title: Giorgio Agamben

text: Within the state of exception, the distinction between "bios" (the life of the citizen) and "zoê" (the life of "homo sacer") is made by those with judicial power. For example, Agamben would argue that Guantánamo Bay exemplifies the concept of 'the state of exception' in the United States following 9–11.


title: Giorgio Agamben

text: Agamben mentions that basic universal human rights of Taliban individuals while captured in Afghanistan and sent to Guantánamo Bay in 2001 were negated by US laws. In reaction to the removal of their basic human rights, detainees of Guantánamo Bay prison went on hunger strikes. Within a state of exception, when a detainee is placed outside the law he is, according to Agamben, reduced to "bare life" in the eyes of the judicial powers. Here, one can see why such measures as hunger strikes can occur in such places as prisons. Within the framework of a system that has deprived the individual of power, and their individual basic human freedoms, the hunger strike can be seen as a weapon or form of resistance. "The body is a model which can stand for any bounded system. Its boundaries can represent any boundaries which are threatened or precarious." Within a state of exception the boundaries of power are precarious and threaten to destabilize not only the law, but one's humanity, as well as their choice of life or death. Forms of resistance to the extended use of power within the state of exception, as suggested in Guantánamo Bay prison, also operate outside the law. In the case of the hunger strike, the prisoners were threatened and endured force feeding not allowing them to die. During the hunger strikes at Guantánamo Bay prison, accusations and founded claims of forced feedings began to surface in the autumn of 2005. In February 2006, "The New York Times" reported that prisoners were being force fed in Guantánamo Bay prison and in March 2006, more than 250 medical experts, as reported by the BBC, voiced their opinions of the forced feedings stating that this was a breach of the government's power and was against the rights of the prisoners.


title: Giorgio Agamben

text: In "The Coming Community", published in 1990 and translated by longtime admirer Michael Hardt in 1993, Agamben describes the social and political manifestation of his philosophical thought. Employing diverse short essays he describes the nature of "whatever singularity" as that which has an "inessential commonality, a solidarity that in no way concerns an essence". It is important to note his understanding of "whatever" not as being indifference but based on the Latin "quodlibet ens" translated as "being such that it always matters".


title: Giorgio Agamben

text: In the same sense, Agamben talks about "ease" as the "place" of love, or "rather love as the experience of taking-place in a whatever singularity", which resonates his use of the concept "use" in the later works.


title: Giorgio Agamben

text: Following the same trend, he employs, among others, the following to describe the "watershed of whatever":


title: Giorgio Agamben

text: Other themes addressed in "The Coming Community" include the commodification of the body, evil, and the messianic.


title: Giorgio Agamben

text: Unlike other continental philosophers he does not reject the dichotomies of subject/object and potentiality/actuality outright, but rather turns them inside-out, pointing out the zone where they become indistinguishable.


title: Giorgio Agamben

text: The political task of humanity, he argues, is to expose the innate potential in this zone of indistinguishability. And although criticised as dreaming the impossible by certain authors, he nonetheless shows a concrete example of "whatever singularity" acting politically:


title: Giorgio Agamben

text: In his main work ""Homo Sacer: Sovereign Power and Bare Life"" (1998), Agamben analyzes an obscure figure of Roman law that poses fundamental questions about the nature of law and power in general. Under the laws of the Roman Empire, a man who committed a certain kind of crime was banned from society and all of his rights as a citizen were revoked. He thus became a ""homo sacer"" (sacred man). In consequence, he could be killed by anybody, while his life on the other hand was deemed "sacred", so he could not be sacrificed in a ritual ceremony.


title: Giorgio Agamben

text: Although Roman law no longer applied to someone deemed a "Homo sacer", they remained "under the spell" of law. Agamben explains the latter idea as "human life… included in the juridical order solely in the form of its exclusion (that is, of its capacity to be killed)". "Homo sacer" was therefore "excluded" from law itself, while being "included" at the same time. This figure is the exact mirror image of the sovereign ("basileus") – a king, emperor, or president – who stands, on the one hand, "within" law (so he can be condemned, e.g., for treason, as a natural person) and "outside" the law (since as a body politic he has power to suspend law for an indefinite time).


title: Giorgio Agamben

text: Giorgio Agamben draws on Carl Schmitt's definition of the Sovereign as the one who has the power to decide the "state of exception" (or "justitium"), where law is indefinitely "suspended" without being abrogated. But if Schmitt's aim is to include the necessity of state of emergency under the rule of law, Agamben on the contrary demonstrates that all life cannot be subsumed by law. As in "Homo sacer", the state of emergency is the inclusion of life and necessity in the juridical order solely in the form of its exclusion.


title: Giorgio Agamben

text: Agamben opines that laws have always assumed the authority to define "bare life" – "zoe", as opposed to "bios", that is 'qualified life' – by making this exclusive operation, while at the same time gaining power over it by making it the subject of political control. The power of law to actively separate "political" beings (citizens) from "bare life" (bodies) has carried on from Antiquity to Modernity – from, literally, Aristotle to Auschwitz. Aristotle, as Agamben notes, constitutes political life via a simultaneous inclusion and exclusion of "bare life": as Aristotle says, man is an animal born to life (Gk. ζῆν, "zen"), but existing with regard to the good life (εὖ ζῆν, "eu zen") which can be achieved through politics. Bare life, in this ancient conception of politics, is that which must be transformed, via the State, into the "good life"; that is, bare life is that which is supposedly excluded from the higher aims of the state, yet is included precisely so that it may be transformed into this "good life". Sovereignty, then, is conceived from ancient times as the power which determines what or who is to be incorporated into the political body (in accord with its "bios") by means of the more originary exclusion (or exception) of what is to remain outside the political body—which is at the same time the source of that body's composition ("zoe"). According to Agamben, biopower, which takes the bare lives of the citizens into its political calculations, may be more marked in the modern state, but has essentially existed since the beginnings of sovereignty in the West, since this structure of "ex-ception" is essential to the core concept of sovereignty.


title: Giorgio Agamben

text: Agamben would continue to expand the theory of the state of exception first introduced in ""Homo Sacer: Sovereign Power and Bare Life"", ultimately leading to the ""State of Exception"" in 2005. Instead of leaving a space between law and life, the space where human action is possible, the space that used to constitute politics, he argues that politics has "contaminated itself with law" in the state of exception. Because "only human action is able to cut the relationship between violence and law", it becomes increasingly difficult within the state of exception for humanity to act against the State.


title: Giorgio Agamben

text: In this book, Agamben traces the concept of 'state of exception' ("Ausnahmezustand") used by Carl Schmitt to Roman "justitium" and "auctoritas". This leads him to a response to Carl Schmitt's definition of sovereignty as the power to proclaim the exception.


title: Giorgio Agamben

text: Agamben's text "State of Exception" investigates the increase of power by governments which they employ in supposed times of crisis. Within a state of emergency, Agamben refers to the states of exception, where constitutional rights can be diminished, superseded and rejected in the process of claiming this extension of power by a government.


title: Giorgio Agamben

text: The state of exception invests one person or government with the power and voice of authority over others extended well beyond where the law has existed in the past. "In every case, the state of exception marks a threshold at which logic and praxis blur with each other and a pure violence without "logos" claims to realize an enunciation without any real reference" (Agamben, pg 40). Agamben refers a continued state of exception to the Nazi state of Germany under Hitler's rule. "The entire Third Reich can be considered a state of exception that lasted twelve years. In this sense, modern totalitarianism can be defined as the establishment, by means of the state of exception, of a legal civil war that allows for the physical elimination not only of political adversaries but of entire categories of citizens who for some reason cannot be integrated into the political system" (Agamben, p. 2).


title: Giorgio Agamben

text: The political power over others acquired through the state of exception, places one government—or one form or branch of government—as all powerful, operating outside the laws. During such times of extension of power, certain forms of knowledge shall be privileged and accepted as true and certain voices shall be heard as valued, while of course, many others are not. This oppressive distinction holds great importance in relation to the production of knowledge. The process of both acquiring knowledge, and suppressing certain knowledge, is a violent act within a time of crisis.


