title: Beef bourguignon

text: In culinary terminology, "bourguignon" is applied to various dishes prepared with wine or with a mushroom and onion garnish in the mid-nineteenth century.


title: Beef bourguignon

text: The dish may be called "bourguignon" or "à la bourguignonne" in both French and English. It is occasionally called "beef/bœuf bourguignonne" in English, but in French, by far the most common name is "bœuf bourguignon".


title: Interrobang

text: The interrobang (), also known as the interabang (often represented by any of ?!, !?, ?!? or !?!), is an unconventional punctuation mark used in various written languages and intended to combine the functions of the question mark, or interrogative point, and the exclamation mark, or exclamation point, known in the jargon of printers and programmers as a "bang". The glyph is a ligature of these two marks and was first proposed in 1962 by Martin K. Speckter.


title: Interrobang

text: A sentence ending with an interrobang asks a question in an excited manner, expresses excitement, disbelief or confusion in the form of a question, or asks a rhetorical question.


title: Interrobang

text: Writers using informal language may use several alternating question marks and exclamation marks for even more emphasis; however, this is regarded as poor style in formal writing.


title: Interrobang

text: Historically, writers have used multiple punctuation marks to end a sentence expressing surprise and question.


title: Interrobang

text: American Martin K. Speckter (1915 – February 14, 1988) conceptualized the interrobang in 1962. As the head of an advertising agency, Speckter believed that advertisements would look better if copywriters conveyed surprised rhetorical questions using a single mark. He proposed the concept of a single punctuation mark in an article in the magazine "TYPEtalks". Speckter solicited possible names for the new character from readers. Contenders included "exclamaquest", "QuizDing", "rhet", and "exclarotive", but he settled on "interrobang". He chose the name to reference the punctuation marks that inspired it: "interrogatio" is Latin for "rhetorical question" or "cross-examination"; "bang" is printers' slang for the exclamation mark. Graphic treatments for the new mark were also submitted in response to the article.


title: Interrobang

text: In 1965, Richard Isbell created the Americana typeface for American Type Founders and included the interrobang as one of the characters. In 1968, an interrobang key was available on some Remington typewriters. In the 1970s, replacement interrobang keycaps and typefaces were available for some Smith-Corona typewriters.


title: Interrobang

text: The interrobang was in vogue for much of the 1960s; the word "interrobang" appeared in some dictionaries, and the mark was used in magazine and newspaper articles.


title: Interrobang

text: Most fonts do not include the interrobang, but it has not disappeared. Lucida Grande, the default font for many UI elements of legacy versions of Apple's OS X operating system, includes the interrobang, and Microsoft provides several versions of the interrobang in the Wingdings 2 character set (on the right bracket and tilde keys on US keyboard layouts), included with Microsoft Office. It was accepted into Unicode and is included in several fonts, including Lucida Sans Unicode, Arial Unicode MS, and Calibri, the default font in the Office 2007, 2010, and 2013 suites.


title: Interrobang

text: A reverse and upside-down interrobang (combining ¿ and ¡, Unicode character: ⸘), suitable for starting phrases in Spanish, Galician and Asturian—which use inverted question and exclamation marks—is called an "inverted interrobang" or a "gnaborretni" ("interrobang" spelled backwards), but the latter is rarely used. In current practice, interrobang-like emphatic ambiguity in Hispanic languages is usually achieved by including both sets of punctuation marks one inside the other ("¿¡De verdad!?" or "¡¿De verdad?!" ["Really!?"]). Older usage, still official but not widespread, recommended mixing the punctuation marks: "¡Verdad?" or "¿Verdad!"


title: Interrobang

text: Few modern typefaces or fonts include a glyph for the interrobang character. The standard interrobang is at Unicode code point . The inverted interrobang is at Unicode code point . Single-character versions of the double-glyph versions are also available at code points and .


title: Interrobang

text: On a Linux system supporting the Compose key, an interrobang can be produced by ; reversing the order () creates the inverted interrobang.


title: Interrobang

text: The interrobang can be displayed in LaTeX by using the package textcomp and the command . The inverted interrobang is the command .


title: Interrobang

text: The State Library of New South Wales, in Australia, uses an interrobang as its logo, as does the educational publishing company Pearson, which thus intends to convey "the excitement and fun of learning".


title: Interrobang

text: Chief Judge Frank H. Easterbrook used an interrobang in the 2012 United States Seventh Circuit opinion "Robert F. Booth Trust v. Crowley".


title: Interrobang

text: Australian Federal Court Justice Michael Wigney used an interrobang in the first paragraph of his 2018 judgment in Faruqi v Latham [2018] FCA 1328 (defamation proceedings between former Federal Opposition Leader, Mark Latham, and political campaigner and writer, Osman Faruqi).


title: Interrobang

text: In chess, an interrobang is used to represent a dubious move, one which is questionable but possibly has merits. (See also the evaluation symbols ?! (dubious move) and !? (interesting move).)


title: Types of volcanic eruptions

text: Several types of volcanic eruptions—during which lava, tephra (ash, lapilli, volcanic bombs and volcanic blocks), and assorted gases are expelled from a volcanic vent or fissure—have been distinguished by volcanologists. These are often named after famous volcanoes where that type of behavior has been observed. Some volcanoes may exhibit only one characteristic type of eruption during a period of activity, while others may display an entire sequence of types all in one eruptive series.


title: Types of volcanic eruptions

text: Within these wide-defining eruptive types are several subtypes. The weakest are Hawaiian and submarine, then Strombolian, followed by Vulcanian and Surtseyan. The stronger eruptive types are Pelean eruptions, followed by Plinian eruptions; the strongest eruptions are called Ultra-Plinian. Subglacial and phreatic eruptions are defined by their eruptive mechanism, and vary in strength. An important measure of eruptive strength is the Volcanic Explosivity Index an order-of-magnitude scale, ranging from 0 to 8, that often correlates to eruptive types


title: Types of volcanic eruptions

text: There are two types of eruptions in terms of activity, explosive eruptions and effusive eruptions. Explosive eruptions are characterized by gas-driven explosions that propels magma and tephra. Effusive eruptions, meanwhile, are characterized by the outpouring of lava without significant explosive eruption.


title: Types of volcanic eruptions

text: Volcanic eruptions vary widely in strength. On the one extreme there are effusive Hawaiian eruptions, which are characterized by lava fountains and fluid lava flows, which are typically not very dangerous. On the other extreme, Plinian eruptions are large, violent, and highly dangerous explosive events. Volcanoes are not bound to one eruptive style, and frequently display many different types, both passive and explosive, even in the span of a single eruptive cycle. Volcanoes do not always erupt vertically from a single crater near their peak, either. Some volcanoes exhibit lateral and Fissure eruptions. Notably, many Hawaiian eruptions start from rift zones. Scientists believed that pulses of magma mixed together in the magma chamber before climbing upward—a process estimated to take several thousands of years. However, Columbia University volcanologists found that the eruption of Costa Rica's Irazú Volcano in 1963 was likely triggered by magma that took a nonstop route from the mantle over just a few months.


title: Types of volcanic eruptions

text: The volcanic explosivity index (commonly shortened to VEI) is a scale, from 0 to 8, for measuring the strength of eruptions. It is used by the Smithsonian Institution's Global Volcanism Program in assessing the impact of historic and prehistoric lava flows. It operates in a way similar to the Richter scale for earthquakes, in that each interval in value represents a tenfold increasing in magnitude (it is logarithmic). The vast majority of volcanic eruptions are of VEIs between 0 and 2.


title: Types of volcanic eruptions

text: Magmatic eruptions produce juvenile clasts during explosive decompression from gas release. They range in intensity from the relatively small lava fountains on Hawaii to catastrophic Ultra-Plinian eruption columns more than high, bigger than the eruption of Mount Vesuvius in 79 that buried Pompeii.


title: Types of volcanic eruptions

text: Hawaiian eruptions are a type of volcanic eruption named after the Hawaiian volcanoes with which this eruptive type is hallmark. Hawaiian eruptions are the calmest types of volcanic events, characterized by the effusive eruption of very fluid basalt-type lavas with low gaseous content. The volume of ejected material from Hawaiian eruptions is less than half of that found in other eruptive types. Steady production of small amounts of lava builds up the large, broad form of a shield volcano. Eruptions are not centralized at the main summit as with other volcanic types, and often occur at vents around the summit and from fissure vents radiating out of the center.


title: Types of volcanic eruptions

text: Hawaiian eruptions often begin as a line of vent eruptions along a fissure vent, a so-called "curtain of fire." These die down as the lava begins to concentrate at a few of the vents. Central-vent eruptions, meanwhile, often take the form of large lava fountains (both continuous and sporadic), which can reach heights of hundreds of meters or more. The particles from lava fountains usually cool in the air before hitting the ground, resulting in the accumulation of cindery scoria fragments; however, when the air is especially thick with clasts, they cannot cool off fast enough due to the surrounding heat, and hit the ground still hot, the accumulation of which forms spatter cones. If eruptive rates are high enough, they may even form splatter-fed lava flows. Hawaiian eruptions are often extremely long lived; Puʻu ʻŌʻō, a volcanic cone on Kilauea, erupted continuously for over 35 years. Another Hawaiian volcanic feature is the formation of active lava lakes, self-maintaining pools of raw lava with a thin crust of semi-cooled rock.


title: Types of volcanic eruptions

text: Flows from Hawaiian eruptions are basaltic, and can be divided into two types by their structural characteristics. Pahoehoe lava is a relatively smooth lava flow that can be billowy or ropey. They can move as one sheet, by the advancement of "toes," or as a snaking lava column. A'a lava flows are denser and more viscous than pahoehoe, and tend to move slower. Flows can measure thick. A'a flows are so thick that the outside layers cools into a rubble-like mass, insulating the still-hot interior and preventing it from cooling. A'a lava moves in a peculiar way—the front of the flow steepens due to pressure from behind until it breaks off, after which the general mass behind it moves forward. Pahoehoe lava can sometimes become A'a lava due to increasing viscosity or increasing rate of shear, but A'a lava never turns into pahoehoe flow.


title: Types of volcanic eruptions

text: Hawaiian eruptions are responsible for several unique volcanological objects. Small volcanic particles are carried and formed by the wind, chilling quickly into teardrop-shaped glassy fragments known as Pele's tears (after Pele, the Hawaiian volcano deity). During especially high winds these chunks may even take the form of long drawn-out strands, known as Pele's hair. Sometimes basalt aerates into reticulite, the lowest density rock type on earth.


