 It has a plasma half-life of 22min, mean clearance rate of 274 mL/kg/min, and apparent volume of distribution of 880 ± 150 mL/kg.Adrenomedullin (AM) exerts its actions through combinations of the calcitonin receptor like receptor (CALCRL) or CLR; and either (Receptor activity-modifying protein) 2 (RAMP2) or RAMP3, (known as AM1 and AM2 receptors respectively).Both transduce the hormone binding to intracellular signaling via second messenger cascades.