title: Giorgio Agamben

text: Agamben's "State of Exception" investigates how the suspension of laws within a state of emergency or crisis can become a prolonged state of being. More specifically, Agamben addresses how this prolonged state of exception operates to deprive individuals of their citizenship. When speaking about the military order issued by President George W. Bush on 13 November 2001, Agamben writes, "What is new about President Bush's order is that it radically erases any legal status of the individual, thus producing a legally unnameable and unclassifiable being. Not only do the Taliban captured in Afghanistan not enjoy the status of POW's (prisoner of war) as defined by the Geneva Convention, they do not even have the status of people charged with a crime according to American laws" (Agamben, pg 3). 780 Taliban and Al-Qaeda fighters in Afghanistan were held at Guantánamo Bay without trial. These individuals were termed "enemy combatants." Until 7 July 2006, these individuals had been treated outside the Geneva Conventions by the United States administration.


title: Giorgio Agamben

text: Agamben shows that "auctoritas" and "potestas" are clearly distinct – although they form together a system". He quotes Mommsen, who explains that "auctoritas" is "less than an order and more than an advice".


title: Giorgio Agamben

text: While "potestas" derives from social function, "auctoritas" "immediately derives from the "patres" personal condition". As such, it is akin to Max Weber's concept of charisma. This is why the tradition ordered, at the king's death, the creation of the sovereign's wax-double in the "funus imaginarium", as Ernst Kantorowicz demonstrated in "The King's Two Bodies" (1957). Hence, it is necessary to distinguish two bodies of the sovereign in order to assure the continuity of "dignitas" (term used by Kantorowicz, here a synonym of "auctoritas"). Moreover, in the person detaining "auctoritas"—the sovereign—public life and private life have become inseparable. Augustus, the first Roman emperor who claimed "auctoritas" as the basis of "princeps" status in a famous passage of "Res Gestae", had opened up his house to public eyes.


title: Giorgio Agamben

text: The concept of "auctoritas" played a key-role in fascism and Nazism, in particular concerning Carl Schmitt's theories, argues Agamben:


title: Giorgio Agamben

text: Thus, Agamben opposes Foucault's concept of "biopolitics" to right (law), as he defines the state of exception, in "Homo sacer", as the inclusion of life by right under the figure of ex-ception, which is simultaneously inclusion and exclusion. Following Walter Benjamin's lead, he explains that our task would be to radically differentiate "pure violence" from right, instead of tying them together, as did Carl Schmitt.


title: Giorgio Agamben

text: Agamben's thoughts on the state of emergency leads him to declare that the difference between dictatorship and democracy is thin indeed, as rule by decree became more and more common, starting from World War I and the reorganization of constitutional balance. Agamben often reminds that Hitler never "abrogated" the Weimar Constitution: he "suspended" it for the duration of the Third Reich with the Reichstag Fire Decree, issued on 28 February 1933. Indefinite suspension of law is what characterizes the state of exception.


title: Giorgio Agamben

text: The English edition was translated by Adam Kotsko. In this study of medieval monastic rules, Agamben offers a genealogical approach to several concepts that Ludwig Wittgenstein established in his late philosophy, primarily the "Philosophical Investigations": rule-following, form-of-life, and the central importance of 'use' (for Wittgenstein: 'the meaning of a word is its use in language', and he uses 'language' not just to speak of word-language but any understandable behaviour). Agamben traces earlier versions of the term 'form-of-life' throughout the development of monastic life, beginning with the establishment of a genre of written rules in the fourth century. The aim of the book is to differentiate between 'law' and a particular use of rule that is opposite to the implementation of law. In order to sketch out the potential of this concept, we would need 'a theory of use – of which Western philosophy lacks even the most elementary principles'. Agamben turns to the Franciscans to survey a unique historical incident of a group organising itself with a rule that "is" their life, and thinking of their own lives not as their own possession but as a communal 'use'; he looks at the ways in which this idea developed and how it eventually lapsed into the Church' law.


title: Giorgio Agamben

text: According to reviewer Nathan Schneider, ""The Highest Poverty" examines two medieval Christian attempts, in the name of eternal life, to live this life beyond the reach of ordinary politics: several centuries of monasticism, and then the brief and momentous epiphany in the movement founded by Francis of Assisi. Each, according to Agamben, fails in revealing ways."


title: Giorgio Agamben

text: Giorgio Agamben is particularly critical of the United States' response to 11 September 2001, and its instrumentalization as a permanent condition that legitimizes a "state of exception" as the dominant paradigm for governing in contemporary politics. He warns against a "generalization of the state of exception" through laws like the USA PATRIOT Act, which means a permanent installation of martial law and emergency powers. In January 2004, he refused to give a lecture in the United States because under the US-VISIT he would have been required to give up his biometric information, which he believed stripped him to a state of "bare life" ("zoe") and was akin to the tattooing that the Nazis did during World War II.


title: Giorgio Agamben

text: However, Agamben's criticisms target a broader scope than the US "war on terror". As he argues in "State of Exception" (2005), rule by decree has become common since World War I in all modern states, and has been since then generalized and abused. Agamben points out a general tendency of modernity, recalling for example that when Francis Galton and Alphonse Bertillon invented "judicial photography" for "anthropometric identification", the procedure was reserved to criminals; to the contrary, today's society is tending toward a generalization of this procedure to all citizens, placing the population under permanent suspicion and surveillance: "The political body thus has become a criminal body". And Agamben notes that the Jews deportation in France and other occupied countries was made possible by the photos taken from identity cards. Furthermore, Agamben's political criticisms open up in a larger philosophical critique of the concept of sovereignty itself, which he argues is intrinsically related to the state of exception.


title: Giorgio Agamben

text: Agamben, in an article published by "Il Manifesto" on 26 February 2020, quoted the NRC in saying that there was no COVID-19 pandemic: "In order to make sense of the frantic, irrational, and absolutely unwarranted emergency measures adopted for a supposed epidemic of coronavirus, we must begin from the declaration of the Italian National Research Council (NRC), according to which 'there is no SARS-CoV2 epidemic in Italy.' and 'the infection, according to the epidemiological data available as of today and based on tens of thousands of cases, causes light/moderate symptoms (a variant of flu) in 80–90% of cases. In 10–15%, there is a chance of pneumonia, but which also has a benign outcome in the large majority of cases. We estimate that only 4% of patients require intensive therapy. Agamben argued that “the health emergency was being exaggerated” to create a state of exception. Agamben's views were strongly criticised by Sergio Benvenuto, Roberto Esposito, Divya Dwivedi, Shaj Mohan, Jean-Luc Nancy and others.


title: Giorgio Agamben

text: Agamben's major books are listed in order of first Italian publication (with the exception of "Potentialities", which first appeared in English), and English translations are listed where available. There are translations of most writings in German, French, Portuguese, and Spanish.


title: Three-star rank

text: An officer of three-star rank is a senior commander in many of the armed services holding a rank described by the NATO code of OF-8. The term is also used by some armed forces which are not NATO members. Typically, three-star officers hold the rank of vice admiral, lieutenant general, or in the case of those air forces with a separate rank structure, air marshal.


title: Three-star rank

text: In the Australian Defence Force the following ranks of commissioned officers are awarded three-star ranks:


title: Three-star rank

text: Official rank insignia for Australian 'three-star' officers do not use stars in the same fashion as the United States. The RAN does incorporate stars into the hardboard rank insignia for flag-rank officers but this is in conjunction with other devices. Unofficial star rank insignia are sometimes worn when serving with or visiting other military organisations in order to facilitate equivalent rank recognition.


title: Three-star rank

text: The Chiefs of all three services within the Australian Defence Force hold three-star rank as well as four joint positions: Vice Chief of Defence Force (VCDF), Chief of Joint Operations (CJOPS), Chief Capability Development Group (CCDG), and Chief of Defence Intelligence.


title: Three-star rank

text: The three-star rank in Brazil is the second rank in a general career. The officers in this position are normally divisional commanders.


title: Three-star rank

text: Three maple leaves appear with St. Edward's crown and crossed sabre and baton. Prince Charles holds the rank of vice-admiral in an honorary capacity. Before unification, the rank of air marshal was the three-star equivalent for the RCAF.


title: Three-star rank

text: Not to be confused with the "Generalleutnant" and "Vizeadmiral" (two-star ranks; OF-7) of the Wehrmacht until 1945 or the National People's Army (East Germany) until 1990.


title: Three-star rank

text: A vice admiral typically commands a numbered fleet which is responsible for all naval ships within its area of responsibility. An Army or Marine Corps lieutenant general typically commands a corps-sized unit (20,000 to 45,000 soldiers), while an Air Force lieutenant general commands a large Numbered Air Force consisting of several wings. Additionally, lieutenant generals and vice admirals of all services serve as high-level staff officers at various major command headquarters and the Pentagon, often as the heads of their departments.


