 The conversion of cytosine to 5-methylcytosine (5mC) in DNA by DNA methyltransferase DNMT3A appears to be an important type of epigenetic modification occurring in the SVZ.In addition, some current theories propose that the SVZ may also serve as a site of proliferation for brain tumor stem cells (BTSCs), which are similar to neural stem cells in their structure and ability to differentiate into neurons, astrocytes, and oligodendrocytes.Studies have confirmed that a small population of BTSCs can not only produce tumors, but they can also maintain it through innate self-renewal and multipotent abilities.