 The replacement enabled substitutions to the CH-group at the 5-position of the central aromatic ring.One of the first DAPY compounds, dapivirine (with R1= 2,4,6-trimethylanilino, R2 = R3 = H and Y = NH) was found to be effective against drug-resistant HIV-1 strains.Systematic chemical substitutions were made at the R1, R2, R3 and Y positions to find new DAPY derivatives.