 The road passes through farmland with some homes a short distance to the west of Short Mountain.The route crosses into Spruce Creek Township and heads into forested areas, curving northwest to run parallel to Norfolk Southern's Pittsburgh Line and the Little Juniata River which are both located northeast of the road.PA 45 turns northeast and comes to a one-lane underpass that carries the route under Norfolk Southern's Pittsburgh Line before it turns southeast and runs between the river to the northeast and the railroad tracks to the southwest as a two-lane road.