 The most well known example is carbamezepine (an anti-convulsant used to treat seizures) hypersensitivity associated with the presence of HLA-B*5801 genetic allele in Asian populations.DIHS is a delayed onset drug eruption, often occurring a few weeks to 3 months after initiation of a drug.Worsening of systemic symptoms occurs 3–4 days after cessation of the offending drug.