title: Airborne early warning and control

text: During the Cold war, United Kingdom deployed a substantial AEW capability, initially with American Douglas AD-4W Skyraiders, designated Skyraider AEW.1, which in turn were replaced by the Fairey Gannet AEW.3, using the same AN/APS-20 radar. With the retirement of conventional aircraft carriers, the Gannet was withdrawn and the Royal Air Force (RAF) installed the radars from the Gannets on Avro Shackleton MR.2 airframes, redesignated Shackleton AEW.2. To replace the Shackleton AEW.2, an AEW variant of the Hawker Siddeley Nimrod, known as the Nimrod AEW3, was ordered in 1974. After a protracted and problematic development, this was cancelled in 1986, and seven E-3Ds, designated Sentry AEW.1 in RAF service, were purchased instead.


title: Airborne early warning and control

text: Many countries have developed their own AEW&C systems, although the Boeing E-3 Sentry and Northrop Grumman E-2 Hawkeye are the most common systems worldwide.


title: Airborne early warning and control

text: Boeing produces a specific system with a "rotodome" rotating radome that incorporates Westinghouse (now Northrop Grumman) radar. It is mounted on either the E-3 Sentry aircraft (Boeing 707) or more recently the Boeing E-767 (Boeing 767), the latter only being used by the Japan Air Self-Defense Force.


title: Airborne early warning and control

text: When AWACS first entered service it represented a major advance in capability, being the first AEW to use a pulse-Doppler radar, which allowed it to track targets normally lost in ground clutter. Previously, low-flying aircraft could only be readily tracked over water. The AWACS features a three-dimensional radar that measures azimuth, range, and elevation simultaneously; the unit installed upon the E-767 has superior surveillance capability over water compared to the AN/APY-1 system on the earlier E-3 models.


title: Airborne early warning and control

text: The E-2 Hawkeye was a specially designed AEW aircraft. Upon its entry to service in 1965, it was initially plagued by technical issues, causing a (later reversed) cancellation. Procurement resumed after efforts to improve reliability, such as replacement of the original rotary drum computer used for processing radar information by a Litton L-304 digital computer. In addition to purchases by the US Navy, the E-2 Hawkeye has been sold to the armed forces of Egypt, France, Israel, Japan, Singapore and Taiwan.


title: Airborne early warning and control

text: The latest E-2 version is the "E-2D Advanced Hawkeye", which features the new AN/APY-9 radar. The APY-9 radar has been speculated to be capable of detecting fighter-sized stealth aircraft, which are typically optimized against high frequencies like Ka, Ku, X, C and parts of the S-bands. Historically, UHF radars had resolution and detection issues that made them ineffective for accurate targeting and fire control; Northrop Grumman and Lockheed claim that the APY-9 has solved these shortcomings in the APY-9 using advanced electronic scanning and high digital computing power via space/time adaptive processing.


title: Airborne early warning and control

text: The Russian Air Force is currently using approximately 15–20 Beriev A-50 and A-50U "Shmel" in the AEW role. The "Mainstay" is based on the Ilyushin Il-76 airframe, with a large non-rotating disk radome on the rear fuselage. These replaced the 12 Tupolev Tu-126 that filled the role previously. The A-50 and A-50U will eventually be replaced by the Beriev A-100, which features an AESA array in the radome and is based on the updated Il-476.


title: Airborne early warning and control

text: In May 1997, Russia and Israel agreed to jointly fulfill an order from China to develop and deliver an early warning system. China reportedly ordered one Phalcon for $250 million, which entailed retrofitting a Russian-made Ilyushin-76 cargo plane [also incorrectly reported as a Beriev A-50 Mainstay] with advanced Elta electronic, computer, radar and communications systems. Beijing was expected to acquire several Phalcon AEW systems, and reportedly could buy at least three more [and possibly up to eight] of these systems, the prototype of which was planned for testing beginning in 2000. In July 2000, the US pressured Israel to back out of the $1 billion agreement to sell China four Phalcon phased-array radar systems. Following the cancelled A-50I/Phalcon deal, China turned to indigenous solutions. The Phalcon radar and other electronic systems were taken off from the unfinished Il-76, and the airframe was handed to China via Russia in 2002. The Chinese AWACS has a unique phased array radar (PAR) carried in a round radome. Unlike the US AWACS aircraft, which rotate their rotodomes to give a 360 degree coverage, the radar antenna of the Chinese AWACS does not rotate. Instead, three PAR antenna modules are placed in a triangular configuration inside the round radome to provide a 360 degree coverage. The installation of equipment at the Il-76 began in late 2002 aircraft by Xian aircraft industries (Xian Aircraft Industry Co.). The first flight of an airplane KJ-2000 made in November 2003. All four machines will be equipped with this type. The last to be introduced into service the Chinese Air Force until the end of 2007.<ref name="http://www.globalsecurity.org/military/world/china/kj-2000.htm"></ref> China is also developing a carrier-based AEW&C, Xian KJ-600 via Y-7 derived Xian JZY-01 testbed.


title: Airborne early warning and control

text: In 2003, the Indian Air Force (IAF) and Defence Research and Development Organisation (DRDO) began a study of requirements for developing an Airborne Early Warning and Control (AWAC) system. In 2015, DRDO delivered 3 AWACs, called Netra, to the IAF with an advanced Indian AESA radar system fitted on the Brazilian Embraer EMB-145 air frame. Netra gives a 240-degree coverage of airspace. The Emb-145 also has air-to-air refuelling capability for longer surveillance time. The IAF also operates three Israeli EL/W-2090 systems, mounted on Ilyushin Il-76 airframes, the first of which first arrived on 25 May 2009. The DRDO proposed a more advanced AWACS with a longer range and with a 360-degree coverage akin to the Phalcon system, based on the Airbus A330 airframe, but given the costs involved there is also the possibility of converting used A320 airliners as well.


title: Airborne early warning and control

text: The Royal Australian Air Force, Republic of Korea Air Force and the Turkish Air Force are deploying Boeing 737 AEW&C aircraft. The Boeing 737 AEW&C has a fixed, active electronically scanned array radar antenna instead of a rotating one, and is capable of simultaneous air and sea search, fighter control and area search, with a maximum range of over 600 km (look-up mode). In addition, the radar antenna array is also doubled as an ELINT array, with a maximum range of over 850 km at altitude.


title: Airborne early warning and control

text: The Swedish Air Force uses the S 100D Argus ASC890 as its AEW platform. The S 100D Argus is based on the Saab 340 with an Ericsson Erieye PS-890 radar. Saab also offers the Bombardier Global 6000-based GlobalEye. In early 2006, the Pakistan Air Force ordered six Erieye AEW equipped Saab 2000s from Sweden. In December 2006, the Pakistan Navy requested three excess P-3 Orion aircraft to be equipped with Hawkeye 2000 AEW systems. China and Pakistan also signed a memorandum of understanding (MoU) for the joint development of AEW&C systems.


title: Airborne early warning and control

text: The Hellenic Air Force, Brazilian Air Force and Mexican Air Force use the Embraer R-99 with an Ericsson Erieye PS-890 radar, as on the S 100D.


title: Airborne early warning and control

text: Israel has developed the IAI/Elta EL/M-2075 Phalcon system, which uses an AESA (active electronically scanned array) in lieu of a rotodome antenna. The system was the first such system to enter service. The original Phalcon was mounted on a Boeing 707 and developed for the Israeli Defense Force and for export. Israel uses IAI EL/W-2085 airborne early warning and control multi-band radar system on Gulfstream G550; this platform is considered to be both more capable and less expensive to operate than the older Boeing 707-based Phalcon fleet.


title: Airborne early warning and control

text: On 3 June 1957, the first of 2 HR2S-1W, a derivative of the Sikorsky CH-37 Mojave, was delivered to the US Navy, it used the AN/APS-32 but proved unreliable due to vibration.


title: Airborne early warning and control

text: The British Sea King ASaC7 naval helicopter was operated from both the s and later the helicopter carrier . The creation of Sea King ASaC7, and earlier AEW.2 and AEW.5 models, came as the consequence of lessons learnt by the Royal Navy during the 1982 Falklands War when the lack of AEW coverage for the task force was a major tactical handicap, and rendered them vulnerable to low-level attack. The Sea King was determined to be both more practical and responsive than the proposed alternative of relying on the RAF's land-based Shackleton AEW.2 fleet. The first examples were a pair of Sea King HAS2s that had the Thorn-EMI ARI 5980/3 Searchwater LAST radar attached to the fuselage on a swivel arm and protected by an inflatable dome. The improved Sea King ASaC7 featured the Searchwater 2000AEW radar, which was capable of simultaneously tracking up to 400 targets, instead of an earlier limit of 250 targets. The Spanish Navy fields the SH-3 Sea King in the same role, operated from the LPH .


title: Airborne early warning and control

text: The AgustaWestland EH-101A AEW of the Italian Navy is operated from the aircraft carriers and . During the 2010s, the Royal Navy opted to replace its Sea Kings with a modular "Crowsnest" system that can be fitted to any of their Merlin HM2 fleet. The Crowsnest system was partially based upon the Sea King ASaC7's equipment; an unsuccessful bid by Lockheed Martin had proposed using a new multi-functional sensor for either the AW101 or another aircraft.


title: Airborne early warning and control

text: The Russian-built Kamov Ka-31 is deployed by the Indian Navy on the aircraft carrier and s and will be deployed on the . The Russian Navy has two Ka-31R variants, at least one of which was deployed on their aircraft carrier in 2016. It is fitted with E-801M Oko (Eye) airborne electronic warfare radar that can track 20 targets simultaneously, detecting aircraft up to away, and surface warships up to distant.


