 Anastasiadis began his career at Heidelberg United before being signed by the Greek club PAOK Thessaloniki FC at the age of 19.He made his debut in 1988 and became an influential part of the team, playing in 18 Alpha Ethniki matches, 5 cup games and 24 friendlies in the 1988/89 season, scoring 12 goals in total.He also took part in the club's brief 1990/91 and 1991/92 UEFA Cup campaigns.