 Lupattelli claims he studied perspective under the mathematician Lemme Rossi.Amedei later opened a studio/school in Perugia.He painted for the chapel of the Madonna Addolorata in the church of Santa Maria Nuova; an altarpiece of the "Sorrowful Virgin before the Cross", and two lateral paintings depicting the "Presentation of Mary at the Temple" and the "Marriage of Mary", and smaller paintings of "Jesus with the crown of thorns" and "St Paul".