title: Prion

text: Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It is not known what causes a normal protein to misfold, but the resulting abnormal three-dimensional structure confers infectious properties by collapsing nearby protein molecules into the same shape.


title: Prion

text: The word "prion" is derived from the term, "proteinaceous infectious particle". In comparison to all other known infectious agents such as viroids, viruses, bacteria, fungi, and parasites, all of which contain nucleic acids (DNA, RNA, or both), the hypothesized role of a protein as an infectious agent stands in contrast.


title: Prion

text: Prion isoforms of the prion protein (PrP), whose specific function is uncertain, are hypothesized as the cause of transmissible spongiform encephalopathies (TSEs), including scrapie in sheep, chronic wasting disease (CWD) in deer, bovine spongiform encephalopathy (BSE) in cattle (commonly known as "mad cow disease") and Creutzfeldt–Jakob disease (CJD) in humans.


title: Prion

text: All known prion diseases in mammals affect the structure of the brain or other neural tissue; all are progressive, have no known effective treatment, and are always fatal. Until 2015, all known mammalian prion diseases were caused by the prion protein (PrP); however, in 2015 it was hypothesized that multiple system atrophy (MSA) was caused by a prion form of alpha-synuclein.


title: Prion

text: Prions are a type of intrinsically disordered protein, which change their conformation unless they are bound to a specific partner such as another protein. With a prion, two protein chains are stabilized if one binds to another in the same conformation. The probability of this happening is low, but once it does the combination of the two is very stable. Then more units can get added, making a sort of "fibril". Prions form abnormal aggregates of proteins called amyloids, which accumulate in infected tissue and are associated with tissue damage and cell death. Amyloids are also responsible for several other neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.


title: Prion

text: A prion disease is a type of proteopathy, or disease of structurally abnormal proteins. In humans, prions are believed to be the cause of Creutzfeldt–Jakob disease (CJD), its variant (vCJD), Gerstmann–Sträussler–Scheinker syndrome (GSS), fatal familial insomnia (FFI), and kuru. There is also evidence suggesting prions may play a part in the process of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS); these have been termed "prion-like diseases". Several yeast proteins have also been identified as having prionogenic properties, as well as a protein involved in modification of synapses during the formation of memories (see ). Prion replication is subject to epimutation and natural selection just as for other forms of replication, and their structure varies slightly between species.


title: Prion

text: Prion aggregates are stable, and this structural stability means that prions are resistant to denaturation by chemical and physical agents: they cannot be destroyed by ordinary disinfection or cooking. This makes disposal and containment of these particles difficult.


title: Prion

text: The word "prion", coined in 1982 by Stanley B. Prusiner, is derived from protein and infection, hence prion, and is short for "proteinaceous infectious particle", in reference to its ability to self-propagate and transmit its conformation to other proteins. Its main pronunciation is , although , as the homographic name of the bird (prions or whalebirds) is pronounced, is also heard. In his 1982 paper introducing the term, Prusiner specified that it is "pronounced "pree-on"".


title: Prion

text: The protein that prions are made of (PrP) is found throughout the body, even in healthy people and animals. However, PrP found in infectious material has a different structure and is resistant to proteases, the enzymes in the body that can normally break down proteins. The normal form of the protein is called PrP, while the infectious form is called PrP – the "C" refers to 'cellular' PrP, while the "Sc" refers to 'scrapie', the prototypic prion disease, occurring in sheep. While PrP is structurally well-defined, PrP is certainly polydisperse and defined at a relatively poor level. PrP can be induced to fold into other more-or-less well-defined isoforms in vitro, and their relationship to the form(s) that are pathogenic in vivo is not yet clear.


title: Prion

text: PrP is a normal protein found on the membranes of cells, "including several blood components of which platelets constitute the largest reservoir in humans." It has 209 amino acids (in humans), one disulfide bond, a molecular mass of 35–36 kDa and a mainly alpha-helical structure. Several topological forms exist; one cell surface form anchored via glycolipid and two transmembrane forms. The normal protein is not sedimentable; meaning that it cannot be separated by centrifuging techniques. Its function is a complex issue that continues to be investigated. PrP binds copper (II) ions with high affinity. The significance of this finding is not clear, but it is presumed to relate to PrP structure or function. PrP is readily digested by proteinase K and can be liberated from the cell surface in vitro by the enzyme phosphoinositide phospholipase C (PI-PLC), which cleaves the glycophosphatidylinositol (GPI) glycolipid anchor. PrP has been reported to play important roles in cell-cell adhesion and intracellular signaling "in vivo", and may therefore be involved in cell-cell communication in the brain.


title: Prion

text: Protease-resistant PrP-like protein (PrP) is the name given to any isoform of PrP which is structurally altered and converted into a misfolded proteinase K-resistant form "in vitro". To model conversion of PrP to PrP in vitro, Saborio "et al". rapidly converted PrP into a PrP by a procedure involving cyclic amplification of protein misfolding. The term "PrP" has been used to distinguish between PrP, which is isolated from infectious tissue and associated with the transmissible spongiform encephalopathy agent. For example, unlike PrP, PrP may not necessarily be infectious.


title: Prion

text: The infectious isoform of PrP, known as PrP, or simply the prion, is able to convert normal PrP proteins into the infectious isoform by changing their conformation, or shape; this, in turn, alters the way the proteins interconnect. PrP always causes prion disease. Although the exact 3D structure of PrP is not known, it has a higher proportion of β-sheet structure in place of the normal α-helix structure. Aggregations of these abnormal isoforms form highly structured amyloid fibers, which accumulate to form plaques. The end of each fiber acts as a template onto which free protein molecules may attach, allowing the fiber to grow. Under most circumstances, only PrP molecules with an identical amino acid sequence to the infectious PrP are incorporated into the growing fiber. However, rare cross-species transmission is also possible.


title: Prion

text: The physiological function of the prion protein remains poorly understood. While data from in vitro experiments suggest many dissimilar roles, studies on PrP knockout mice have provided only limited information because these animals exhibit only minor abnormalities. In research done in mice, it was found that the cleavage of PrP in peripheral nerves causes the activation of myelin repair in Schwann cells and that the lack of PrP proteins caused demyelination in those cells.


title: Prion

text: MAVS, RIP1, and RIP3 are prion-like proteins found in other parts of the body. They also polymerise into filamentous amyloid fibers which initiate regulated cell death in the case of a viral infection to prevent the spread of virions to other, surrounding cells.


title: Prion

text: A review of evidence in 2005 suggested that PrP may have a normal function in maintenance of long-term memory. As well, a 2004 study found that mice lacking genes for normal cellular PrP protein show altered hippocampal long-term potentiation. A recent study that might explain why this is found that neuronal protein CPEB has a similar genetic sequence to yeast prion proteins. The prion-like formation of CPEB is essential for maintaining long-term synaptic changes associated with long-term memory formation.


title: Prion

text: A 2006 article from the Whitehead Institute for Biomedical Research indicates that PrP expression on stem cells is necessary for an organism's self-renewal of bone marrow. The study showed that all long-term hematopoietic stem cells express PrP on their cell membrane and that hematopoietic tissues with PrP-null stem cells exhibit increased sensitivity to cell depletion.


title: Prion

text: There is some evidence that PrP may play a role in innate immunity, as the expression of PRNP, the PrP gene, is upregulated in many viral infections and PrP has antiviral properties against many viruses, including HIV.


title: Prion

text: The first hypothesis that tried to explain how prions replicate in a protein-only manner was the heterodimer model. This model assumed that a single PrP molecule binds to a single PrP molecule and catalyzes its conversion into PrP. The two PrP molecules then come apart and can go on to convert more PrP. However, a model of prion replication must explain both how prions propagate, and why their spontaneous appearance is so rare. Manfred Eigen showed that the heterodimer model requires PrP to be an extraordinarily effective catalyst, increasing the rate of the conversion reaction by a factor of around 10. This problem does not arise if PrP exists only in aggregated forms such as amyloid, where cooperativity may act as a barrier to spontaneous conversion. What is more, despite considerable effort, infectious monomeric PrP has never been isolated.


title: Prion

text: An alternative model assumes that PrP exists only as fibrils, and that fibril ends bind PrP and convert it into PrP. If this were all, then the quantity of prions would increase linearly, forming ever longer fibrils. But exponential growth of both PrP and of the quantity of infectious particles is observed during prion disease. This can be explained by taking into account fibril breakage. A mathematical solution for the exponential growth rate resulting from the combination of fibril growth and fibril breakage has been found. The exponential growth rate depends largely on the square root of the PrP concentration. The incubation period is determined by the exponential growth rate, and in vivo data on prion diseases in transgenic mice match this prediction. The same square root dependence is also seen in vitro in experiments with a variety of different amyloid proteins.


title: Prion

text: The mechanism of prion replication has implications for designing drugs. Since the incubation period of prion diseases is so long, an effective drug does not need to eliminate all prions, but simply needs to slow down the rate of exponential growth. Models predict that the most effective way to achieve this, using a drug with the lowest possible dose, is to find a drug that binds to fibril ends and blocks them from growing any further.


title: Prion

text: Researchers at Dartmouth College discovered that endogenous host cofactor molecules such as the phospholipid molecule (e.g. phosphatidylethanolamine) and polyanions (e.g. single stranded RNA molecules) are necessary to form PrP molecules with high levels of specific infectivity "in vitro", whereas protein-only PrP molecules appear to lack significant levels of biological infectivity.


title: Prion

text: Prions cause neurodegenerative disease by aggregating extracellularly within the central nervous system to form plaques known as amyloids, which disrupt the normal tissue structure. This disruption is characterized by "holes" in the tissue with resultant spongy architecture due to the vacuole formation in the neurons. Other histological changes include astrogliosis and the absence of an inflammatory reaction. While the incubation period for prion diseases is relatively long (5 to 20 years), once symptoms appear the disease progresses rapidly, leading to brain damage and death. Neurodegenerative symptoms can include convulsions, dementia, ataxia (balance and coordination dysfunction), and behavioural or personality changes.


title: Prion

text: Many different mammalian species can be affected by prion diseases, as the prion protein (PrP) is very similar in all mammals. Due to small differences in PrP between different species it is unusual for a prion disease to transmit from one species to another. The human prion disease variant Creutzfeldt–Jakob disease, however, is thought to be caused by a prion that typically infects cattle, causing bovine spongiform encephalopathy and is transmitted through infected meat.


title: Prion

text: All known prion diseases are untreatable and fatal. However, a vaccine developed in mice may provide insight into providing a vaccine to resist prion infections in humans. Additionally, in 2006 scientists announced that they had genetically engineered cattle lacking a necessary gene for prion production – thus theoretically making them immune to BSE, building on research indicating that mice lacking normally occurring prion protein are resistant to infection by scrapie prion protein. In 2013, a study revealed that 1 in 2,000 people in the United Kingdom might harbour the infectious prion protein that causes vCJD.


