 In Week 17, he collected a career-high 16 combined tackles (11 solo) and deflected a pass in a 34–20 loss at the Cincinnati Bengals.He finished his fourth season in the league with 96 combined tackles (80 solo), ten pass deflections, two interceptions, a touchdown, and was credited with half a sack in 16 games and 16 starts.Pro Football Focus gave Weddle an overall grade of +12.6 in 2010.