 Prior to his service in the federal government, Agwunobi served as Florida's secretary of health under Governor Jeb Bush from 2000 to 2005.He led Florida's public health response to four major hurricanes that struck the state in 2004.In addition, Agwunobi led the Department's response to the nation's first anthrax attack, subsequently guiding the state's nationally recognized efforts to prepare for, prevent and mitigate the effects of a bioterrorism attack.