title: Prion

text: Until 2015 all known mammalian prion diseases were considered to be caused by the prion protein, PrP; in 2015 multiple system atrophy was found to be transmissible and was hypothesized to be caused by a new prion, the misfolded form of a protein called alpha-synuclein. The endogenous, properly folded form of the prion protein is denoted PrP (for Common" or Cellular"), whereas the disease-linked, misfolded form is denoted PrP (for "Scrapie"), after one of the diseases first linked to prions and neurodegeneration. The precise structure of the prion is not known, though they can be formed spontaneously by combining PrP, homopolymeric polyadenylic acid, and lipids in a protein misfolding cyclic amplification (PMCA) reaction even in the absence of pre-existing infectious prions. This result is further evidence that prion replication does not require genetic information.


title: Prion

text: It has been recognized that prion diseases can arise in three different ways: acquired, familial, or sporadic. It is often assumed that the diseased form directly interacts with the normal form to make it rearrange its structure. One idea, the "Protein X" hypothesis, is that an as-yet unidentified cellular protein (Protein X) enables the conversion of PrP to PrP by bringing a molecule of each of the two together into a complex.


title: Prion

text: The primary method of infection in animals is through ingestion. It is thought that prions may be deposited in the environment through the remains of dead animals and via urine, saliva, and other body fluids. They may then linger in the soil by binding to clay and other minerals.


title: Prion

text: A University of California research team has provided evidence for the theory that infection can occur from prions in manure. And, since manure is present in many areas surrounding water reservoirs, as well as used on many crop fields, it raises the possibility of widespread transmission. It was reported in January 2011 that researchers had discovered prions spreading through airborne transmission on aerosol particles, in an animal testing experiment focusing on scrapie infection in laboratory mice. Preliminary evidence supporting the notion that prions can be transmitted through use of urine-derived human menopausal gonadotropin, administered for the treatment of infertility, was published in 2011.


title: Prion

text: In 2015, researchers at The University of Texas Health Science Center at Houston found that plants can be a vector for prions. When researchers fed hamsters grass that grew on ground where a deer that died with chronic wasting disease (CWD) was buried, the hamsters became ill with CWD, suggesting that prions can bind to plants, which then take them up into the leaf and stem structure, where they can be eaten by herbivores, thus completing the cycle. It is thus possible that there is a progressively accumulating number of prions in the environment.


title: Prion

text: Infectious particles possessing nucleic acid are dependent upon it to direct their continued replication. Prions, however, are infectious by their effect on normal versions of the protein. Sterilizing prions, therefore, requires the denaturation of the protein to a state in which the molecule is no longer able to induce the abnormal folding of normal proteins. In general, prions are quite resistant to proteases, heat, ionizing radiation, and formaldehyde treatments, although their infectivity can be reduced by such treatments. Effective prion decontamination relies upon protein hydrolysis or reduction or destruction of protein tertiary structure. Examples include sodium hypochlorite, sodium hydroxide, and strongly acidic detergents such as LpH.


title: Prion

text: The World Health Organization recommends any of the following three procedures for the sterilization of all heat-resistant surgical instruments to ensure that they are not contaminated with prions:


title: Prion

text: Renaturation of a completely denatured prion to infectious status has not yet been achieved; however, partially denatured prions can be renatured to an infective status under certain artificial conditions.


title: Prion

text: Overwhelming evidence shows that prions resist degradation and persist in the environment for years, and proteases do not degrade them. Experimental evidence shows that "unbound" prions degrade over time, while soil-bound prions remain at stable or increasing levels, suggesting that prions likely accumulate in the environment. One 2015 study by US scientists found that repeated drying and wetting may render soil bound prions less infectious, although this was dependent on the soil type they were bound to.


title: Prion

text: Proteins showing prion-type behavior are also found in some fungi, which has been useful in helping to understand mammalian prions. Fungal prions do not appear to cause disease in their hosts. In yeast, protein refolding to the prion configuration is assisted by chaperone proteins such as Hsp104. All known prions induce the formation of an amyloid fold, in which the protein polymerises into an aggregate consisting of tightly packed beta sheets. Amyloid aggregates are fibrils, growing at their ends, and replicate when breakage causes two growing ends to become four growing ends. The incubation period of prion diseases is determined by the exponential growth rate associated with prion replication, which is a balance between the linear growth and the breakage of aggregates.


title: Prion

text: Fungal proteins exhibiting templated conformational change were discovered in the yeast "Saccharomyces cerevisiae" by Reed Wickner in the early 1990s. For their mechanistic similarity to mammalian prions, they were termed yeast prions. Subsequent to this, a prion has also been found in the fungus "Podospora anserina". These prions behave similarly to PrP, but, in general, are nontoxic to their hosts. Susan Lindquist's group at the Whitehead Institute has argued some of the fungal prions are not associated with any disease state, but may have a useful role; however, researchers at the NIH have also provided arguments suggesting that fungal prions could be considered a diseased state. There is evidence that fungal proteins have evolved specific functions that are beneficial to the microorganism that enhance their ability to adapt to their diverse environments.


title: Prion

text: Research into fungal prions has given strong support to the protein-only concept, since purified protein extracted from cells with a prion state has been demonstrated to convert the normal form of the protein into a misfolded form "in vitro", and in the process, preserve the information corresponding to different strains of the prion state. It has also shed some light on prion domains, which are regions in a protein that promote the conversion into a prion. Fungal prions have helped to suggest mechanisms of conversion that may apply to all prions, though fungal prions appear distinct from infectious mammalian prions in the lack of cofactor required for propagation. The characteristic prion domains may vary between species – e.g., characteristic fungal prion domains are not found in mammalian prions.


title: Prion

text: There are no effective treatments for prion diseases. Clinical trials in humans have not met with success and have been hampered by the rarity of prion diseases. Although some potential treatments have shown promise in the laboratory, none have been effective once the disease has commenced.


title: Prion

text: Prion-like domains have been found in a variety of other mammalian proteins. Some of these proteins have been implicated in the ontogeny of age-related neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U), Alzheimer's disease, Parkinson's disease, and Huntington's disease. They are also implicated in some forms of systemic amyloidosis including AA amyloidosis that develops in humans and animals with inflammatory and infectious diseases such as tuberculosis, Crohn's disease, rheumatoid arthritis, and HIV/AIDS. AA amyloidosis, like prion disease, may be transmissible. This has given rise to the 'prion paradigm', where otherwise harmless proteins can be converted to a pathogenic form by a small number of misfolded, nucleating proteins.


title: Prion

text: The definition of a prion-like domain arises from the study of fungal prions. In yeast, prionogenic proteins have a portable prion domain that is both necessary and sufficient for self-templating and protein aggregation. This has been shown by attaching the prion domain to a reporter protein, which then aggregates like a known prion. Similarly, removing the prion domain from a fungal prion protein inhibits prionogenesis. This modular view of prion behaviour has led to the hypothesis that similar prion domains are present in animal proteins, in addition to PrP. These fungal prion domains have several characteristic sequence features. They are typically enriched in asparagine, glutamine, tyrosine and glycine residues, with an asparagine bias being particularly conducive to the aggregative property of prions. Historically, prionogenesis has been seen as independent of sequence and only dependent on relative residue content. However, this has been shown to be false, with the spacing of prolines and charged residues having been shown to be critical in amyloid formation.


title: Prion

text: Bioinformatic screens have predicted that over 250 human proteins contain prion-like domains (PrLD). These domains are hypothesized to have the same transmissible, amyloidogenic properties of PrP and known fungal proteins. As in yeast, proteins involved in gene expression and RNA binding seem to be particularly enriched in PrLD's, compared to other classes of protein. In particular, 29 of the known 210 proteins with an RNA recognition motif also have a putative prion domain. Meanwhile, several of these RNA-binding proteins have been independently identified as pathogenic in cases of ALS, FTLD-U, Alzheimer's disease, and Huntington's disease.


title: Prion

text: The pathogenicity of prions and proteins with prion-like domains is hypothesized to arise from their self-templating ability and the resulting exponential growth of amyloid fibrils. The presence of amyloid fibrils in patients with degenerative diseases has been well documented. These amyloid fibrils are seen as the result of pathogenic proteins that self-propagate and form highly stable, non-functional aggregates. While this does not necessarily imply a causal relationship between amyloid and degenerative diseases, the toxicity of certain amyloid forms and the overproduction of amyloid in familial cases of degenerative disorders supports the idea that amyloid formation is generally toxic.


title: Prion

text: Specifically, aggregation of TDP-43, an RNA-binding protein, has been found in ALS/MND patients, and mutations in the genes coding for these proteins have been identified in familial cases of ALS/MND. These mutations promote the misfolding of the proteins into a prion-like conformation. The misfolded form of TDP-43 forms cytoplasmic inclusions in affected neurons, and is found depleted in the nucleus. In addition to ALS/MND and FTLD-U, TDP-43 pathology is a feature of many cases of Alzheimer's disease, Parkinson's disease and Huntington's disease. The misfolding of TDP-43 is largely directed by its prion-like domain. This domain is inherently prone to misfolding, while pathological mutations in TDP-43 have been found to increase this propensity to misfold, explaining the presence of these mutations in familial cases of ALS/MND. As in yeast, the prion-like domain of TDP-43 has been shown to be both necessary and sufficient for protein misfolding and aggregation.


title: Prion

text: Similarly, pathogenic mutations have been identified in the prion-like domains of heterogeneous nuclear riboproteins hnRNPA2B1 and hnRNPA1 in familial cases of muscle, brain, bone and motor neuron degeneration. The wild-type form of all of these proteins show a tendency to self-assemble into amyloid fibrils, while the pathogenic mutations exacerbate this behaviour and lead to excess accumulation.


title: Prion

text: Prions could theoretically be employed as a weaponized agent. With potential fatality rates of 100%, prions could be an effective bio-weapon. An unfavorable aspect is prions' very long incubation periods. Persistent heavy exposure of prions to the intestine might shorten the overall onset. Another aspect of using prions in warfare is the difficulty of detection and decontamination.


title: Prion

text: In the 18th and 19th centuries, exportation of sheep from Spain was observed to coincide with a disease called scrapie. This disease caused the affected animals to ""lie down, bite at their feet and legs, rub their backs against posts, fail to thrive, stop feeding and finally become lame"". The disease was also observed to have the long incubation period that is a key characteristic of transmissible spongiform encephalopathies (TSEs). Although the cause of scrapie was not known back then, it is probably the first transmissible spongiform encephalopathy to be recorded.