title: Types of volcanic eruptions

text: Although Hawaiian eruptions are named after the volcanoes of Hawaii, they are not necessarily restricted to them; the highest lava fountain recorded was during the 23 November 2013 eruption of Mount Etna in Italy, which reached a stable height of around for 18 minutes, briefly peaking at a height of .


title: Types of volcanic eruptions

text: Strombolian eruptions are a type of volcanic eruption named after the volcano Stromboli, which has been erupting nearly continuously for centuries. Strombolian eruptions are driven by the bursting of gas bubbles within the magma. These gas bubbles within the magma accumulate and coalesce into large bubbles, called gas slugs. These grow large enough to rise through the lava column. Upon reaching the surface, the difference in air pressure causes the bubble to burst with a loud pop, throwing magma in the air in a way similar to a soap bubble. Because of the high gas pressures associated with the lavas, continued activity is generally in the form of episodic explosive eruptions accompanied by the distinctive loud blasts. During eruptions, these blasts occur as often as every few minutes.


title: Types of volcanic eruptions

text: The term "Strombolian" has been used indiscriminately to describe a wide variety of volcanic eruptions, varying from small volcanic blasts to large eruptive columns. In reality, true Strombolian eruptions are characterized by short-lived and explosive eruptions of lavas with intermediate viscosity, often ejected high into the air. Columns can measure hundreds of meters in height. The lavas formed by Strombolian eruptions are a form of relatively viscous basaltic lava, and its end product is mostly scoria. The relative passivity of Strombolian eruptions, and its non-damaging nature to its source vent allow Strombolian eruptions to continue unabated for thousands of years, and also makes it one of the least dangerous eruptive types.


title: Types of volcanic eruptions

text: Strombolian eruptions eject volcanic bombs and lapilli fragments that travel in parabolic paths before landing around their source vent. The steady accumulation of small fragments builds cinder cones composed completely of basaltic pyroclasts. This form of accumulation tends to result in well-ordered rings of tephra.


title: Types of volcanic eruptions

text: Strombolian eruptions are similar to Hawaiian eruptions, but there are differences. Strombolian eruptions are noisier, produce no sustained eruptive columns, do not produce some volcanic products associated with Hawaiian volcanism (specifically Pele's tears and Pele's hair), and produce fewer molten lava flows (although the eruptive material does tend to form small rivulets).


title: Types of volcanic eruptions

text: Vulcanian eruptions are a type of volcanic eruption named after the volcano Vulcano. It was named so following Giuseppe Mercalli's observations of its 1888–1890 eruptions. In Vulcanian eruptions, intermediate viscous magma within the volcano make it difficult for vesiculate gases to escape. Similar to Strombolian eruptions, this leads to the buildup of high gas pressure, eventually popping the cap holding the magma down and resulting in an explosive eruption. However, unlike Strombolian eruptions, ejected lava fragments are not aerodynamic; this is due to the higher viscosity of Vulcanian magma and the greater incorporation of crystalline material broken off from the former cap. They are also more explosive than their Strombolian counterparts, with eruptive columns often reaching between high. Lastly, Vulcanian deposits are andesitic to dacitic rather than basaltic.


title: Types of volcanic eruptions

text: Initial Vulcanian activity is characterized by a series of short-lived explosions, lasting a few minutes to a few hours and typified by the ejection of volcanic bombs and blocks. These eruptions wear down the lava dome holding the magma down, and it disintegrates, leading to much more quiet and continuous eruptions. Thus an early sign of future Vulcanian activity is lava dome growth, and its collapse generates an outpouring of pyroclastic material down the volcano's slope.


title: Types of volcanic eruptions

text: Deposits near the source vent consist of large volcanic blocks and bombs, with so-called "bread-crust bombs" being especially common. These deeply cracked volcanic chunks form when the exterior of ejected lava cools quickly into a glassy or fine-grained shell, but the inside continues to cool and vesiculate. The center of the fragment expands, cracking the exterior. However the bulk of Vulcanian deposits are fine grained ash. The ash is only moderately dispersed, and its abundance indicates a high degree of fragmentation, the result of high gas contents within the magma. In some cases these have been found to be the result of interaction with meteoric water, suggesting that Vulcanian eruptions are partially hydrovolcanic.


title: Types of volcanic eruptions

text: Peléan eruptions (or nuée ardente) are a type of volcanic eruption named after the volcano Mount Pelée in Martinique, the site of a Peléan eruption in 1902 that is one of the worst natural disasters in history. In Peléan eruptions, a large amount of gas, dust, ash, and lava fragments are blown out the volcano's central crater, driven by the collapse of rhyolite, dacite, and andesite lava dome collapses that often create large eruptive columns. An early sign of a coming eruption is the growth of a so-called Peléan or lava spine, a bulge in the volcano's summit preempting its total collapse. The material collapses upon itself, forming a fast-moving pyroclastic flow (known as a block-and-ash flow) that moves down the side of the mountain at tremendous speeds, often over per hour. These landslides make Peléan eruptions one of the most dangerous in the world, capable of tearing through populated areas and causing serious loss of life. The 1902 eruption of Mount Pelée caused tremendous destruction, killing more than 30,000 people and completely destroying St. Pierre, the worst volcanic event in the 20th century.


title: Types of volcanic eruptions

text: Peléan eruptions are characterized most prominently by the incandescent pyroclastic flows that they drive. The mechanics of a Peléan eruption are very similar to that of a Vulcanian eruption, except that in Peléan eruptions the volcano's structure is able to withstand more pressure, hence the eruption occurs as one large explosion rather than several smaller ones.


title: Types of volcanic eruptions

text: Plinian eruptions (or Vesuvian eruptions) are a type of volcanic eruption named for the historical eruption of Mount Vesuvius in 79 AD that buried the Roman towns of Pompeii and Herculaneum and, specifically, for its chronicler Pliny the Younger. The process powering Plinian eruptions starts in the magma chamber, where dissolved volatile gases are stored in the magma. The gases vesiculate and accumulate as they rise through the magma conduit. These bubbles agglutinate and once they reach a certain size (about 75% of the total volume of the magma conduit) they explode. The narrow confines of the conduit force the gases and associated magma up, forming an eruptive column. Eruption velocity is controlled by the gas contents of the column, and low-strength surface rocks commonly crack under the pressure of the eruption, forming a flared outgoing structure that pushes the gases even faster.


title: Types of volcanic eruptions

text: These massive eruptive columns are the distinctive feature of a Plinian eruption, and reach up into the atmosphere. The densest part of the plume, directly above the volcano, is driven internally by gas expansion. As it reaches higher into the air the plume expands and becomes less dense, convection and thermal expansion of volcanic ash drive it even further up into the stratosphere. At the top of the plume, powerful prevailing winds drive the plume away from the volcano.


title: Types of volcanic eruptions

text: These highly explosive eruptions are usually associated with volatile-rich dacitic to rhyolitic lavas, and occur most typically at stratovolcanoes. Eruptions can last anywhere from hours to days, with longer eruptions being associated with more felsic volcanoes. Although they are usually associated with felsic magma, Plinian eruptions can occur at basaltic volcanoes, if the magma chamber differentiates with upper portions rich in silicon dioxide, or if magma ascends rapidly.


title: Types of volcanic eruptions

text: Plinian eruptions are similar to both Vulcanian and Strombolian eruptions, except that rather than creating discrete explosive events, Plinian eruptions form sustained eruptive columns. They are also similar to Hawaiian lava fountains in that both eruptive types produce sustained eruption columns maintained by the growth of bubbles that move up at about the same speed as the magma surrounding them.


title: Types of volcanic eruptions

text: Regions affected by Plinian eruptions are subjected to heavy pumice airfall affecting an area in size. The material in the ash plume eventually finds its way back to the ground, covering the landscape in a thick layer of many cubic kilometers of ash.


title: Types of volcanic eruptions

text: However the most dangerous eruptive feature are the pyroclastic flows generated by material collapse, which move down the side of the mountain at extreme speeds of up to per hour and with the ability to extend the reach of the eruption hundreds of kilometers. The ejection of hot material from the volcano's summit melts snowbanks and ice deposits on the volcano, which mixes with tephra to form lahars, fast moving mudflows with the consistency of wet concrete that move at the speed of a river rapid.


title: Types of volcanic eruptions

text: Phreatomagmatic eruptions are eruptions that arise from interactions between water and magma. They are driven by thermal contraction of magma when it comes in contact with water (as distinguished from magmatic eruptions, which are driven by thermal expansion). This temperature difference between the two causes violent water-lava interactions that make up the eruption. The products of phreatomagmatic eruptions are believed to be more regular in shape and finer grained than the products of magmatic eruptions because of the differences in eruptive mechanisms.


title: Types of volcanic eruptions

text: There is debate about the exact nature of phreatomagmatic eruptions, and some scientists believe that fuel-coolant reactions may be more critical to the explosive nature than thermal contraction. Fuel coolant reactions may fragment the volcanic material by propagating stress waves, widening cracks and increasing surface area that ultimately leads to rapid cooling and explosive contraction-driven eruptions.


title: Types of volcanic eruptions

text: A Surtseyan (or hydrovolcanic) eruption is a type of volcanic eruption characterized by shallow-water interactions between water and lava, named after its most famous example, the eruption and formation of the island of Surtsey off the coast of Iceland in 1963. Surtseyan eruptions are the "wet" equivalent of ground-based Strombolian eruptions, but because they take place in water they are much more explosive. As water is heated by lava, it flashes into steam and expands violently, fragmenting the magma it contacts into fine-grained ash. Surtseyan eruptions are typical of shallow-water volcanic oceanic islands, but they are not confined to seamounts. They can happen on land as well, where rising magma that comes into contact with an aquifer (water-bearing rock formation) at shallow levels under the volcano can cause them. The products of Surtseyan eruptions are generally oxidized palagonite basalts (though andesitic eruptions do occur, albeit rarely), and like Strombolian eruptions Surtseyan eruptions are generally continuous or otherwise rhythmic.


title: Types of volcanic eruptions

text: A defining feature of a Surtseyan eruption is the formation of a pyroclastic surge (or "base surge"), a ground hugging radial cloud that develops along with the eruption column. Base surges are caused by the gravitational collapse of a vaporous eruptive column, one that is denser overall than a regular volcanic column. The densest part of the cloud is nearest to the vent, resulting in a wedge shape. Associated with these laterally moving rings are dune-shaped depositions of rock left behind by the lateral movement. These are occasionally disrupted by bomb sags, rock that was flung out by the explosive eruption and followed a ballistic path to the ground. Accumulations of wet, spherical ash known as accretionary lapilli are another common surge indicator.


