 Meanwhile the Guaycura were being devastated by introduced European diseases such as measles and smallpox.In 1748, after many years of frustration, the Jesuits decided to concentrate the southern bands of the Guaycura into a single settlement at Misión Todos Santos.There, the Jesuits forcibly detained the Guaycura children at the mission and their parents and relatives "for love of the children remained pacified."