title: Prion

text: In the 1950s, Carleton Gajdusek began research which eventually showed that kuru could be transmitted to chimpanzees by what was possibly a new infectious agent, work for which he eventually won the 1976 Nobel prize. During the 1960s, two London-based researchers, radiation biologist Tikvah Alper and biophysicist John Stanley Griffith, developed the hypothesis that the transmissible spongiform encephalopathies are caused by an infectious agent consisting solely of proteins. Earlier investigations by E.J. Field into scrapie and kuru had found evidence for the transfer of pathologically inert polysaccharides that only become infectious post-transfer, in the new host. Alper and Griffith wanted to account for the discovery that the mysterious infectious agent causing the diseases scrapie and Creutzfeldt–Jakob disease resisted ionizing radiation. Griffith proposed three ways in which a protein could be a pathogen.


title: Prion

text: In the first hypothesis, he suggested that if the protein is the product of a normally suppressed gene, and introducing the protein could induce the gene's expression, that is, wake the dormant gene up, then the result would be a process indistinguishable from replication, as the gene's expression would produce the protein, which would then go wake the gene up in other cells.


title: Prion

text: His second hypothesis forms the basis of the modern prion theory, and proposed that an abnormal form of a cellular protein can convert normal proteins of the same type into its abnormal form, thus leading to replication.


title: Prion

text: His third hypothesis proposed that the agent could be an antibody if the antibody was its own target antigen, as such an antibody would result in more and more antibody being produced against itself. However, Griffith acknowledged that this third hypothesis was unlikely to be true due to the lack of a detectable immune response.


title: Prion

text: Francis Crick recognized the potential significance of the Griffith protein-only hypothesis for scrapie propagation in the second edition of his "Central dogma of molecular biology" (1970): While asserting that the flow of sequence information from protein to protein, or from protein to RNA and DNA was "precluded", he noted that Griffith's hypothesis was a potential contradiction (although it was not so promoted by Griffith). The revised hypothesis was later formulated, in part, to accommodate reverse transcription (which both Howard Temin and David Baltimore discovered in 1970).


title: Prion

text: In 1982, Stanley B. Prusiner of the University of California, San Francisco, announced that his team had purified the hypothetical infectious protein, which did not appear to be present in healthy hosts, though they did not manage to isolate the protein until two years after Prusiner's announcement. The protein was named a prion, for "proteinacious infectious particle", derived from the words protein and infection. When the prion was discovered, Griffith's first hypothesis, that the protein was the product of a normally silent gene was favored by many. It was subsequently discovered, however, that the same protein exists in normal hosts but in different form.


title: Prion

text: Following the discovery of the same protein in different form in uninfected individuals, the specific protein that the prion was composed of was named the prion protein (PrP), and Griffith's second hypothesis that an abnormal form of a host protein can convert other proteins of the same type into its abnormal form, became the dominant theory. Prusiner won the Nobel Prize in Physiology or Medicine in 1997 for his research into prions.


title: S.S. Lazio

text: Società Sportiva Lazio (; ; "Lazio Sport Club"), commonly referred to as Lazio, is an Italian professional sports club based in Rome, most known for its football activity. The society, founded in 1900, plays in the Serie A and have spent most of their history in the top tier of Italian football. Lazio have been Italian champions twice (1974, 2000), and have won the Coppa Italia seven times, the Supercoppa Italiana three times, and both the UEFA Cup Winners' Cup and UEFA Super Cup on one occasion.


title: S.S. Lazio

text: The club had their first major success in 1958, winning the domestic cup. In 1974, they won their first Serie A title. The 1990s were the most successful period in Lazio's history, with the team reaching the UEFA Cup final in 1998, winning the UEFA Cup Winners' Cup and UEFA Super Cup in 1999, and clinching the Serie A title in 2000. Due to a severe economic crisis in 2002 that forced president Sergio Cragnotti out of the club along with several star players being sold, Lazio's success in the league declined. In spite of the lower funds, the club has won four Coppa Italia titles since then; in 2004, 2009, 2013 and 2019. Current president Claudio Lotito took charge of the club in 2004, filling the vacuum that had existed following Cragnotti's departure.


title: S.S. Lazio

text: Lazio's traditional kit colours are sky blue shirts and white shorts with white socks; the colours are reminiscent of Rome's ancient Hellenic legacy. Sky blue socks have also been interchangeably used as home colours. Their home is the 70,634 capacity Stadio Olimpico in Rome, which they share with A.S. Roma. Lazio have a long-standing rivalry with Roma, with whom they have contested the "Derby della Capitale" (in English "Derby of the capital city" or Rome derby) since 1929.


title: S.S. Lazio

text: Despite initially not having any parent–subsidiary relation with the male and female professional team (that was incorporated as S.S. Lazio S.p.A.), the founding of Società Sportiva Lazio allowed for the club that participates in over 40 sports disciplines in total, more than any other sports association in the world.


title: S.S. Lazio

text: "Società Podistica Lazio" was founded on 9 January 1900 in the Prati district of Rome. Until 1910, the club played at an amateur level until it officially joined the league competition in 1912 as soon as the Italian Football Federation began organising championships in the center and south of Italy, and reached the final of the national championship playoff three times, but never won, losing in 1913 to Pro Vercelli, in 1914 to Casale and in 1923 to Genoa 1893.


title: S.S. Lazio

text: In 1927, Lazio was the only major Roman club which resisted the Fascist regime's attempts to merge all the city's teams into what would become A.S. Roma the same year.


title: S.S. Lazio

text: The club played in the first organised Serie A in 1929 and, led by legendary Italian striker Silvio Piola, achieved a second-place finish in 1937 – its highest pre-war result.


title: S.S. Lazio

text: The 1950s produced a mix of mid and upper table results with a Coppa Italia win in 1958. Lazio was relegated for the first time in 1961 to the Serie B, but returned in the top flight two years later. After a number of mid-table placements, another relegation followed in 1970–71. Back to Serie A in 1972–73, Lazio immediately emerged as surprise challengers for the "Scudetto" to Milan and Juventus in 1972–73, only losing out on the final day of the season, with a team comprising captain Giuseppe Wilson, as well as midfielders Luciano Re Cecconi and Mario Frustalupi, striker Giorgio Chinaglia, and head coach Tommaso Maestrelli. Lazio improved such successes the following season, ensuring its first title in 1973–74. However, tragic deaths of Re Cecconi and "Scudetto" trainer Maestrelli, as well as the departure of Chinaglia, would be a triple blow for Lazio. The emergence of Bruno Giordano during this period provided some relief as he finished League top scorer in 1979, when Lazio finished eighth.


title: S.S. Lazio

text: Lazio were forcibly relegated to Serie B in 1980 due to a remarkable scandal concerning illegal bets on their own matches, along with Milan. They remained in Italy's second division for three seasons in what would mark the darkest period in Lazio's history. They would return in 1983 and manage a last-day escape from relegation the following season. The 1984–85 season would prove harrowing, with a pitiful 15 points and bottom place finish.


title: S.S. Lazio

text: In 1986, Lazio was hit with a nine-point deduction (a true deathblow back in the day of the two-point win) for a betting scandal involving player Claudio Vinazzani. An epic struggle against relegation followed the same season in Serie B, with the club led by trainer Eugenio Fascetti only avoiding relegation to the Serie C after play-off wins over Taranto and Campobasso. This would prove a turning point in the club's history, with Lazio returning to Serie A in 1988 and, under the careful financial management of Gianmarco Calleri, the consolidation of the club's position as a solid top-flight club.


title: S.S. Lazio

text: The arrival of Sergio Cragnotti in 1992 changed the club's history due to his long-term investments in new players to make the team a "Scudetto" competitor. A notable early transfer during his tenure was the capture of English midfielder Paul Gascoigne from Tottenham Hotspur for £5.5 million. Gascoigne's transfer to Lazio is credited with the increase of interest in Serie A in the United Kingdom during the 1990s. Cragnotti repeatedly broke transfer records in pursuit of players who were considered major stars – Juan Sebastián Verón for £18 million, Christian Vieri for £19 million and breaking the world transfer record, albeit only for a matter of weeks, to sign Hernán Crespo from Parma for £35 million.


title: S.S. Lazio

text: Lazio were Serie A runners-up in 1995, third in 1996 and fourth in 1997, then losing the championship just by one point to Milan on the last championship's match in 1999 before, with the likes of Siniša Mihajlović, Alessandro Nesta, Marcelo Salas and Pavel Nedvěd in the side, winning its second "Scudetto" in 2000, as well as the Coppa Italia double with Sven-Göran Eriksson (1997–2001) as manager.


title: S.S. Lazio

text: Lazio had two more Coppa Italia triumphs in 1998 and 2004, as well as the last UEFA Cup Winners' Cup in 1999. They also reached the UEFA Cup, but lost 0–3 against Internazionale.


title: S.S. Lazio

text: In addition, Lazio won the Supercoppa Italiana twice and defeated Manchester United in 1999 to win the UEFA Super Cup.


title: S.S. Lazio

text: In 2000, Lazio became also the first Italian football club to be quoted on the Italian Piazza Affari stock market.


title: S.S. Lazio

text: With money running out, however, Lazio's results slowly worsened in the years. In 2002, a financial scandal involving Cragnotti and his food products multinational Cirio forced him to leave the club, and Lazio was controlled until 2004 by caretaker financial managers and a bank pool. This forced the club to sell their star players and even fan favourite captain Alessandro Nesta. In 2004, entrepreneur Claudio Lotito acquired the majority of the club.


title: S.S. Lazio

text: In 2006, the club qualified to the 2006–07 UEFA Cup under coach Delio Rossi. The club, however, was excluded from European competitions due to their involvement in a match-fixing scandal.


title: S.S. Lazio

text: In the 2006–07 season, despite a later-reduced points deduction, Lazio achieved a third-place finish, thus gaining qualification to the UEFA Champions League third qualifying round, where they defeated Dinamo București to reach the group phase, and ended fourth place in the group composed of Real Madrid, Werder Bremen and Olympiacos. Things in the league did not go much better, with the team spending most of the season in the bottom half of the table, sparking the protests of the fans, and eventually ending the Serie A season in 12th place. In the 2008–09 season, Lazio won their fifth Coppa Italia, beating Sampdoria in the final.


title: S.S. Lazio

text: Lazio started the 2009–10 season playing the Supercoppa Italiana against Inter in Beijing and winning the match 2–1, with goals from Matuzalém and Tommaso Rocchi.


title: S.S. Lazio

text: Lazio won the 2012–13 Coppa Italia 1–0 over rivals Roma with the lone goal coming from Senad Lulić. Lazio won the 2018–19 Coppa Italia 2–0 over Atalanta, winning their seventh title overall.


title: S.S. Lazio

text: On 22 December 2019, Lazio won their fifth Supercoppa Italiana title, following a 3–1 victory over Juventus. Lazio mounted an unexpected title challenge during the 2019–20 Serie A season. A poor run of form following the restart of the Serie A campaign after the COVID-19 suspension saw Lazio fall out of the title race. On 24 July 2020, Lazio qualified for the Champions League for the first time in 12 years after securing a top 4 finish.


