"Lange began the new millennium with a London stage production of Eugene O'Neill's "Long Day's Journey into Night", playing the part of the morphine-addicted Mary Tyrone, for which she became the first American actress to receive an Olivier Award nomination.She appeared mostly in supporting roles thereafter, most notably opposite Christina Ricci in the 2001 adaptation of Elizabeth Wurtzel's best-selling memoir on depression, "Prozac Nation".