 Weddle later stated he was able to play and he was told he was unable to travel with the team due to the limited size of the plane.Head coach John Harbaugh officially named Weddle the starting strong safety to begin the regular season, alongside free safety Lardarius Webb.On September 18, 2016, Weddle recorded six combined tackles, a pass deflection, and intercepted a pass by Josh McCown in a 25–20 victory at the Cleveland Browns.