 SH-46 begins at US-60/US-283/SH-51 on the west side of Arnett.The road runs north to the junction of SH-15 at Gage, then continues another to May, where it crosses US-270/US-412/SH-3.Three miles north of May, SH-46 crosses the North Canadian River, and after that, SH-149 branches off to the west, connecting to the town of Laverne.