 Dendritic cells have been found to be suppressed by a CTLA-4-CD80 interaction and this interaction also promotes the suppressive effects of regulatory T cells, which can prevent an immune response to self-antigen.In addition to interactions with CD28 and CTLA-4, CD80 is also thought to interact with a separate ligand on Natural Killer cells, triggering the Natural Killer cell-mediated cell death of the CD80 carrier.CD80 may also play a role in the negative regulation of effector and memory T-cells.