 The route becomes a divided highway and comes to a partial interchange with the US 322 freeway, with a ramp to westbound US 322 and a ramp from eastbound US 322; the missing movements are provided by US 322 Bus.Past this interchange, the road becomes undivided again and heads east-northeast through a mix of farmland and housing developments, passing to the north of a golf course.PA 45 heads into Potter Township, at which point it continues into the Penns Valley.