 Though Henry did not participate directly, historian sees him as the royal most responsible for the massacre, which involved the targeted killing of many key Huguenot leaders.Henry III's reign as King of France, like those of his elder brothers Francis and Charles, would see France in constant turmoil over religion.Henry continued to take an active role in the Wars of Religion, and in 1572/1573 led the siege of La Rochelle, a massive military assault on the Huguenot-held city.