 Because of social allowance, Little was able to take new ideas of ‘pure genetic strains’ merging from plant genetics as well as work with "Drosophila" and run with them.The idea of inbreeding to achieve this goal of a ‘pure strain’ in mice was one that may have created a negative response to the fertility of the mice thus discontinuing the strain.Little achieved his goal of a genetically pure strain of mice by 1911 and published his finding shortly thereafter.