 The Galveston Hurricane of 1900 is the deadliest natural disaster in the United States, killing an estimated 6,000 to 12,000 people in Galveston, Texas.Hurricane Mitch caused more than 10,000 fatalities in Central America, making it the second deadliest Atlantic hurricane in history.Hurricane Iniki in 1992 was the most powerful storm to strike Hawaii in recorded history, hitting Kauai as a Category 4 hurricane, killing six people, and causing U.S. $3 billion in damage.