 Along with Fray Toribio de Benavente Motolinia he built the first European settlement at Puebla, Puebla.Before arriving in the New World, Salmerón earned a doctor of law degree and was counselor to Emperor Charles V. Later he was alcalde of Castilla de Oro, in Central America.After the criminal disaster of the First Audiencia of Mexico City, Emperor Charles V carefully chose five upstanding men to replace them, as the Second Audiencia.