 In his 2010–11 campaign, he was one of the protagonists of Lazio's surprising start that led the Rome club to even top the Serie A table for a few weeks between October and November.Lazio ended their 2011–12 season campaign qualifying once again for Europa League and only just missing out to Udinese by goal difference in a Champions League spot.On 1 July 2015 Ledesma was released, after not having his contract renewed.