title: Infection

text: An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection.


title: Infection

text: Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune system. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response.


title: Infection

text: Specific medications used to treat infections include antibiotics, antivirals, antifungals, antiprotozoals, and antihelminthics. Infectious diseases resulted in 9.2 million deaths in 2013 (about 17% of all deaths). The branch of medicine that focuses on infections is referred to as infectious disease.


title: Infection

text: The signs and symptoms of an infection depend on the type of disease. Some signs of infection affect the whole body generally, such as fatigue, loss of appetite, weight loss, fevers, night sweats, chills, aches and pains. Others are specific to individual body parts, such as skin rashes, coughing, or a runny nose.


title: Infection

text: In certain cases, infectious diseases may be asymptomatic for much or even all of their course in a given host. In the latter case, the disease may only be defined as a "disease" (which by definition means an illness) in hosts who secondarily become ill after contact with an asymptomatic carrier. An infection is not synonymous with an infectious disease, as some infections do not cause illness in a host.


title: Infection

text: As bacterial and viral infections can both cause the same kinds of symptoms, it can be difficult to distinguish which is the cause of a specific infection. Distinguishing the two is important, since viral infections cannot be cured by antibiotics whereas bacterial infections can.


title: Infection

text: There is a general chain of events that applies to infections, sometimes called the chain of infection. The chain of events involves several stepswhich include the infectious agent, reservoir, entering a susceptible host, exit and transmission to new hosts. Each of the links must be present in a chronological order for an infection to develop. Understanding these steps helps health care workers target the infection and prevent it from occurring in the first place.


title: Infection

text: Infection begins when an organism successfully enters the body, grows and multiplies. This is referred to as colonization. Most humans are not easily infected. Those with compromised or weakened immune systems have an increased susceptibility to chronic or persistent infections. Individuals who have a suppressed immune system are particularly susceptible to opportunistic infections. Entrance to the host at host-pathogen interface, generally occurs through the mucosa in orifices like the oral cavity, nose, eyes, genitalia, anus, or the microbe can enter through open wounds. While a few organisms can grow at the initial site of entry, many migrate and cause systemic infection in different organs. Some pathogens grow within the host cells (intracellular) whereas others grow freely in bodily fluids.


title: Infection

text: Wound colonization refers to non-replicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon, and an example of the latter are the various species of staphylococcus that exist on human skin. Neither of these colonizations are considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as "Corynebacteria sp." and "viridans streptococci", prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing.


title: Infection

text: The variables involved in the outcome of a host becoming inoculated by a pathogen and the ultimate outcome include:


title: Infection

text: As an example, several staphylococcal species remain harmless on the skin, but, when present in a normally sterile space, such as in the capsule of a joint or the peritoneum, multiply without resistance and cause harm.


title: Infection

text: An interesting fact that gas chromatography–mass spectrometry, 16S ribosomal RNA analysis, omics, and other advanced technologies have made more apparent to humans in recent decades is that microbial colonization is very common even in environments that humans think of as being nearly sterile. Because it is normal to have bacterial colonization, it is difficult to know which chronic wounds can be classified as infected and how much risk of progression exists. Despite the huge number of wounds seen in clinical practice, there are limited quality data for evaluated symptoms and signs. A review of chronic wounds in the Journal of the American Medical Association's "Rational Clinical Examination Series" quantified the importance of increased pain as an indicator of infection. The review showed that the most useful finding is an increase in the level of pain [likelihood ratio (LR) range, 11–20] makes infection much more likely, but the absence of pain (negative likelihood ratio range, 0.64–0.88) does not rule out infection (summary LR 0.64–0.88).


title: Infection

text: Disease can arise if the host's protective immune mechanisms are compromised and the organism inflicts damage on the host. Microorganisms can cause tissue damage by releasing a variety of toxins or destructive enzymes. For example, "Clostridium tetani" releases a toxin that paralyzes muscles, and staphylococcus releases toxins that produce shock and sepsis. Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop disease. On the other hand, some infectious agents are highly virulent. The prion causing mad cow disease and Creutzfeldt–Jakob disease invariably kills all animals and people that are infected.


title: Infection

text: Persistent infections occur because the body is unable to clear the organism after the initial infection. Persistent infections are characterized by the continual presence of the infectious organism, often as latent infection with occasional recurrent relapses of active infection. There are some viruses that can maintain a persistent infection by infecting different cells of the body. Some viruses once acquired never leave the body. A typical example is the herpes virus, which tends to hide in nerves and become reactivated when specific circumstances arise.


title: Infection

text: Persistent infections cause millions of deaths globally each year. Chronic infections by parasites account for a high morbidity and mortality in many underdeveloped countries.


title: Infection

text: For infecting organisms to survive and repeat the infection cycle in other hosts, they (or their progeny) must leave an existing reservoir and cause infection elsewhere. Infection transmission can take place via many potential routes:


title: Infection

text: The relationship between "virulence versus transmissibility" is complex; with studies have shown that there were no clear relationship between the two. There is still a small number of evidence that partially suggests a link between virulence and transmissibility.


title: Infection

text: Diagnosis of infectious disease sometimes involves identifying an infectious agent either directly or indirectly. In practice most minor infectious diseases such as warts, cutaneous abscesses, respiratory system infections and diarrheal diseases are diagnosed by their clinical presentation and treated without knowledge of the specific causative agent. Conclusions about the cause of the disease are based upon the likelihood that a patient came in contact with a particular agent, the presence of a microbe in a community, and other epidemiological considerations. Given sufficient effort, all known infectious agents can be specifically identified. The benefits of identification, however, are often greatly outweighed by the cost, as often there is no specific treatment, the cause is obvious, or the outcome of an infection is benign.


title: Infection

text: Diagnosis of infectious disease is nearly always initiated by medical history and physical examination. More detailed identification techniques involve the culture of infectious agents isolated from a patient. Culture allows identification of infectious organisms by examining their microscopic features, by detecting the presence of substances produced by pathogens, and by directly identifying an organism by its genotype. Other techniques (such as X-rays, CAT scans, PET scans or NMR) are used to produce images of internal abnormalities resulting from the growth of an infectious agent. The images are useful in detection of, for example, a bone abscess or a spongiform encephalopathy produced by a prion.


title: Infection

text: The diagnosis is aided by the presenting symptoms in any individual with an infectious disease, yet it usually needs additional diagnostic techniques to confirm the suspicion. Some signs are specifically characteristic and indicative of a disease and are called pathognomonic signs; but these are rare. Not all infections are symptomatic.


title: Infection

text: In children the presence of cyanosis, rapid breathing, poor peripheral perfusion, or a petechial rash increases the risk of a serious infection by greater than 5 fold. Other important indicators include parental concern, clinical instinct, and temperature greater than 40 °C.


title: Infection

text: Many diagnostic approaches depend on microbiological culture to isolate a pathogen from the appropriate clinical specimen. In a microbial culture, a growth medium is provided for a specific agent. A sample taken from potentially diseased tissue or fluid is then tested for the presence of an infectious agent able to grow within that medium. Many pathogenic bacteria are easily grown on nutrient agar, a form of solid medium that supplies carbohydrates and proteins necessary for growth, along with copious amounts of water. A single bacterium will grow into a visible mound on the surface of the plate called a colony, which may be separated from other colonies or melded together into a "lawn". The size, color, shape and form of a colony is characteristic of the bacterial species, its specific genetic makeup (its strain), and the environment that supports its growth. Other ingredients are often added to the plate to aid in identification. Plates may contain substances that permit the growth of some bacteria and not others, or that change color in response to certain bacteria and not others. Bacteriological plates such as these are commonly used in the clinical identification of infectious bacterium. Microbial culture may also be used in the identification of viruses: the medium, in this case, being cells grown in culture that the virus can infect, and then alter or kill. In the case of viral identification, a region of dead cells results from viral growth, and is called a "plaque". Eukaryotic parasites may also be grown in culture as a means of identifying a particular agent.


title: Infection

text: In the absence of suitable plate culture techniques, some microbes require culture within live animals. Bacteria such as "Mycobacterium leprae" and "Treponema pallidum" can be grown in animals, although serological and microscopic techniques make the use of live animals unnecessary. Viruses are also usually identified using alternatives to growth in culture or animals. Some viruses may be grown in embryonated eggs. Another useful identification method is Xenodiagnosis, or the use of a vector to support the growth of an infectious agent. Chagas disease is the most significant example, because it is difficult to directly demonstrate the presence of the causative agent, "Trypanosoma cruzi" in a patient, which therefore makes it difficult to definitively make a diagnosis. In this case, xenodiagnosis involves the use of the vector of the Chagas agent "T. cruzi", an uninfected triatomine bug, which takes a blood meal from a person suspected of having been infected. The bug is later inspected for growth of "T. cruzi" within its gut.


title: Infection

text: Another principal tool in the diagnosis of infectious disease is microscopy. Virtually all of the culture techniques discussed above rely, at some point, on microscopic examination for definitive identification of the infectious agent. Microscopy may be carried out with simple instruments, such as the compound light microscope, or with instruments as complex as an electron microscope. Samples obtained from patients may be viewed directly under the light microscope, and can often rapidly lead to identification. Microscopy is often also used in conjunction with biochemical staining techniques, and can be made exquisitely specific when used in combination with antibody based techniques. For example, the use of antibodies made artificially fluorescent (fluorescently labeled antibodies) can be directed to bind to and identify a specific antigens present on a pathogen. A fluorescence microscope is then used to detect fluorescently labeled antibodies bound to internalized antigens within clinical samples or cultured cells. This technique is especially useful in the diagnosis of viral diseases, where the light microscope is incapable of identifying a virus directly.


