 During the 2007 combine, Weddle ran a 1.43 10 yard time, tying him with Aundrae Allison and Marcus McCauley for the then fastest split time recorded at the NFL combine.The San Diego Chargers selected Weddle in the second round (37th overall) of the 2007 NFL Draft.The Chargers traded their second round pick (62nd overall), third round pick (93rd overall), and fifth round pick (167th overall) in the 2007 NFL Draft, as well as their third round pick (90th overall) in the 2008 NFL Draft to the Chicago Bears in order to move up in the second round and draft Weddle.