 Head coach Norv Turner named Weddle and Hart the starters to begin the regular season.Weddle made his first NFL start in the season-opener against the Carolina Panthers and recorded a season-high 11 combined tackles (seven solo) and deflected a pass in their 26–24 loss.On September 22, 2008, Weddle recorded seven combined tackles, a pass deflection, and intercepted a pass by Brett Favre during a 48–29 victory on Monday Night Football against the New York Jets in a Week 3.