title: Three-star rank

text: In the Russian and Soviet armies, the three-star rank is colonel-general (Russian: генерал-полковник) and full admiral (Russian: адмирал). These military ranks, along with other general and admiralty ranks, appeared in 1940. Most Warsaw Pact and Soviet-aligned countries adopted this rank. The rank is often held by commanders of the ground forces, chiefs of military academies and commanders of military districts. Colonel general is considered a stepping stone to the rank of general of the army, itself essential to achieving the high rank of marshal of the Russian Federation. This title also applies to three star officers of the air force, MVD, police and militia, internal troops, FSB/KGB, border guards and some others. In the navy, the three star rank is admiral (Russian: адмирал).


title: Three-star rank

text: From June 16, 1920, in Ukraine, a colonel general becomes a three-star general (before that rank was two-star). Since 1921, the UPR ceased to exist due to the liberation by Red Army.


title: Three-star rank

text: In 1991, Ukraine became independent. In the Armed Forces of Ukraine (as in other countries formed on the ruins of the USSR), the ranks and insignia were kept to the Soviet standard. Three stars on the shoulder straps have a colonel general () and an admiral ().


title: Three-star rank

text: On July 5, 2016 the President of Ukraine approved “The Unicorn Project and the Distinction Marks of the Armed Forces of Ukraine”. The draft addresses, among other things, the insignia of military personnel. It was supposed to reform the list of military ranks, among others the rank of brigadier general and commodore were to appear, and the rank of lieutenant general and vice admiral were three-star ranks.


title: Three-star rank

text: On November 20, 2017, the decree of the Ministry of Defense of Ukraine № 606 was issued, which specifies the rules for wearing and using unilateral servicemen. Colonels and admirals continued to wear three stars on the shoulder straps, but the stars instead of five rays became four rays.


title: Histone

text: In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn are wrapped into 30-nanometer fibers that form tightly packed chromatin. Histones prevent DNA from becoming tangled and protect it from DNA damage. In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 90 micrometers (0.09 mm) of 30 nm diameter chromatin fibers.


title: Histone

text: There are five families of histones which are designated H1/H5 (linker histones), H2, H3, and H4 (core histones). The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer. The tight wrapping of DNA around histones is to a large degree a result of electrostatic attraction between the positively charged histones and negatively charged phosphate backbone of DNA.


title: Histone

text: Histones may be chemically modified through the action of enzymes to regulate gene transcription. The most common modification are the methylation of arginine or lysine residues or the acetylation of lysine. Methylation can affect how other protein such as transcription factors interact with the nucleosomes. Lysine acetylation eliminates a positive charge on lysine thereby weakening the electrostatic attraction between histone and DNA resulting in partial unwinding of the DNA making it more accessible for gene expression.


title: Histone

text: Five major families of histones exist: H1/H5, H2A, H2B, H3, and H4. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1/H5 are known as the linker histones.


title: Histone

text: The core histones all exist as dimers, which are similar in that they all possess the histone fold domain: three alpha helices linked by two loops. It is this helical structure that allows for interaction between distinct dimers, particularly in a head-tail fashion (also called the handshake motif). The resulting four distinct dimers then come together to form one octameric nucleosome core, approximately 63 Angstroms in diameter (a solenoid (DNA)-like particle). Around 146 base pairs (bp) of DNA wrap around this core particle 1.65 times in a left-handed super-helical turn to give a particle of around 100 Angstroms across. The linker histone H1 binds the nucleosome at the entry and exit sites of the DNA, thus locking the DNA into place and allowing the formation of higher order structure. The most basic such formation is the 10 nm fiber or beads on a string conformation. This involves the wrapping of DNA around nucleosomes with approximately 50 base pairs of DNA separating each pair of nucleosomes (also referred to as linker DNA). Higher-order structures include the 30 nm fiber (forming an irregular zigzag) and 100 nm fiber, these being the structures found in normal cells. During mitosis and meiosis, the condensed chromosomes are assembled through interactions between nucleosomes and other regulatory proteins.


title: Histone

text: Histones are subdivided into canonical replication-dependent histones that are expressed during the S-phase of the cell cycle and replication-independent histone variants, expressed during the whole cell cycle. In animals, genes encoding canonical histones are typically clustered along the chromosome, lack introns and use a stem loop structure at the 3' end instead of a polyA tail. Genes encoding histone variants are usually not clustered, have introns and their mRNAs are regulated with polyA tails. Complex multicellular organisms typically have a higher number of histone variants providing a variety of different functions. Recent data are accumulating about the roles of diverse histone variants highlighting the functional links between variants and the delicate regulation of organism development. Histone variants from different organisms, their classification and variant specific features can be found in "HistoneDB 2.0 - Variants" database.


title: Histone

text: The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer, forming two nearly symmetrical halves by tertiary structure (C2 symmetry; one macromolecule is the mirror image of the other). The H2A-H2B dimers and H3-H4 tetramer also show pseudodyad symmetry. The 4 'core' histones (H2A, H2B, H3 and H4) are relatively similar in structure and are highly conserved through evolution, all featuring a 'helix turn helix turn helix' motif (DNA-binding protein motif that recognize specific DNA sequence). They also share the feature of long 'tails' on one end of the amino acid structure - this being the location of post-translational modification (see below).


title: Histone

text: Archaeal histone only contains a H3-H4 like dimeric structure made out of a single type of unit. Such dimeric structures can stack into a tall superhelix ("hypernucleosome") onto which DNA coils in a manner similar to nucleosome spools. Only some archaeal histones have tails.


title: Histone

text: The distance between the spools around which eukaryotic cells wind their DNA has been determined to range from 59 to 70 Å.


title: Histone

text: The highly basic nature of histones, aside from facilitating DNA-histone interactions, contributes to their water solubility.


title: Histone

text: Histones are subject to post translational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, SUMOylation, ubiquitination, and ADP-ribosylation. This affects their function of gene regulation.


title: Histone

text: In general, genes that are active have less bound histone, while inactive genes are highly associated with histones during interphase. It also appears that the structure of histones has been evolutionarily conserved, as any deleterious mutations would be severely maladaptive. All histones have a highly positively charged N-terminus with many lysine and arginine residues.


title: Histone

text: Core histones are found in the nuclei of eukaryotic cells and in most Archaeal phyla, but not in bacteria. The unicellular algae known as dinoflagellates were previously thought to be the only eukaryotes that completely lack histones, but later studies showed that their DNA still encodes histone genes. Unlike the core histones, homologs of the lysine-rich linker histone (H1) proteins are found in bacteria, otherwise known as nucleoprotein HC1/HC2.


title: Histone

text: It has been proposed that core histone proteins are evolutionarily related to the helical part of the extended AAA+ ATPase domain, the C-domain, and to the N-terminal substrate recognition domain of Clp/Hsp100 proteins. Despite the differences in their topology, these three folds share a homologous helix-strand-helix (HSH) motif. It’s also proposed that they may have evolved from ribosomal proteins (RPS6/RPS15), both being short and basic proteins.


title: Histone

text: Archaeal histones may well resemble the evolutionary precursors to eukaryotic histones. Histone proteins are among the most highly conserved proteins in eukaryotes, emphasizing their important role in the biology of the nucleus. In contrast mature sperm cells largely use protamines to package their genomic DNA, most likely because this allows them to achieve an even higher packaging ratio.


title: Histone

text: There are some "variant" forms in some of the major classes. They share amino acid sequence homology and core structural similarity to a specific class of major histones but also have their own feature that is distinct from the major histones. These "minor histones" usually carry out specific functions of the chromatin metabolism. For example, histone H3-like CENPA is associated with only the centromere region of the chromosome. Histone H2A variant H2A.Z is associated with the promoters of actively transcribed genes and also involved in the prevention of the spread of silent heterochromatin. Furthermore, H2A.Z has roles in chromatin for genome stability. Another H2A variant H2A.X is phosphorylated at S139 in regions around double-strand breaks and marks the region undergoing DNA repair. Histone H3.3 is associated with the body of actively transcribed genes.


title: Histone

text: Histones act as spools around which DNA winds. This enables the compaction necessary to fit the large genomes of eukaryotes inside cell nuclei: the compacted molecule is 40,000 times shorter than an unpacked molecule.


title: Histone

text: Histones undergo posttranslational modifications that alter their interaction with DNA and nuclear proteins. The H3 and H4 histones have long tails protruding from the nucleosome, which can be covalently modified at several places. Modifications of the tail include methylation, acetylation, phosphorylation, ubiquitination, SUMOylation, citrullination, and ADP-ribosylation. The core of the histones H2A and H2B can also be modified. Combinations of modifications, known as "histone marks", are thought to constitute a code, the so-called "histone code". Histone modifications act in diverse biological processes such as gene regulation, DNA repair, chromosome condensation (mitosis) and spermatogenesis (meiosis).


