 Today, much effort is being made to characterize the regulation of kisspeptin and its gene expression, as well as to more specifically determine the mechanism behind kisspeptin's action on GnRH and LH release.Kisspeptin is most notably expressed in the hypothalamus, but is also found in other areas of the brain including the hippocampal dentate gyrus.The hippocampus is known to integrate information on a person's spatial environment and memory.