title: S.S. Lazio

text: Lazio's colours of white and sky blue were inspired by the national emblem of Greece, due to the fact that Lazio is a mixed sports club this was chosen in recognition of the fact that the Ancient Olympic Games and along with it the sporting tradition in Europe is linked to Greece.


title: S.S. Lazio

text: Originally, Lazio wore a shirt which was divided into white and sky blue quarters, with black shorts and socks. After a while of wearing a plain white shirt very early on, Lazio reverted to the colours which they wear today. Some seasons Lazio have used a sky blue and white shirt with stripes, but usually it is sky blue with a white trim, with the white shorts and socks. The club's colours have led to their Italian nickname of "Biancocelesti".


title: S.S. Lazio

text: Lazio's traditional club badge and symbol is the eagle, which was chosen by founding member Luigi Bigiarelli. It is an acknowledgment to the emblem of Zeus (the god of sky and thunder in Greek mythology) commonly referred to as Aquila; Lazio's use of the symbol has led to two of their nicknames; "le Aquile" ("the Eagles") and "Aquilotti" ("Eaglets"). The current club badge features a golden eagle above a white shield with a blue border; inside the shield is the club's name and a smaller tripartite shield with the colours of the club.


title: S.S. Lazio

text: Stadio Olimpico, located on the Foro Italico, is the major stadium of Rome. It is the home of the Italy national football team as well as of both local teams Lazio and Roma. It was opened in 1937 and after its latest renovation in 2008, the stadium has a capacity of 70,634 seats. It was the site of the 1960 Summer Olympics, but has also served as the location of the 1987 World Athletics Championships, the 1980 European Championship final, the 1990 World Cup and the Champions League Final in 1996 and 2009.


title: S.S. Lazio

text: Also on the Foro Italico lies the Stadio dei Marmi, or "marble stadium", which was built in 1932 and designed by Enrico Del Debbio. It has tiers topped by 60 white marble statues that were gifts from Italian cities in commemoration of 60 athletes.


title: S.S. Lazio

text: During the 1989–90 season, Lazio and Roma played their games at the Stadio Flaminio of Rome, located in the district Flaminio, because of the renovation works carried out at the Stadio Olimpico.


title: S.S. Lazio

text: In June 2018, Lazio President Claudio Lotito stated that "Lazio should be granted the same favour and treatment as Roma – the ability to also build a new stadium. He also added that "Lazio's stadium will be built before Roma's stadium."


title: S.S. Lazio

text: In June 2019, Lazio President Claudio Lotito was set to present the designs of a potential future stadium for Lazio, named the Stadio delle Aquile. However, this did not occur for reasons unknown.


title: S.S. Lazio

text: Lazio is the sixth-most supported football club in Italy and the second in Rome, with around 2% of Italian football fans supporting the club (according to "La Repubblica's" research of August 2008). Historically, the largest section of Lazio supporters in the city of Rome has come from the far northern section, creating an arch-like shape across Rome with affluent areas such as Parioli, Prati, Flaminio, Cassia and Monte Mario.


title: S.S. Lazio

text: Founded in 1987, "Irriducibili Lazio" were the club's biggest ultras group for over 30 years. They typically create traditional Italian ultra displays during the "Derby della Capitale" (Rome Derby), the match between Lazio and their main rivals, Roma. It is amongst the most heated and emotional footballing rivalries in the world, such as where Lazio fan Vincenzo Paparelli was killed at one of the derby games during the 1979–80 season after being hit in the eye by an emergency rocket thrown by a Roma fan. A minority of Lazio's ultras used to use swastikas and fascist symbols on their banners, and they have displayed racist behaviour in several occasions during the derbies. Most notably, at a derby of the season 1998–99, laziali unfurled a 50-metre banner around the Curva Nord that read, "Auschwitz is your town, the ovens are your houses". Black players of Roma have often been receivers of racist and offensive behaviour. After 33 years, the Irriducibili disbanded on 27 February 2020, citing "too much blood, too many banning orders, too many arrests." Lazio's ultras now go by the name "Ultras Lazio". Lazio also have a strong rivalry with Napoli and Livorno, as well as with Pescara and Atalanta. The club also maintains strong competitive rivalries with Fiorentina, Juventus, and Milan.


title: S.S. Lazio

text: Conversely, the ultras have friendly relationships with Internazionale, Triestina, and Hellas Verona. Internationally, Lazio's fans maintain a long-standing strong friendship with the supporters of the Bulgarian club Levski Sofia and as such, Lazio were invited to participate in the centenary football match honouring the birthday of the Bulgarian club.


title: S.S. Lazio

text: 12 – Since the 2003–04 season, the Curva Nord of Stadio Olimpico, as a sign of recognition, is considered the 12th man on the pitch.


title: S.S. Lazio

text: Ștefan Radu holds Lazio's official appearance record, having played 416 appearances. The record for total appearances by a goalkeeper is held by Luca Marchegiani, with 339 appearances, while the record for most league appearances is held by Aldo Puccinelli with 339.


title: S.S. Lazio

text: The all-time leading goalscorer for Lazio is Ciro Immobile, with 170 goals scored, followed by Silvio Piola with 159 goals. Piola, who played also with Pro Vercelli, Torino, Juventus and Novara, is also the highest goalscorer in Serie A history, with 274 goals. Simone Inzaghi is the all-time top goalscorer in European competitions, with 20 goals. He is also one of the five players who scored four goals in a single UEFA Champions League match.


title: S.S. Lazio

text: Officially, Lazio's highest home attendance is approximately 80,000 for a Serie A match against Foggia on 12 May 1974, the match that awarded to Lazio their first "Scudetto". This is also the record for the Stadio Olimpico, including matches held by Roma and the Italy national football team.


title: S.S. Lazio

text: In 1998, during Sergio Cragnotti's period in charge as the chairman, Società Sportiva Lazio S.p.A. became a listed company: Lazio were the first Italian club to do so. However, Cragnotti resigned as chairman in 2001, after a "huge hole in the budget" of the club.


title: S.S. Lazio

text: Claudio Lotito, the current chairman of Lazio, purchased the club from Cragnotti in 2004, but owned just 26.969% of shares as the largest shareholders at that time. It was followed by banking group Capitalia (and its subsidiaries Mediocredito Centrale, Banca di Roma and Banco di Sicilia) as the second largest shareholders for 17.717%. Capitalia also hold 49% stake of Italpetroli (via Capitalia's subsidiary Banca di Roma), the parent company of city rival Roma (via Italpetroli's subsidiary "Roma 2000"). Lotito later purchased the minority stake from Capitalia.


title: S.S. Lazio

text: , Claudio Lotito owns just over two-thirds of the shares of Lazio. Lazio is one of only three Italian clubs listed on the Borsa Italiana, the others being Juventus and Roma. In the past, Lazio was the only one with a single primary share holder (Lotito). However, following several capital increases by Roma and Juventus, they also are significantly owned by a shareholder. According to The Football Money League, published by consultants Deloitte, in the 2004–05 season, Lazio was the 20th highest earning football club in the world with an estimated revenue of €83 million; the 2005 ranking of the club was 15th. However, in 2016 ranking (the rank used data in 2014–15 season), Lazio was not in the top 20.


title: S.S. Lazio

text: Lazio was one of the few clubs that self-sustain from the financial support of a shareholder, and also consistently make an aggregate profit after every season. Unlike Inter Milan, Roma and Milan, who were sanctioned by UEFA due to breaches of Financial Fair Play, Lazio passed the regulations held by the administrative body with the high achievements. Lotito also received a prize that joint awarded by and DGS Sport&Cultura, due to Lazio's financial health.


title: S.S. Lazio

text: In 2017, the club renewed their sponsorship deal with shirt manufacturer Macron. It was worth €16 million a season, plus variables of about €9 million stemming from league and European competition finishes.


title: S.S. Lazio

text: In February 2022, Lazio announced that they had parted ways with Macron after 10 years. Mizuno would become the team’s new sportswear and technical gear provider, with the Biancocelesti receiving €20 million over the next five years as a result of their new agreement with the Japanese company.


title: S.S. Lazio

text: In March 2022, Lazio released their financial reports from June to December 2021 which showed a decrease in revenue (from €106.66 to €71.56 million) but an increase in profit (from -€0.12 million to €4.6 million) compared to the previous six months.


title: Nebuchadnezzar II

text: Nebuchadnezzar II (Babylonian cuneiform: "Nabû-kudurri-uṣur", meaning "Nabu, watch over my heir"; Biblical Hebrew: "Nəḇūḵaḏneʾṣṣar"), also spelled Nebuchadrezzar II, was the second king of the Neo-Babylonian Empire, ruling from the death of his father Nabopolassar in 605 BC to his own death in 562 BC. Historically known as Nebuchadnezzar the Great, he is typically regarded as the empire's greatest king. Nebuchadnezzar remains famous for his military campaigns in the Levant, for his construction projects in his capital, Babylon, and for the important part he played in Jewish history. Ruling for 43 years, Nebuchadnezzar was the longest-reigning king of the Chaldean dynasty. At the time of his death, Nebuchadnezzar was among the most powerful rulers in the world.


title: Nebuchadnezzar II

text: Possibly named after his grandfather of the same name, or after Nebuchadnezzar I ( 1125–1104 BC), one of Babylon's greatest ancient warrior-kings, Nebuchadnezzar II already secured renown for himself during his father's reign, leading armies in the Medo-Babylonian war against the Assyrian Empire. At the Battle of Carchemish in 605 BC, Nebuchadnezzar inflicted a crushing defeat on an Egyptian army led by Pharaoh Necho II, and ensured that the Neo-Babylonian Empire would succeed the Neo-Assyrian Empire as the dominant power in the ancient Near East. Shortly after this victory, Nabopolassar died and Nebuchadnezzar became king. Despite his successful military career during his father's reign, the first third or so of Nebuchadnezzar's reign saw little to no major military achievements, and notably a disastrous failure in an attempted invasion of Egypt. These years of lacklustre military performance saw some of Babylon's vassals, particularly in the Levant, beginning to doubt Babylon's power, viewing the Neo-Babylonian Empire as a "paper tiger" rather than a power truly on the level of the Neo-Assyrian Empire. The situation grew so severe that people in Babylonia itself began disobeying the king, some going as far as to revolt against Nebuchadnezzar's rule.