title: Histone

text: So H3K4me1 denotes the monomethylation of the 4th residue (a lysine) from the start (i.e., the N-terminal) of the H3 protein.


title: Histone

text: A huge catalogue of histone modifications have been described, but a functional understanding of most is still lacking. Collectively, it is thought that histone modifications may underlie a histone code, whereby combinations of histone modifications have specific meanings. However, most functional data concerns individual prominent histone modifications that are biochemically amenable to detailed study.


title: Histone

text: The addition of one, two, or many methyl groups to lysine has little effect on the chemistry of the histone; methylation leaves the charge of the lysine intact and adds a minimal number of atoms so steric interactions are mostly unaffected. However, proteins containing Tudor, chromo or PHD domains, amongst others, can recognise lysine methylation with exquisite sensitivity and differentiate mono, di and tri-methyl lysine, to the extent that, for some lysines (e.g.: H4K20) mono, di and tri-methylation appear to have different meanings. Because of this, lysine methylation tends to be a very informative mark and dominates the known histone modification functions.


title: Histone

text: Recently it has been shown, that the addition of a serotonin group to the position 5 glutamine of H3, happens in serotonergic cells such as neurons. This is part of the differentiation of the serotonergic cells. This post-translational modification happens in conjunction with the H3K4me3 modification. The serotonylation potentiates the binding of the general transcription factor TFIID to the TATA box.


title: Histone

text: What was said above of the chemistry of lysine methylation also applies to arginine methylation, and some protein domains—e.g., Tudor domains—can be specific for methyl arginine instead of methyl lysine. Arginine is known to be mono- or di-methylated, and methylation can be symmetric or asymmetric, potentially with different meanings.


title: Histone

text: Enzymes called peptidylarginine deiminases (PADs) hydrolyze the imine group of arginines and attach a keto group, so that there is one less positive charge on the amino acid residue. This process has been involved in the activation of gene expression by making the modified histones less tightly bound to DNA and thus making the chromatin more accessible. PADs can also produce the opposite effect by removing or inhibiting mono-methylation of arginine residues on histones and thus antagonizing the positive effect arginine methylation has on transcriptional activity.


title: Histone

text: Addition of an acetyl group has a major chemical effect on lysine as it neutralises the positive charge. This reduces electrostatic attraction between the histone and the negatively charged DNA backbone, loosening the chromatin structure; highly acetylated histones form more accessible chromatin and tend to be associated with active transcription. Lysine acetylation appears to be less precise in meaning than methylation, in that histone acetyltransferases tend to act on more than one lysine; presumably this reflects the need to alter multiple lysines to have a significant effect on chromatin structure. The modification includes H3K27ac.


title: Histone

text: Addition of a negatively charged phosphate group can lead to major changes in protein structure, leading to the well-characterised role of phosphorylation in controlling protein function. It is not clear what structural implications histone phosphorylation has, but histone phosphorylation has clear functions as a post-translational modification, and binding domains such as BRCT have been characterised.


title: Histone

text: Analysis of histone modifications in embryonic stem cells (and other stem cells) revealed many gene promoters carrying both H3K4Me3 and H3K27Me3, in other words these promoters display both activating and repressing marks simultaneously. This peculiar combination of modifications marks genes that are poised for transcription; they are not required in stem cells, but are rapidly required after differentiation into some lineages. Once the cell starts to differentiate, these bivalent promoters are resolved to either active or repressive states depending on the chosen lineage.


title: Histone

text: Marking sites of DNA damage is an important function for histone modifications. It also protects DNA from getting destroyed by ultraviolet radiation of sun.


title: Histone

text: H3K36me3 has the ability to recruit the MSH2-MSH6 (hMutSα) complex of the DNA mismatch repair pathway. Consistently, regions of the human genome with high levels of H3K36me3 accumulate less somatic mutations due to mismatch repair activity.


title: Histone

text: Epigenetic modifications of histone tails in specific regions of the brain are of central importance in addictions. Once particular epigenetic alterations occur, they appear to be long lasting "molecular scars" that may account for the persistence of addictions.


title: Histone

text: Cigarette smokers (about 15% of the US population) are usually addicted to nicotine. After 7 days of nicotine treatment of mice, acetylation of both histone H3 and histone H4 was increased at the FosB promoter in the nucleus accumbens of the brain, causing 61% increase in FosB expression. This would also increase expression of the splice variant Delta FosB. In the nucleus accumbens of the brain, Delta FosB functions as a "sustained molecular switch" and "master control protein" in the development of an addiction.


title: Histone

text: About 7% of the US population is addicted to alcohol. In rats exposed to alcohol for up to 5 days, there was an increase in histone 3 lysine 9 acetylation in the pronociceptin promoter in the brain amygdala complex. This acetylation is an activating mark for pronociceptin. The nociceptin/nociceptin opioid receptor system is involved in the reinforcing or conditioning effects of alcohol.


title: Histone

text: Methamphetamine addiction occurs in about 0.2% of the US population. Chronic methamphetamine use causes methylation of the lysine in position 4 of histone 3 located at the promoters of the "c-fos" and the "C-C chemokine receptor 2 (ccr2)" genes, activating those genes in the nucleus accumbens (NAc). c-fos is well known to be important in addiction. The "ccr2" gene is also important in addiction, since mutational inactivation of this gene impairs addiction.


title: Histone

text: The first step of chromatin structure duplication is the synthesis of histone proteins: H1, H2A, H2B, H3, H4. These proteins are synthesized during S phase of the cell cycle. There are different mechanisms which contribute to the increase of histone synthesis.


title: Histone

text: Yeast carry one or two copies of each histone gene, which are not clustered but rather scattered throughout chromosomes. Histone gene transcription is controlled by multiple gene regulatory proteins such as transcription factors which bind to histone promoter regions. In budding yeast, the candidate gene for activation of histone gene expression is SBF. SBF is a transcription factor that is activated in late G1 phase, when it dissociates from its repressor Whi5. This occurs when Whi5 is phosphorylated by Cdc8 which is a G1/S Cdk. Suppression of histone gene expression outside of S phases is dependent on Hir proteins which form inactive chromatin structure at the locus of histone genes, causing transcriptional activators to be blocked.


title: Histone

text: In metazoans the increase in the rate of histone synthesis is due to the increase in processing of pre-mRNA to its mature form as well as decrease in mRNA degradation; this results in an increase of active mRNA for translation of histone proteins. The mechanism for mRNA activation has been found to be the removal of a segment of the 3' end of the mRNA strand, and is dependent on association with stem-loop binding protein (SLBP). SLBP also stabilizes histone mRNAs during S phase by blocking degradation by the 3'hExo nuclease. SLBP levels are controlled by cell-cycle proteins, causing SLBP to accumulate as cells enter S phase and degrade as cells leave S phase. SLBP are marked for degradation by phosphorylation at two threonine residues by cyclin dependent kinases, possibly cyclin A/ cdk2, at the end of S phase. Metazoans also have multiple copies of histone genes clustered on chromosomes which are localized in structures called Cajal bodies as determined by genome-wide chromosome conformation capture analysis (4C-Seq).


title: Histone

text: Nuclear protein Ataxia-Telangiectasia (NPAT), also known as nuclear protein coactivator of histone transcription, is a transcription factor which activates histone gene transcription on chromosomes 1 and 6 of human cells. NPAT is also a substrate of cyclin E-Cdk2, which is required for the transition between G1 phase and S phase. NPAT activates histone gene expression only after it has been phosphorylated by the G1/S-Cdk cyclin E-Cdk2 in early S phase. This shows an important regulatory link between cell-cycle control and histone synthesis.


title: Histone

text: Histones were discovered in 1884 by Albrecht Kossel. The word "histone" dates from the late 19th century and is derived from the German word ""Histon"", a word itself of uncertain origin, perhaps from Ancient Greek "ἵστημι" (hístēmi, “make stand”) or "ἱστός" (histós, “loom”).


