 The series was produced by Brillstein Entertainment Partners and Touchstone Television partnered with ABC Studios and executive produced by Christina Applegate, Donald Todd, Peter Traugott, Bob Kushell, Alex Reid, and Marco Pennette.The show centered on Samantha Newly (Christina Applegate), a 30-year-old vice president of a real estate firm who develops retrograde amnesia after a hit and run accident.After awakening, she progressively realizes to her dismay that she had been selfish and unlikable before her accident, and therefore sets out to make amends and become a better daughter to her somewhat dysfunctional parents, Howard (Kevin Dunn) and Regina (Jean Smart), a better friend to self-centered Andrea (Jennifer Esposito), and needy but well-meaning Dena (Melissa McCarthy), and a better on-again, off-again girlfriend to her roommate and ex-boyfriend, Todd (Barry Watson).