 Furthermore, she showed that the heterogeneity of the microenvironment within SCCs with regard to TGF-β signaling resulted in cells rich in TGF-β that were chemotherapy resistant to be cells located close to the perivasculature.She showed the ability of TGF-β to cause upregulation of the glutathione pathway, which allowed the SCCs to counter the radical oxygen species often used in radiotherapy and chemotherapy.Fuchs determined that both the factors internal to the cell and the cell's external surrounding environment have an effect on the stem cells’ niche in both their ability to divide and how they divide.