 It showed good disease stability and tolerance in Phase I solid tumor trials and good tolerance in advanced cancer in combination with Etoposide.However, its efficacy was not proven to be adequate.Tanomastat showed significant hepatotoxicity in a cancer therapy combined with Cisplatin and Etoposide, although in a treatment with Doxorubicin it showed good tolerance and lowered toxicity with 5-fluorouracil and Leucovorin.Many compounds in the thiol zinc-binding groups have good water solubility and are air stable in plasma and these groups will be continued in MMP inhibitor designing.