 In Week 4, Weddle recorded a season-high eight combined tackles, two pass deflections, and an interception in the Ravens' 26–9 loss to the Pittsburgh Steelers.On December 3, 2017, Weddle made three combined tackles, a pass deflection, recorded a strip/sack, and returned an interception for a touchdown during a 44–20 victory against the Detroit Lions in Week 13.He returned an interception by quarterback Jake Rudock for a 45-yard touchdown in the fourth quarter and recorded a strip/sack on Matthew Stafford that was recovered by teammate Willie Henry in the second quarter.