title: Infection

text: Other microscopic procedures may also aid in identifying infectious agents. Almost all cells readily stain with a number of basic dyes due to the electrostatic attraction between negatively charged cellular molecules and the positive charge on the dye. A cell is normally transparent under a microscope, and using a stain increases the contrast of a cell with its background. Staining a cell with a dye such as Giemsa stain or crystal violet allows a microscopist to describe its size, shape, internal and external components and its associations with other cells. The response of bacteria to different staining procedures is used in the taxonomic classification of microbes as well. Two methods, the Gram stain and the acid-fast stain, are the standard approaches used to classify bacteria and to diagnosis of disease. The Gram stain identifies the bacterial groups Bacillota and Actinomycetota, both of which contain many significant human pathogens. The acid-fast staining procedure identifies the Actinomycetota genera "Mycobacterium" and "Nocardia".


title: Infection

text: Biochemical tests used in the identification of infectious agents include the detection of metabolic or enzymatic products characteristic of a particular infectious agent. Since bacteria ferment carbohydrates in patterns characteristic of their genus and species, the detection of fermentation products is commonly used in bacterial identification. Acids, alcohols and gases are usually detected in these tests when bacteria are grown in selective liquid or solid media.


title: Infection

text: The isolation of enzymes from infected tissue can also provide the basis of a biochemical diagnosis of an infectious disease. For example, humans can make neither RNA replicases nor reverse transcriptase, and the presence of these enzymes are characteristic., of specific types of viral infections. The ability of the viral protein hemagglutinin to bind red blood cells together into a detectable matrix may also be characterized as a biochemical test for viral infection, although strictly speaking hemagglutinin is not an "enzyme" and has no metabolic function.


title: Infection

text: Serological methods are highly sensitive, specific and often extremely rapid tests used to identify microorganisms. These tests are based upon the ability of an antibody to bind specifically to an antigen. The antigen, usually a protein or carbohydrate made by an infectious agent, is bound by the antibody. This binding then sets off a chain of events that can be visibly obvious in various ways, dependent upon the test. For example, "Strep throat" is often diagnosed within minutes, and is based on the appearance of antigens made by the causative agent, "S. pyogenes", that is retrieved from a patient's throat with a cotton swab. Serological tests, if available, are usually the preferred route of identification, however the tests are costly to develop and the reagents used in the test often require refrigeration. Some serological methods are extremely costly, although when commonly used, such as with the "strep test", they can be inexpensive.


title: Infection

text: Complex serological techniques have been developed into what are known as immunoassays. Immunoassays can use the basic antibody – antigen binding as the basis to produce an electro-magnetic or particle radiation signal, which can be detected by some form of instrumentation. Signal of unknowns can be compared to that of standards allowing quantitation of the target antigen. To aid in the diagnosis of infectious diseases, immunoassays can detect or measure antigens from either infectious agents or proteins generated by an infected organism in response to a foreign agent. For example, immunoassay A may detect the presence of a surface protein from a virus particle. Immunoassay B on the other hand may detect or measure antibodies produced by an organism's immune system that are made to neutralize and allow the destruction of the virus.


title: Infection

text: Instrumentation can be used to read extremely small signals created by secondary reactions linked to the antibody – antigen binding. Instrumentation can control sampling, reagent use, reaction times, signal detection, calculation of results, and data management to yield a cost-effective automated process for diagnosis of infectious disease.


title: Infection

text: Technologies based upon the polymerase chain reaction (PCR) method will become nearly ubiquitous gold standards of diagnostics of the near future, for several reasons. First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the human population have been identified. Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids in order to cause a disease. This amplification of nucleic acid in infected tissue offers an opportunity to detect the infectious agent by using PCR. Third, the essential tools for directing PCR, primers, are derived from the genomes of infectious agents, and with time those genomes will be known, if they are not already.


title: Infection

text: Thus, the technological ability to detect any infectious agent rapidly and specifically are currently available. The only remaining blockades to the use of PCR as a standard tool of diagnosis are in its cost and application, neither of which is insurmountable. The diagnosis of a few diseases will not benefit from the development of PCR methods, such as some of the clostridial diseases (tetanus and botulism). These diseases are fundamentally biological poisonings by relatively small numbers of infectious bacteria that produce extremely potent neurotoxins. A significant proliferation of the infectious agent does not occur, this limits the ability of PCR to detect the presence of any bacteria.


title: Infection

text: Given the wide range of bacterial, viral, fungal, protozoal, and helminthic pathogens that cause debilitating and life-threatening illnesses, the ability to quickly identify the cause of infection is important yet often challenging. For example, more than half of cases of encephalitis, a severe illness affecting the brain, remain undiagnosed, despite extensive testing using the standard of care (microbiological culture) and state-of-the-art clinical laboratory methods. Metagenomic sequencing-based diagnostic tests are currently being developed for clinical use and show promise as a sensitive, specific, and rapid way to diagnose infection using a single all-encompassing test. This test is similar to current PCR tests; however, an untargeted whole genome amplification is used rather than primers for a specific infectious agent. This amplification step is followed by next-generation sequencing or third-generation sequencing, alignment comparisons, and taxonomic classification using large databases of thousands of pathogen and commensal reference genomes. Simultaneously, antimicrobial resistance genes within pathogen and plasmid genomes are sequenced and aligned to the taxonomically classified pathogen genomes to generate an antimicrobial resistance profile – analogous to antibiotic sensitivity testing – to facilitate antimicrobial stewardship and allow for the optimization of treatment using the most effective drugs for a patient's infection.


title: Infection

text: Metagenomic sequencing could prove especially useful for diagnosis when the patient is immunocompromised. An ever-wider array of infectious agents can cause serious harm to individuals with immunosuppression, so clinical screening must often be broader. Additionally, the expression of symptoms is often atypical, making a clinical diagnosis based on presentation more difficult. Thirdly, diagnostic methods that rely on the detection of antibodies are more likely to fail. A rapid, sensitive, specific, and untargeted test for all known human pathogens that detects the presence of the organism's DNA rather than antibodies is therefore highly desirable.


title: Infection

text: There is usually an indication for a specific identification of an infectious agent only when such identification can aid in the treatment or prevention of the disease, or to advance knowledge of the course of an illness prior to the development of effective therapeutic or preventative measures. For example, in the early 1980s, prior to the appearance of AZT for the treatment of AIDS, the course of the disease was closely followed by monitoring the composition of patient blood samples, even though the outcome would not offer the patient any further treatment options. In part, these studies on the appearance of HIV in specific communities permitted the advancement of hypotheses as to the route of transmission of the virus. By understanding how the disease was transmitted, resources could be targeted to the communities at greatest risk in campaigns aimed at reducing the number of new infections. The specific serological diagnostic identification, and later genotypic or molecular identification, of HIV also enabled the development of hypotheses as to the temporal and geographical origins of the virus, as well as a myriad of other hypothesis. The development of molecular diagnostic tools have enabled physicians and researchers to monitor the efficacy of treatment with anti-retroviral drugs. Molecular diagnostics are now commonly used to identify HIV in healthy people long before the onset of illness and have been used to demonstrate the existence of people who are genetically resistant to HIV infection. Thus, while there still is no cure for AIDS, there is great therapeutic and predictive benefit to identifying the virus and monitoring the virus levels within the blood of infected individuals, both for the patient and for the community at large.


title: Infection

text: Symptomatic infections are "apparent" and "clinical", whereas an infection that is active but does not produce noticeable symptoms may be called "inapparent," "silent," "subclinical", or occult. An infection that is inactive or dormant is called a "latent infection". An example of a latent bacterial infection is latent tuberculosis. Some viral infections can also be latent, examples of latent viral infections are any of those from the "Herpesviridae" family.


title: Infection

text: The word "infection" can denote any presence of a particular pathogen at all (no matter how little) but also is often used in a sense implying a "clinically apparent" infection (in other words, a case of infectious disease). This fact occasionally creates some ambiguity or prompts some usage discussion; to get around this it is common for health professionals to speak of "colonization" (rather than "infection") when they mean that some of the pathogens are present but that no clinically apparent infection (no disease) is present.


title: Infection

text: Different terms are used to describe how and where infections present over time. In an "acute" infection, symptoms develop rapidly; its course can either be rapid or protracted. In "chronic" infection, symptoms usually develop gradually over weeks or months and are slow to resolve. In "subacute" infections, symptoms take longer to develop than in acute infections but arise more quickly than those of chronic infections. A "focal" infection is an initial site of infection from which organisms travel via the bloodstream to another area of the body.


title: Infection

text: Among the many varieties of microorganisms, relatively few cause disease in otherwise healthy individuals. Infectious disease results from the interplay between those few pathogens and the defenses of the hosts they infect. The appearance and severity of disease resulting from any pathogen depend upon the ability of that pathogen to damage the host as well as the ability of the host to resist the pathogen. However, a host's immune system can also cause damage to the host itself in an attempt to control the infection. Clinicians, therefore, classify infectious microorganisms or microbes according to the status of host defenses – either as "primary pathogens" or as "opportunistic pathogens".


title: Infection

text: Primary pathogens cause disease as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence (the severity of the disease they cause) is, in part, a necessary consequence of their need to reproduce and spread. Many of the most common primary pathogens of humans only infect humans, however, many serious diseases are caused by organisms acquired from the environment or that infect non-human hosts.


