 ColD is a PLP-dependent enzyme responsible for the removal of the C-3' hydroxyl group during the biosynthesis of GDP-colitose.It is a product of the "Wbdk" or "ColD" genes in "Escherichia coli" O55 or "Salmonella enterica", respectively, and is commonly referred to as ColD.Although the sugar is relatively rare, recent work with glycosyltransferases suggests that obscure sugars such as colitose can be incorporated into existing natural-product scaffolds, thereby constructing novel and potentially therapeutic compounds.