 The road along the east bank of the Mystic River, connecting the villages of Mystic and Old Mystic, was a secondary state highway in the 1920s, with designation Highway 344.In the 1932 state highway renumbering, old Highway 344 was renumbered to Route 169.In 1950, a new state highway was established, Route 27, which connected the village of Poquetanuck in the town of Preston (at Route 12), through Ledyard Center, to Burnetts Corner in Groton (at Route 184).