 The Colorado Eastern Plains, Nebraska Panhandle and Albany County, Wyoming, among other areas, are culturally and economically tied to the region, though they are not considered to be a part of it.The region was established, along with ten other megaregions throughout the United States, by America 2050 in response to President Barack Obama’s efforts to improve the country’s infrastructure.The megaregions were initially identified by America 2050 as areas that should have highspeed rail by 2050.