 The city is the economic and cultural hub of the Cincinnati metropolitan area, the fastest growing economic power in the Midwestern United States based on increase of economic output, which had a population of 2,190,209 as of the 2018 census estimates.This makes it Ohio's largest metropolitan area and the nation's 29th-largest.With a city population estimated at 303,940, Cincinnati is the third-largest city in Ohio and 64th in the United States.