 There are genetic risk alleles that are predictive of the development of DIHS for particular drugs and ethnic populations.The most important of which is abacavir (an anti-viral used in the treatment of HIV) hypersensitivity associated with the presence of the HLA-B*5701 allele in European and African population in the United States and Australians.AGEP is often caused by antimicrobial, anti-fungal or antimalarial drugs.