 He first became involved with the Sicilian Mafia in 1945, and in the following years he became a full-fledged member of the Porta Nuova mandamento, where he worked mostly in cigarette smuggling.Buscetta married his first wife Melchiorra Cavallaro in 1944 and had three children.In 1949, he moved to Argentina and then to Brazil, where he opened a glassworks store, but in 1956, he returned to Palermo where he joined Angelo La Barbera and Salvatore "Ciaschiteddu" Greco together with mafiosi Antonino Sorci, Pietro Davì and Gaetano Badalamenti, dealing with the cigarette and drug smuggling.