title: Nebuchadnezzar II

text: After this disappointing early period as king, Nebuchadnezzar's luck turned. In the 580s BC, Nebuchadnezzar engaged in a successful string of military actions in the Levant against the vassal states in rebellion there, likely with the ultimate intent of curbing Egyptian influence in the region. In 587 BC, Nebuchadnezzar destroyed the Kingdom of Judah, and its capital, Jerusalem. The destruction of Jerusalem led to the Babylonian captivity as the city's population, and people from the surrounding lands, were deported to Babylonia. The Jews thereafter referred to Nebuchadnezzar, the greatest enemy they had faced until that point, as a "destroyer of nations". The biblical Book of Jeremiah paints Nebuchadnezzar as a cruel enemy, but also as God's appointed ruler of the world and a divine instrument to punish disobedience. Through the destruction of Jerusalem, the capture of the rebellious Phoenician city of Tyre, and other campaigns in the Levant, Nebuchadnezzar completed the Neo-Babylonian Empire's transformation into the new great power of the ancient Near East.


title: Nebuchadnezzar II

text: In addition to his military campaigns, Nebuchadnezzar is remembered as a great builder king. The prosperity ensured by his wars allowed Nebuchadnezzar to conduct great building projects in Babylon, and elsewhere in Mesopotamia. The modern image of Babylon is largely of the city as it was after Nebuchadnezzar's projects, during which he, among other work, rebuilt many of the city's religious buildings, including the Esagila and Etemenanki, repaired its current palace and constructed a brand new palace, and beautified its ceremonial centre through renovations to the city's Processional Street and the Ishtar Gate. As most of Nebuchadnezzar's inscriptions deal with his building projects, rather than military accomplishments, he was for a time seen by historians mostly as a builder, rather than a warrior.


title: Nebuchadnezzar II

text: There are very few cuneiform sources for the period between 594 BC and 557 BC, covering much of the reign of Nebuchadnezzar II, and the reigns of his three immediate successors; Amel-Marduk, Neriglissar and Labashi-Marduk. This lack of sources has the unfortunate effect that even though Nebuchadnezzar had the longest reign of all of them, less is confidently known of Nebuchadnezzar's reign than of the reigns of almost all the other Neo-Babylonian kings. Though the handful of cuneiform sources recovered, notably the Babylonian Chronicle, confirm some events of his reign, such as conflicts with the Kingdom of Judah, other events, such as the 586 BC destruction of Solomon's Temple and other potential military campaigns Nebuchadnezzar conducted, are not covered in any known cuneiform documents.


title: Nebuchadnezzar II

text: As such, historical reconstructions of this period generally follow secondary sources in Hebrew, Greek and Latin to determine what events transpired at the time, in addition to contract tablets from Babylonia. Though using the sources written by later authors, many of them created several centuries after Nebuchadnezzar's time and often including their own cultural attitudes to the events and figures discussed, presents problems in and of itself, blurring the line between history and tradition, it is the only possible approach to gain insight into Nebuchadnezzar's reign.


title: Nebuchadnezzar II

text: Nebuchadnezzar II's name in Akkadian was "Nabû-kudurri-uṣur", meaning "Nabu, watch over my heir". The name was often interpreted in earlier scholarship as "Nabu, protect the boundary", given that the word "kudurru" can also mean 'boundary' or 'line'. Modern historians support the 'heir' interpretation over the 'boundary' interpretation in terms of this name. There is no reason to believe that the Babylonians intended the name to be difficult to interpret or to have a double meaning.


title: Nebuchadnezzar II

text: "Nabû-kudurri-uṣur" is typically anglicised to 'Nebuchadnezzar', following how the name is most commonly rendered in Hebrew and Greek, particularly in most of the Bible. In Hebrew, the name was rendered as נְבוּכַדְנֶאצַּר ("Nəḇūḵaḏneʾṣṣar") and in Greek it was rendered as Ναβουχοδονόσορ ("Nabouchodonosor"). Some scholars, such as Donald Wiseman, prefer the anglicisation "Nebuchadrezzar", with an "r" rather than an "n", following the assumption that "Nebuchadnezzar" is a later, corrupted form of the contemporary "Nabû-kudurri-uṣur". The alternate anglicisation "Nebuchadrezzar" derives from how the name is rendered in the books of Jeremiah and Ezekiel, נְבוּכַדְרֶאצַּר ("Nəḇūḵaḏreʾṣṣar"), a more faithful transliteration of the original Akkadian name. The Assyriologist Adrianus van Selms suggested in 1974 that the variant with an "n" rather than an "r" was a rude nickname, deriving from an Akkadian rendition like "Nabû-kūdanu-uṣur", which means 'Nabu, protect the mule', though there is no concrete evidence for this idea. Van Selms believed that a nickname like that could derive from Nebuchadnezzar's early reign, which was plagued by political instability.


title: Nebuchadnezzar II

text: Nebuchadnezzar II's name, "Nabû-kudurri-uṣur", was identical to the name of his distant predecessor, Nebuchadnezzar I ( 1125–1104 BC), who ruled more than five centuries before Nebuchadnezzar II's time. Like Nebuchadnezzar II, Nebuchadnezzar I was a renowned warrior-king, who appeared in a time of political upheaval and defeated the forces of Babylon's enemies, in Nebuchadnezzar I's case the Elamites. Although theophoric names using the god Nabu are common in texts from the early Neo-Babylonian Empire, the name Nebuchadnezzar is relatively rare, only being mentioned four times with certainty. Though there is no evidence that Nabopolassar named his son after Nebuchadnezzar I, Nabopolassar was knowledgeable in history and actively worked to connect his rule to the rule of the Akkadian Empire, which preceded him by nearly two thousand years. The significance of his son and heir bearing the name of one of Babylon's greatest kings would not have been lost on Nabopolassar.


title: Nebuchadnezzar II

text: If Jursa's theory concerning Nabopolassar's origin is correct, it is alternatively possible that Nebuchadnezzar II was named after his grandfather of the same name, as the Babylonians employed patronymics, rather than after the previous king.


title: Nebuchadnezzar II

text: Nebuchadnezzar was the eldest son of Nabopolassar (626–605 BC), the founder of the Neo-Babylonian Empire. This is confirmed by Nabopolassar's inscriptions, which explicitly name Nebuchadnezzar as his "eldest son", as well as inscriptions from Nebuchadnezzar's reign, which refer to him as the "first" or "chief son" of Nabopolassar, and as Nabopolassar's "true" or "legitimate heir". The Neo-Babylonian Empire was founded through Nabopolassar's rebellion, and later war, against the Neo-Assyrian Empire, which liberated Babylonia after nearly a century of Assyrian control. The war resulted in the complete destruction of Assyria, and the Neo-Babylonian Empire, which rose in its place, was powerful, but hastily built and politically unstable.


title: Nebuchadnezzar II

text: As Nabopolassar never clarified his ancestry in lineage in any of his inscriptions, his origin is not entirely clear. Subsequent historians have variously identified Nabopolassar as a Chaldean, an Assyrian or a Babylonian. Although no evidence conclusively confirms him as being of Chaldean origin, the term "Chaldean dynasty" is frequently used by modern historians for the royal family he founded, and the term "Chaldean Empire" remains in use as an alternate historiographical name for the Neo-Babylonian Empire.


title: Nebuchadnezzar II

text: Nabopolassar appears to, regardless of his ethnic origin, have been strongly connected to the city of Uruk, located south of Babylon. It is possible that he was a member of its ruling elite before becoming king and there is a growing body of evidence that Nabopolassar's family originated in Uruk, for instance that Nebuchadnezzar's daughters lived in the city. In 2007, Michael Jursa advanced the theory that Nabopolassar was a member of a prominent political family in Uruk, whose members are attested since the reign of Esarhaddon (681–669 BC). To support his theory, Jursa pointed to how documents describe how the grave and body of "Kudurru", a deceased governor of Uruk, was desecrated due to the anti-Assyrian activities of Kudurru's two sons, Nabu-shumu-ukin and a son whose name is mostly missing. The desecration went so far as to drag Kudurru's body through the streets of Uruk. Kudurru can be identified with Nebuchadnezzar ("Nabû-kudurri-uṣur", "Kudurru" simply being a common and shortened nickname), a prominent official in Uruk who served as its governor under the Assyrian king Ashurbanipal (669–631 BC) in the 640s BC. In Assyrian tradition, the desecration of a dead body showed that the deceased individual and their surviving family were traitors and enemies of the state, and that they had to be completely eradicated, serving to punish them even after death. The name of the son whose name is unpreserved in the letter ended with either "ahi", "nâsir" or "uṣur", and the remaining traces can fit with the name "Nabû-apla-uṣur", meaning that Nabopolassar could be the other son mentioned in the letter and thus a son of Kudurru.


title: Nebuchadnezzar II

text: Strengthening this connection is that Nebuchadnezzar II is attested very early during his father's reign, from 626/625 to 617 BC, as high priest of the Eanna temple in Uruk, where he is often attested under the nickname "Kudurru". Nebuchadnezzar must have been made high priest at a very young age, considering that his year of death, 562 BC, is 64 years after 626 BC. The original Kudurru's second son, Nabu-shumu-ukin, also appears to be attested as a prominent general under Nabopolassar, and the name was also used by Nebuchadnezzar II for one of his sons, possibly honoring his dead uncle.


title: Nebuchadnezzar II

text: Nebuchadnezzar's military career began in the reign of his father, though little information survives. Based on a letter sent to the temple administration of the Eanna temple, it appears that Nebuchadnezzar participated in his father's campaign to take the city of Harran in 610 BC. Harran was the seat of Ashur-uballit II, who had rallied what remained of the Assyrian army and ruled what was left of the Neo-Assyrian Empire."" The Babylonian victory in the Harran campaign, and the defeat of Ashur-uballit, in 609 BC marked the end of the ancient Assyrian monarchy, which would never be restored. According to the Babylonian Chronicle, Nebuchadnezzar also commanded an army in an unspecified mountainous region for several months in 607 BC.


title: Nebuchadnezzar II

text: In the war against the Babylonians and Medes, Assyria had allied with Pharaoh Psamtik I of Egypt, who had been interested in ensuring Assyria's survival so that Assyria could remain as a buffer state between his own kingdom and the Babylonian and Median kingdoms. After the fall of Harran, Psamtik's successor, Pharaoh Necho II, personally led a large army into former Assyrian lands to turn the tide of the war and restore the Neo-Assyrian Empire, even though it was more or less a lost cause as Assyria had already collapsed. As Nabopolassar was occupied with fighting the Kingdom of Urartu in the north, the Egyptians took control of the Levant largely unopposed, capturing territories as far north as the city of Carchemish in Syria, where Necho established his base of operations.


