 The road enters the town of Middlefield, where it crosses the Susquehanna River and intersects with CR 33 and CR 35B.The two-lane highway remains rural after leaving Milford, paralleling the Susquehanna back into the town of Milford for a short distance before returning to Middlefield.NY 166 continues northeastward, bending riverside northward past several farms until an intersection with CR 43.