 DE 48 crosses Little Mill Creek and comes to an intersection with DE 100/DE 141, at which point DE 100 forms a concurrency with DE 48.The two routes head southeast as a four-lane undivided road, crossing Chestnut Run and passing through residential and commercial areas.The road crosses an East Penn Railroad line at-grade and runs to the north of a cemetery, with DE 100 splitting from DE 48 by turning south on South Dupont Road as it passes south of the Cab Calloway School of the Arts and Charter School of Wilmington.