"Some of the team's oldest and most frequent enmities have involved such foes as the Mole Man, the Skrulls, Namor the Sub-Mariner, Doctor Doom, the Puppet Master, Kang the Conqueror/Rama-Tut/Immortus, Blastaar, the Frightful Four, Annihilus, Galactus, and Klaw.Other prominent antagonists of the Fantastic Four have included the Wizard, the Impossible Man, the Red Ghost and the Super-Apes, the Mad Thinker, the Super-Skrull, the Molecule Man, Diablo, Dragon Man, Psycho-Man, Ronan the Accuser, Salem's Seven, Terrax the Tamer, Terminus, Hyperstorm and Lucia von Bardas.