 Depending on the type of analyte, other species may be formed, such as multiple charged adducts .DART categorized under soft ionization technique.Fragmentation can be rarely observed for some molecules.Use of DART compared to traditional methods minimizes sample amount, sample preparation, eliminates extraction steps, decreases limit of detection and analysis time.Also it provides a broad range sensitivity, simultaneous determination of multi-drug analytes and sufficient mass accuracy for formulation determination.