 It is hoped that caloric restriction reduces the incidence of cardiovascular disease and cancer and leads to a longer life, as has been demonstrated previously in numerous animal studies.CALERIE is the first study to investigate prolonged calorie restriction in healthy humans, which is practiced and advocated for by the members of the Calorie Restriction Society.Study subjects are selected from people who are not obese (because calorie restriction on obese people is already known to lengthen life, but possibly for different reasons).