 Due to the role of MMPs in pathological conditions, inhibitors of MMPs may have therapeutic potential.Several other proteins have similar inhibitory effects, however none as effective (netrins, procollagen C-terminal proteinase enhancer (PCPE), reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and tissue factor pathway inhibitor (TFPI-2)).They might have other biological activities which have yet been fully characterised.