 The interception marked his first pick as a member of the Ravens and 
became his 20th interception of his career.On December 12, 2016, Weddle collected a season-high 11 combined tackles (six solo), deflected a pass, a sack, and intercepted a pass attempt by quarterback Tom Brady during a 23–30 loss at the New England Patriots in Week 14.On December 21, 2016, it was announced that Weddle was selected to be a second-team alternate for the 2017 Pro Bowl.