 Further developed from previously introduced BINAP-Ru dicarboxylate catalyst, the BINAP-Ru dihalide catalyzes the asymmetric hydrogenation of various α-,β- functionalized ketones.The reaction is limited to ketones that are functionalized with nearby nitrogen, oxygen or halide substituents.Unlike the BINAP-Ru dihalide catalyst that requires functionalized ketone, the BINAP/diamine-Ru catalyst is effective for the asymmetric reduction of both functionalized and simple ketones, and BINAP/diamine-Ru catalyst can catalyze aromatic, heteroaromatic, and olefinic ketones enantioselectively.