 PA 45 turns northeast into wooded areas with some farm fields and comes to its eastern terminus at an intersection with PA 642.From approximately 1830 to 1903, the section between Lewisburg and Mifflinburg was owned and operated by the Lewisburg and Mifflinburg Turnpike Company.The section west of Mifflinburg (formerly Youngmanstown) was built by the Bellefonte, Aaronsburg and Youngmanstown Turnpike Company, chartered in 1825.