title: Histone

text: In the early 1960s, before the types of histones were known and before histones were known to be highly conserved across taxonomically diverse organisms, James F. Bonner and his collaborators began a study of these proteins that were known to be tightly associated with the DNA in the nucleus of higher organisms. Bonner and his postdoctoral fellow Ru Chih C. Huang showed that isolated chromatin would not support RNA transcription in the test tube, but if the histones were extracted from the chromatin, RNA could be transcribed from the remaining DNA. Their paper became a citation classic. Paul T'so and James Bonner had called together a World Congress on Histone Chemistry and Biology in 1964, in which it became clear that there was no consensus on the number of kinds of histone and that no one knew how they would compare when isolated from different organisms. Bonner and his collaborators then developed methods to separate each type of histone, purified individual histones, compared amino acid compositions in the same histone from different organisms, and compared amino acid sequences  of the same histone from different organisms in collaboration with Emil Smith from UCLA. For example, they found Histone IV sequence to be highly conserved between peas and calf thymus. However, their work on the biochemical characteristics of individual histones did not reveal how the histones interacted with each other or with DNA to which they were tightly bound.


title: Histone

text: Also in the 1960s, Vincent Allfrey and Alfred Mirsky had suggested, based on their analyses of histones, that acetylation and methylation of histones could provide a transcriptional control mechanism, but did not have available the kind of detailed analysis that later investigators were able to conduct to show how such regulation could be gene-specific. Until the early 1990s, histones were dismissed by most as inert packing material for eukaryotic nuclear DNA, a view based in part on the models of Mark Ptashne and others, who believed that transcription was activated by protein-DNA and protein-protein interactions on largely naked DNA templates, as is the case in bacteria.


title: Histone

text: During the 1980s, Yahli Lorch and Roger Kornberg showed that a nucleosome on a core promoter prevents the initiation of transcription in vitro, and Michael Grunstein demonstrated that histones repress transcription in vivo, leading to the idea of the nucleosome as a general gene repressor. Relief from repression is believed to involve both histone modification and the action of chromatin-remodeling complexes. Vincent Allfrey and Alfred Mirsky had earlier proposed a role of histone modification in transcriptional activation, regarded as a molecular manifestation of epigenetics. Michael Grunstein and David Allis found support for this proposal, in the importance of histone acetylation for transcription in yeast and the activity of the transcriptional activator Gcn5 as a histone acetyltransferase.


title: Histone

text: The discovery of the H5 histone appears to date back to the 1970s, and it is now considered an isoform of Histone H1.


title: Nirosha

text: Nirosha is an Indian film and television actress. She is known for her works predominantly in Tamil, Telugu, Malayalam and Kannada films.


title: Nirosha

text: After her debut in Tamil in the film "Agni Natchathiram" (1988, directed by Mani Ratnam), Nirosha went on to appear in many successful and critically acclaimed films. She was one of the leading actress from 1988 to 1996. After her marriage to actor Ramki in 1995, she quit acting. After a hiatus, in 2000, she again started to work as a supporting actress.


title: Informed consent

text: Informed consent is a principle in medical ethics and medical law, that a patient must have sufficient information and understanding before making decisions about their medical care. Pertinent information may include risks and benefits of treatments, alternative treatments, the patient's role in treatment, and their right to refuse treatment. In most systems, healthcare providers have a legal and ethical responsibility to ensure that a patient's consent is informed. This principle applies more broadly than healthcare intervention, for example to conduct research and to disclosing a person's medical information.


title: Informed consent

text: Definitions of informed consent vary, and the standard required is generally determined by the state. Informed consent requires a clear appreciation and understanding of the facts, implications, and consequences of an action. To give informed consent, the individual concerned must have adequate reasoning faculties and possess all relevant facts. Impairments to reasoning and judgment that may preclude informed consent include intellectual or emotional immaturity, high levels of stress such as post-traumatic stress disorder or a severe intellectual disability, severe mental disorder, intoxication, severe sleep deprivation, dementia, or coma.


title: Informed consent

text: Obtaining informed consent is not always required. If an individual is considered unable to give informed consent, another person is generally authorized to give consent on their behalf—for example, the parents or legal guardians of a child (though in this circumstance the child may be required to provide informed assent) and conservators for the mentally disordered. Alternatively, the doctrine of implied consent permits treatment in limited cases, for example when an unconscious person will die without immediate intervention. Cases in which an individual is provided insufficient information to form a reasoned decision raise serious ethical issues. When these issues occur, or are anticipated to occur, in a clinical trial, they are subject to review by an ethics committee or institutional review board.


title: Informed consent

text: Informed consent is codified in both national and international law. 'Free consent' is a cognate term in the International Covenant on Civil and Political Rights, adopted in 1966 by the United Nations, and intended to be in force by 23 March 1976. Article 7 of the covenant prohibits experiments conducted without the "free consent to medical or scientific experimentation" of the subject. , the covenant has 173 parties and six more signatories without ratification.


title: Informed consent

text: Informed consent can be complex to evaluate, because neither expressions of consent, nor expressions of understanding of implications, necessarily mean that full adult consent was in fact given, nor that full comprehension of relevant issues is internally digested. Consent may be implied within the usual subtleties of human communication, rather than explicitly negotiated verbally or in writing. In some cases consent cannot legally be possible, even if the person protests he does indeed understand and wish. There are also structured instruments for evaluating capacity to give informed consent, although no ideal instrument presently exists.


title: Informed consent

text: Thus, there is always a degree to which informed consent must be assumed or inferred based upon observation, or knowledge, or legal reliance. This especially is the case in sexual or relational issues. In medical or formal circumstances, explicit agreement by means of signature—normally relied on legally—regardless of actual consent, is the norm. This is the case with certain procedures, such as a "do not resuscitate" directive that a patient signed before onset of their illness.


title: Informed consent

text: For an individual to give valid informed consent, three components must be present: disclosure, capacity and voluntariness.


title: Informed consent

text: Waiver of the consent requirement may be applied in certain circumstances where no foreseeable harm is expected to result from the study or when permitted by law, federal regulations, or if an ethical review committee has approved the non-disclosure of certain information.


title: Informed consent

text: Besides studies with minimal risk, waivers of consent may be obtained in a military setting. According to 10 USC 980, the United States Code for the Armed Forces, Limitations on the Use of Humans as Experimental Subjects, a waiver of advanced informed consent may be granted by the Secretary of Defense if a research project would:


title: Informed consent

text: While informed consent is a basic right and should be carried out effectively, if a patient is incapacitated due to injury or illness, it is still important that patients benefit from emergency experimentation. The Food and Drug Administration (FDA) and the Department of Health and Human Services (DHHS) joined to create federal guidelines to permit emergency research, without informed consent. However, they can only proceed with the research if they obtain a waiver of informed consent (WIC) or an emergency exception from informed consent (EFIC).


title: Informed consent

text: The 21st Century Cures Act enacted by the 114th United States Congress in December 2016 allows researchers to waive the requirement for informed consent when clinical testing "poses no more than minimal risk" and "includes appropriate safeguards to protect the rights, safety, and welfare of the human subject."


title: Informed consent

text: Medical sociologists have studied informed consent as well bioethics more generally. Oonagh Corrigan, looking at informed consent for research in patients, argues that much of the conceptualization of informed consent comes from research ethics and bioethics with a focus on patient autonomy, and notes that this aligns with a neoliberal worldview. Corrigan argues that a model based solely around individual decision making does not accurately describe the reality of consent because of social processes: a view that has started to be acknowledged in bioethics. She feels that the liberal principles of informed consent are often in opposition with autocratic medical practices such that norms values and systems of expertise often shape and individuals ability to apply choice.


title: Informed consent

text: Patients who agree to participate in trials often do so because they feel that the trial was suggested by a doctor as the best intervention. Patients may find being asked to consent within a limited time frame a burdensome intrusion on their care when it arises because a patient has to deal with a new condition. Patients involved in trials may not be fully aware of the alternative treatments, and an awareness that there is uncertainty in the best treatment can help make patients more aware of this. Corrigan notes that patients generally expect that doctors are acting exclusively in their interest in interactions and that this combined with "clinical equipose" where a healthcare practictioner does not know which treatment is better in a randomized control trial can be harmful to the doctor-patient relationship.


title: Informed consent

text: "Informed consent" is a technical term first used by attorney, Paul G. Gebhard, in a medical malpractice United States court case in 1957. In tracing its history, some scholars have suggested tracing the history of checking for any of these practices:


title: Informed consent

text: These practices are part of what constitutes informed consent, and their history is the history of informed consent. They combine to form the modern concept of informed consent—which rose in response to particular incidents in modern research. Whereas various cultures in various places practiced informed consent, the modern concept of informed consent was developed by people who drew influence from Western tradition.


