 When NY 160 was originally assigned in 1930, it began at NY 5S south of Amsterdam and proceeded southeast through the town of Florida on Thayer Road to the hamlet of Scotch Church near the Montgomery–Schenectady County line.Here, it turned northeast to follow Scotch Church Road through the Rotterdam to the hamlet of Pattersonville, where it rejoined NY 5S.South of Scotch Church, what is now NY 160 was designated as NY 407 around the same time.