 It was during this period that American Bison began a periodic east–west trek through Indiana, crossing the Falls of the Ohio and the Wabash River near modern-day Vincennes.These herds became important to civilizations in southern Indiana and created a well-established Buffalo Trace, later used by European-American pioneers moving west.Before 1600, a major war broke out in eastern North America among Native Americans; it was later called the Beaver Wars.