 He started his club career in the youth teams of Livorno and Ternana, and later played for the Pistoiese senior side (1925–1929), before joining the senior team of Fiorentina, where he played between 1929 and 1936, playing 197 matches and scoring three goals.Pizziolo played twelve matches for Italy between 1933 and 1934, scoring one goal.He was a part of the side that won the 1934 FIFA World Cup on home soil, in which he played one game, the first leg of the quarter-finals against Spain, in which he was roughly hit (he had one of his legs broken) in an eventual 1–1 draw after extra-time.