title: Infection

text: Opportunistic pathogens can cause an infectious disease in a host with depressed resistance (immunodeficiency) or if they have unusual access to the inside of the body (for example, via trauma). Opportunistic infection may be caused by microbes ordinarily in contact with the host, such as pathogenic bacteria or fungi in the gastrointestinal or the upper respiratory tract, and they may also result from (otherwise innocuous) microbes acquired from other hosts (as in "Clostridium difficile" colitis) or from the environment as a result of traumatic introduction (as in surgical wound infections or compound fractures). An opportunistic disease requires impairment of host defenses, which may occur as a result of genetic defects (such as chronic granulomatous disease), exposure to antimicrobial drugs or immunosuppressive chemicals (as might occur following poisoning or cancer chemotherapy), exposure to ionizing radiation, or as a result of an infectious disease with immunosuppressive activity (such as with measles, malaria or HIV disease). Primary pathogens may also cause more severe disease in a host with depressed resistance than would normally occur in an immunosufficient host.


title: Infection

text: While a primary infection can practically be viewed as the root cause of an individual's current health problem, a secondary infection is a sequela or complication of that root cause. For example, an infection due to a burn or penetrating trauma (the root cause) is a secondary infection. Primary pathogens often cause primary infection and often cause secondary infection. Usually, opportunistic infections are viewed as secondary infections (because immunodeficiency or injury was the predisposing factor).


title: Infection

text: Other types of infection consist of mixed, iatrogenic, nosocomial, and community-acquired infection. A mixed infection is an infection that is caused by two or more pathogens. An example of this is appendicitis, which is caused by "Bacteroides fragilis" and "Escherichia coli". The second is an iatrogenic infection. This type of infection is one that is transmitted from a health care worker to a patient. A nosocomial infection is also one that occurs in a health care setting. Nosocomial infections are those that are acquired during a hospital stay. Lastly, a community-acquired infection is one in which the infection is acquired from a whole community.


title: Infection

text: One manner of proving that a given disease is infectious, is to satisfy Koch's postulates (first proposed by Robert Koch), which require that first, the infectious agent be identifiable only in patients who have the disease, and not in healthy controls, and second, that patients who contract the infectious agent also develop the disease. These postulates were first used in the discovery that Mycobacteria species cause tuberculosis.


title: Infection

text: However, Koch's postulates cannot usually be tested in modern practice for ethical reasons. Proving them would require experimental infection of a healthy individual with a pathogen produced as a pure culture. Conversely, even clearly infectious diseases do not always meet the infectious criteria; for example, "Treponema pallidum", the causative spirochete of syphilis, cannot be cultured "in vitro" – however the organism can be cultured in rabbit testes. It is less clear that a pure culture comes from an animal source serving as host than it is when derived from microbes derived from plate culture.


title: Infection

text: Epidemiology, or the study and analysis of who, why and where disease occurs, and what determines whether various populations have a disease, is another important tool used to understand infectious disease. Epidemiologists may determine differences among groups within a population, such as whether certain age groups have a greater or lesser rate of infection; whether groups living in different neighborhoods are more likely to be infected; and by other factors, such as gender and race. Researchers also may assess whether a disease outbreak is sporadic, or just an occasional occurrence; endemic, with a steady level of regular cases occurring in a region; epidemic, with a fast arising, and unusually high number of cases in a region; or pandemic, which is a global epidemic. If the cause of the infectious disease is unknown, epidemiology can be used to assist with tracking down the sources of infection.


title: Infection

text: Infectious diseases are sometimes called contagious diseases when they are easily transmitted by contact with an ill person or their secretions (e.g., influenza). Thus, a contagious disease is a subset of infectious disease that is especially infective or easily transmitted. Other types of infectious, transmissible, or communicable diseases with more specialized routes of infection, such as vector transmission or sexual transmission, are usually not regarded as "contagious", and often do not require medical isolation (sometimes loosely called quarantine) of those affected. However, this specialized connotation of the word "contagious" and "contagious disease" (easy transmissibility) is not always respected in popular use.


title: Infection

text: Infectious diseases are commonly transmitted from person to person through direct contact. The types of contact are through person to person and droplet spread. Indirect contact such as airborne transmission, contaminated objects, food and drinking water, animal person contact, animal reservoirs, insect bites, and environmental reservoirs are another way infectious diseases are transmitted.


title: Infection

text: In addition, locations of inflammation where infection is the most common cause include pneumonia, meningitis and salpingitis.


title: Infection

text: Techniques like hand washing, wearing gowns, and wearing face masks can help prevent infections from being passed from one person to another. Aseptic technique was introduced in medicine and surgery in the late 19th century and greatly reduced the incidence of infections caused by surgery. Frequent hand washing remains the most important defense against the spread of unwanted organisms. There are other forms of prevention such as avoiding the use of illicit drugs, using a condom, wearing gloves, and having a healthy lifestyle with a balanced diet and regular exercise. Cooking foods well and avoiding foods that have been left outside for a long time is also important.


title: Infection

text: One of the ways to prevent or slow down the transmission of infectious diseases is to recognize the different characteristics of various diseases. Some critical disease characteristics that should be evaluated include virulence, distance traveled by those affected, and level of contagiousness. The human strains of Ebola virus, for example, incapacitate those infected extremely quickly and kill them soon after. As a result, those affected by this disease do not have the opportunity to travel very far from the initial infection zone. Also, this virus must spread through skin lesions or permeable membranes such as the eye. Thus, the initial stage of Ebola is not very contagious since its victims experience only internal hemorrhaging. As a result of the above features, the spread of Ebola is very rapid and usually stays within a relatively confined geographical area. In contrast, the human immunodeficiency virus (HIV) kills its victims very slowly by attacking their immune system. As a result, many of its victims transmit the virus to other individuals before even realizing that they are carrying the disease. Also, the relatively low virulence allows its victims to travel long distances, increasing the likelihood of an epidemic.


title: Infection

text: Another effective way to decrease the transmission rate of infectious diseases is to recognize the effects of small-world networks. In epidemics, there are often extensive interactions within hubs or groups of infected individuals and other interactions within discrete hubs of susceptible individuals. Despite the low interaction between discrete hubs, the disease can jump and spread in a susceptible hub via a single or few interactions with an infected hub. Thus, infection rates in small-world networks can be reduced somewhat if interactions between individuals within infected hubs are eliminated (Figure 1). However, infection rates can be drastically reduced if the main focus is on the prevention of transmission jumps between hubs. The use of needle exchange programs in areas with a high density of drug users with HIV is an example of the successful implementation of this treatment method. Another example is the use of ring culling or vaccination of potentially susceptible livestock in adjacent farms to prevent the spread of the foot-and-mouth virus in 2001.


title: Infection

text: In cases where infection is merely suspected, individuals may be quarantined until the incubation period has passed and the disease manifests itself or the person remains healthy. Groups may undergo quarantine, or in the case of communities, a cordon sanitaire may be imposed to prevent infection from spreading beyond the community, or in the case of protective sequestration, into a community. Public health authorities may implement other forms of social distancing, such as school closings, to control an epidemic.


title: Infection

text: Infection with most pathogens does not result in death of the host and the offending organism is ultimately cleared after the symptoms of the disease have waned. This process requires immune mechanisms to kill or inactivate the inoculum of the pathogen. Specific acquired immunity against infectious diseases may be mediated by antibodies and/or T lymphocytes. Immunity mediated by these two factors may be manifested by:


title: Infection

text: The immune system response to a microorganism often causes symptoms such as a high fever and inflammation, and has the potential to be more devastating than direct damage caused by a microbe.


title: Infection

text: Resistance to infection (immunity) may be acquired following a disease, by asymptomatic carriage of the pathogen, by harboring an organism with a similar structure (crossreacting), or by vaccination. Knowledge of the protective antigens and specific acquired host immune factors is more complete for primary pathogens than for opportunistic pathogens.


title: Infection

text: There is also the phenomenon of herd immunity which offers a measure of protection to those otherwise vulnerable people when a large enough proportion of the population has acquired immunity from certain infections.


title: Infection

text: Immune resistance to an infectious disease requires a critical level of either antigen-specific antibodies and/or T cells when the host encounters the pathogen. Some individuals develop natural serum antibodies to the surface polysaccharides of some agents although they have had little or no contact with the agent, these natural antibodies confer specific protection to adults and are passively transmitted to newborns.


title: Infection

text: The organism that is the target of an infecting action of a specific infectious agent is called the host. The host harbouring an agent that is in a mature or sexually active stage phase is called the definitive host. The intermediate host comes in contact during the larvae stage. A host can be anything living and can attain to asexual and sexual reproduction.


title: Infection

text: The clearance of the pathogens, either treatment-induced or spontaneous, it can be influenced by the genetic variants carried by the individual patients. For instance, for genotype 1 hepatitis C treated with Pegylated interferon-alpha-2a or Pegylated interferon-alpha-2b (brand names Pegasys or PEG-Intron) combined with ribavirin, it has been shown that genetic polymorphisms near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in the treatment-induced clearance of the virus. This finding, originally reported in Nature, showed that genotype 1 hepatitis C patients carrying certain genetic variant alleles near the IL28B gene are more possibly to achieve sustained virological response after the treatment than others. Later report from Nature demonstrated that the same genetic variants are also associated with the natural clearance of the genotype 1 hepatitis C virus.


title: Infection

text: When infection attacks the body, "anti-infective" drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic; including antitubercular), antiviral, antifungal and antiparasitic (including antiprotozoal and antihelminthic) agents. Depending on the severity and the type of infection, the antibiotic may be given by mouth or by injection, or may be applied topically. Severe infections of the brain are usually treated with intravenous antibiotics. Sometimes, multiple antibiotics are used in case there is resistance to one antibiotic. Antibiotics only work for bacteria and do not affect viruses. Antibiotics work by slowing down the multiplication of bacteria or killing the bacteria. The most common classes of antibiotics used in medicine include penicillin, cephalosporins, aminoglycosides, macrolides, quinolones and tetracyclines.


