 This experiment represents the first in-vivo model of Alzheimer's Disease that features both beta-amyloid plaques and hyperphosphorylated tau protein.This study also demonstrates that BMAA, an environmental toxin, can trigger neurodegenerative disease as a result of a gene-environment interaction.Degenerative locomotor diseases have been described in animals grazing on cycad species, fueling interest in a possible link between the plant and the etiology of ALS/PDC.