 The first two volumes each feature 120 of the artists' favorite "Cyanide & Happiness" comics, and 30 previously unpublished comics.The third volume featured many "Cyanide & Happiness" comics from their Depressing Comic Weeks with 40 previously unpublished comics,
while the fourth is another compilation of the artists' favorites.In addition to creating "Cyanide & Happiness" comic strips, the cartoonists have done animations drawn in a similar stick figure style.