 Thus the following form the core of currently characterised drug-reward circuitry; GABAergic afferents to the mesolimbic dopamine neurons (primary substrate of opiate reward), the mesolimbic dopamine neurons themselves (primary substrate of psychomotor stimulant reward), and GABAergic efferents to the mesolimbic dopamine neurons (a secondary site of opiate reward).Dysfunctional motivational salience appears in a number of psychiatric symptoms and disorders.Anhedonia, traditionally defined as a reduced capacity to feel pleasure, has been reexamined as reflecting blunted incentive salience, as most anhedonic populations exhibit intact “liking”.