 After being linked with a move to Internazionale, he ultimately stayed at Lazio and, immediately after the replacement of head coach Davide Ballardini with veteran manager Edoardo Reja, he made his 2009–10 season debut on 14 February, being featured in the starting lineup in a 2–0 win at Parma.Since his return on the pitch, Ledesma immediately established himself back into being a key player for the "biancazzurri".On 23 August 2010, Ledesma signed a new contract with Lazio, extending his link until 2015.