title: Nebuchadnezzar II

text: Nebuchadnezzar's greatest victory from his time as crown prince came at the Battle of Carchemish in 605 BC, which put an end to Necho's campaign in the Levant by inflicting a crushing defeat on the Egyptians. Nebuchadnezzar had been the sole commander of the Babylonian army at this battle as his father had chosen to stay in Babylon, perhaps on account of illness. Necho's forces were completely annihilated by Nebuchadnezzar's army, with Babylonian sources claiming that not a single Egyptian escaped alive. The account of the battle in the Babylonian Chronicle reads as follows:


title: Nebuchadnezzar II

text: The story of Nebuchadnezzar's victory at Carchemish reverberated through history, appearing in many later ancient accounts, including in the Book of Jeremiah and the Books of Kings in the Bible. It is possible to conclude, based on subsequent geopolitics, that the victory resulted in all of Syria and Palestine coming under the control of the Neo-Babylonian Empire, a feat which the Assyrians under Tiglath-Pileser III (745–727 BC) only accomplished after five years of protracted military campaigns. The defeat of Egypt at Carchemish ensured that the Neo-Babylonian Empire would grow to become the major power of the ancient Near East, and the uncontested successor of the Neo-Assyrian Empire.


title: Nebuchadnezzar II

text: Nabopolassar died just a few weeks after Nebuchadnezzar's victory at Carchemish. At this point in time, Nebuchadnezzar was still away on his campaign against the Egyptians, having chased the retreating Egyptian forces to the region around the city of Hamath. The news of Nabopolassar's death reached Nebuchadnezzar's camp on 8 Abu (late July), and Nebuchadnezzar quickly arranged affairs with the Egyptians and rushed back to Babylon, where he was proclaimed king on 1 Ulūlu (mid-August). The speed in which Nebuchadnezzar returned to Babylon might be due to the threat that one of his brothers (two are known by name: Nabu-shum-lishir and Nabu-zer-ushabshi) could claim the throne in his absence. Though Nebuchadnezzar had been recognised as the eldest son and heir by Nabopolassar, Nabu-shum-lishir, Nabopolassar's second-born son, had been recognised as "his equal brother", a dangerously vague title. Despite these possible fears, there were no attempts made at usurping his throne at this time.


title: Nebuchadnezzar II

text: One of Nebuchadnezzar's first acts as king was to bury his father. Nabopolassar was laid in a huge coffin, adorned with ornamented gold plates and fine dresses with golden beads, which was then placed within a small palace he had constructed in Babylon. Shortly thereafter, before the end of the month in which he had been crowned, Nebuchadnezzar returned to Syria to resume his campaign. The Babylonian Chronicle records that "he marched about victoriously" (meaning that he faced little to no resistance), returning to Babylon after several months of campaigning. The Syrian campaign, though it resulted in a certain amount of plunder, was not a complete success in that it did not ensure Nebuchadnezzar's grasp on the region. He had seemingly failed to inspire fear, given that none of the westernmost states in the Levant swore fealty to him and paid tribute.


title: Nebuchadnezzar II

text: Though little information survives concerning them, the Babylonian Chronicle preserves brief accounts of Nebuchadnezzar's military activities in his first eleven years as king. In 604 BC, Nebuchadnezzar campaigned in the Levant once again, conquering the city of Ashkelon. According to the Babylonian Chronicle, Ashkelon's king was captured and taken to Babylon, and the city was plundered and levelled to the ground. Modern excavations at Ashkelon have confirmed that the city was more or less destroyed at this point in time. The Ashkelon campaign was preceded by a campaign in Syria, which was more successful than Nebuchadnezzar's first, resulting in oaths of fealty from the rulers of Phoenicia.


title: Nebuchadnezzar II

text: In 603 BC, Nebuchadnezzar campaigned in a land whose name is not preserved in the surviving copy of the chronicle. The chronicle records that this campaign was extensive, given that the account mentions the construction of large siege towers and a siege of a city, the name of which does not survive either. Anson Rainey speculated in 1975 that the city taken was Gaza, whereas Nadav Na'aman thought in 1992 that it was Kummuh in south-eastern Anatolia. In the second half of the 5th century BC, some documents mentioned the towns Isqalanu (the name derived from Ashkelon) and Hazzatu (the name possibly derived from Gaza) near the city of Nippur, indicating that deportees from both of these cities lived near Nippur, and as such possibly that they had been captured at around the same time.


title: Nebuchadnezzar II

text: In both 602 BC and 601 BC, Nebuchadnezzar campaigned in the Levant, though little information survives beyond that a "vast" amount of booty was brought from the Levant to Babylonia in 602 BC. On account of the entry for 602 BC also referring to Nabu-shum-lishir, Nebuchadnezzar's younger brother, in a fragmentary and unclear context, it is possible that Nabu-shum-lishir led a revolt against his brother in an attempt to usurp the throne in that year, especially since he is no longer mentioned in any sources after 602 BC. The damage to the text however makes this idea speculative and conjectural.


title: Nebuchadnezzar II

text: In the 601 BC campaign, Nebuchadnezzar departed from the Levant and then marched into Egypt. Despite the defeat at Carchemish in 605 BC, Egypt still had a great amount of influence in the Levant, even though the region was ostensibly under Babylonian rule. Thus, a campaign against Egypt was logical in order to assert Babylonian dominance, and also carried enormous economic and propagandistic benefits, but it was also risky and ambitious. The path into Egypt was difficult, and the lack of secure control of either side of the Sinai Desert could spell disaster. Nebuchadnezzar's invasion of Egypt did fail – the Babylonian Chronicle states that both the Egyptian and Babylonian armies suffered a huge number of casualties. Though Egypt was not conquered, the campaign did result in momentarily curbing Egyptian interest in the Levant, given that Necho II gave up his ambitions in the region. In 599 BC, Nebuchadnezzar marched his army into the Levant and then attacked and raided the Arabs in the Syrian desert. Though apparently successful, it is unclear what the achievements gained in this campaign were.


title: Nebuchadnezzar II

text: In 598 BC, Nebuchadnezzar campaigned against the Kingdom of Judah, succeeding in capturing the city of Jerusalem. Judah represented a prime target of Babylonian attention given that it was at the epicenter of competition between Babylon and Egypt. By 601 BC, Judah's king, Jehoiakim, had begun to openly challenge Babylonian authority, counting on that Egypt would lend support to his cause. Nebuchadnezzar's first, 598–597 BC, assault on Jerusalem is recorded in the Bible, but also in the Babylonian Chronicle, which describes it as follows:


title: Nebuchadnezzar II

text: Jehoiakim had died during Nebuchadnezzar's siege and been replaced by his son, Jeconiah, who was captured and taken to Babylon, with his uncle Zedekiah installed in his place as king of Judah. Jeconiah is recorded as being alive in Babylonia thereafter, with records as late as 592 or 591 BC listing him among the recipients of food at Nebuchadnezzar's palace and still referring to him as the 'king of the land of Judah'.


title: Nebuchadnezzar II

text: In 597 BC, the Babylonian army departed for the Levant again, but appears to not have engaged in any military activities as they turned back immediately after reaching the Euphrates. The following year, Nebuchadnezzar marched his army along the Tigris river to do battle with the Elamites, but no actual battle happened as the Elamites retreated out of fear once Nebuchadnezzar was a day's march away. In 595 BC, Nebuchadnezzar stayed at home in Babylon but soon had to face a rebellion against his rule there, though he defeated the rebels, with the chronicle stating that the king "put his large army to the sword and conquered his foe." Shortly thereafter, Nebuchadnezzar again campaigned in the Levant and secured large amounts of tribute. In the last year recorded in the chronicle, 594 BC, Nebuchadnezzar campaigned in the Levant yet again.


title: Nebuchadnezzar II

text: There were several years without any noteworthy military activity at all. Notably, Nebuchadnezzar spent all of 600 BC in Babylon, when the chronicle excuses the king by stating that he stayed in Babylon to "refit his numerous horses and chariotry". Some of the years when Nebuchadnezzar was victorious can also hardly be considered real challenges. Raiding the Arabs in 599 BC was not a major military accomplishment and the victory over Judah and the retreat of the Elamites were not secured on the battlefield. It thus appears that Nebuchadnezzar achieved little military success after the failure of his invasion of Egypt. Nebuchadnezzar's poor military record had dangerous geopolitical consequences. According to the Bible, in Zedekiah's fourth year as king of Judah (594 BC), the kings of Ammon, Edom, Moab, Sidon and Tyre met in Jerusalem to deal with the possibility of throwing off Babylonian control. Evidence that Babylonian control was beginning to unravel is also clear from contemporary Babylonian records, such as the aforementioned rebellion in Babylonia itself, as well as records of a man being executed in 594 BC at Borspippa for "breaking his oath to the king". The oath-breaking was serious enough that the judge in the trial was Nebuchadnezzar himself. It is also possible that Babylonian–Median relations were becoming strained, with records of a "Median defector" being housed in Nebuchadnezzar's palace and some inscriptions indicating that the Medes were beginning to be seen as "enemies". By 594 BC, the failure of the Egyptian invasion, and the lacklustre state of Nebuchadnezzar's other campaigns, loomed high. According to the Assyriologist Israel Ephʿal, Babylon at this time was seen by its contemporaries more like a "paper tiger" (i. e. an ineffectual threat) than a great empire, like Assyria just a few decades prior.


title: Nebuchadnezzar II

text: From his appointment as king of Judah, Zedekiah waited for the opportune moment to throw off Babylonian control. After Pharaoh Necho II's death in 595 BC, Egyptian intervention in affairs in the Levant increased once again under his successors, Psamtik II (595–589 BC) and Apries (589–570 BC), who both worked to encourage anti-Babylonian rebellions. It is possible that the Babylonian failure to invade Egypt in 601 BC helped inspire revolts against the Babylonian Empire. The outcome of these efforts was Zedekiah's open revolt against Nebuchadnezzar's authority. Unfortunately, no cuneiform sources are preserved from this time and the only known account of the fall of Judah is the biblical account.


title: Nebuchadnezzar II

text: In 589 BC, Zedekiah refused to pay tribute to Nebuchadnezzar, and he was closely followed in this by Ithobaal III, the king of Tyre. In response to Zedekiah's uprising, Nebuchadnezzar conquered and destroyed the Kingdom of Judah in 586 BC, one of the great achievements of his reign. The campaign, which probably ended in the summer of 586 BC, resulted in the plunder and destruction of the city of Jerusalem, a permanent end to Judah, and it led to the Babylonian captivity, as the Jews were captured and deported to Babylonia. Archaeological excavations confirm that Jerusalem and the surrounding area was destroyed and depopulated. It is possible that the intensity of the destruction carried out by Nebuchadnezzar at Jerusalem and elsewhere in the Levant was due to the implementation of something akin to a scorched earth-policy, aimed at stopping Egypt from gaining a foothold there.


