 In 1932, a western section of PA 45 was opened from Belsano to US 22 near Sankertown and Cresson.The route replaced US 422 from Belsano to Ebensburg and US 22 from Ebensburg to Cresson when those designations were placed on a straighter route.In 1936, the eastern terminus of the middle section was moved from Montandon to Mausdale.