 The road reaches the commercial downtown of Mifflinburg, where it reaches an intersection with the western terminus of PA 304.Following this, the route continues through residential areas before it heads into business areas as a three-lane road with a center left-turn lane, becoming the border between West Buffalo Township to the north and Mifflinburg to the south.PA 45 fully enters West Buffalo Township briefly before it crosses into Buffalo Township, where it becomes two-lane undivided Old Turnpike Road.