 Binding of psalmotoxin to ASIC1a is reported to increase the affinity of ASIC1a for H+.This increase in affinity for H+ results in the shift of ASIC1a into the desensitized state at resting H+-concentrations (pH = 7.4).The channel being desensitized means that the ion channel is bound to its ligand, H+, but is not able to let ions pass through the ion channel.