 Deoxyadenosine triphosphate is able to be enzymatically synthesized with DNA as the starting material using deoxyribonuclease (DNase), nuclease P1, adenylate kinase, and pyruvate kinase.The synthesis starts with the heat denaturation of DNA followed by treatment with DNase I to produce oligomers.Next, the solution is treated with nuclease P1 to form deoxynucleoside monophosphates.