 Beginning in the early 1900s "Drosophila" entered the research laboratories and opened up the doors for other model organisms like Tobacco mosaic virus, E. coli, C57BL/6 (lab mice), etc.These organisms have led to many advances in the past century.Some of the first work with what would be considered model organisms started because Gregor Johann Mendel felt that the views of Darwin were insufficient in describing the formation of a new species and he began his work with the pea plants that are so famously known today.