 Agwunobi has served as vice-chair of the United States African Development Foundation,.He has served as a board adviser to Shopko, a specialty retail store holding corporation and board director for Magellan Health Services 

Agwunobi has a master degree in public health from Johns Hopkins University, a master of business administration from Georgetown University, and a certification as a managed care executive from the American Association of Health Plans (AAHP).He completed his pediatric residency at Howard University Hospital in Washington, DC, rotating between Children's National Medical Center and the District of Columbia General Hospital.