 In Week 14, he made three combined tackles, a pass deflection, and recorded his seventh interception of the season in a 37–10 win against the Buffalo Bills.On December 26, 2011, Weddle was voted to play in the 2012 Pro Bowl, marking the first selection of his career.Weddle finished the season with 88 combined tackles (70 solo), 11 passes defensed, and a career-high seven interceptions in 16 games and 16 starts.