title: Infection

text: Not all infections require treatment, and for many self-limiting infections the treatment may cause more side-effects than benefits. Antimicrobial stewardship is the concept that healthcare providers should treat an infection with an antimicrobial that specifically works well for the target pathogen for the shortest amount of time and to only treat when there is a known or highly suspected pathogen that will respond to the medication.


title: Infection

text: The World Health Organization collects information on global deaths by International Classification of Disease (ICD) code categories. The following table lists the top infectious disease by number of deaths in 2002. 1993 data is included for comparison.


title: Infection

text: The top three single agent/disease killers are HIV/AIDS, TB and malaria. While the number of deaths due to nearly every disease have decreased, deaths due to HIV/AIDS have increased fourfold. Childhood diseases include pertussis, poliomyelitis, diphtheria, measles and tetanus. Children also make up a large percentage of lower respiratory and diarrheal deaths. In 2012, approximately 3.1 million people have died due to lower respiratory infections, making it the number 4 leading cause of death in the world.


title: Infection

text: With their potential for unpredictable and explosive impacts, infectious diseases have been major actors in human history. A pandemic (or global epidemic) is a disease that affects people over an extensive geographical area. For example:


title: Infection

text: In most cases, microorganisms live in harmony with their hosts via mutual or commensal interactions. Diseases can emerge when existing parasites become pathogenic or when new pathogenic parasites enter a new host.


title: Infection

text: Several human activities have led to the emergence of zoonotic human pathogens, including viruses, bacteria, protozoa, and rickettsia, and spread of vector-borne diseases, see also globalization and disease and wildlife disease:


title: Infection

text: In Antiquity, the Greek historian Thucydides ( – ) was the first person to write, in his account of the plague of Athens, that diseases could spread from an infected person to others. In his "On the Different Types of Fever" (), the Greco-Roman physician Galen speculated that plagues were spread by "certain seeds of plague", which were present in the air. In the Sushruta Samhita, the ancient Indian physician Sushruta theorized: "Leprosy, fever, consumption, diseases of the eye, and other infectious diseases spread from one person to another by sexual union, physical contact, eating together, sleeping together, sitting together, and the use of same clothes, garlands and pastes." This book has been dated to about the sixth century BC.


title: Infection

text: A basic form of contagion theory was proposed by Persian physician Ibn Sina (known as Avicenna in Europe) in "The Canon of Medicine" (1025), which later became the most authoritative medical textbook in Europe up until the 16th century. In Book IV of the "Canon", Ibn Sina discussed epidemics, outlining the classical miasma theory and attempting to blend it with his own early contagion theory. He mentioned that people can transmit disease to others by breath, noted contagion with tuberculosis, and discussed the transmission of disease through water and dirt. The concept of invisible contagion was later discussed by several Islamic scholars in the Ayyubid Sultanate who referred to them as "najasat" ("impure substances"). The fiqh scholar Ibn al-Haj al-Abdari (–1336), while discussing Islamic diet and hygiene, gave warnings about how contagion can contaminate water, food, and garments, and could spread through the water supply, and may have implied contagion to be unseen particles.


title: Infection

text: When the Black Death bubonic plague reached Al-Andalus in the 14th century, the Arab physicians Ibn Khatima () and Ibn al-Khatib (1313–1374) hypothesised that infectious diseases were caused by "minute bodies" and described how they can be transmitted through garments, vessels and earrings. Ideas of contagion became more popular in Europe during the Renaissance, particularly through the writing of the Italian physician Girolamo Fracastoro. Anton van Leeuwenhoek (1632–1723) advanced the science of microscopy by being the first to observe microorganisms, allowing for easy visualization of bacteria.


title: Infection

text: In the mid-19th century John Snow and William Budd did important work demonstrating the contagiousness of typhoid and cholera through contaminated water. Both are credited with decreasing epidemics of cholera in their towns by implementing measures to prevent contamination of water. Louis Pasteur proved beyond doubt that certain diseases are caused by infectious agents, and developed a vaccine for rabies. Robert Koch provided the study of infectious diseases with a scientific basis known as Koch's postulates. Edward Jenner, Jonas Salk and Albert Sabin developed effective vaccines for smallpox and polio, which would later result in the eradication and near-eradication of these diseases, respectively. Alexander Fleming discovered the world's first antibiotic, penicillin, which Florey and Chain then developed. Gerhard Domagk developed sulphonamides, the first broad spectrum synthetic antibacterial drugs.


title: Infection

text: The medical treatment of infectious diseases falls into the medical field of Infectious Disease and in some cases the study of propagation pertains to the field of Epidemiology. Generally, infections are initially diagnosed by primary care physicians or internal medicine specialists. For example, an "uncomplicated" pneumonia will generally be treated by the internist or the pulmonologist (lung physician). The work of the infectious diseases specialist therefore entails working with both patients and general practitioners, as well as laboratory scientists, immunologists, bacteriologists and other specialists.


title: Infection

text: Several studies have reported associations between pathogen load in an area and human behavior. Higher pathogen load is associated with decreased size of ethnic and religious groups in an area. This may be due high pathogen load favoring avoidance of other groups, which may reduce pathogen transmission, or a high pathogen load preventing the creation of large settlements and armies that enforce a common culture. Higher pathogen load is also associated with more restricted sexual behavior, which may reduce pathogen transmission. It also associated with higher preferences for health and attractiveness in mates. Higher fertility rates and shorter or less parental care per child is another association that may be a compensation for the higher mortality rate. There is also an association with polygyny which may be due to higher pathogen load, making selecting males with a high genetic resistance increasingly important. Higher pathogen load is also associated with more collectivism and less individualism, which may limit contacts with outside groups and infections. There are alternative explanations for at least some of the associations although some of these explanations may in turn ultimately be due to pathogen load. Thus, polygyny may also be due to a lower male: female ratio in these areas but this may ultimately be due to male infants having increased mortality from infectious diseases. Another example is that poor socioeconomic factors may ultimately in part be due to high pathogen load preventing economic development.


title: Infection

text: Evidence of infection in fossil remains is a subject of interest for paleopathologists, scientists who study occurrences of injuries and illness in extinct life forms. Signs of infection have been discovered in the bones of carnivorous dinosaurs. When present, however, these infections seem to tend to be confined to only small regions of the body. A skull attributed to the early carnivorous dinosaur "Herrerasaurus ischigualastensis" exhibits pit-like wounds surrounded by swollen and porous bone. The unusual texture of the bone around the wounds suggests they were affected by a short-lived, non-lethal infection. Scientists who studied the skull speculated that the bite marks were received in a fight with another "Herrerasaurus". Other carnivorous dinosaurs with documented evidence of infection include "Acrocanthosaurus", "Allosaurus", "Tyrannosaurus" and a tyrannosaur from the Kirtland Formation. The infections from both tyrannosaurs were received by being bitten during a fight, like the "Herrerasaurus" specimen.


title: Infection

text: A 2006 Space Shuttle experiment found that "Salmonella typhimurium", a bacterium that can cause food poisoning, became more virulent when cultivated in space. On April 29, 2013, scientists in Rensselaer Polytechnic Institute, funded by NASA, reported that, during spaceflight on the International Space Station, microbes seem to adapt to the space environment in ways "not observed on Earth" and in ways that "can lead to increases in growth and virulence". More recently, in 2017, bacteria were found to be more resistant to antibiotics and to thrive in the near-weightlessness of space. Microorganisms have been observed to survive the vacuum of outer space.


The University of North Carolina at Chapel Hill (UNC, UNC-Chapel Hill, Chapel Hill, North Carolina, or simply Carolina) is a public research university in Chapel Hill, North Carolina. The flagship of the University of North Carolina system, it is considered a Public Ivy, or a public institution which offers an academic experience similar to that of an Ivy League university. After being chartered in 1789, the university first began enrolling students in 1795, making it one of the oldest public universities in the United States. Among the claimants, the University of North Carolina at Chapel Hill is the only one to have held classes and graduated students as a public university in the eighteenth century.


title: University of North Carolina at Chapel Hill

text: The first public institution of higher education in North Carolina, the school opened its doors to students on February 12, 1795. However, North Carolina became coeducational under the leadership of President Kemp Plummer Battle in 1877, and began the process of desegregation under Chancellor Robert Burton House when African-American graduate students were admitted in 1951, 156 years after the university opened its doors. In 1952, North Carolina opened its own hospital, UNC Health Care, for research and treatment, and has since specialized in cancer care through UNC's Lineberger Comprehensive Cancer Center which is one of only 51 national NCI designated comprehensive centers.


text: The university offers degrees in over 70 courses of study and is administratively divided into 13 separate professional schools and a primary unit, the College of Arts & Sciences. Five of the schools have been named: the UNC Kenan–Flagler Business School, the UNC Hussman School of Journalism and Media, the UNC Gillings School of Global Public Health, the UNC Eshelman School of Pharmacy, and the UNC Adams School of Dentistry. All undergraduates receive a liberal arts education and have the option to pursue a major within the professional schools of the university or within the College of Arts and Sciences from the time they obtain junior status. It is classified among "R1: Doctoral Universities – Very high research activity", and is a member of the Association of American Universities (AAU). According to the National Science Foundation, UNC spent $1.14 billion on research and development in 2018, ranking 12th in the nation.


text: UNC's faculty and alumni include 9 Nobel Prize laureates, 23 Pulitzer Prize winners, and 51 Rhodes Scholars. Additional notable alumni include a U.S. President, a U.S. Vice President, 38 Governors of U.S. States, 98 members of the United States Congress, and nine Cabinet members as well as CEOs of Fortune 500 companies, Olympians and professional athletes.


