 The northern terminus is at PA 144 in the Snow Shoe Township community of Moshannon.PA 53 begins at an interchange with the US 219 freeway in Croyle Township, Cambria County, heading east-northeast on four-lane divided Railroad Street.The road narrows into a two-lane undivided road as it heads through wooded areas to the south of Norfolk Southern's Pittsburgh Line, crossing the Little Conemaugh River into the borough of Summerhill.