 The Gap and Newport Turnpike was charted in 1807 to run from Gap southeast to the Delaware border, where it was to continue to Newport, Delaware.PA 41 was first designated in 1926 to run between US 22/PA 3/PA 13 in Harrisburg and US 22/PA 3 and US 120/PA 13 in Reading, following US 230 between Harrisburg and Lancaster and US 222 between Lancaster and Reading.PA 41 was rerouted at Lancaster to run southeast to the Delaware border in 1928, heading south from Lancaster to Lampeter along US 222/PA 72 before it turned east to Gap and southeast along the Gap Newport Pike.