title: Informed consent

text: Historians cite a series of medical guidelines to trace the history of informed consent in medical practice.


title: Informed consent

text: The Hippocratic Oath, a Greek text dating to 500 B.C.E., was the first set of Western writings giving guidelines for the conduct of medical professionals. Consent by patients as well as several other, now considered fundamental issues, is not mentioned. The Hippocratic Corpus advises that physicians conceal most information from patients to give the patients the best care. The rationale is a beneficence model for care—the doctor knows better than the patient, and therefore should direct the patient's care, because the patient is not likely to have better ideas than the doctor.


title: Informed consent

text: Henri de Mondeville, a French surgeon who in the 14th century, wrote about medical practice. He traced his ideas to the Hippocratic Oath. Among his recommendations were that doctors "promise a cure to every patient" in hopes that the good prognosis would inspire a good outcome to treatment. Mondeville never mentioned getting consent, but did emphasize the need for the patient to have confidence in the doctor. He also advised that when deciding therapeutically unimportant details the doctor should meet the patients' requests "so far as they do not interfere with treatment".


title: Informed consent

text: In Ottoman Empire records there exists an agreement from 1539 in which negotiates details of a surgery, including fee and a commitment not to sue in case of death. This is the oldest identified written document in which a patient acknowledges risk of medical treatment and writes to express their willingness to proceed.


title: Informed consent

text: Benjamin Rush was an 18th-century United States physician who was influenced by the Age of Enlightenment cultural movement. Because of this, he advised that doctors ought to share as much information as possible with patients. He recommended that doctors educate the public and respect a patient's informed decision to accept therapy. There is no evidence that he supported seeking a consent from patients. In a lecture titled "On the duties of patients to their physicians", he stated that patients should be strictly obedient to the physician's orders; this was representative of much of his writings. John Gregory, Rush's teacher, wrote similar views that a doctor could best practice beneficence by making decisions for the patients without their consent.


title: Informed consent

text: Thomas Percival was a British physician who published a book called "Medical Ethics" in 1803. Percival was a student of the works of Gregory and various earlier Hippocratic physicians. Like all previous works, Percival's "Medical Ethics" makes no mention of soliciting for the consent of patients or respecting their decisions. Percival said that patients have a right to truth, but when the physician could provide better treatment by lying or withholding information, he advised that the physician do as he thought best.


title: Informed consent

text: When the American Medical Association was founded they in 1847 produced a work called the first edition of the "American Medical Association Code of Medical Ethics". Many sections of this book are verbatim copies of passages from Percival's "Medical Ethics". A new concept in this book was the idea that physicians should fully disclose all patient details truthfully when talking to other physicians, but the text does not also apply this idea to disclosing information to patients. Through this text, Percival's ideas became pervasive guidelines throughout the United States as other texts were derived from them.


title: Informed consent

text: Worthington Hooker was an American physician who in 1849 published "Physician and Patient". This medical ethics book was radical demonstrating understanding of the AMA's guidelines and Percival's philosophy and soundly rejecting all directives that a doctor should lie to patients. In Hooker's view, benevolent deception is not fair to the patient, and he lectured widely on this topic. Hooker's ideas were not broadly influential.


title: Informed consent

text: The US Canterbury v. Spence case established the principle of informed consent in US law. Earlier legal cases had created the underpinnings for informed consent, but his judgment gave a detailed and thought through discourse on the matter. The judgment cites cases going back to 1914 as precedent for informed consent.


title: Informed consent

text: Historians cite a series of human subject research experiments to trace the history of informed consent in research.


title: Informed consent

text: The U.S. Army Yellow Fever Commission "is considered the first research group in history to use consent forms." In 1900, Major Walter Reed was appointed head of the four man U.S. Army Yellow Fever Commission in Cuba that determined mosquitoes were the vector for yellow fever transmission. His earliest experiments were probably done without formal documentation of informed consent. In later experiments he obtained support from appropriate military and administrative authorities. He then drafted what is now "one of the oldest series of extant informed consent documents." The three surviving examples are in Spanish with English translations; two have an individual's signature and one is marked with an X.


title: Informed consent

text: "Tearoom Trade" is the name of a book by American psychologist Laud Humphreys. In it he describes his research into male homosexual acts. In conducting this research he never sought consent from his research subjects and other researchers raised concerns that he violated the right to privacy for research participants.


title: Informed consent

text: Henrietta Lacks On Jan. 29, 1951, shortly after the birth of her son Joseph, Lacks entered Johns Hopkins Hospital in Baltimore with profuse bleeding. She was diagnosed with cervical cancer and was treated with inserts of radium tubes. During her radiation treatments for the tumor, two samples—one of healthy cells, the other of malignant cells—were removed from her cervix without her permission. Later that year, 31-year-old Henrietta Lacks died from the cancer. Her cells were cultured creating Hela cells, but the family was not informed until 1973, the family learned the truth when scientists asked for DNA samples after finding that HeLa had contaminated other samples. In 2013 researchers published the genome without the Lacks family consent.


title: Informed consent

text: The Milgram experiment is the name of a 1961 experiment conducted by American psychologist Stanley Milgram. In the experiment Milgram had an authority figure order research participants to commit a disturbing act of harming another person. After the experiment he would reveal that he had deceived the participants and that they had not hurt anyone, but the research participants were upset at the experience of having participated in the research. The experiment raised broad discussion on the ethics of recruiting participants for research without giving them full information about the nature of the research.


title: Informed consent

text: Chester M. Southam used HeLa cells to inject into cancer patients and Ohio State Penitentiary inmates without informed consent to determine if people could become immune to cancer and if cancer could be transmitted.


title: Informed consent

text: The doctrine of informed consent relates to professional negligence and establishes a breach of the duty of care owed to the patient (see duty of care, breach of the duty, and respect for persons). The doctrine of informed consent also has significant implications for medical trials of medications, devices, or procedures.


title: Informed consent

text: Until 2015 in the United Kingdom and in countries such as Malaysia and Singapore, informed consent in medical procedures requires proof as to the standard of care to expect as a recognised standard of acceptable professional practice (the Bolam Test), that is, what risks would a medical professional usually disclose in the circumstances (see Loss of right in English law). Arguably, this is "sufficient consent" rather than "informed consent." The UK has since departed from the Bolam test for judging standards of informed consent, due to the landmark ruling in "Montgomery v Lanarkshire Health Board". This moves away from the concept of a reasonable physician and instead uses the standard of a reasonable patient, and what risks an individual would attach significance to.


title: Informed consent

text: Medicine in the United States, Australia, and Canada also takes this patient-centric approach to "informed consent." Informed consent in these jurisdictions requires healthcare providers to disclose significant risks, as well as risks of particular importance to that patient. This approach combines an objective (a hypothetical reasonable patient) and subjective (this particular patient) approach.


title: Informed consent

text: The doctrine of informed consent should be contrasted with the general doctrine of medical consent, which applies to assault or battery. The consent standard here is only that the person understands, in general terms, the nature of and purpose of the intended intervention. As the higher standard of informed consent applies to negligence, not battery, the other elements of negligence must be made out. Significantly, causation must be shown: That had the individual been made aware of the risk he would not have proceeded with the operation (or perhaps with that surgeon).


title: Informed consent

text: Optimal establishment of an informed consent requires adaptation to cultural or other individual factors of the patient. For example, people from Mediterranean and Arab appear to rely more on the context of the delivery of the information, with the information being carried more by who is saying it and where, when, and how it is being said, rather than "what" is said, which is of relatively more importance in typical "Western" countries.


title: Informed consent

text: The informed consent doctrine is generally implemented through good healthcare practice: pre-operation discussions with patients and the use of medical consent forms in hospitals. However, reliance on a signed form should not undermine the basis of the doctrine in giving the patient an opportunity to weigh and respond to the risk. In one British case, a doctor performing routine surgery on a woman noticed that she had cancerous tissue in her womb. He took the initiative to remove the woman's womb; however, as she had not given informed consent for this operation, the doctor was judged by the General Medical Council to have acted negligently. The council stated that the woman should have been informed of her condition, and allowed to make her own decision.


title: Informed consent

text: To document that informed consent has been given for a procedure, healthcare organisations have traditionally used paper-based consent forms on which the procedure and its risks and benefits are noted, and is signed by both patient and clinician. In a number of healthcare organisations consent forms are scanned and maintained in an electronic document store. The paper consent process has been demonstrated to be associated with significant errors of omission, and therefore increasing numbers of organisations are using digital consent applications where the risk of errors can be minimised, a patient's decision making and comprehension can be supported by additional lay-friendly and accessible information, consent can be completed remotely, and the process can become paperless. One form of digital consent is dynamic consent, which invites participants to provide consent in a granular way, and makes it easier for them to withdraw consent if they wish.


