 He made his first Premier League appearance of the season on 2 January 2012 when he replaced midfielder Aaron Ramsey for the last ten minutes against Fulham after centre-back Johan Djourou was sent off.Arsenal went on to lose the match 2–1 as Squillaci's clearing header in the 92nd minute of the match fell to the feet of Bobby Zamora, who scored a volley to give Fulham all three points.On 17 February, Squillaci came on as an early substitute in Arsenal's fifth round FA Cup match at Sunderland after Francis Coquelin sustained an injury, with regular defenders Per Mertesacker and Laurent Koscielny already missing through injury.