text: The campus covers of Chapel Hill's downtown area, encompassing the Morehead Planetarium and the many stores and shops located on Franklin Street. Students can participate in over 550 officially recognized student organizations. The student-run newspaper "The Daily Tar Heel" has won national awards for collegiate media, while the student radio station WXYC provided the world's first internet radio broadcast. UNC Chapel Hill is one of the charter members of the Atlantic Coast Conference, which was founded on June 14, 1953. Competing athletically as the Tar Heels, UNC has achieved great success in sports, most notably in men's basketball, women's soccer, and women's field hockey.


text: Chartered by the North Carolina General Assembly on December 11, 1789, the university's cornerstone was laid on October 12, 1793, near the ruins of a chapel, chosen because of its central location within the state. The first public university chartered under the US Constitution, the University of North Carolina is one of three universities that claims to be the oldest public university in the United States and the only such institution to confer degrees in the eighteenth century as a public institution.


text: During the Civil War, North Carolina Governor David Lowry Swain persuaded Confederate President Jefferson Davis to exempt some students from the draft, so the university was one of the few in the Confederacy that managed to stay open. However, Chapel Hill suffered the loss of more of its population during the war than any village in the South, and when student numbers did not recover, the university was forced to close during Reconstruction from December 1, 1870, until September 6, 1875. Following the reopening, enrollment was slow to increase and university administrators offered free tuition for the sons of teachers and ministers, as well as loans for those who could not afford attendance.


text: Following the Civil War, the university began to modernize its programs and onboard faculty with prestigious degrees. The creation of a new gymnasium, funding for a new Chemistry laboratory, and organization of the Graduate Department were accomplishments touted by UNC president Francis Venable at the 1905 “University Day” celebration.


text: Despite initial skepticism from university President Frank Porter Graham, on March 27, 1931, legislation was passed to group the University of North Carolina with the State College of Agriculture and Engineering and Woman's College of the University of North Carolina to form the Consolidated University of North Carolina. In 1963, the consolidated university was made fully coeducational, although most women still attended Woman's College for their first two years, transferring to Chapel Hill as juniors, since freshmen were required to live on campus and there was only one women's residence hall. As a result, Woman's College was renamed the "University of North Carolina at Greensboro", and the University of North Carolina became the "University of North Carolina at Chapel Hill." In 1955, UNC officially desegregated its undergraduate divisions.


text: During World War II, UNC was one of 131 colleges and universities nationally that took part in the V-12 Navy College Training Program which offered students a path to a Navy commission.


text: During the 1960s, the campus was the location of significant political protest. Prior to the passage of the Civil Rights Act of 1964, protests about local racial segregation which began quietly in Franklin Street restaurants led to mass demonstrations and disturbance. The climate of civil unrest prompted the 1963 Speaker Ban Law prohibiting speeches by communists on state campuses in North Carolina. The law was immediately criticized by university Chancellor William Brantley Aycock and university President William Friday, but was not reviewed by the North Carolina General Assembly until 1965. Small amendments to allow "infrequent" visits failed to placate the student body, especially when the university's board of trustees overruled new Chancellor Paul Frederick Sharp's decision to allow speaking invitations to Marxist speaker Herbert Aptheker and civil liberties activist Frank Wilkinson; however, the two speakers came to Chapel Hill anyway. Wilkinson spoke off campus, while more than 1,500 students viewed Aptheker's speech across a low campus wall at the edge of campus, christened "Dan Moore's Wall" by "The Daily Tar Heel" for Governor Dan K. Moore. A group of UNC-Chapel Hill students, led by Student Body President Paul Dickson, filed a lawsuit in U.S. federal court, and on February 20, 1968, the Speaker Ban Law was struck down. In 1969, campus food workers of Lenoir Hall went on strike protesting perceived racial injustices that impacted their employment, garnering the support of student groups and members of the university and Chapel Hill community.


text: From the late 1990s and onward, UNC-Chapel Hill expanded rapidly with a 15% increase in total student population to more than 28,000 by 2007. This is accompanied by the construction of new facilities, funded in part by the "Carolina First" fundraising campaign and an endowment that increased fourfold to more than $2 billion within ten years. Professor Oliver Smithies was awarded the Nobel Prize in Medicine in 2007 for his work in genetics. Additionally, Professor Aziz Sancar was awarded the Nobel Prize in Chemistry in 2015 for his work in understanding the molecular repair mechanisms of DNA.


text: In 2011, the first of several investigations found fraud and academic dishonesty at the university related to its athletic program. Following a lesser scandal that began in 2010 involving academic fraud and improper benefits with the university's football program, two hundred questionable classes offered by the university's African and Afro-American Studies department came to light. As a result, the university was placed on probation by its accrediting agency in 2015. It was removed from probation in 2016.


text: That same year, the public universities in North Carolina had to share a budget cut of $414 million, of which the Chapel Hill campus lost more than $100 million in 2011. This followed state budget cuts that trimmed university spending by $231 million since 2007; Provost Bruce Carney said more than 130 faculty members have left UNC since 2009., with poor staff retention. The Board of Trustees for UNC-CH recommended a 15.6 percent increase in tuition, a historically large increase. The budget cuts in 2011 greatly affected the university and set this increased tuition plan in motion and UNC students protested. On February 10, 2012, the UNC Board of Governors approved tuition and fee increases of 8.8 percent for in-state undergraduates across all 16 campuses.


text: In June 2018, the Department of Education found that the University of North Carolina at Chapel Hill had violated Title IX in handling reports of sexual assault, five years after four students and an administrator filed complaints. The university was also featured in "The Hunting Ground", a 2015 documentary about sexual assault on college campuses. Annie E. Clark and Andrea Pino, two students featured in the film, helped to establish the survivor advocacy organization End Rape on Campus.


text: In August 2018, the university came to national attention after the toppling of Silent Sam, a Confederate monument which had been erected on campus in 1913 by the United Daughters of the Confederacy. The statue had been dogged by controversy at various points since the 1960s, with critics claiming that the monument invokes memories of racism and slavery. Many critics cited the explicitly racist views espoused in the dedication speech that local industrialist and UNC Trustee Julian Carr gave at the statue's unveiling on June 2, 1913, and the approval with which they had been met by the crowd at the dedication. Shortly before the beginning of the 2018–2019 school year, the Silent Sam was toppled by protestors and damaged, and has been absent from campus ever since. In July 2020, the University's Carr Hall, which was named after Julian Carr, was renamed the "Student Affairs Building." Carr had supported white supremacy and also the Ku Klux Klan.


text: After reopening its campus in August 2020, UNC-Chapel Hill reported 135 new COVID-19 cases and four infection clusters within a week of having started in-person classes for the Fall 2020 semester. On 10 August, faculty and staff from several of UNC's constituent institutions filed a complaint against its board of governors, asking the system to default to online-only instruction for the fall. On 17 August, UNC's management announced that the university would be moving all undergraduate classes online from 19 August, becoming the first university to send students home after having reopened.


text: Notable leaders of the university include the 26th Governor of North Carolina, David Lowry Swain (president 1835–1868); and Edwin Anderson Alderman (1896–1900), who was also president of Tulane University and the University of Virginia. On December 13, 2019 the UNC System Board of Governors unanimously voted to name Kevin Guskiewicz the university's 12th chancellor.


text: UNC-Chapel Hill's campus is dominated by two central quads: Polk Place and McCorkle Place. Polk Place is named after North Carolina native and university alumnus President James K. Polk, and McCorkle Place is named in honor of Samuel Eusebius McCorkle, the original author of the bill requesting the university's charter. Adjacent to Polk Place is a sunken brick courtyard known as the Pit where students will gather, often engaging in lively debate with speakers such as the Pit Preacher. The Morehead–Patterson Bell Tower, located in the heart of campus, tolls the quarter-hour. In 1999, UNC-Chapel Hill was one of sixteen recipients of the American Society of Landscape Architects Medallion Awards and was identified as one of 50 college or university "works of art" by T.A. Gaines in his book "The Campus as a Work of Art".


text: The university's campus is informally divided into three regions, usually referred to as "north campus," "middle campus," and "south campus." North campus includes the two quads along with the Pit, Frank Porter Graham Student Union, and the Davis, House, and Wilson libraries. Almost all classrooms are located in north campus along with several undergraduate residence halls. Middle campus includes Fetzer Field and Woollen Gymnasium along with the Student Recreation Center, Kenan Memorial Stadium, Irwin Belk outdoor track, Eddie Smith Field House, Boshamer Stadium, Carmichael Auditorium, Sonja Haynes Stone Center for Black Culture and History, School of Government, School of Law, George Watts Hill Alumni Center, Ram's Head complex (with a dining hall, parking garage, grocery store, and gymnasium), and various residence halls. South campus includes the Dean Smith Center for men's basketball, Koury Natatorium, School of Medicine, UNC Hospitals, Kenan–Flagler Business School, and the newest student residence halls.


text: A new satellite campus, Carolina North, to be built on the site of Horace Williams Airport was approved in 2007. This is planned to be primarily a research park with expanded science facilities, but will also add classrooms and residence halls to cope with future increases in student population.


text: The principles of sustainability have been integrated throughout much of UNC-Chapel Hill. In the area of green building, the university requires that all new projects meet the requirements for LEED Silver certification and is in the process of building the first building in North Carolina to receive LEED Platinum status.


text: UNC-Chapel Hill's award-winning co-generation facility produces one-fourth of the electricity and all of the steam used on campus.


text: In 2006, the university and the Town of Chapel Hill jointly agreed to reduce greenhouse gas emissions 60% by 2050, becoming the first town-gown partnership in the country to do so.


text: Through these efforts, the university achieved a "A−" grade on the Sustainable Endowment Institute's College Sustainability Report Card 2010.


