 In Week 2, Weddle recorded a season-high 11 combined tackles (eight solo) in a 35–21 loss at the New England Patriots.On October 31, 2011, he made seven solo tackles, two pass deflections, and intercepted two pass attempts by quarterback Matt Cassel in the Chargers' 23–20 overtime loss at the Kansas City Chiefs in Week 8.His performance marked the first game of his career with multiple interceptions.