 Switched from linebacker to fullback before his first season with USC, Powdrell rushed for 9 yards on 2 carries, and caught 4 passes for 72 yards and a touchdown in USC Trojans' 2006 season opening 50-14 win against the Arkansas Razorbacks but suffered a season-ending injury early in the second game against Nebraska.After going undrafted in the 2007 NFL Draft, Powdrell signed with the Green Bay Packers on May 4, 2007.He spent his rookie season on injured reserve.