 In fact, all of the wolves' DNA on Isle Royale can be traced back to one ancestor.Inbreeding leads to inbreeding depression and fitness problems, often accompanied by violent social rejection by other wolves.When the study began in 1958, many researchers believed the two species would eventually reach a population equilibrium of about 25 wolves and 1,500 moose; but there has been no sign of this, with populations fluctuating unpredictably.