 Crown efforts against these groups began in earnest in the late sixteenth century, but a major rebellion broke out in 1606 in the areas of Villa Rica, Nueva Veracruz, Antón Lizardo, and the Rio Blanco area.However, the gravest of these occurred in the Orizaba area, where there were about 500 fugitive slaves.In 1609, a leader named Gaspar Yanga led an insurrection against the Spanish but was defeated in battle.