 Based on these case studies, most evidence suggests that the abnormal lining of lesions found in Ollier disease would suggest that the condition is caused by a post-zygotic somatic mutation thus resulting in a mosaic genetic disorder.Approximately 8-10% of cases of patients with Ollier disease have been linked to PTH1R mutations.A particular case study the mutant heterozygous PTHR1 (R150C) receptor was observed in two unrelated patients with Ollier disease.