 In 2007, alongside Gayle Smith, Prendergast co-founded the Enough Project, a policy organization aimed at countering genocide and crimes against humanity.He is also a co-founder along with George Clooney of The Sentry, an investigative initiative created to uncover the financial networks behind conflicts in Africa and whose Board of Directors includes Clooney, Don Cheadle, Matt Damon, and Brad Pitt.Together, Clooney and Prendergast had also previously co-founded the Satellite Sentinel Project, which aimed to prevent conflict and human rights abuses through satellite imagery.