 The transformation can also performed biologically by methane monooxygenase.Overall Transformation

RH + H2O + [PtCl6]2− → ROH + 2H+ + PtCl2 + 4Cl−

The initial and rate limiting step involving the electrophilic activation of RH2C-H by a PtII center to produce a PtII-CH2R species and a proton.The mechanism of this activation is debated.