title: Informed consent

text: Electronic consent methods have been used to support indexing and retrieval of consent data, thus enhancing the ability to honor to patient intent and identify willing research participants. More recently, Health Sciences South Carolina, a statewide research collaborative focused on transforming healthcare quality, health information systems and patient outcomes, developed an open-source system called Research Permissions Management System (RPMS).


title: Informed consent

text: The ability to give informed consent is governed by a general requirement of competency. In common law jurisdictions, adults are presumed competent to consent. This presumption can be rebutted, for instance, in circumstances of mental illness or other incompetence. This may be prescribed in legislation or based on a common-law standard of inability to understand the nature of the procedure. In cases of incompetent adults, a health care proxy makes medical decisions. In the absence of a proxy, the medical practitioner is expected to act in the patient's best interests until a proxy can be found.


title: Informed consent

text: By contrast, 'minors' (which may be defined differently in different jurisdictions) are generally presumed incompetent to consent, but depending on their age and other factors may be required to provide Informed assent. In some jurisdictions (e.g. much of the U.S.), this is a strict standard. In other jurisdictions (e.g. England, Australia, Canada), this presumption may be rebutted through proof that the minor is 'mature' (the 'Gillick standard'). In cases of incompetent minors, informed consent is usually required from the parent (rather than the 'best interests standard') although a parens patriae order may apply, allowing the court to dispense with parental consent in cases of refusal.


title: Informed consent

text: Research involving deception is controversial given the requirement for informed consent. Deception typically arises in social psychology, when researching a particular psychological process requires that investigators deceive subjects. For example, in the Milgram experiment, researchers wanted to determine the willingness of participants to obey authority figures despite their personal conscientious objections. They had authority figures demand that participants deliver what they thought was an electric shock to another research participant. For the study to succeed, it was necessary to deceive the participants so they believed that the subject was a peer and that their electric shocks caused the peer actual pain.


title: Informed consent

text: Nonetheless, research involving deception prevents subjects from exercising their basic right of autonomous informed decision-making and conflicts with the ethical principle of respect for persons.


title: Informed consent

text: The Ethical Principles of Psychologists and Code of Conduct set by the American Psychological Association says that psychologists may conduct research that includes a deceptive compartment only if they can both justify the act by the value and importance of the study's results and show they could not obtain the results by some other way. Moreover, the research should bear no potential harm to the subject as an outcome of deception, either physical pain or emotional distress. Finally, the code requires a debriefing session in which the experimenter both tells the subject about the deception and gives subject the option of withdrawing the data.


title: Informed consent

text: In some U.S. states, informed consent laws (sometimes called "right to know" laws) require that a woman seeking an elective abortion receive information from the abortion provider about her legal rights, alternatives to abortion (such as adoption), available public and private assistance, and other information specified in the law, before the abortion is performed. Other countries with such laws (e.g. Germany) require that the information giver be properly certified to make sure that no abortion is carried out for the financial gain of the abortion provider and to ensure that the decision to have an abortion is not swayed by any form of incentive.


title: Informed consent

text: Some informed consent laws have been criticized for allegedly using "loaded language in an apparently deliberate attempt to 'personify' the fetus," but those critics acknowledge that "most of the information in the [legally mandated] materials about abortion comports with recent scientific findings and the principles of informed consent", although "some content is either misleading or altogether incorrect."


title: Informed consent

text: As children often lack the decision-making ability or legal power (competence) to provide true informed consent for medical decisions, it often falls on parents or legal guardians to provide "informed permission" for medical decisions. This "consent by proxy" usually works reasonably well, but can lead to ethical dilemmas when the judgment of the parents or guardians and the medical professional differ with regard to what constitutes appropriate decisions "in the best interest of the child". Children who are legally emancipated, and certain situations such as decisions regarding sexually transmitted diseases or pregnancy, or for unemancipated minors who are deemed to have medical decision making capacity, may be able to provide consent without the need for parental permission depending on the laws of the jurisdiction the child lives in. The American Academy of Pediatrics encourages medical professionals also to seek the assent of older children and adolescents by providing age appropriate information to these children to help empower them in the decision-making process.


title: Informed consent

text: Research on children has benefited society in many ways. The only effective way to establish normal patterns of growth and metabolism is to do research on infants and young children. When addressing the issue of informed consent with children, the primary response is parental consent. This is valid, although only legal guardians are able to consent for a child, not adult siblings. Additionally, parents may not order the termination of a treatment that is required to keep a child alive, even if they feel it is in the best interest. Guardians are typically involved in the consent of children, however a number of doctrines have developed that allow children to receive health treatments without parental consent. For example, emancipated minors may consent to medical treatment, and minors can also consent in an emergency.


title: Informed consent

text: Informed consent is part of the ethical clinical research as well, in which a human subject voluntarily confirms his or her willingness to participate in a particular clinical trial, after having been informed of all aspects of the trial that are relevant to the subject's decision to participate. Informed consent is documented by means of a written, signed, and dated informed consent form.


title: Informed consent

text: In medical research, the Nuremberg Code set a base international standard in 1947, which continued to develop, for example in response to the ethical violation in the Holocaust. Nowadays, medical research is overseen by an ethics committee that also oversees the informed consent process.


title: Informed consent

text: As the medical guidelines established in the Nuremberg Code were imported into the ethical guidelines for the social sciences, informed consent became a common part of the research procedure. However, while informed consent is the default in medical settings, it is not always required in the social science. Here, research often involves low or no risk for participants, unlike in many medical experiments. Second, the mere knowledge that they participate in a study can cause people to alter their behavior, as in the Hawthorne Effect: "In the typical lab experiment, subjects enter an environment in which they are keenly aware that their behavior is being monitored, recorded, and subsequently scrutinized."


title: Informed consent

text: In such cases, seeking informed consent directly interferes with the ability to conduct the research, because the very act of revealing that a study is being conducted is likely to alter the behavior studied. List exemplifies the potential dilemma that can result: "if one were interested in exploring whether, and to what extent, race or gender influences the prices that buyers pay for used cars, it would be difficult to measure accurately the degree of discrimination among used car dealers who know that they are taking part in an experiment." In cases where such interference is likely, and after careful consideration, a researcher may forgo the informed consent process. This is commonly done after weighting the risk to study participants versus the benefit to society and whether participants are present in the study out of their own wish and treated fairly. Researchers often consult with an ethics committee or institutional review board to render a decision.


title: Informed consent

text: The birth of new online media, such as social media, has complicated the idea of informed consent. In an online environment people pay little attention to Terms of Use agreements and can subject themselves to research without thorough knowledge. This issue came to the public light following a study conducted by Facebook Inc. in 2014, and published by that company and Cornell University. Facebook conducted a study where they altered the Facebook News Feeds of roughly 700,000 users to reduce either the amount of positive or negative posts they saw for a week. The study then analyzed if the users status updates changed during the different conditions. The study was published in the Proceedings of the National Academy of Sciences.


title: Informed consent

text: The lack of informed consent led to outrage among many researchers and users. Many believed that by potentially altering the mood of users by altering what posts they see, Facebook put at-risk individuals at higher dangers for depression and suicide. However, supports of Facebook claim that Facebook details that they have the right to use information for research in their terms of use. Others say the experiment is just a part of Facebook's current work, which alters News Feeds algorithms continually to keep people interested and coming back to the site. Others pointed out that this specific study is not along but that news organizations constantly try out different headlines using algorithms to elicit emotions and garner clicks or Facebook shares. They say this Facebook study is no different from things people already accept. Still, others say that Facebook broke the law when conducting the experiment on user that didn't give informed consent.


title: Informed consent

text: The Facebook study controversy raises numerous questions about informed consent and the differences in the ethical review process between publicly and privately funded research. Some say Facebook was within its limits and others see the need for more informed consent and/or the establishment of in-house private review boards.


title: Informed consent

text: Other, long-standing controversies underscore the role for conflicts of interest among medical school faculty and researchers. For example, coverage of University of California (UC) medical school faculty members has included news of ongoing corporate payments to researchers and practitioners from companies that market and produce the very devices and treatments they recommend to patients. Robert Pedowitz, the former chairman of UCLA's orthopedic surgery department, reported concern that his colleague's financial conflicts of interest could negatively affect patient care or research into new treatments. In a subsequent lawsuit about whistleblower retaliation, the university provided a $10 million settlement to Pedowitz while acknowledging no wrongdoing. Consumer Watchdog, an oversight group, observed that University of California policies were "either inadequate or unenforced...Patients in UC hospitals deserve the most reliable surgical devices and medication…and they shouldn't be treated as subjects in expensive experiments." Other UC incidents include taking the eggs of women for implantation into other women without consent and injecting live bacteria into human brains, resulting in potentially premature deaths.


