller sex steroid and gonadotropin concentration in the circulating blood and even sterility.These observations prompted the research on how kisspeptin is involved during the beginning of puberty.This research led to the discovery that kisspeptin stimulates the neurons that were involved in the release of gonadotropin-releasing hormone (GnRH) and possibly may have some impact on the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).