 She became a person of confidence for the Secretary-General of the Socialist Party Pedro Sánchez and he appointed her in 2017 as Secretary for Equality of the Socialist Workers' Party.On June 5, 2018, it was announced that Prime Minister Pedro Sánchez would appoint Calvo as Deputy Prime Minister and Minister of the Presidency, Relations with the Cortes and Equality being this the first time that the Ministry of the Presidency assume also the competencies over equality.She was sworn in before the King at Palace of Zarzuela on 7 June 2018.