 Recent studies have shown that most cases of Ollier disease are believed to have been caused by isocitrate dhydrogenases IDH1 and IDH2 mutations.In one study, 35 of 43 (81%) patients with Ollier disease had either a IDH1 or IDH2 mutation.Another study suggests that R132C IDH1 mutations which are particularly dominant at exon 4 of IDH genes are linked to the growth of vascular lesions.