 On September 20, 2009, Weddle collected a season-high ten combined tackles (nine solo) during a 31–26 loss to the Baltimore Ravens in Week 2.The following week, Weddle recorded seven combined tackles, a pass deflection, and returned an interception for his first career touchdown in a 23–13 win against the Miami Dolphins in Week 3.Weddle intercepted a pass by quarterback Chad Henne, that was intended for wide receiver Davone Bess, and returned it for a 31-yard touchdown in the fourth quarter.