text: The university has come under recent criticism for abandoning a promise to shutter its coal-fired power plant by 2020. The university has announced plans to become carbon neutral by 2050. In December 2019, the university was sued by the Sierra Club and the Center for Biological Diversity for violations of the Clean Air Act.


text: McCorkle Place, a green square on campus of the University of North Carolina at Chapel Hill, North Carolina, commemorates Samuel Eusebius McCorkle, the inceptor and progenitor of the university.


text: A symbol of the university is the Old Well, a small neoclassical rotunda based on the Temple of Love in the Gardens of Versailles, in the same location as the original well that provided water for the school. The well stands at the south end of McCorkle Place, the northern quad, between two of the campus's oldest buildings, Old East, and Old West.


text: Also located in McCorkle Place is the Davie Poplar tree under which the university's founder, William Richardson Davie, supposedly selected the location for the university. The legend of the Davie Poplar says that as long as the tree stands, so will the university. Because of the tree's questionable health from damage caused by severe weather such as Hurricane Fran in 1996, the university has planted two genetic clones nearby called Davie Poplar Jr. and Davie Poplar III. The second clone, Davie Poplar III, was planted in conjunction with the university's bicentennial celebration in 1993. The student members of the university's Dialectic and Philanthropic Societies are not allowed to walk on the grass of McCorkle Place out of respect for the unknown resting place of Joseph Caldwell, the university's first president.


text: The Morehead–Patterson bell tower was commissioned by John Motley Morehead III, the benefactor of the Morehead-Cain Scholarship. The hedge and surrounding landscape was designed by William C. Coker, botany professor and creator of the campus arboretum. Traditionally, seniors have the opportunity to climb the tower a few days prior to May commencement.


text: The historic Playmakers Theatre is located on Cameron Avenue between McCorkle Place and Polk Place. It was designed by Alexander Jackson Davis, the same architect who renovated the northern façade of Old East in 1844. The east-facing building was completed in 1851 and initially served as a library and as a ballroom. It was originally named Smith Hall after North Carolina Governor General Benjamin Smith, who was a special aide to George Washington during the American Revolutionary War and was an early benefactor to the university. When the library moved to Hill Hall in 1907, the School of Law occupied Smith Hall until 1923. In 1925, the structure was renovated and used as a stage by the university theater group, the Carolina Playmakers. It has remained a theater to the present day. Louis Round Wilson wrote in 1957 that Playmakers Theatre is the "architectural gem of the campus." Playmakers Theatre was declared a National Historic Landmark in 1973. Today, the building is a venue for student drama productions, concerts, and events sponsored by academic departments.


text: UNC-Chapel Hill offers 71 bachelor's, 107 master's and 74 doctoral degree programs. The university enrolls more than 28,000 students from all 100 North Carolina counties, the other 49 states, and 47 other countries. It is the third largest university in North Carolina, just behind North Carolina State University and the University of North Carolina at Charlotte in enrollment. State law requires that the percentage of students from North Carolina in each freshman class meet or exceed 82%. The student body consists of 17,981 undergraduate students and 10,935 graduate and professional students (as of Fall 2009). Racial and ethnic minorities comprise 30.8% of UNC-Chapel Hill's undergraduate population as of 2010 and applications from international students have more than doubled in the last five years (from 702 in 2004 to 1,629 in 2009). Eighty-nine percent of enrolling first year students in 2009 reported a GPA of 4.0 or higher on a weighted 4.0 scale. UNC-Chapel Hill students are strong competitors for national and international scholarships. The most popular majors at UNC-Chapel Hill are biology, business administration, psychology, media and journalism, and political science. UNC-Chapel Hill also offers 300 study abroad programs in 70 countries.


text: At the undergraduate level, all students must fulfill a number of general education requirements as part of the Making Connections curriculum, which was introduced in 2006. English, social science, history, foreign language, mathematics, and natural science courses are required of all students, ensuring that they receive a broad liberal arts education. The university also offers a wide range of first year seminars for incoming freshmen. After their second year, students move on to the College of Arts and Sciences, or choose an undergraduate professional school program within the schools of medicine, nursing, business, education, pharmacy, information and library science, public health, or media and journalism. Undergraduates are held to an eight-semester limit of study.


text: UNC-Chapel Hill's admissions process is "most selective" according to "U.S. News & World Report". For the Class of 2025 (enrolled fall 2021), UNC-Chapel Hill received 53,776 applications and accepted 10,347 (19.2%). Of those accepted, 4,689 enrolled, a yield rate (the percentage of accepted students who choose to attend the university) of 45.3%. UNC-Chapel Hill's freshman retention rate is 96.5%, with 91.9% going on to graduate within six years.


text: Of the 60% of enrolled freshmen in 2021 who submitted ACT scores; the middle 50 percent Composite score was between 29 and 33. Of the 15% of the incoming freshman class who submitted SAT scores; the middle 50 percent Composite scores were 1330-1500. In the 2020–2021 academic year, 20 freshman students were National Merit Scholars.


text: The UNC-Chapel Hill Department of Public Policy, established in 2001, is a public policy program offering specializations in areas such as global health policy, education policy, tax policy, and social justice.


text: Established in 1979, the Curriculum in Public Policy Analysis was one of the first undergraduate degree programs in public policy, and a charter member of the national Association for Public Policy Analysis and Management. It was augmented in 1991 by an interdisciplinary PhD Curriculum in Public Policy Analysis. In 1995 the two curricula were combined and began recruiting their own core faculty. In 2001 the combined curriculum became the present Department of Public Policy.


text: The university has a longstanding Honor Code known as the "Instrument of Student Judicial Governance," supplemented by a mostly student-run Honor System to resolve issues with students accused of academic and conduct offenses against the university community. The Honor System is divided into three branches: the Student Attorney General Staff, the Honor Court, and the Honor System Outreach, and further bifurcated by constituency (Undergraduate Attorney General and Graduate and Professional Student Attorney General). The Attorneys General are appointed by their constituency's President to investigate all reports of Honor Code violations and determine whether or not to bring charges against the student as detailed in the "Instrument." The Attorney General is supported by a select staff of around 40 students, representative of the diversity of the student body. The Honor Court is led by the Chair, who is appointed by their constituency's President, and supported by Vice Chairs who adjudicate all students' hearings. The Honor Court as a whole is made up of some 80 selected students. The Honor System Outreach is a branch of the System solely devoted to promoting honor and integrity in the university community. UNC-Chapel Hill is the only public university, with the exception of the military academies, that has a completely student-run system from the beginning to the end of the process.


text: UNC-Chapel Hill's library system includes a number of individual libraries housed throughout the campus and holds more than 7.0 million volumes in total. UNC-Chapel Hill's North Carolina Collection (NCC) is the largest and most comprehensive collection of holdings about any single state nationwide. The unparalleled assemblage of literary, visual, and artifactual materials documents four centuries of North Carolina history and culture. The North Carolina Collection is housed in Wilson Library, named after Louis Round Wilson, along with the Southern Historical Collection, the Rare Books Collection, and the Southern Folklife Collection. The university is home to ibiblio, one of the world's largest collections of freely available information including software, music, literature, art, history, science, politics, and cultural studies.


text: The Davis Library, situated near the Pit, is the main library and the largest academic facility and state-owned building in North Carolina. It was named after North Carolina philanthropist Walter Royal Davis and opened on February 6, 1984. The first book checked out of Davis Library was George Orwell's "1984". The R.B. House Undergraduate Library is located between the Pit area and Wilson Library. It is named after Robert B. House, the Chancellor of UNC from 1945 to 1957, and opened in 1968. In 2001, the R.B. House Undergraduate Library underwent a $9.9 million renovation that modernized the furnishings, equipment, and infrastructure of the building. Prior to the construction of Davis, Wilson Library was the university's main library, but now Wilson hosts special events and houses special collections, rare books, and temporary exhibits.


text: The library oversees Documenting the American South, a free public access website of "digitized primary materials that offer Southern perspectives on American history and culture." The project began in 1996. In 2009 the library launched the North Carolina Digital Heritage Center, a statewide digital library, in partnership with other organizations.


text: For 2022, "U.S. News & World Report" ranks UNC-Chapel Hill tied for 5th among the public universities and tied for 28th among national universities in the United States. The Wall Street Journal ranked UNC-Chapel Hill 3rd best public university behind University of Michigan and UCLA.


text: The university was named a Public Ivy by Richard Moll in his 1985 book "The Public Ivies: A Guide to America's Best Public Undergraduate Colleges and Universities", and in later guides by Howard and Matthew Greene. Many of UNC-Chapel Hill's professional schools have achieved high rankings in publications such as "Forbes" magazine, as well as annual "U.S. News & World Report" surveys. In 2020, "US News & World Report" ranked the School of Medicine #1 in primary care and #23 in research. In 2016, "U.S. News & World Report" ranked UNC-Chapel Hill business school's MBA program as the 16th best in the nation. In the 2019 edition, "U.S. News & World Report" ranked the UNC Gillings School of Global Public Health as the second best school of public health in the United States (behind Johns Hopkins and tied with Harvard). The UNC Eshelman School of Pharmacy was ranked #1 among pharmacy schools in the United States in 2020 by "U.S. News & World Report". In 2005, "Business Week" ranked UNC-Chapel Hill business school's Executive MBA program as the 5th best in the United States. UNC also offers an online MBA program, MBA@UNC, that is ranked #1 in the country in 2019 for Best Online MBA Programs (tied with the Kelley School of Business at Indiana University). Other highly ranked schools include journalism and mass communication, law, library and information science, medicine, dentistry, and city and regional planning. Nationally, UNC-Chapel Hill is in the top ten public universities for research.


