 The Guaycura were initially resistant to the missionary endeavors of the Jesuits.In 1716, the first attempt, led by Jesuit Juan María de Salvatierra, to establish a mission and a Spanish settlement among the Guaycura at La Paz resulted in the death of several Guaycura women at the hands of Indian followers of the Jesuits.The first Jesuit mission among the Guaycura was at La Paz and it was intended to serve not only as a missionary center, but as a rest and resupply stop for the Manila galleons returning from the Philippines.