 Spicer is an ambassador for World Vision, the World Wide Fund for Nature (WWF), the Queensland University of Technology's Learning Potential Fund and the Penguin Foundation, and Patron of the NSW Cancer Council, the newborn care unit at the Royal Hospital for Women, the Life's Little Treasures Foundation and the National Premmie Foundation.She is also an Ambassador for Dying with Dignity, and is the face of the Garvan Institute of Medical Research’s research into pancreatic cancer, the disease responsible for her mother's death.In January 2011, Spicer interviewed anti-vaccination campaigner, Meryl Dorey (Australian Vaccination Network now Australian Vaccination-Skeptics Network) on 2UE.