 One of the better-characterized genes responsible for hereditary haemochromatosis is "HFE" on chromosome 6, which codes for a protein that participates in the regulation of iron absorption.The "HFE" gene has three common mutations, C282Y, H63D and S65C.The C282Y allele is a transition point mutation from guanine to adenine at nucleotide 845 in "HFE", resulting in a missense mutation that replaces the cysteine residue at position 282 with a tyrosine amino acid.