 It is available to high-risk individuals in England through the IMPACT trial, which has a cohort size of 26,000.This was made available following the PROUD trial, a randomised control trial and a high-court battle in 2016.Use of PrEP in London, both as part of a trial and from private purchases, was partially credited in a drop in diagnoses among men who have sex with men, after a five-year plateau in diagnoses.