 As with all Northside ISD schools, Holmes is named for a former or current United States Supreme Court justice, in this case Oliver Wendell Holmes, Jr. Holmes High School is also the parent school for Business Careers High School, a magnet school in NISD.In 2017, the Holmes was rated "Met Standard" by the Texas Education Agency, with a 6-Star Distinction for Academic Achievements in ELA/Reading, Mathematics, Social Studies, Top 25 Percent Student Progress, Top 25 Percent Closing Performance Gaps, and Postsecondary Readiness.Holmes serves a little more than 2,000 students in grades 9-12 from neighborhoods and subdivisions along the IH-410 Loop corridsor.