title: Types of volcanic eruptions

text: Over time Surtseyan eruptions tend to form maars, broad low-relief volcanic craters dug into the ground, and tuff rings, circular structures built of rapidly quenched lava. These structures are associated with single vent eruptions. However, if eruptions arise along fracture zones, rift zones may be dug out. Such eruptions tend to be more violent than those which form tuff rings or maars, an example being the 1886 eruption of Mount Tarawera. Littoral cones are another hydrovolcanic feature, generated by the explosive deposition of basaltic tephra (although they are not truly volcanic vents). They form when lava accumulates within cracks in lava, superheats and explodes in a steam explosion, breaking the rock apart and depositing it on the volcano's flank. Consecutive explosions of this type eventually generate the cone.


title: Types of volcanic eruptions

text: Submarine eruptions occur underwater. An estimated 75% of volcanic eruptive volume is generated by submarine eruptions near mid ocean ridges alone, however problems detecting deep sea volcanics meant they remained virtually unknown until advances in the 1990s made it possible to observe them.


title: Types of volcanic eruptions

text: Submarine volcanism is driven by various processes. Volcanoes near plate boundaries and mid-ocean ridges are built by the decompression melting of mantle rock that rises on an upwelling portion of a convection cell to the crustal surface. Eruptions associated with subducting zones, meanwhile, are driven by subducting plates that add volatiles to the rising plate, lowering its melting point. Each process generates different rock; mid-ocean ridge volcanics are primarily basaltic, whereas subduction flows are mostly calc-alkaline, and more explosive and viscous.


title: Types of volcanic eruptions

text: Spreading rates along mid-ocean ridges vary widely, from per year at the Mid-Atlantic Ridge, to up to along the East Pacific Rise. Higher spreading rates are a probable cause for higher levels of volcanism. The technology for studying seamount eruptions did not exist until advancements in hydrophone technology made it possible to "listen" to acoustic waves, known as T-waves, released by submarine earthquakes associated with submarine volcanic eruptions. The reason for this is that land-based seismometers cannot detect sea-based earthquakes below a magnitude of 4, but acoustic waves travel well in water and over long periods of time. A system in the North Pacific, maintained by the United States Navy and originally intended for the detection of submarines, has detected an event on average every 2 to 3 years.


title: Types of volcanic eruptions

text: The most common underwater flow is pillow lava, a rounded lava flow named for its unusual shape. Less common are glassy, marginal sheet flows, indicative of larger-scale flows. Volcaniclastic sedimentary rocks are common in shallow-water environments. As plate movement starts to carry the volcanoes away from their eruptive source, eruption rates start to die down, and water erosion grinds the volcano down. The final stages of eruption cap the seamount in alkalic flows. There are about 100,000 deepwater volcanoes in the world, although most are beyond the active stage of their life. Some exemplary seamounts are Kamaʻehuakanaloa (formerly Loihi), Bowie Seamount, Davidson Seamount, and Axial Seamount.


title: Types of volcanic eruptions

text: Subglacial eruptions are a type of volcanic eruption characterized by interactions between lava and ice, often under a glacier. The nature of glaciovolcanism dictates that it occurs at areas of high latitude and high altitude. It has been suggested that subglacial volcanoes that are not actively erupting often dump heat into the ice covering them, producing meltwater. This meltwater mix means that subglacial eruptions often generate dangerous jökulhlaups (floods) and lahars.


title: Types of volcanic eruptions

text: The study of glaciovolcanism is still a relatively new field. Early accounts described the unusual flat-topped steep-sided volcanoes (called tuyas) in Iceland that were suggested to have formed from eruptions below ice. The first English-language paper on the subject was published in 1947 by William Henry Mathews, describing the Tuya Butte field in northwest British Columbia, Canada. The eruptive process that builds these structures, originally inferred in the paper, begins with volcanic growth below the glacier. At first the eruptions resemble those that occur in the deep sea, forming piles of pillow lava at the base of the volcanic structure. Some of the lava shatters when it comes in contact with the cold ice, forming a glassy breccia called hyaloclastite. After a while the ice finally melts into a lake, and the more explosive eruptions of Surtseyan activity begins, building up flanks made up of mostly hyaloclastite. Eventually the lake boils off from continued volcanism, and the lava flows become more effusive and thicken as the lava cools much more slowly, often forming columnar jointing. Well-preserved tuyas show all of these stages, for example Hjorleifshofdi in Iceland.


title: Types of volcanic eruptions

text: Products of volcano-ice interactions stand as various structures, whose shape is dependent on complex eruptive and environmental interactions. Glacial volcanism is a good indicator of past ice distribution, making it an important climatic marker. Since they are embedded in ice, as glacial ice retreats worldwide there are concerns that tuyas and other structures may destabilize, resulting in mass landslides. Evidence of volcanic-glacial interactions are evident in Iceland and parts of British Columbia, and it is even possible that they play a role in deglaciation.


title: Types of volcanic eruptions

text: Glaciovolcanic products have been identified in Iceland, the Canadian province of British Columbia, the U.S. states of Hawaii and Alaska, the Cascade Range of western North America, South America and even on the planet Mars. Volcanoes known to have subglacial activity include:


title: Types of volcanic eruptions

text: Phreatic eruptions (or steam-blast eruptions) are a type of eruption driven by the expansion of steam. When cold ground or surface water come into contact with hot rock or magma it superheats and explodes, fracturing the surrounding rock and thrusting out a mixture of steam, water, ash, volcanic bombs, and volcanic blocks. The distinguishing feature of phreatic explosions is that they only blast out fragments of pre-existing solid rock from the volcanic conduit; no new magma is erupted. Because they are driven by the cracking of rock strata under pressure, phreatic activity does not always result in an eruption; if the rock face is strong enough to withstand the explosive force, outright eruptions may not occur, although cracks in the rock will probably develop and weaken it, furthering future eruptions.


title: Types of volcanic eruptions

text: Often a precursor of future volcanic activity, phreatic eruptions are generally weak, although there have been exceptions. Some phreatic events may be triggered by earthquake activity, another volcanic precursor, and they may also travel along dike lines. Phreatic eruptions form base surges, lahars, avalanches, and volcanic block "rain." They may also release deadly toxic gas able to suffocate anyone in range of the eruption.


title: Brian Connolly

text: Brian Francis Connolly (5 October 1945 – 9 February 1997) was a Scottish singer-songwriter, musician and actor, best known as the lead singer of glam rock band The Sweet between 1968 and 1979 and renowned for his charismatic stage presence and distinctive voice.


title: Brian Connolly

text: Connolly was born in 1945 in Hamilton, South Lanarkshire. His mother was a teenage waitress, Frances Connolly, who left him in a Glasgow hospital as an infant whilst he was possibly suffering from meningitis. The identity of his biological father was never made public. Connolly was fostered at the age of two by Jim and Helen McManus of Blantyre, South Lanarkshire and took their family name. After inadvertently discovering his lineage, he eventually reverted to the name Connolly. The McManuses were the family of Mark McManus, of "Taggart" fame. Both men perceived a resemblance between them, and supposed McManus's father to have also been Connolly's.


title: Brian Connolly

text: In a radio interview, Connolly reported that singing was a large part of growing up since there was no television, and that he was regularly called upon to sing for family and friends. Connolly has credited the Everly Brothers as being his earliest musical influence.


title: Brian Connolly

text: At the age of 12, Connolly moved to Harefield, Greater London, where he attended the local secondary modern school. In his mid-teens he joined the Merchant Navy, and got a tiger's head tattooed on his right arm during his Navy service. On his discharge from the Merchant Navy in 1963 he returned to Harefield and played in a number of local bands, including Generation X (not to be confused with the punk rock band from the late 70s, fronted by Billy Idol) from mid-1965 until about October 1966. The group recorded four tracks but these were not commercially released. The lineup featured Connolly on vocals, Chris Eldridge and Lee Mordecai on guitars, Mark Conway (bass) and drummer Martin Lass. Connolly eventually replaced singer Ian Gillan (later of Deep Purple fame) in a band called Wainwright's Gentlemen, which included drummer Mick Tucker.


title: Brian Connolly

text: Tucker and Connolly left Wainwright's Gentlemen in late 1967 and recruited guitarist Frank Torpey, and bassist Steve Priest, naming their new band The Sweetshop. On the eve of releasing their debut single, Slow Motion, in July 1968, the band shortened their name to The Sweet. They recorded a further three unsuccessful singles; Andy Scott joined the line-up in late 1970, just before the release of their first hit single "Funny, Funny." After this, Connolly was propelled into the limelight, with many appearances on "Top of the Pops", with the other members of the Sweet.


title: Brian Connolly

text: In 1974, Connolly was badly beaten after leaving a nightclub in Staines where he received several kicks to his throat resulting in his being unable to sing for some time and permanently losing some of his previously wide vocal range. This incident also meant the band missed out on supporting The Who at Charlton Athletic Football Ground. Several songs on the "Sweet Fanny Adams" album had to be sung by other members of the band.


title: Brian Connolly

text: As time progressed issues between Connolly and other members of Sweet developed and he would find the band excluding him from decisions. Connolly developed a significant problem with alcoholism in the mid-1970s. During 1977, when no tours were undertaken and two of Sweet's most successful albums were recorded, the power struggle within the band became even more apparent. Connolly's chronic alcohol abuse further compromised his role with the band as his voice began showing the impact in recordings and on stage during Sweet's 1978 US tour. He played his last British show with the classic Sweet line-up at Hammersmith Odeon, London on 24 February 1978. His final live performance with the band was in July 1978 in Florida, US, when they supported Alice Cooper. His departure was not made public until March 1979.


title: Brian Connolly

text: After news of his leaving Sweet broke, Connolly was interviewed by the German music magazine "Bravo", in which he said he was taking time off to be with his family, and considering a new musical direction (countrified rock). By mid- to late 1979 he had recorded several new tracks at Chipping Norton Recording Studios, in Oxfordshire, with the assistance of friend and producer Mick Angus. The following year one of the tracks, "Take Away The Music", was re-recorded at the Marquee Studios, London with then Polydor producer Pip Williams,


title: Brian Connolly

text: On 22 June 1979, Connolly made his first major appearance since leaving the Sweet, at the Bravo Super Disco '79 at the Olympiahalle, Munich. Ten thousand people heard Connolly perform a preview of first solo Polydor single: "Take Away The Music". The single was issued in 1980 by Polydor, and was included on the 1980 Polydor Germany "High Life" compilation album.


title: Brian Connolly

text: In 1981, Connolly was admitted to hospital with bloating, and he sustained multiple heart attacks. His health was permanently affected with some paralysis on his left side which would later develop into a nervous system condition. These problems were most likely related to Connolly's excessive alcohol consumption and heavy smoking, coupled with the use of prescription diuretic medicine.


