 In the 2010–11 season Biava made 36 appearances, guiding Lazio to a strong 5th-place finish.In the 2011–12 season, Biava was limited to 31 appearances due to muscle issues.He made a career high 43 appearances in all competitions in the 2012–13 season, leading Lazio to the quarter finals of 2012–13 UEFA Europa League where they were knocked out by Fenerbahçe, and helped Lazio defeat traditional rivals A.S. Roma to win the 2012–13 Coppa Italia.