 Unlike the BINAP-Ru, the BINAP/diamine-Ru catalytic system forms the six membered pericyclic transition state(Transition state model on the left) which directly leads to the product.This non-classical metal-ligand bifunctional transition state facilitates the hydrogenation of C=O bond with higher rate and the higher chemoselectivity.The RuCl2 (diphosphane)2 (diamine)2 catalyst can hydrogenate simple cyclic ketones diastereoselectively.