title: Nebuchadnezzar II

text: Some Jewish administration was allowed to remain in the region under the governor Gedaliah, governing from Mizpah under close Babylonian monitoring. According to the Bible, and the 1st-century AD Jewish historian Flavius Josephus, Zedekiah attempted to flee after resisting the Babylonians, but was captured at Jericho and suffered a terrible fate. According to the narrative, Nebuchadnezzar wanted to make an example out of him given that Zedekiah was not an ordinary vassal, but a vassal directly appointed by Nebuchadnezzar. As such, Zedekiah was supposedly taken to Riblah in northern Syria, where he had to watch his sons being executed before having his eyes gouged out and sent to be imprisoned in Babylon.


title: Nebuchadnezzar II

text: Per the Books of Kings in the Bible, the campaign against Judah was longer than typical Mesopotamian wars, with the siege of Jerusalem lasting 18–30 months (depending on the calculation), rather than the typical length of less than a year. Whether the unusual length of the siege indicates that the Babylonian army was weak, unable to break into the city for more than a year, or that Nebuchadnezzar by this time had succeeded in stabilising his rule in Babylonia and could thus wage war patiently without being pressured by time to escalate the siege, is not certain.


title: Nebuchadnezzar II

text: It is possible that the Egyptians took advantage of the Babylonians being preoccupied with besieging Jerusalem. Herodotus describes Pharaoh Apries as campaigning in the Levant, taking the city of Sidon and fighting the Tyrians, which indicates a renewed Egyptian invasion of the Levant. Apries is unlikely to have been as successful as Herodotus describes, given that it is unclear how the Egyptian navy would have defeated the superior navies of the Phoenician cities, and even if some cities had been taken, they must have shortly thereafter fallen into Babylonian hands again. Tyre had rebelled against Nebuchadnezzar at around the same time as Judah, and Nebuchadnezzar moved to retake the city after his successful subduing of the Jews.


title: Nebuchadnezzar II

text: The biblical Book of Ezekiel describes Tyre in 571 BC as if it had been recently captured by the Babylonian army. The supposed length of the siege, 13 years, is only given by Flavius Josephus, and is subject to debate among modern scholars. Josephus's account of Nebuchadnezzar's reign is obviously not entirely historic, as he describes Nebuchadnezzar as, five years after the destruction of Jerusalem, invading Egypt, capturing the Pharaoh and appointing another Pharaoh in his place. Josephus states that Nebuchadnezzar besieged Tyre in the seventh year of "his" reign, though it is unclear whether "his" in this context refers to Nebuchadnezzar or to Ithobaal III of Tyre. If it refers to Nebuchadnezzar, a siege begun in 598 BC and lasting for thirteen years, later simultaneously with the siege of Jerusalem, is unlikely to have gone unmentioned in Babylonian records. If the seventh year of Ithobaal is intended, the beginning of the siege may conjecturally be placed after Jerusalem's fall. If the siege lasting 13 years is taken at face value, the siege would then not have ended before 573 or 572 BC. The supposed length of the siege can be ascribed to the difficulty in besieging the city: Tyre was located on an island 800 metres from the coast, and could not be taken without naval support. Though the city withstood numerous sieges, it would not be captured until Alexander the Great's siege in 332 BC.


title: Nebuchadnezzar II

text: In the end, the siege was resolved without a need of battle and did not result in the Tyre being conquered. It seems Tyre's king and Nebuchadnezzar came to an agreement for Tyre to continue to be ruled by vassal kings, though probably under heavier Babylonian control than before. Documents from Tyre near the end of Nebuchadnezzar's reign demonstrate that the city had become a centre for Babylonian military affairs in the region. According to later Jewish tradition, it is possible that Ithobaal III was deposed and taken as a prisoner to Babylon, with another king, Baal II, proclaimed by Nebuchadnezzar in his place.


title: Nebuchadnezzar II

text: It is possible that Nebuchadnezzar campaigned against Egypt in 568 BC, given that a fragmentary Babylonian inscription, given the modern designation BM 33041, from that year records the word "Egypt" as well as possibly traces of the name "Amasis" (the name of the then incumbent Pharaoh, Amasis II, 570–526 BC). A stele of Amasis, also fragmentary, may also describe a combined naval and land attack by the Babylonians. The evidence for this campaign is scant however, and the readings of the relevant inscriptions are not certain. If Nebuchadnezzar did campaign against Egypt again, he was unsuccessful again, given that Egypt did not come under Babylonian rule.


title: Nebuchadnezzar II

text: Nebuchadnezzar's campaigns in the Levant, most notably those directed towards Jerusalem and Tyre, completed the Neo-Babylonian Empire's transformation from a rump state of the Neo-Assyrian Empire to the new dominant power of the ancient Near East. Still, Nebuchadnezzar's military accomplishments can be questioned, given that the borders of his empire, by the end of his reign, had not noticeably increased in size and that he had not managed to conquer Egypt. Even after a reign of several decades, Nebuchadnezzar's greatest victory remained his victory over the Egyptians at Carchemish in 605 BC, before he even became king.


title: Nebuchadnezzar II

text: The Babylonian king was traditionally a builder and restorer, and as such large-scale building projects were important as a legitimizing factor for Babylonian rulers. Nebuchadnezzar extensively expanded and rebuilt his capital city of Babylon and the most modern historical and archaeological interpretations of the city reflect it as it appeared after Nebuchadnezzar's construction projects. The projects were made possible through the prospering economy during Nebuchadnezzar's reign, sustained by his conquests. His building inscriptions record work done to numerous temples, notably the restoration of the Esagila, the main temple of Babylon's national deity Marduk, and the completion of the Etemenanki, a great ziggurat dedicated to Marduk.


title: Nebuchadnezzar II

text: Extensive work was also conducted on civil and military structures. Among the most impressive efforts was the work done surrounding the city's northern ceremonial entrance, the Ishtar Gate. These projects included restoration work on the South Palace, inside the city walls, the construction of a completely new North Palace, on the other side of the walls facing the gate, as well as the restoration of Babylon's Processional Street, which led through the gate, and of the gate itself. The ruins of Nebuchadnezzar's North Palace are poorly preserved and as such its structure and appearance are not entirely understood. Nebuchadnezzar also constructed a third palace, the Summer Palace, built some distance north of the inner city walls in the northernmost corner of the outer walls.


title: Nebuchadnezzar II

text: The restored Ishtar Gate was decorated with blue and yellow glazed bricks and depictions of bulls (symbols of the god Adad) and dragons (symbols of the god Marduk). Similar bricks were used for the walls surrounding the Processional Street, which also featured depictions of lions (symbols of the goddess Ishtar). Babylon's Processional Street, the only such street yet excavated in Mesopotamia, ran along the eastern walls of the South Palace and exited the inner city walls at the Ishtar Gate, running past the North Palace. To the south, this street went by the Etemenanki, turning to the west and going over a bridge constructed either under the reign of Nabopolassar or Nebuchadnezzar. Some of the bricks of the Processional Street bear the name of the Neo-Assyrian king Sennacherib (705–681 BC) on their underside, perhaps indicating that construction of the street had begun already during his reign, but the fact that the upper side of the bricks all bear the name of Nebuchadnezzar suggests that construction of the street was completed under Nebuchadnezzar's reign. Glazed bricks such as the ones used in the Procession Street were also used in the throne room of the South Palace, which was decorated with depictions of lions and tall, stylized palm trees.


title: Nebuchadnezzar II

text: Nebuchadnezzar also directed building efforts on the city of Borsippa, with several of his inscriptions recording restoration work on that city's temple, the Ezida, dedicated to the god Nabu. Additionally, Nebuchadnezzar also restored the ziggurat of the Ezida, the E-urme-imin-anki, and also worked on the temple of Gula, Etila, as well as numerous other temples and shrines in the city. Nebuchadnezzar also repaired Borsippa's walls.


title: Nebuchadnezzar II

text: Other great building projects by Nebuchadnezzar include the Nar-Shamash, a canal to bring water from the Euphrates close to the city of Sippar, and the Median Wall, a large defensive structure built to defend Babylonia against incursions from the north. The Median Wall was one of two walls built to protect Babylonia's northern border. Further evidence that Nebuchadnezzar believed the north to be the most likely point of attack for his enemies comes from that he fortified the walls of northern cities, such as Babylon, Borsippa and Kish, but left the walls of southern cities, such as Ur and Uruk, as they were. Nebuchadnezzar also began work on the Royal Canal, also known as Nebuchadnezzar's Canal, a great canal linking the Euphrates to the Tigris which in time completely transformed the agriculture of the region, but the structure was not completed until the reign of Nabonidus, who ruled as the last king of the Neo-Babylonian Empire from 556 to 539 BC.


title: Nebuchadnezzar II

text: Nebuchadnezzar died at Babylon in 562 BC. The last known tablet dated to Nebuchadnezzar's reign, from Uruk, is dated to the same day, 7 October, as the first known tablet of his successor, Amel-Marduk, from Sippar. Amel-Marduk's administrative duties probably began before he became king, during the last few weeks or months of his father's reign when Nebuchadnezzar was ill and dying. Having ruled for 43 years, Nebuchadnezzar's reign was the longest of his dynasty and he would be remembered favourably by the Babylonians.


title: Nebuchadnezzar II

text: Amel-Marduk's accession does not appear to have gone smoothly. Amel-Marduk was not the eldest living son of Nebuchadnezzar and the reason why he was picked as crown prince is not known. The choice is especially strange given that some sources suggest that the relationship between Nebuchadnezzar and Amel-Marduk was particularly poor, with one surviving text describing both as parties in some form of conspiracy and accusing one of them (the text is too fragmentary to determine which one) of failing in the most important duties of Babylonian kingship through exploiting Babylon's populace and desecrating its temples. Amel-Marduk also at one point appears to have been imprisoned by his father, possibly on account of the Babylonian aristocracy having proclaimed him as king while Nebuchadnezzar was away. It is possible that Nebuchadnezzar intended to replace Amel-Marduk as heir with another son, but died before doing so.


title: Nebuchadnezzar II

text: In one of Nebuchadnezzar's late inscriptions, written more than forty years into his reign, he wrote that he had been chosen for the kingship by the gods before he was even born. Mesopotamian rulers typically only stressed divine legitimacy in this fashion when their actual legitimacy was questionable, a method often employed by usurpers. Given that Nebuchadnezzar at this point had been king for several decades and was the legitimate heir of his predecessor, the inscription is very strange, unless it was intended to help legitimize Nebuchadnezzar's successor, Amel-Marduk, who as a younger son and a former conspirator could be seen as politically problematic.


