 He finished the 2016 season with 89 combined tackles (48 solo), a career-high 13 pass deflections, four interceptions, a sack, and a forced fumble in 16 games and 16 starts.Weddle earned an overall grade of 92.4 from Pro Football Focus which was the highest among all qualified safeties in 2016.On January 23, 2017, it was announced that Weddle was selected to play in the 2017 Pro Bowl to replace safety Devin McCourty who reached Super Bowl LI as a member of the New England Patriots.