 βCTF recruits APPL1 to rab5 endosomes, where it stabilizes active GTP-rab5, leading to pathologically accelerated endocytosis, endosome swelling and selectively impaired axonal transport of rab5 endosomes.PKR and Tau phosphorylation

It is reported earlier that phosphorylated PKR could co-localize with phosphorylated Tau protein in affected neurons.A protein phosphatase-2A inhibitor (PP2A inhibitor) – Okadaic acid (OA) – is known to increase tau phosphorylation, Aβ deposition and neuronal death.