 However, in some notable cases, gloveboxes used for aseptic processing have provided no more sterile product protection than the traditional laminar air flow hood (LAF) design of the 1960s.In these cases, the glove boxes were problematic due to inappropriate design or controls (e.g., insufficient disinfection, transfer of contaminated materials, ingress of lower quality air into glovebox, poor design/integrity, poor transfers).However, if gloveboxes are very meticulously designed, thoroughly disinfected (e.g., using a sporadical) and carefully operated by well-trained aseptic processing personnel to prevent introduction of microbial contamination, it is possible to obtain some degree of increased sterile product protection versus the simple traditional LAF hood.