 Most, if not all, males homozygous for "HFE" C282Y show manifestations of liver dysfunction such as elevated liver-specific enzymes such as serum gamma glutamyltransferase by late middle age.Each patient with the susceptible genotype accumulates iron at different rates depending on iron intake, the exact nature of the mutation, and the presence of other insults to the liver, such as alcohol and viral disease.As such, the degree to which the liver and other organs are affected is highly variable and is dependent on these factors and co-morbidities, as well as age at which they are studied for manifestations of disease.