 Maffucci syndrome can be distinguished clinically by the presence of hemangiomas and lymphangiomas and genetically through R132C IDH1 hotspot mutations.Hereditary multiple exostoses (HME) features osteochondromas which are near the surface the bone whereas enchondromas featured in Ollier disease and Maffucci are more towards the center of the bone.Also, neural compressions are more commonly found in hereditary multiple exostoses (HME) than in Ollier disease.