title: Nebuchadnezzar II

text: No surviving contemporary Babylonian documents provide the name of Nebuchadnezzar's wife. According to Berossus, her name was Amytis, daughter of Astyages, king of the Medes. Berossus writes that '[Nabopolassar] sent troops to the assistance of Astyages, the tribal chieftain and satrap of the Medes in order to obtain a daughter of Astyages, Amyitis, as wife for his son [Nebuchadnezzar]'. Though the ancient Greek historian Ctesias instead wrote that Amytis was the name of a daughter of Astyages who had married Cyrus I of Persia, it seems more likely that a Median princess would marry a member of the Babylonian royal family, considering the good relations established between the two during Nabopolassar's reign. Given that Astyages was still too young during Nabopolassar's reign to already have children, and was not yet king, it seems more probable that Amytis was Astyages's sister, and thus a daughter of his predecessor, Cyaxares. By marrying his son to a daughter of Cyaxares, Nebuchadnezzar's father Nabopolassar likely sought to seal the alliance between the Babylonians and the Medes. According to tradition, Nebuchadnezzar constructed the Hanging Gardens of Babylon, one of the Seven Wonders of the Ancient World, featuring exotic shrubs, vines and trees as well as artificial hills, watercourses and knolls, so that Amytis would feel less homesick for the mountains of Media. No archaeological evidence for these gardens has yet been found.


title: Nebuchadnezzar II

text: Nebuchadnezzar had six known sons. Most of the sons, with the exceptions of Marduk-nadin-ahi and Eanna-sharra-usur, are attested very late in their father's reign. It is possible that they might have been the product of a second marriage and that they could have been born relatively late in Nebuchadnezzar's reign, possibly after his known daughters. The known sons of Nebuchadnezzar are:


title: Nebuchadnezzar II

text: It is possible that one of Nebuchadnezzar's daughters married the high official Nabonidus. Marriage to a daughter of Nebuchadnezzar could explain how Nabonidus could become king, and also explain why certain later traditions, such as the Book of Daniel in the Bible, describe Nabonidus's son, Belshazzar, as Nebuchadnezzar's son (descendant). Alternatively, these later traditions might instead derive from royal propaganda. The ancient Greek historian Herodotus names the "last great queen" of the Babylonian Empire as "Nitocris", though that name (nor any other name) is not attested in contemporary Babylonian sources. Herodotus's description of Nitocris contains a wealth of legendary material that makes it difficult to determine whether he uses the name to refer to Nabonidus's wife or mother, but William H. Shea proposed in 1982 that Nitocris may tentatively be identified as the name of Nabonidus's wife and Belshazzar's mother.


title: Nebuchadnezzar II

text: Because of the scarcity of sources, assessment by historians of Nebuchadnezzar's character and the nature of his reign have differed considerably over time. He has typically been regarded as the greatest and most prestigious king of the Neo-Babylonian Empire.


title: Nebuchadnezzar II

text: Since military activity was not a major issue described in the inscriptions of any Neo-Babylonian king regardless of their actual military accomplishments, in sharp contrast to the inscriptions of their Neo-Assyrian predecessors, Nebuchadnezzar's own inscriptions talk very little about his wars. Out of the fifty or so known inscriptions by the king, only a single one deals with military action, and in this case only small-scale conflicts in the Lebanon region. Many Assyriologists, such as Wolfram von Soden in 1954, thus initially assumed that Nebuchadnezzar had mainly been a builder-king, devoting his energy and efforts to building and restoring his country. A major change in evaluations of Nebuchadnezzar came with the publication of the tablets of the Babylonian Chronicle by Donald Wiseman in 1956, which cover the geopolitical events of Nebuchadnezzar's first eleven years as king. From the publication of these tablets and onwards, historians have shifted to perceiving Nebuchadnezzar as a great warrior, devoting special attention to the military achievements of his reign.


title: Nebuchadnezzar II

text: According to the historian Josette Elayi, writing in 2018, Nebuchadnezzar is somewhat difficult to characterise on account of the scarcity of Babylonian source material. Elayi wrote, about Nebuchadnezzar, that "He was a conqueror, even though reservations can be had about his military capabilities. There was no lack of statesmanlike qualities, given his success in building the Babylonian Empire. He was a great builder, who restored a country that for a long time had been devastated by war. That is roughly all we know about him because the Babylonian Chronicles and other texts say little about his personality."


title: Nebuchadnezzar II

text: The Babylonian captivity initiated by Nebuchadnezzar came to an end with the fall of Babylon to the Achaemenid king Cyrus the Great in 539 BC. Within a year of their liberation, some captured Jews returned to their homeland. Their liberation did little to erase the memory of five decades of imprisonment and oppression. Instead, Jewish literary accounts ensured that accounts of the hardship endured by the Jews, as well as the monarch responsible for it, would be remembered for all time. The Book of Jeremiah calls Nebuchadnezzar a "lion" and a "destroyer of nations".


title: Nebuchadnezzar II

text: Nebuchadnezzar's story thus found its way into the Old Testament of the Bible. The Bible narrates how Nebuchadnezzar destroyed the Kingdom of Judah, besieged, plundered and destroyed Jerusalem, and how he took away the Jews in captivity, portraying him as a cruel enemy of the Jewish people. The Bible also portrays Nebuchadnezzar as the legitimate ruler of all the nations of the world, appointed to rule the world by God. As such, Judah, through divine ruling, should have obeyed Nebuchadnezzar and not rebelled. Nebuchadnezzar is also depicted as carrying out death sentences pronounced by God, slaying two false prophets. Nebuchadnezzar's campaigns of conquest against other nations are portrayed as being in-line with God's will for Nebuchadnezzar's dominance.Despite Nebuchadnezzar's negative portrayal, he is notably referred with the epithet 'my servant' (i.e. God's servant) in three places in the Book of Jeremiah. Nebuchadnezzar's attack on the Kingdom of Judah is theologically justified in the Book of Jeremiah on account of its populace's 'disobedience' of God, and the king is called "Nebuchadnezzar the king of Babylon, my servant". The Book of Jeremiah also states that God has made all the Earth and given it to whom it seemed proper to give it to, deciding upon giving all of the lands of the world to "Nebuchadnezzar the king of Babylon, my servant". The Book of Jeremiah also prophesises Nebuchadnezzar's victory over Egypt, stating that "Nebuchadnezzar the king of Babylon, my servant" will invade Egypt and "deliver to death those appointed for death, and to captivity those appointed for captivity, and to the sword those appointed for the sword". Given that Nebuchadnezzar was the enemy of what the Bible proclaims as God's chosen people, possibly the worst enemy they had faced until this point, there must be a special reason for referring to him with the epithet "my servant". Other uses of this epithet are usually limited to some of the most positively portrayed figures, such as the various prophets, Jacob (the symbol of the chosen people) and David (the chosen king). Klaas A. D. Smelik noted in 2004 that "in the Hebrew Bible, there is no better company conceivable than these; at the same time, there is no candidate less likely for this title of honour than the Babylonian king Nebuchadnezzar". It is possible that the epithet is a later addition, as it is missing in the Septuagint version of the Old Testament, perhaps added after Nabuchadnezzar began to be seen in a slightly more favourable light than immediately after Jerusalem's destruction. Alternatively, possible theological explanations include Nebuchadnezzar, despite his cruelty, being seen as an instrument in fulfilling God's universal plan, or perhaps that designating him as a "servant" of God was to show that readers should not fear Nebuchadnezzar, but his true master, God.


title: Nebuchadnezzar II

text: In the Book of Daniel, recognised by scholars as a work of historical fiction, Nebuchadnezzar is given a portrayal that differs considerably from his portrayal in the Book of Jeremiah. He is for the most part depicted as a merciless and despotic ruler. The king has a nightmare, and asks his wise men, including Daniel and his three companions Shadrach, Meshach and Abednego, to interpret the dream, but refuses to state the dream's contents. When the servants protest, Nebuchadnezzar sentences all of them (including Daniel and his companions) to death. By the end of the story, when Daniel successfully interpreted the dream, Nebuchadnezzar is nevertheless shown to be very grateful, showering Daniel with gifts, making him the governor of the "province of Babylon" and making him the chief of the kingdoms' wisemen. A second story again casts Nebuchadnezzar as a tyrannical and pagan king, who after Shadrach, Meshach and Abednego refuse to worship a newly erected golden statue sentences them to death through being thrown into a furnace. They are miraculously delivered, and Nebuchadnezzar then acknowledges God as the "lord of kings" and "god of gods". Though Nebuchadnezzar is also mentioned as acknowledging the God as the true god in other passages of the Book of Daniel, it is apparent that his supposed conversion to Judaism does not change his violent character, given that he proclaims that anyone who speaks amiss of God "shall be cut in pieces and their houses shall be made a dunghill". In a third story, Daniel interprets another dream as meaning that Nebuchadnezzar will lose his mind and live like an animal for seven years before being restored to his normal state (Daniel 1-4). The portrayal of Nebuchadnezzar in the Book of Daniel is a fickle tyrant who is not particularly consistent in his faith, far from the typical "servants of God" in other books of the Bible.


title: Nebuchadnezzar II

text: Given that Nebuchadnezzar is referred to as the father of Belshazzar in the Book of Daniel, it is probable that this portrayal of Nebuchadnezzar, especially the story of his madness, was actually based on Belshazzar's real father, Nabonidus, the last king of the Neo-Babylonian Empire (556–539 BC). Separate Jewish and Hellenistic traditions exist concerning Nabonidus having been mad, and it is likely that this madness was simply reattributed to Nebuchadnezzar in the Book of Daniel through conflation. Some later traditions conflated Nebuchadnezzar with other rulers as well, such as the Assyrian Ashurbanipal (669–631 BC), the Persian Artaxerxes III (358–338 BC), the Seleucids Antiochus IV Epiphanes (175–164 BC) and Demetrius I Soter (161–150 BC) and the Armenian Tigranes the Great (95–55 BC). The apocryphal Book of Judith, which probably applies the name Nebuchadnezzar to Tigranes the Great of Armenia, refers to Nebuchadnezzar as a king of the Assyrians, rather than Babylonians, and demonstrates that Nebuchadnezzar was still viewed as an evil king, responsible for destroying Jerusalem, looting its temple, taking the Jews hostage in Babylon, and for the various misdeeds ascribed to him in later Jewish writings.


title: Nebuchadnezzar II

text: In most of his inscriptions, Nebuchadnezzar is typically only titled as "Nebuchadnezzar, king of Babylon, son of Nabopolassar, king of Babylon" or "Nebuchadnezzar, king of Babylon, the one who provides for Esagil and Ezida, son of Nabopolassar, king of Babylon". In economic documents, Nebuchadnezzar is also ascribed the ancient title "king of the Universe", and he sometimes also used the title "king of Sumer and Akkad", used by all the Neo-Babylonian kings. Some inscriptions accord Nebuchadnezzar more elaborate version of his titles, including the following variant, attested in an inscription from Babylon:


title: Steampunk

text: Steampunk is a subgenre of science fiction that incorporates retrofuturistic technology and aesthetics inspired by 19th-century industrial steam-powered machinery. Steampunk works are often set in an alternative history of the Victorian era or the American "Wild West", where steam power remains in mainstream use, or in a fantasy world that similarly employs steam power.