 On May 9, 1966, the eastern terminus of PA 45 was cut back from Easton to its current location at PA 642 in Mooresburg.The former alignment east of Mooresburg became PA 642 between Mooresburg and Mausdale, an extended PA 54 between Mausdale and Nesquehoning, solely US 209 between Nesquehoning and Weissport, and newly-designated PA 248 between Weissport and Easton.This change was made to remove several concurrencies, while the extension of PA 54 to replace PA 45 between Mausdale and Nesquehoning was made to provide a direct connection with I-80.