 Unconjugated hyperbilirubinemia in a newborn can lead to accumulation of bilirubin in certain brain regions (particularly the basal nuclei) with consequent irreversible damage to these areas manifesting as various neurological deficits, seizures, abnormal reflexes and eye movements.This type of neurological injury is known as kernicterus.The spectrum of clinical effect is called bilirubin encephalopathy.