text: Internationally, the 2016 QS World University Rankings ranked North Carolina 78th in the world (in 2010 Times Higher Education World University Rankings and QS World University Rankings parted ways to produce separate rankings).


text: "Kiplinger's Personal Finance" in 2015 ranked UNC-Chapel Hill as the number one "best value" public college in the country. The university also topped "The Princeton Review"'s list of the Best Value Colleges in 2014. Similarly, the university is first among public universities and ninth overall in "Great Schools, Great Prices", on the basis of academic quality, net cost of attendance and average student debt.


text: The university is also a large recipient of National Institute of Health grants and funds. For fiscal year 2020, the university received $509.9 million in NIH funds for research. This amount makes Chapel Hill the 10th overall recipient of research funds in the nation by the NIH.


text: For decades, UNC-Chapel Hill has offered an undergraduate merit scholarship known as the Morehead-Cain Scholarship. Recipients receive full tuition, room and board, books, and funds for summer study for four years. Since the inception of the Morehead, 29 alumni of the program have been named Rhodes Scholars. Since 2001, North Carolina has also co-hosted the Robertson Scholars Leadership Program, a merit scholarship and leadership development program granting recipients full student privileges at both UNC-Chapel Hill and neighboring Duke University. Additionally, the university provides scholarships based on merit and leadership qualities, including the Carolina, Colonel Robinson, Johnston and Pogue Scholars programs.


text: In 2003, Chancellor James Moeser announced the Carolina Covenant, wherein UNC offers a debt free education to low-income students who are accepted to the university. The program was the first of its kind at a public university and the second overall in the nation (following Princeton University). About 80 other universities have since followed suit.


text: North Carolina's athletic teams are known as the Tar Heels. They compete as a member of the National Collegiate Athletic Association (NCAA) Division I level (Football Bowl Subdivision (FBS) sub-level for football), primarily competing in the Atlantic Coast Conference (ACC) for all sports since the 1953–54 season. Men's sports include baseball, basketball, cross country, fencing, football, golf, lacrosse, soccer, swimming & diving, tennis, track & field and wrestling; while women's sports include basketball, cross country, fencing, field hockey, golf, gymnastics, lacrosse, rowing, soccer, softball, swimming and diving, tennis, track & field and volleyball.


text: The NCAA refers to UNC-Chapel Hill as the "University of North Carolina" for athletics. As of Fall 2011, the university had won 40 NCAA team championships in six different sports, eighth all-time. These include twenty one NCAA championships in women's soccer, six in women's field hockey, four in men's lacrosse, six in men's basketball, one in women's basketball, and two in men's soccer. The Men's basketball team won its 6th NCAA basketball championship in 2017, the third for Coach Roy Williams since he took the job as head coach. UNC was also retroactively given the title of National Champion for the 1924 championship, but is typically not included in the official tally. Other recent successes include the 2011 College Cup in men's soccer, and four consecutive College World Series appearances by the baseball team from 2006 to 2009. In 1994, the university's athletic programs won the Sears Directors Cup "all-sports national championship" awarded for cumulative performance in NCAA competition. Consensus collegiate national athletes of the year from North Carolina include Rachel Dawson in field hockey; Phil Ford, Tyler Hansbrough, Antawn Jamison, Vince Carter, James Worthy and Michael Jordan in men's basketball; and Mia Hamm (twice), Shannon Higgins, Kristine Lilly, and Tisha Venturini in women's soccer.


text: The university's teams are nicknamed the "Tar Heels," in reference to the state's eighteenth century prominence as a tar and pitch producer. The nickname's cultural relevance, however, has a complex history that includes anecdotal tales from both the American Civil War and the American Revolution. The mascot is a live Dorset ram named Rameses, a tradition that dates back to 1924, when the team manager brought a ram to the annual game against Virginia Military Institute, inspired by the play of former football player Jack "The Battering Ram" Merrit. The kicker rubbed his head for good luck before a game-winning field goal, and the ram stayed. There is also an anthropomorphic ram mascot who appears at games. The modern Rameses is depicted in a sailor's hat, a reference to a United States Navy flight training program that was attached to the university during World War II.


text: Basketball coach Dean Smith was widely known for his idea of "The Carolina Way", in which he challenged his players to, "Play hard, play smart, play together." "The Carolina Way" was an idea of excellence in the classroom, as well as on the court. In Coach Smith's book, "The Carolina Way", former player Scott Williams said, regarding Dean Smith, "Winning was very important at Carolina, and there was much pressure to win, but Coach cared more about our getting a sound education and turning into good citizens than he did about winning."


text: The October 22, 2014 release of the Wainstein Report alleged institutionalized academic fraud that involved over 3,100 students and student athletes, over an 18-year period from 1993 to 2011 that began during the final years of the Dean Smith era, challenged "The Carolina Way" image. The report alleged that at least 54 players during the Dean Smith era were enrolled in what came to be known as "paper classes." The report noted that the questionable classes began in the spring of 1993, the year of Smith's final championship, so those grades would not have been entered until after the championship game was played. In response to the allegations of the Wainstein report, the NCAA launched their own investigation and on June 5, 2015 the NCAA accused the institution of five major violations including: “two instances of unethical conduct and failure to cooperate“ as well as “unethical conduct and extra benefits related to student-athletes' access to and assistance in the paper courses; unethical conduct by the instructor/counselor for providing impermissible academic assistance to student-athletes; and a failure to monitor and lack of institutional control". In October, 2017, the NCAA issued its findings and concluded "that the only violations in this case are the department chair's and the secretary's failure to cooperate."


text: The South's Oldest Rivalry between North Carolina and its first opponent, the University of Virginia, was prominent throughout the first third of the twentieth century. The 119th meeting in football between two of the top public universities in the east occurred in October 2014.


text: One of the fiercest rivalries is with Durham's Duke University. Located only eight miles from each other, the schools regularly compete in both athletics and academics. The Carolina-Duke rivalry is most intense, however, in basketball. With a combined eleven national championships in men's basketball, both teams have been frequent contenders for the national championship for the past thirty years. The rivalry has been the focus of several books, including Will Blythe's "To Hate Like This Is to Be Happy Forever" and was the focus of the HBO documentary "Battle for Tobacco Road: Duke vs Carolina". Duke was Carolina's biggest rival from the 1930s until the early 1960s, when Duke's declining athletic program shifted Carolina's rival focus to North Carolina State.


text: Carolina holds an in-state rivalry with fellow Tobacco Road school, North Carolina State University. Since the mid-1970s, however, the Tar Heels have shifted their attention to Duke following a severe decline in NC State's basketball program (and the resurgence of Duke's basketball program) that reached rock bottom during Roy Williams' tenure as evidenced by their 4–36 record against the Tar Heels. The Wolfpack faithful still consider the rivalry the most bitter in the state despite the fact that it's been decades since Tar Heel supporters have acknowledged NC State as a rival. Combined, the two schools hold eight NCAA Championships and 27 ACC Championships in basketball. Students from each school often exchange pranks before basketball and football games.


text: While students previously held "Beat Duke" parades on Franklin Street before sporting events, today students and sports fans have been known to spill out of bars and residence halls upon the victory of one of Carolina's sports teams. In most cases, a Franklin Street "bonfire" celebration is due to a victory by the men's basketball team, although other Franklin Street celebrations have stemmed from wins by the women's basketball team and women's soccer team. The first known student celebration on Franklin Street came after the 1957 men's basketball team capped their perfect season with a national championship victory over the Kansas Jayhawks. From then on, students have flooded the street after important victories. After a Final Four victory in 1981 and the men's basketball team won the 1982 NCAA Championship, Franklin Street was painted blue by the fans who had rushed the street. This event has led local vendors to stop selling Carolina blue paint as the Tar Heels near the national championship.


text: Since the beginning of intercollegiate athletics at UNC in the late nineteenth century, the school's colors have been blue and white. The colors were chosen years before by the Dialectic (blue) and Philanthropic (white) Societies, the oldest student organization at the university. The school had required participation in one of the clubs, and traditionally the "Di"s were from the western part of North Carolina while the "Phi"s were from the eastern part of the state.


text: Society members would wear a blue or white ribbon at university functions, and blue or white ribbons were attached to their diplomas at graduation. On public occasions, both groups were equally represented, and eventually both colors were used by processional leaders to signify the unity of both groups as part of the university. When football became a popular collegiate sport in the 1880s, the Carolina football team adopted the light blue and white of the Di-Phi Societies as the school colors.


text: Notable among a number of songs commonly played and sung at various events such as commencement, convocation, and athletic games are the university fight songs "I'm a Tar Heel Born" and "Here Comes Carolina". The fight songs are often played by the bell tower near the center of campus, as well as after major victories. "I'm a Tar Heel Born" originated in the late 1920s as a tag to the school's alma mater, "Hark The Sound". "Hark the Sound" was usually played at the end of games, but as of late it has been played at the beginning of games as well.


text: The Institute of Folk Music at the University of North Carolina at Chapel Hill was founded by Lamar Stringfield in 1930, followed by the founding of the North Carolina Symphony in 1932.


text: Most student organizations at UNC-Chapel Hill are officially recognized and provided with assistance by the Carolina Union, an administrative unit of the university. Funding is derived from the student government student activity fee, which is allocated at the discretion of the Undergraduate Senate (UGS) or the Graduate and Professional Student Government Senate (GPSG Senate).


text: The largest student fundraiser, the UNC Dance Marathon, involves thousands of students, faculty, and community members in raising funds for the North Carolina Children's Hospital. The organization conducts fundraising and volunteer activities throughout the year and, , had donated $1.4 million since its inception in 1999.