 Typically, odd-numbered Interstates run south-north, with lower numbers in the west and higher numbers in the east; even-numbered Interstates run west-east, with lower numbers in the south and higher numbers in the north.Highways whose route numbers are divisible by "5" usually represent major coast-to-coast or border-to-border routes (ex.I-10 travels from Santa Monica, California, to Jacksonville, Florida, traveling from the Pacific to Atlantic oceans).