title: Brian Connolly

text: Connolly's next release was "Don't You Know a Lady", composed by Roger Greenaway. The song was recorded by British four-piece band Brooks shortly after Connolly's release. The track failed to make an impact. In 1982 with his Polydor contract expired, Connolly signed with French independent label, Carrere Records. Carrere then released the hard-rock single "Hypnotized", written by Joe Lynn Turner. A Fandango cover, the track was released in Europe with wide distribution by RCA but failed to chart. During this time Connolly recorded several new tracks for an album schedued for release in August 1983, however the album was not released.


title: Brian Connolly

text: In January 1983, Connolly supported Pat Benatar for three shows in Birmingham, Newcastle and the Hammersmith Odeon, London. Connolly's band Encore, included most of the members of Verity, fronted by ex-Argent guitarist John Verity, and Terry Uttley, the bass player from Smokie. Songs played included "Windy City", "Fox on the Run", "Hypnotized" and new numbers, "Sick and Tired", "Red Hair Rage" and "Burning The Candle". The new tracks were made available on a bootleg 7" single and CD.


title: Brian Connolly

text: The Inland Revenue served Connolly and the other members of the Sweet with a multimillion-pound tax assessment for the income earned from their hit records. Connolly sold his house to pay his share of the tax bill.


title: Brian Connolly

text: From early 1984 onward, despite recurrent ill health, Connolly toured the UK and Europe with his band The New Sweet. His most successful concerts were annual appearances in West Germany, before and after Germany's reunification. He visited other countries including Denmark, and continued to perform sporadically in the UK. In 1985, Connolly had reportedly stopped. The same year he separated from his wife Marilyn, with the divorce finalised in 1986.


title: Brian Connolly

text: During 1987, Connolly again encountered Frank Torpey, the original Sweet lead guitarist from 1968 to 1969. According to Torpey, Connolly was seeking a German recording deal. Torpey subsequently invited Connolly to record with him, as an informal project. Running late, Connolly turned up and the track "Sharontina" was recorded, but would not be released until Torpey's 1998 album, "Sweeter".


title: Brian Connolly

text: In 1988, the producer Mike Chapman arranged for Connolly and former band members Mick Tucker, Steve Priest and Andy Scott to reunite in Los Angeles, California, and rework studio versions of "Action" and "The Ballroom Blitz". The reunion was with a view to producing a new album for MCA Records, however due to problems with Connolly's voice, the project failed and Connolly returned to The New Sweet.


title: Brian Connolly

text: In 1990, he reunited with the original Sweet line-up for the promotion of a music video documentary at Tower Records, London.


title: Brian Connolly

text: By July 1990, plans were made for Connolly and The New Sweet to tour Australia. A number of dates were planned, with the tour starting in Adelaide, and proceeded during November. However, during the long flight to Australia, Connolly's suffered health issues and he was hospitalised in Adelaide Hospital for dehydration and related problems. The band played a show in Adelaide without Connolly. Other shows included one at the Dingley Powerhouse, with the final Australian show at Melbourne's Old Greek Theatre. It was felt at the time that Connolly's health was sufficient reason for the tour not to be extended, and some of the later planned dates were abandoned. Connolly returned to England and his band appeared on "The Bob Downe Christmas Show", on 18 December 1990.


title: Brian Connolly

text: During the early 1990s, Connolly played the European "oldies" circuit and occasional outdoor festivals in Europe with the band.


title: Brian Connolly

text: On 22 March 1992, a heavy-duty tape recorder was stolen from the band's van while they were performing the Bristol Hippodrome with Mud. The tape recorder contained demos of four new songs and approximately 20 mixes.


title: Brian Connolly

text: Legal problems continued over use of the Sweet name between Connolly and Andy Scott. In something of a truce, both parties agreed to distinguish their group's name to help promoters and fans. The New Sweet became Brian Connolly's Sweet and Andy Scott's band became Andy Scott's Sweet. Connolly and The New Sweet continued to tour UK and Europe.


title: Brian Connolly

text: In 1994, The New Sweet played in Dubai, and appeared at the Galleria Theatre, Hyatt Regency and Bahrain. By this time, Connolly had healed the differences with Steve Priest and Mick Tucker, and was invited to the wedding of Priest's eldest daughter, Lisa. At the private function, for which Priest specially flew back to England, Priest and Connolly performed together.


title: Brian Connolly

text: In 1995, Connolly released a new album, "Let's Go", backed up with merchandising. His partner Jean, whom he had met a few years earlier, gave birth to a son that year. In 1995, Jean succeeded in locating Connolly's biological family. An aunt in Ontario, Canada, revealed that Connolly's true birth mother had died in 1989. She also informed him that he had a living brother and sister, whom he met up with in England.


title: Brian Connolly

text: On 2 November 1996, British TV network Channel 4 aired a programme "Don't Leave Me This Way", which examined Connolly's time as a pop star with The Sweet, the subsequent decline in the band's popularity, and the impact on the band members. The show revealed Connolly's ill health, but also that he was continuing with his concert dates at Butlins, where Connolly and his band had appeared a number of times on tour during the early 1990s.


title: Brian Connolly

text: Connolly's final concert was at the Bristol Hippodrome on 5 December 1996, with Slade II and John Rossall's Glitter Band Experience.


title: Brian Connolly

text: In January 1997, Connolly had a heart attack and was hospitalised in Slough. After a week in hospital he discharged himself, but was readmitted the following week. Connolly died around midnight of 9–10 February 1997, as a result of kidney and liver failure and repeated heart attacks. He was 51 years old.


title: Brian Connolly

text: On 17 February 1997, Connolly was cremated after a ceremony at Most Holy Name Roman Catholic Church at Old Mill Road, Denham, Buckinghamshire. His ashes were scattered over the water by his daughters Nicola and Michelle. He was also survived by his ex-wife, Marilyn, his girlfriend Jean and their one-year-old son Brian, born 26 May 1995. On 11 October 1998, fans organised a memorial concert for Connolly at the Camden Palace in London.


title: Brian Connolly

text: Money was raised for a plaque dedicated to Connolly at Breakspear Crematorium, Breakspear Road, Ruislip, Middlesex. It was unveiled on 9 February 2000.


title: Brian Connolly

text: In 2013, Connolly's son, Brian Jr., competed in the television talent show "The X Factor". Brian Jr.'s mother, Jean, married and now lives with a former band member, Glenn Williams, in Spain.


title: Interferon

text: Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.


title: Interferon

text: IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. Interferons are named for their ability to "interfere" with viral replication by protecting cells from virus infections. However, virus-encoded genetic elements have the ability to antagonize the IFN response contributing to viral pathogenesis and viral diseases. IFNs also have various other functions: they activate immune cells, such as natural killer cells and macrophages, and they increase host defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility complex (MHC) antigens. Certain symptoms of infections, such as fever, muscle pain and "flu-like symptoms", are also caused by the production of IFNs and other cytokines.


title: Interferon

text: More than twenty distinct IFN genes and proteins have been identified in animals, including humans. They are typically divided among three classes: Type I IFN, Type II IFN, and Type III IFN. IFNs belonging to all three classes are important for fighting viral infections and for the regulation of the immune system.


title: Interferon

text: Based on the type of receptor through which they signal, human interferons have been classified into three major types.


title: Interferon

text: In general, type I and II interferons are responsible for regulating and activating the immune response. Expression of type I and III IFNs can be induced in virtually all cell types upon recognition of viral components, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells.


title: Interferon

text: All interferons share several common effects: they are antiviral agents and they modulate functions of the immune system. Administration of Type I IFN has been shown experimentally to inhibit tumor growth in animals, but the beneficial action in human tumors has not been widely documented.


title: Interferon

text: A virus-infected cell releases viral particles that can infect nearby cells. However, the infected cell can protect neighboring cells against a potential infection of the virus by releasing interferons. In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). This enzyme phosphorylates a protein known as eIF-2 in response to new viral infections; the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the cell. Another cellular enzyme, RNAse L—also induced by interferon action—destroys RNA within the cells to further reduce protein synthesis of both viral and host genes. Inhibited protein synthesis impairs both virus replication and infected host cells. In addition, interferons induce production of hundreds of other proteins—known collectively as interferon-stimulated genes (ISGs)—that have roles in combating viruses and other actions produced by interferon.


title: Interferon

text: They also limit viral spread by increasing p53 activity, which kills virus-infected cells by promoting apoptosis. The effect of IFN on p53 is also linked to its protective role against certain cancers.


title: Interferon

text: Another function of interferons is to up-regulate major histocompatibility complex molecules, MHC I and MHC II, and increase immunoproteasome activity. All interferons significantly enhance the presentation of MHC I dependent antigens. Interferon gamma (IFN-gamma) also significantly stimulates the MHC II-dependent presentation of antigens. Higher MHC I expression increases presentation of viral and abnormal peptides from cancer cells to cytotoxic T cells, while the immunoproteasome processes these peptides for loading onto the MHC I molecule, thereby increasing the recognition and killing of infected or malignant cells. Higher MHC II expression increases presentation of these peptides to helper T cells; these cells release cytokines (such as more interferons and interleukins, among others) that signal to and co-ordinate the activity of other immune cells.


title: Interferon

text: Interferons can also suppress angiogenesis by down regulation of angiogenic stimuli deriving from tumor cells. They also suppress the proliferation of endothelial cells. Such suppression causes a decrease in tumor angiogenesis, a decrease in its vascularization and subsequent growth inhibition. Interferons, such as interferon gamma, directly activate other immune cells, such as macrophages and natural killer cells.


title: Interferon

text: Production of interferons occurs mainly in response to microbes, such as viruses and bacteria, and their products. Binding of molecules uniquely found in microbes—viral glycoproteins, viral RNA, bacterial endotoxin (lipopolysaccharide), bacterial flagella, CpG motifs—by pattern recognition receptors, such as membrane bound toll like receptors or the cytoplasmic receptors RIG-I or MDA5, can trigger release of IFNs.


title: Interferon

text: Toll Like Receptor 3 (TLR3) is important for inducing interferons in response to the presence of double-stranded RNA viruses; the ligand for this receptor is double-stranded RNA (dsRNA). After binding dsRNA, this receptor activates the transcription factors IRF3 and NF-κB, which are important for initiating synthesis of many inflammatory proteins. RNA interference technology tools such as siRNA or vector-based reagents can either silence or stimulate interferon pathways. Release of IFN from cells (specifically IFN-γ in lymphoid cells) is also induced by mitogens. Other cytokines, such as interleukin 1, interleukin 2, interleukin-12, tumor necrosis factor and colony-stimulating factor, can also enhance interferon production.


