 Much of NY 166's southern portion is near Cooperstown, and various county routes serve as connectors between NY 166 and Cooperstown.In Cherry Valley, NY 166 intersects the former western terminus of the First Great Western Turnpike.After passing under US 20, the road continues as County Route 32, which becomes County Route 82 at the Montgomery County line, north to Sprout Brook in Montgomery County, where it meets NY 163.