 In contrast, unvaccinated individuals typically have a fever of 102, 200-500 skin lesions and macules (lesions that are not elevated) evolve to papules and vesicular lesions.Additionally, infection in unvaccinated individuals tends to last for a longer period of time than in individuals who have been infected.The majority of cases of breakthrough varicella are attributed to the failure of an individual to uptake the varicella vaccine.