title: Interferon

text: By interacting with their specific receptors, IFNs activate "signal transducer and activator of transcription" (STAT) complexes; STATs are a family of transcription factors that regulate the expression of certain immune system genes. Some STATs are activated by both type I and type II IFNs. However each IFN type can also activate unique STATs.


title: Interferon

text: STAT activation initiates the most well-defined cell signaling pathway for all IFNs, the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called "IFN-stimulated response elements" (ISREs) in the promoters of certain genes, known as IFN stimulated genes ISGs. Binding of ISGF3 and other transcriptional complexes activated by IFN signaling to these specific regulatory elements induces transcription of those genes. A collection of known ISGs is available on Interferome, a curated online database of ISGs (www.interferome.org); Additionally, STAT homodimers or heterodimers form from different combinations of STAT-1, -3, -4, -5, or -6 during IFN signaling; these dimers initiate gene transcription by binding to IFN-activated site (GAS) elements in gene promoters. Type I IFNs can induce expression of genes with either ISRE or GAS elements, but gene induction by type II IFN can occur only in the presence of a GAS element.


title: Interferon

text: In addition to the JAK-STAT pathway, IFNs can activate several other signaling cascades. For instance, both type I and type II IFNs activate a member of the CRK family of adaptor proteins called CRKL, a nuclear adaptor for STAT5 that also regulates signaling through the C3G/Rap1 pathway. Type I IFNs further activate "p38 mitogen-activated protein kinase" (MAP kinase) to induce gene transcription. Antiviral and antiproliferative effects specific to type I IFNs result from p38 MAP kinase signaling. The "phosphatidylinositol 3-kinase" (PI3K) signaling pathway is also regulated by both type I and type II IFNs. PI3K activates P70-S6 Kinase 1, an enzyme that increases protein synthesis and cell proliferation; phosphorylates ribosomal protein s6, which is involved in protein synthesis; and phosphorylates a translational repressor protein called "eukaryotic translation-initiation factor 4E-binding protein 1" (EIF4EBP1) in order to deactivate it.


title: Interferon

text: Interferons can disrupt signaling by other stimuli. For example, Interferon alpha induces RIG-G, which disrupts the CSN5-containing COP9 signalosome (CSN), a highly conserved multiprotein complex implicated in protein deneddylation, deubiquitination, and phosphorylation. RIG-G has shown the capacity to inhibit NF-κB and STAT3 signaling in lung cancer cells, which demonstrates the potential of type I IFNs.


title: Interferon

text: Many viruses have evolved mechanisms to resist interferon activity. They circumvent the IFN response by blocking downstream signaling events that occur after the cytokine binds to its receptor, by preventing further IFN production, and by inhibiting the functions of proteins that are induced by IFN. Viruses that inhibit IFN signaling include Japanese Encephalitis Virus (JEV), dengue type 2 virus (DEN-2), and viruses of the herpesvirus family, such as human cytomegalovirus (HCMV) and Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8). Viral proteins proven to affect IFN signaling include EBV nuclear antigen 1 (EBNA1) and EBV nuclear antigen 2 (EBNA-2) from Epstein-Barr virus, the large T antigen of Polyomavirus, the E7 protein of Human papillomavirus (HPV), and the B18R protein of vaccinia virus. Reducing IFN-α activity may prevent signaling via STAT1, STAT2, or IRF9 (as with JEV infection) or through the JAK-STAT pathway (as with DEN-2 infection). Several poxviruses encode soluble IFN receptor homologs—like the B18R protein of the vaccinia virus—that bind to and prevent IFN interacting with its cellular receptor, impeding communication between this cytokine and its target cells. Some viruses can encode proteins that bind to double-stranded RNA (dsRNA) to prevent the activity of RNA-dependent protein kinases; this is the mechanism reovirus adopts using its sigma 3 (σ3) protein, and vaccinia virus employs using the gene product of its E3L gene, p25. The ability of interferon to induce protein production from interferon stimulated genes (ISGs) can also be affected. Production of protein kinase R, for example, can be disrupted in cells infected with JEV. Some viruses escape the anti-viral activities of interferons by gene (and thus protein) mutation. The H5N1 influenza virus, also known as bird flu, has resistance to interferon and other anti-viral cytokines that is attributed to a single amino acid change in its Non-Structural Protein 1 (NS1), although the precise mechanism of how this confers immunity is unclear.


title: Interferon

text: Coronaviruses evade innate immunity during the first ten days of viral infection. In the early stages of infection, SARS-CoV-2 induces an even lower interferon type I (IFN-I) response than SARS-CoV, which itself is a weak IFN-I inducer in human cells. SARS-CoV-2 limits the IFN-III response as well. Reduced numbers of plasmacytoid dendritic cells with age is associated with increased COVID-19 severity, possibly because these cells are substantial interferon producers.


title: Interferon

text: Ten percent of patients with life-threatening COVID-19 have autoantibodies against type I interferon.


title: Interferon

text: Delayed IFN-I response contributes to the pathogenic inflammation (cytokine storm) seen in later stages of COVID-19 disease. Application of IFN-I prior to (or in the very early stages of) viral infection can be protective, which should be validated in randomized clinical trials.


title: Interferon

text: Interferon beta-1a and interferon beta-1b are used to treat and control multiple sclerosis, an autoimmune disorder. This treatment may help in reducing attacks in relapsing-remitting multiple sclerosis and slowing disease progression and activity in secondary progressive multiple sclerosis.


title: Interferon

text: Interferon therapy is used (in combination with chemotherapy and radiation) as a treatment for some cancers. This treatment can be used in hematological malignancy, such as in leukemia and lymphomas including hairy cell leukemia, chronic myeloid leukemia, nodular lymphoma, and cutaneous T-cell lymphoma. Patients with recurrent melanomas receive recombinant IFN-α2b.


title: Interferon

text: Both hepatitis B and hepatitis C are treated with IFN-α, often in combination with other antiviral drugs. Some of those treated with interferon have a sustained virological response and can eliminate hepatitis virus. The most harmful strain—hepatitis C genotype I virus—can be treated with a 60-80% success rate with the current standard-of-care treatment of interferon-α, ribavirin and recently approved protease inhibitors such as Telaprevir (Incivek) May 2011, Boceprevir (Victrelis) May 2011 or the nucleotide analog polymerase inhibitor Sofosbuvir (Sovaldi) December 2013. Biopsies of patients given the treatment show reductions in liver damage and cirrhosis. Some evidence shows giving interferon immediately following infection can prevent chronic hepatitis C, although diagnosis early in infection is difficult since physical symptoms are sparse in early hepatitis C infection. Control of chronic hepatitis C by IFN is associated with reduced hepatocellular carcinoma.


title: Interferon

text: Unconfirmed results suggested that interferon eye drops may be an effective treatment for people who have herpes simplex virus epithelial keratitis, a type of eye infection. There is no clear evidence to suggest that removing the infected tissue (debridement) followed by interferon drops is an effective treatment approach for these types of eye infections. Unconfirmed results suggested that the combination of interferon and an antiviral agent may speed the healing process compared to antiviral therapy alone.


title: Interferon

text: When used in systemic therapy, IFNs are mostly administered by an intramuscular injection. The injection of IFNs in the muscle or under the skin is generally well tolerated. The most frequent adverse effects are flu-like symptoms: increased body temperature, feeling ill, fatigue, headache, muscle pain, convulsion, dizziness, hair thinning, and depression. Erythema, pain, and hardness at the site of injection are also frequently observed. IFN therapy causes immunosuppression, in particular through neutropenia and can result in some infections manifesting in unusual ways.


title: Interferon

text: Several different types of interferons are approved for use in humans. One was first approved for medical use in 1986. For example, in January 2001, the Food and Drug Administration (FDA) approved the use of PEGylated interferon-alpha in the USA; in this formulation, PEGylated interferon-alpha-2b ("Pegintron"), polyethylene glycol is linked to the interferon molecule to make the interferon last longer in the body. Approval for PEGylated interferon-alpha-2a ("Pegasys") followed in October 2002. These PEGylated drugs are injected once weekly, rather than administering two or three times per week, as is necessary for conventional interferon-alpha. When used with the antiviral drug ribavirin, PEGylated interferon is effective in treatment of hepatitis C; at least 75% of people with hepatitis C genotypes 2 or 3 benefit from interferon treatment, although this is effective in less than 50% of people infected with genotype 1 (the more common form of hepatitis C virus in both the U.S. and Western Europe). Interferon-containing regimens may also include protease inhibitors such as boceprevir and telaprevir.


title: Interferon

text: There are also interferon-inducing drugs, notably tilorone that is shown to be effective against Ebola virus.


title: Interferon

text: Interferons were first described in 1957 by Alick Isaacs and Jean Lindenmann at the National Institute for Medical Research in London; the discovery was a result of their studies of viral interference. Viral interference refers to the inhibition of virus growth caused by previous exposure of cells to an active or a heat-inactivated virus. Isaacs and Lindenmann were working with a system that involved the inhibition of the growth of live influenza virus in chicken embryo chorioallantoic membranes by heat-inactivated influenza virus. Their experiments revealed that this interference was mediated by a protein released by cells in the heat-inactivated influenza virus-treated membranes. They published their results in 1957 naming the antiviral factor they had discovered "interferon". The findings of Isaacs and Lindenmann have been widely confirmed and corroborated in the literature.


title: Interferon

text: Furthermore, others may have made observations on interferons before the 1957 publication of Isaacs and Lindenmann. For example, during research to produce a more efficient vaccine for smallpox, Yasu-ichi Nagano and Yasuhiko Kojima—two Japanese virologists working at the Institute for Infectious Diseases at the University of Tokyo—noticed inhibition of viral growth in an area of rabbit-skin or testis previously inoculated with UV-inactivated virus. They hypothesised that some "viral inhibitory factor" was present in the tissues infected with virus and attempted to isolate and characterize this factor from tissue homogenates. Independently, Monto Ho, in John Enders's lab, observed in 1957 that attenuated poliovirus conferred a species specific anti-viral effect in human amniotic cell cultures. They described these observations in a 1959 publication, naming the responsible factor "viral inhibitory factor" (VIF). It took another fifteen to twenty years, using somatic cell genetics, to show that the interferon action gene and interferon gene reside in different human chromosomes. The purification of human beta interferon did not occur until 1977. Y.H. Tan and his co-workers purified and produced biologically active, radio-labeled human beta interferon by superinducing the interferon gene in fibroblast cells, and they showed its active site contains tyrosine residues. Tan's laboratory isolated sufficient amounts of human beta interferon to perform the first amino acid, sugar composition and N-terminal analyses. They showed that human beta interferon was an unusually hydrophobic glycoprotein. This explained the large loss of interferon activity when preparations were transferred from test tube to test tube or from vessel to vessel during purification. The analyses showed the reality of interferon activity by chemical verification. The purification of human alpha interferon was not reported until 1978. A series of publications from the laboratories of Sidney Pestka and Alan Waldman between 1978 and 1981, describe the purification of the type I interferons IFN-α and IFN-β. By the early 1980s, genes for these interferons had been cloned, adding further definitive proof that interferons were responsible for interfering with viral replication. Gene cloning also confirmed that IFN-α was encoded by a family of many related genes. The type II IFN (IFN-γ) gene was also isolated around this time.


