 PA 41 was first designated in 1926 to run from US 22/PA 3/PA 13 in Harrisburg to US 22/PA 3 and US 120/PA 13 in Reading, heading southeast through Middletown, Elizabethtown, and Mount Joy to Lancaster, where it turned northeast and passed through Ephrata on its way to Reading.PA 41 ran concurrent with US 230 between Harrisburg and Lancaster and US 222 between Lancaster and Reading.In 1928, PA 41 was rerouted at Lancaster to head southeast to the Delaware border near Kaolin.