title: Interferon

text: Interferon was first synthesized manually at Rockefeller University in the lab of Dr. Bruce Merrifield, using solid phase peptide synthesis, one amino acid at a time. He later won the Nobel Prize in chemistry. Interferon was scarce and expensive until 1980, when the interferon gene was inserted into bacteria using recombinant DNA technology, allowing mass cultivation and purification from bacterial cultures or derived from yeasts. Interferon can also be produced by recombinant mammalian cells.


title: Interferon

text: Before the early 1970s, large scale production of human interferon had been pioneered by Kari Cantell. He produced large amounts of human alpha interferon from large quantities of human white blood cells collected by the Finnish Blood Bank. Large amounts of human beta interferon were made by superinducing the beta interferon gene in human fibroblast cells.


title: Interferon

text: Cantell's and Tan's methods of making large amounts of natural interferon were critical for chemical characterisation, clinical trials and the preparation of small amounts of interferon messenger RNA to clone the human alpha and beta interferon genes. The superinduced human beta interferon messenger RNA was prepared by Tan's lab for Cetus corp. to clone the human beta interferon gene in bacteria and the recombinant interferon was developed as 'betaseron' and approved for the treatment of MS. Superinduction of the human beta interferon gene was also used by Israeli scientists to manufacture human beta interferon.


title: Iron Butterfly

text: Iron Butterfly is an American rock band formed in San Diego, California, in 1966. They are best known for the 1968 hit "In-A-Gadda-Da-Vida", providing a dramatic sound that led the way towards the development of hard rock and heavy metal music. Although their heyday was the late 1960s, the band has been reincarnated with various members with varying levels of success with no new recordings since 1975. Their second album "In-A-Gadda-Da-Vida" (1968) remains a best-seller, and Iron Butterfly was the first group to receive an In-House platinum album award from Atlantic Records. Their music has found a significant impact on the international rock scenes, influencing numerous acts such as Black Sabbath, AC/DC, Rush, Alice Cooper, Mountain, Uriah Heep, Soundgarden, Stone Temple Pilots and Queens of the Stone Age.


title: Iron Butterfly

text: The band formed in 1966 in San Diego. The original members were Doug Ingle (vocals, organ, formerly of Jeri and the Jeritones and Palace Pages, Iron Butterfly's forerunner), Jack Pinney (drums), Greg Willis (bass), and Danny Weis (guitar, also of Palace Pages). The group were soon joined by vocalist and tambourine player Darryl DeLoach. DeLoach's parents’ garage served as the site for their almost nightly rehearsals.


title: Iron Butterfly

text: Jerry Penrod replaced Willis after the band relocated to Los Angeles in the summer of 1966. Pinney eventually left to return to school. Bruce Morse then replaced Pinney until Ron Bushy (from a group called the Voxmen) came aboard when Morse left due to a family emergency. A booking at Bido Lito's club in Hollywood soon led to regular appearances at the Galaxy Club and the Whisky a Go Go.


title: Iron Butterfly

text: In early 1968, after the band signed a deal with Atco Records, an Atlantic Records subsidiary, the band's debut album "Heavy" was released. The group was signed by Atlantic's Charles Greene, who was co-producer of "Heavy". All but Ingle and Bushy left the band after completing the album in the late summer of 1967. The two remaining musicians, faced with the possibility of the record not being released, quickly found replacements in bassist Lee Dorman and 17-year-old guitarist Erik Brann (also known as "Erik Braunn" and "Erik Braun") and resumed touring. In a 1986 interview with IB's fan club fanzine, "The Butterfly Net", Brann stated that Jeff Beck, Neil Young, and Michael Monarch (who would go on to join Steppenwolf) had also expressed interest in joining the group to replace Weis.


title: Iron Butterfly

text: After Brann was chosen, Penrod and DeLoach, uncomfortable with Brann's young age and frustrated with the time it was taking him to learn the band's repertoire, left the group after Weis did. Weis and Penrod went on to form the group Rhinoceros. In 1970 DeLoach formed Flintwhistle along with Jerry Penrod and Erik Brann. They performed live for about a year before breaking up.


title: Iron Butterfly

text: The 17-minute "In-A-Gadda-Da-Vida", the title track of Iron Butterfly's second album, became a top-30 hit (edited down to 2:52) in the U. S. The album was awarded a gold disc by the RIAA in December 1968. The album stayed on the "Billboard" charts for 140 weeks and ultimately sold over 30 million copies.


title: Iron Butterfly

text: During this time, the band was represented by the William Morris Agency, which booked all their live concerts. Iron Butterfly played its first national tour in the summer of 1968 alongside Jefferson Airplane. By the end of 1968, the band was back in the studio at work on their next album. Iron Butterfly's third album, "Ball", was released in January 1969 and went gold, reaching #3 on the Billboard charts.


title: Iron Butterfly

text: The band had been booked to play at Woodstock in August 1969 but got stuck at New York City's LaGuardia Airport. They explained their situation to the concert promoters and asked for patience. Their manager, however, sent a telegram demanding that Iron Butterfly be flown in by helicopter, whereupon they would "immediately" take the stage. After their set, they would be paid and flown back to the airport. According to drummer Bushy, "We went down to the Port Authority three times and waited for the helicopter, but it never showed up". Woodstock Production Coordinator John Morris claims he sent the manager a telegram reading: "For reasons I can't go into / Until you are here / Clarifying your situation / Knowing you are having problems / You will have to find / Other transportation / Unless you plan not to come." The acrostic formed by the first letter of each line in the telegram made it clear that the band was not welcome.


title: Iron Butterfly

text: Erik Brann left the band after a final show in San Diego on December 15, 1969. Brann was frustrated with the band's unwillingness to move towards a harder rock sound. He was replaced in the line-up by two new musicians: guitarist/vocalist Mike Pinera (whose Blues Image had opened for Iron Butterfly's Vida tour) and guitarist Larry Reinhardt (from the Allman Brothers Band forerunner Second Coming). Both Pinera and Larry "Rhino" Reinhardt had been rehearsing secretly with the band since September 1969 after Brann had voiced his objections to continuing. In August 1970 Iron Butterfly released its fourth studio album "Metamorphosis". The album managed to get into the Billboard top 20.


title: Iron Butterfly

text: While Iron Butterfly was touring in Europe with Yes in early 1971, Doug Ingle announced his intention to leave the group. Ingle had grown tired of endless touring and wasn't totally on board with the band's new guitar-oriented blues and soul direction. The remaining four members cut the 45 rpm single, "Silly Sally" (with Bushy eventually being replaced on the record by a session drummer, at the producer's prompting). Putting forth a horn-based sound more characteristic of groups like Blood Sweat and Tears, the single failed to chart and proved to be their last recording before their mid-1970s reformation.


title: Iron Butterfly

text: The band, with Ingle in tow, decided to play one final tour, pairing with Black Oak Arkansas. Pinera's band-mate from Blues Image, drummer Manny Bertematti, filled in for Bushy for most of the tour dates because of the latter's shoulder injury. The group then broke up after playing the tour's final show at Central Oregon Community College in Bend, Oregon on May 23, 1971. Another reason for the band not continuing at this time, according to a later interview by Pinera, was the U. S. Internal Revenue Service's effort to collect unpaid taxes.


title: Iron Butterfly

text: In 1974 Brann was contacted by a promoter about reforming Iron Butterfly, so he reunited with Ron Bushy to form a new version of the group, signing with MCA Records and joined by Bushy's friend, bassist Philip Taylor Kramer, and keyboardist Howard Reitzes, a friend of Brann's who worked in a music store. Brann, who had done occasional lead vocals during Iron Butterfly's original run, served as the band's main lead vocalist this time. The album "Scorching Beauty" was released in January 1975 with Reitzes and "Sun and Steel" in October 1975 with Bill DeMartines replacing Reitzes. Both albums were criticized for bearing little resemblance to the original tone of the group and sold poorly compared to their earlier releases.


title: Iron Butterfly

text: In 1977 the Bushy/Brann/Kramer/DeMartines grouping wound down after being plagued with bad management and tour dates that had started off in theaters but ended up in bars and clubs. Bushy, Kramer and DeMartines formed Magic and Lee Dorman put together a new IB lineup with Rhino that contained British singer Jimi Henderson, Larry Kiernan on keyboards, David Love on guitar and Kevin Karamitros on drums. This grouping toured mostly in the South. By 1978 the lineup was Dorman, Karamitros, Pinera and John Leimseider on keyboards.


title: Iron Butterfly

text: In the late fall of 1978, a German promoter made an offer for the band to tour. The "Metamorphosis" lineup (Ingle, Bushy, Dorman, Pinera and Rhino) made preparations, but just before they were to depart for Germany, Dorman's father took ill and another bassist, Keith Ellis (formerly of Boxer), was brought in to cover for Dorman in case he had to suddenly return to the US. During the tour, Ellis died in Darmstadt, Germany on December 12, 1978.


title: Iron Butterfly

text: After their return to the US, the "Metamorphosis" group played a few homecoming shows in early 1979, joined by Erik Brann for guest appearances. Later in 1979, Bushy returned to his other group, Gold, and the next IB lineup was: Mike Pinera, Lee Dorman, Doug Ingle, a returning John Leimseider and Dorman's Captain Beyond band-mate, drummer Bobby Caldwell. Still later that same year, Bobby Hasbrook, from Hawaii, joined the band as lead guitarist and lead vocals alongside Dorman, Pinera, Caldwell and Leimseider.


title: Iron Butterfly

text: IB's lineup was in a constant state of flux from late 1979 on as exhibited in the following groupings: Brann, Dorman, Leimseider, Caldwell and Hasbrook (1979); Pinera, Brann, Dorman, Hasbrook, Caldwell and Nathan Pino – keyboards (1979); Dorman, Brann, Hasbrook, Tim Kislan – keyboards, Zam Johnson – drums and Starz Vanderlocket – vocals, percussion (1980); Dorman, Rhino, Leimseider, Randy Skirvin – guitar, Jimmy Rock – drums and Luke – vocals, percussion (1981–1982); Pinera, Dorman, Rhino, Guy Babylon – keyboards and Jan Uvena – drums (1982) plus Pinera, Dorman, Rhino, Babylon and Bushy (1982).


title: Iron Butterfly

text: On July 31, 1982, the Pinera, Dorman, Rhino, Babylon and Bushy lineup went into Music Sound Connection Studio in Studio City, California to record some material, none of which has ever been released.


title: Iron Butterfly

text: At the tail end of 1982, Ingle returned to the fold once more as John Shearer (from Steve Hackett's band) came in on drums and percussionist Luke also rejoined since Bushy had taken a sales job outside of music for Makita Tools. Brann (who had guested at some shows during 1982) soon ended his association with the band at this time as well.


title: Iron Butterfly

text: Pinera left again, as did Luke, in 1983 and IB worked on some more material in September of that year, with drummer Jerry Sommers playing on some tracks. But once again, nothing ever came of it.


title: Iron Butterfly

text: Then Ingle, Dorman, Rhino and drummer Rick Rotante undertook the "Wings of Flight Tour" in early 1984, with Lenny Campanero (ex-Badfinger) replacing Rotante for more recording sessions at Salty Dog Studios in Van Nuys, California.


title: Iron Butterfly

text: The "Legends Tour" took place in the fall of 1984 with Ingle, Dorman, Campanero and guitarist Steve Fister (later of Steppenwolf) and another Steppenwolf alumnus, bassist Kurtis Teel, took Dorman's spot for the "Phoenix Tour" in the fall of '85, which ended in late November, shortly after which, Teel suddenly died of a heart murmur on December 2. The group then disbanded once again due to managerial problems.


title: Iron Butterfly

text: In the spring of 1987, Bushy and Pinera got back together to tour as Iron Butterfly for the "Wings of Flight 87" tour (Dorman was captaining a fishing boat, so was not available at this time) with Ace Baker (keyboards) and Kelly Reubens (bass). Tim Von Hoffman and Glen Rappold (guitar, bass) soon replaced Ace Baker and drummer Donny Vosburgh (who'd been in Thee Image with Pinera) guested at some of these 1987 shows and subbed for Bushy on others. But this was short-lived, as Bushy and then Brann both rehearsed different IB lineups in August and September of that year (see Lineups below) that never made it to the concert stage.


title: Iron Butterfly

text: In December 1987 the "classic lineup" of Ingle, Brann, Dorman and Bushy got together at The Roxy Theatre to prepare for a thirty date tour of the East Coast in the winter and spring of 1988 that culminated with an appearance at Atlantic Records 40th Anniversary celebration at Madison Square Garden on May 14, 1988, alongside Led Zeppelin and many others.


title: Iron Butterfly

text: After this, Brann and Dorman decided to continue on, bringing in Rhino, keyboardist Derek Hilland and drummer Sal Rodriguez (replaced by Kenny Suarez). They were joined by singer/frontman Steve "Mick" Feldman and backup singers JoAnne Kurman-Montana and Cecelia Noel also appeared with the band for a few shows in 1989, as well as another drummer, Doug Freedman, who subbed for Suarez in the fall of '89. The 1989 IB lineup of Brann, Dorman, Rhino, Hilland, Feldman and Suarez appeared at Woodstock '89, which took place in August 1989 twenty years to the day of and on the site of the original Woodstock concert of 1969 as a spontaneous celebration of the event's 20th anniversary.


title: Iron Butterfly

text: In 1990 after Brann fell out with the others and left Iron Butterfly for good, Dorman, Rhino, Hilland and Suarez recorded an album with singer Robert Tepper that was meant to be an IB album called "We Will Rise" but instead was shelved and eventually reworked into Tepper's 1996 solo album, "No Rest For The Wounded Heart".


title: Iron Butterfly

text: After the Tepper-led lineup failed to break through, Tepper left to continue his solo career and Dorman, Rhino and Bushy went back on the road in early 1993 with keyboardist Burt Diaz.


title: Iron Butterfly

text: Doug Ingle rejoined the band in July 1994. In the spring of 1997 the band did a tour of Europe with "classic era" members Ingle, Bushy and Dorman, along with Hilland and Barnett. A DVD of live performances from this tour was released in 2008. Hilland was dropped in 1997 and Ingle officially retired from performing in early 1999. Singer/keysman Damian Bujanda had a brief tenure, but after leaving for personal reasons, Larry Rust joined the band as vocalist/keyboardist from 1999 to 2005.


title: Iron Butterfly

text: Guitarist/vocalist Charlie Marinkovich joined the band in 2002. Originally from Seattle, Marinkovich had played with Randy Hansen and others.


title: Iron Butterfly

text: Original vocalist Darryl DeLoach (born on September 12, 1947) died of liver cancer on October 3, 2002, at the age of 55.


title: Iron Butterfly

text: Derek Hilland returned to play keyboards for the group's 2003 dates when Larry Rust was not available.


title: Iron Butterfly

text: Larry Rust parted ways with the band in 2005 and was replaced by German violinist, keyboardist, and composer Martin Gerschwitz, who had formerly worked with Lita Ford, Meat Loaf, Walter Trout, and most recently Eric Burdon and The Animals.


title: Iron Butterfly

text: In early 2010, an announcement was made that Iron Butterfly would receive the Lifetime Achievement Award at the 20th Annual San Diego Music Awards, which took place on September 12, 2010. The award was presented by San Diego Mayor Jerry Sanders. Later the same year, Ray Weston (formerly of Wishbone Ash) came in to substitute on drums for Ron Bushy after he was sidelined by health issues.


title: Iron Butterfly

text: In early 2012, Phil Parlapiano substituted for Martin Gerschwitz for a few shows when Gerschwitz was unable to play due to his own solo-tour schedule.


title: Iron Butterfly

text: Former guitarist Larry "Rhino" Reinhardt died on January 2, 2012, at the age of 63, due to cirrhosis of the liver. Bassist Lee Dorman, who had a history of heart trouble, died on December 21, 2012, at the age of 70. Both Reinhardt and Dorman were also founding members of Captain Beyond.


title: Iron Butterfly

text: Following Dorman's death, Iron Butterfly dissolved once more. Charlie Marinkovich revealed in 2013 that he had departed the band altogether and that Ron Bushy was very ill, shrouding the band's future in doubt. At times during his recovery in 2014, Ron Bushy entertained the idea of putting a new Iron Butterfly band together, possibly with Martin Gerschwitz returning on keyboards and lead vocals.


title: Iron Butterfly

text: In late 2014, reports surfaced of the band reforming, with a lineup consisting of Bushy, Mike Pinera, Doug Ingle, Jr. on keyboards and an unnamed bassist. However, this reformation did not come to fruition and in 2015 the band unveiled a lineup consisting of Bushy and returning guitarist Eric Barnett, along with new members Mike Green (percussion), Dave Meros (bass), Phil Parlapiano (keyboards) and Ray Weston (drums). Meros, Parlapiano and Weston had all previously played with Iron Butterfly as substitute musicians; Meros for Dorman (in 2006) Parlapiano for Gerschwitz (in 2012) and Weston for Bushy (in 2010) respectively.


title: Iron Butterfly

text: At that time, Ron Bushy was still involved with Iron Butterfly, but was retired from performing due to his health concerns.


title: Iron Butterfly

text: This left Weston as the only active drummer in the band at all appearances from the 2015 reunion through the end of 2019. In the summer of 2018, Bushy made a rare guest appearance with the band at a gig in California. This turned out to be his first performance on stage with Iron Butterfly since 2012 and his very last one with the band.


title: Iron Butterfly

text: Former Butterfly keyboardist Larry Rust died peacefully at his home near Los Angeles on November 25, 2016, at the age of 63. Founding bassist Greg Willis died on November 11, 2016. A tribute concert was staged November 30 at Nicky Rottens in El Cajon.


title: Iron Butterfly

text: On January 15, 2020, the Official Iron Butterfly website and their booking agent announced the lineup of the band for 2020: Eric Barnett (guitar, vocals), Dave Meros (bass, vocals), Bernie Pershey (drums, percussion), Martin Gerschwitz (keyboards, vocals), with occasional guests or fill in musicians being Ron Bushy (drums, percussion), Ray Weston (drums, percussion) and Michael Thomas Franklin (keyboards).


title: Iron Butterfly

text: On August 29, 2021 TMZ reported that Ron Bushy had died that morning at the UCLA Medical Center at the age of 79 after a battle with esophageal cancer, leaving him as the third member of the "In-A-Gadda-Da-Vida" lineup to die, following Erik Brann and Lee Dorman in 2003 and 2012 respectively, and Doug Ingle as the only surviving member of this lineup.


title: Iron Butterfly

text: (Contained video performances of "Easy Rider" (3:21), "In-A-Gadda-Da-Vida" (17:03) and "Butterfly Bleu" (19:51))


title: An Officer and a Spy (film)

text: An Officer and a Spy () is a 2019 historical drama film directed by Roman Polanski about the Dreyfus affair, with a screenplay by Polanski and Robert Harris based on Harris's 2013 novel of the same name. The name J'Accuse has its origins in Émile Zola's bold article in "l'Aurore" in January 1898 in which the famous author accused many persons of France of continuing to support the increasingly blatantly erroneous accusations against Dreyfus.


title: An Officer and a Spy (film)

text: The film had its premiere at the 76th Venice International Film Festival on 30 August 2019, winning the Grand Jury Prize and the FIPRESCI Prize. It received twelve nominations for the 45th César Awards, the most nominations of any eligible film, and eventually won the awards for Best Adaptation, Best Costume Design, and Best Director. The film was also nominated in four categories at the 32nd European Film Awards, including for Best Film, Best Director, Best Actor, and Best Screenwriter, ultimately winning none. It received David di Donatello and Polish Film Awards nominations as Best Foreign and Best European film respectively.


title: An Officer and a Spy (film)

text: In 1894, Alfred Dreyfus, captain in the French army, is found guilty of high treason for passing military secrets to the German Empire. He is degraded and condemned to exile on Devil's Island; his affair triggers a noticeable echo in France since Dreyfus is Jewish. One year later, officer Georges Picquart, former superior of Dreyfus himself, is appointed head of the secret service section in the French army ("Deuxième Bureau"). The man, despite alleged anti-Semitic sentiments, is aware that the trial against Dreyfus was rather summary and biased by his origin; therefore, noticing some irregularities in the dossier of the affair, he decides to conduct an investigation to verify the man's guilt. Picquart discovers that the so-called "bordereau", the document that would prove his guilt, was not written by Dreyfus, as the graphologist Alphonse Bertillon had declared, but by another soldier: Major Ferdinand Walsin Esterhazy. According to Picquart, he is the real spy, but the evidence has been prejudiced or even falsified to the detriment of Dreyfus.


title: An Officer and a Spy (film)

text: Picquart is convinced of Dreyfus' innocence and tries to reopen the trial to exonerate him and arrest Esterhazy, but meets the opposition of his superiors: admitting Dreyfus' innocence would result in a great scandal that would lead to the discovery of corruption in the army, while the man, as a Jew, is the perfect scapegoat. Picquart is then removed from office and sent on a mission far from Paris; However, he manages to return and tell everything to his friend, the lawyer Louis Leblois, who begins to organise a committee for the rehabilitation of Dreyfus, involving his colleague Fernand Labori, members of the Parliament and intellectuals, including the famous author Émile Zola.


title: An Officer and a Spy (film)

text: Picquart's insubordination leads to his arrest, but on the same day Zola publishes in the newspaper "L'Aurore" the article entitled "J'accuse", which would become famous, where he fiercely criticises the irregularities of the trial of Dreyfus and exposes all the people involved in the case. Zola, on a complaint from the government, is tried for defamation and, due to the false declarations made in the courtroom by the soldiers called to witness, the writer is sentenced to one year in prison. While the whole of France is divided between innocent and guilty parties, the intellectuals signing the pro-Dreyfus petition are targeted by popular hatred. Later, after losing a duel against Picquart, Lieutenant Colonel Hubert Joseph Henry, who had testified against Dreyfus, admits he perjured himself, and died shortly after, apparently by suicide.


title: An Officer and a Spy (film)

text: Following Henry's depositions, Picquart is acquitted and released, while Dreyfus is repatriated for a second trial; shortly before the decisive hearing, the lawyer Labori suffers an assassination attempt and is unable to defend Dreyfus. The man is sentenced again, but the sentence to be served is made lighter by the recognition of the extenuating circumstances. In 1899, the Prime Minister grants Dreyfus a pardon. Picquart would like to continue fighting to prove his innocence, but Dreyfus, exhausted, accepts it. Seven years later there will be full acquittal and reintegration into the army.


title: An Officer and a Spy (film)

text: In 1907, Picquart is appointed Minister of War, also thanks to the recognition of the judicial error to the detriment of him. Dreyfus asks him for an audience and protests because the years in which he has unfairly served his sentence have not been recognised, preventing him from reaching the rank of lieutenant colonel. Picquart cannot make this concession to him as the political climate has changed again, which causes Dreyfus' outrage. The two men greet each other with respect, never to see each other again.


title: An Officer and a Spy (film)

text: Robert Harris was inspired to write the novel by his friend Polanski, who has long had an interest in the Dreyfus affair. Harris followed the novel with a script of the same story, titled "D", with Polanski announced as director in 2012.


title: An Officer and a Spy (film)

text: This film was the third occasion Harris has worked with Polanski. Harris previously co-wrote "The Ghost Writer" with Polanski, which was also an adaptation of one of Harris's novels, "The Ghost". The two first worked together in 2007 on a film adaptation of Harris's novel "Pompeii", which was cancelled just before filming due to a looming actors' strike.


title: An Officer and a Spy (film)

text: Although set in Paris, the film was first scheduled to shoot in Warsaw in 2014, for economic reasons. Production was postponed after Polanski moved to Poland for filming, and the US government filed extradition papers. The Polish government eventually rejected them. By that point, new French film tax credits had been introduced, which allowed the film to shoot on location in Paris.


title: An Officer and a Spy (film)

text: The film was budgeted at €60m and was next set to start production in July 2016, but its production was postponed again while Polanski waited on the availability of a star, whose name was never announced.


title: An Officer and a Spy (film)

text: Filming began on 26 November 2018 and was completed on 28 April 2019. The film was produced by Alain Goldman's Légende Films and distributed by Gaumont.


title: An Officer and a Spy (film)

text: The film had its world premiere at the Venice Film Festival on 30 August 2019. At the Venice Film Festival, the film won the Grand Jury Prize. It was released in France on 13 November 2019, and in Italy on 21 November 2019.


title: An Officer and a Spy (film)

text: "An Officer and a Spy" holds approval rating on review aggregator website Rotten Tomatoes, based on reviews, with an average of . On Metacritic, the film holds a rating of 56 out of 100, based on nine critics, indicating "mixed or average reviews". The film received a standing ovation during its premiere in Venice.


title: An Officer and a Spy (film)

text: David Sexton, writing for the "Evening Standard", gave the film a rating of four out of five, declaring that: "It's an absolute masterclass in how to make a historical film".


title: An Officer and a Spy (film)

text: The film has received backlash due to parallels Polanski allegedly made between his sexual abuse case and the film's plot.


title: An Officer and a Spy (film)

text: Polanski's attendance at the Venice Film Festival was his first appearance at a major film event since he was expelled from the Academy of Motion Picture Arts and Sciences in May 2018. During the festival, the head of the jury Lucrecia Martel stated: "I don't separate the man from the art. I think that important aspects of the work emerges in the man. [...] A man who commits a crime of this size who is then condemned, and the victim considers herself satisfied with the compensation is difficult for me to judge... It is difficult to define what is the right approach we have to take with people who have committed certain acts and were judged for them. I think these questions are part of the debate in our times." Martel also stated she would not attend a gala dinner in support of the film.


title: An Officer and a Spy (film)

text: Polanski's producers threatened to pull the film from the festival lineup. Martel later clarified her comments, stating: "According to some reports after today's press conference, I believe my words were deeply misunderstood. Since I don't separate the work from the author and I have recognized a lot of humanity in Polanski's previous films, I am not opposed to the presence of the film in competition. I don't have any prejudice towards it and of course I will watch the film like any other in the competition. If I had any prejudice, I would have resigned my duty as the president of the jury."


title: An Officer and a Spy (film)

text: Alberto Barbera, the festival director of Venice, had previously defended the film being in the lineup, stating: "We are here to see works of art, not to judge the person behind it. I hope we can just discuss about the quality of the film and not about Polanski and the case with L.A. County."


title: An Officer and a Spy (film)

text: U.S. distribution companies rejected invitations to a buyers' presentation during the Cannes Film Festival. Howard Cohen of Roadside Attractions stated: "I think we would consider it, though I'm not even sure how I personally feel. People have been releasing his films for years. Now, we are looking at it through a different lens, with good reason. We have to search our souls if it's the right thing to do. What does it mean to release this movie? I don't think that's a settled question even in my mind."


title: An Officer and a Spy (film)

text: In November 2019, five days before the official release of "An Officer and a Spy" in France, Polanski faced accusations of rape by a French woman, Valentine Monnier. Upon the release, French feminist groups invaded or blockaded several cinemas, having the film cancelled in some places.


title: An Officer and a Spy (film)

text: When the film was nominated for 12 César Awards in January 2020, women's groups said that the French film academy was acclaiming "an abuser and rapist on the run". Eventually, Polanski as well as other crew members of "An Officer and a Spy" did not attend the 45th César Awards ceremony. No one was there to accept the awards on Polanski's behalf. The César Award for Best Director to Polanski was poorly received by the audience. Several people walked out in disgust, including Best Actress nominee Adèle Haenel.


title: Saturn Corporation

text: The Saturn Corporation, also known as Saturn LLC, was an American automobile manufacturer, a registered trademark established on January 7, 1985, as a subsidiary of General Motors. The company was an attempt by GM to compete directly with Japanese imports and transplants, initially in the US compact car market.


title: Saturn Corporation

text: The brand marketed itself as a "different kind of car company" and operated quasi-independently from its parent company,—comprehensively introducing a new car, dealer network, pricing structure, workforce and independently managed manufacturing plant in Spring Hill, Tennessee. The first cars themselves launched five years after the company's inception, and they advanced GM's spaceframe construction—manifesting Saturn's market proposition with their dent-resistant polymer exterior panels.


title: Saturn Corporation

text: Over time, as Saturn drained resources from GM's extensive brand network and as GM struggled with the 2008 economic collapse, the parent company curtailed Saturn's development budgets — leaving Saturn to badge engineer products from other divisions, notably a series of federalized models from Opel. With this, Saturn gradually lost its unique selling proposition, and the market lost interest. Annual sales achieved their highest level in 1994, with 286,003 vehicles marketed.


title: Saturn Corporation

text: Following a failed attempt by Penske Automotive to acquire Saturn in September 2009, GM ended production in October of 2009, ended outstanding franchises in October of 2010, and discontinued the brand 25 years after it began.


title: Saturn Corporation

text: Alex C. Mair began discussions of a "revolutionary new" small car project, codenamed Saturn, in June 1982, soon after the GM J platform was introduced internationally. In November 1983, the Saturn idea was publicized by General Motors' Chairman Roger B. Smith and GM's President F. James McDonald. Twelve months later, the first Saturn demonstration vehicle was revealed. On January 7, 1985, the Saturn Corporation was officially founded. Citing full disclosure, Saturn was founded as a private, employee-owned company, by former GM leadership. They remained private until GM bought them out, and effectively "rewrote" company history.


title: Saturn Corporation

text: In the mid-1980s, GM released the Saturn Concept Car. The car, which resembled the first Saturn SL, was not originally meant to start up a brand, however; GM planned to release the Saturn car under one of its brands, which, at the time, were Chevrolet, Pontiac, Oldsmobile, Buick, Cadillac and GMC. In 1985, GM changed their plan and founded Saturn as its own brand, with its first cars being the Saturn SC and Saturn SL. Production of both Saturn vehicles started in 1990 as early 1991 model year vehicles. The Saturn SW was later added for 1993. GM had plans for a sedan, a coupe, a convertible, a wagon, and even a sport utility vehicle; however, Saturn's first sport utility vehicle, the Vue did not appear until the 2002 model year. and Saturn's first convertible the Sky did not appear until the 2006 model year.


title: Saturn Corporation

text: On July 30, 1990, the first Saturn was built, a red 1991 model-year Saturn SL2. The first Saturn dealership opened in Memphis, Tennessee. Saturn Corporation was launched as a "different kind of car company", and Saturn even had its own unique car models (although later models shared platforms with other GM vehicles to be more cost effective in the market), and their own dealership network that was separate from the rest of GM.