title: Sonia Kapoor

text: Sonia Kapoor Reshammiya is an Indian television and film actress who has appeared in many television series and Bollywood films.


title: Sonia Kapoor

text: She married Bollywood actor, singer, music director Himesh Reshammiya on 11 May 2018 in a private ceremony in Mumbai.


title: Edward Mulhare

text: Edward Mulhare (8 April 1923 – 24 May 1997) was an Irish actor whose career spanned five decades. He is best known for his starring roles in two television series: "The Ghost & Mrs. Muir" and "Knight Rider".


title: Edward Mulhare

text: Mulhare, one of three brothers, was born at 22 Quaker Road, Cork City, County Cork, Ireland, to John and Catherine (née Keane) Mulhare. As a child, he received his education at St. Nessan's Christian Brothers School, and later North Monastery. Mulhare, as a young adult, began schooling at the National University of Ireland in medicine, but eventually decided upon a career in theatre. After acting in various Irish venues including the Gate Theatre in Dublin, he moved to London, where he worked with Orson Welles and John Gielgud. He co-starred with Orson Welles in a 1951 production of "Othello" directed by Laurence Olivier, and played in Pygmalion before going to America.


title: Edward Mulhare

text: In 1955 Mulhare starred as James Finnegan in the first feature film produced in Israel – Hill 24 Doesn't Answer.


title: Edward Mulhare

text: His best-known stage role was as Professor Higgins in the original Broadway production of "My Fair Lady," having taken over the role from Rex Harrison in 1957. Mulhare was understudy to Harrison until that time, going on to play the part for three years in New York for 1000 performances, then continuing the role on an international tour, which included an extensive tour of Russia. He continued to perform the role in summer theatres and for touring companies into the 1970s. A notable East Lansing MI university campus performance of My Fair Lady was originally canceled due to blizzard, but played to a packed house of 4000 when word was sent out that any student could get into the performance free, if they could get there. Many showed up on skis; as told by Mulhare and Anne Rogers on The Irv Kupcinet Show in a 1978 interview. Mulhare and Rogers continued their acting partnership, playing King Arthur and Guenevere in Camelot.


title: Edward Mulhare

text: His first television appearance was in 1956 in a production of "The Adventures of Robin Hood". He was a guest panelist in 1958, and again in 1963, on the CBS television game show "What's My Line?" By 1965, he was back in Hollywood appearing in films and television shows. He earned a role in the films "Von Ryan's Express" in 1965, "Our Man Flint" in 1966, and "Caprice" in 1967. He guest-starred in television programs, including the "Twelve O'Clock High" episode "Siren Voices" as Luftwaffe Colonel Kurt Halland. In "The Ghost & Mrs. Muir", a supernatural sitcom that ran from 1968 to 1970, he starred as Captain Daniel Gregg, and again was something of a successor to Rex Harrison, who had originated the role of "The Ghost" in the original 1947 film.


title: Edward Mulhare

text: In 1969 Mulhare starred in Gidget Grows Up, an American made-for-television comedy film with Karen Valentine in the title role. He plays Alex Mac Laughlin, a love interest for Gidget. Harlan Carraher, who played Jonathan Muir in The Ghost and Mrs Muir with Edward, has a small part as well.


title: Edward Mulhare

text: Mulhare co-starred as Devon Miles, director of the Foundation for Law and Government, on "Knight Rider" (1982–1986), alongside David Hasselhoff's Michael Knight.


title: Edward Mulhare

text: In the mid-1980s, Mulhare hosted the television series "Secrets & Mysteries," also called "Secrets of the Unknown," a magazine show that examined historical mysteries and the paranormal.


title: Edward Mulhare

text: He starred in a number of films in his career including "Megaforce" and "Out to Sea". His final role was on "Baywatch Nights" alongside former "Knight Rider" co-star David Hasselhoff in December 1996.


title: Edward Mulhare

text: A heavy smoker, he died of lung cancer on 24 May 1997, aged 74, at his home in Van Nuys, California. He had been battling the cancer for five months prior to his death. "Team Knight Rider" dedicated an episode titled "K.R.O.", to Mulhare's memory (broadcast 27 October 1997). According to the annual magazine, "Who's Who in TV, 1968-1969" Mulhare was "a real ladies' man"; however, he remained a lifelong bachelor. He is buried in St. Joseph's Cemetery, Tory Top Road, Cork City, Ireland.


title: Glycoprotein

text: Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. Secreted extracellular proteins are often glycosylated.


title: Glycoprotein

text: In proteins that have segments extending extracellularly, the extracellular segments are also often glycosylated. Glycoproteins are also often important integral membrane proteins, where they play a role in cell–cell interactions. It is important to distinguish endoplasmic reticulum-based glycosylation of the secretory system from reversible cytosolic-nuclear glycosylation. Glycoproteins of the cytosol and nucleus can be modified through the reversible addition of a single GlcNAc residue that is considered reciprocal to phosphorylation and the functions of these are likely to be an additional regulatory mechanism that controls phosphorylation-based signalling. In contrast, classical secretory glycosylation can be structurally essential. For example, inhibition of asparagine-linked, i.e. N-linked, glycosylation can prevent proper glycoprotein folding and full inhibition can be toxic to an individual cell. In contrast, perturbation of glycan processing (enzymatic removal/addition of carbohydrate residues to the glycan), which occurs in both the endoplasmic reticulum and Golgi apparatus, is dispensable for isolated cells (as evidenced by survival with glycosides inhibitors) but can lead to human disease (congenital disorders of glycosylation) and can be lethal in animal models. It is therefore likely that the fine processing of glycans is important for endogenous functionality, such as cell trafficking, but that this is likely to have been secondary to its role in host-pathogen interactions. A famous example of this latter effect is the ABO blood group system.


title: Glycoprotein

text: Though there are different types of glycoproteins, the most common are N-linked and O-linked glycoproteins. These two types of glycoproteins are distinguished by structural differences that give them their names. Glycoproteins vary greatly in composition, making many different compounds such as antibodies or hormones. Due to the wide array of functions within the body, interest in glycoprotein synthesis for medical use has increased. There are now several methods to synthesize glycoproteins, including recombination and glycosylation of proteins.


title: Glycoprotein

text: The sugar group(s) can assist in protein folding, improve proteins' stability and are involved in cell signalling.


title: Glycoprotein

text: The critical structural element of all glycoproteins is having oligosaccharides bonded covalently to a protein. There are 10 common monosaccharides in mammalian glycans including: glucose (Glc), fucose (Fuc), xylose (Xyl), mannose (Man), galactose (Gal), N-acetylglucosamine (GlcNAc), glucuronic acid (GlcA), iduronic acid (IdoA), N-acetylgalactosamine (GalNAc), sialic acid, and 5-N-acetylneuraminic acid (Neu5Ac). These glycans link themselves to specific areas of the protein amino acid chain.


title: Glycoprotein

text: The two most common linkages in glycoproteins are N-linked and O-linked glycoproteins. An N-linked glycoprotein has glycan bonds to the nitrogen containing an asparagine amino acid within the protein sequence. An O-linked glycoprotein is where the sugar is bonded to an oxygen atom of a serine or threonine amino acid in the protein.


title: Glycoprotein

text: Glycoprotein size and composition can vary largely, with carbohydrate composition ranges from 1% to 70% of the total mass of the glycoprotein. Within the cell, they appear in the blood, the extracellular matrix, or on the outer surface of the plasma membrane, and make up a large portion of the proteins secreted by eukaryotic cells. They are very broad in their applications and can function as a variety of chemicals from antibodies to hormones.


title: Glycoprotein

text: Glycomics is the study of the carbohydrate components of cells. Though not exclusive to glycoproteins, it can reveal more information about different glycoproteins and their structure. One of the purposes of this field of study is to determine which proteins are glycosylated and where in the amino acid sequence the glycosylation occurs. Historically, mass spectrometry has been used to identify the structure of glycoproteins and characterize the carbohydrate chains attached.


title: Glycoprotein

text: The unique interaction between the oligosaccharide chains have different applications. First, it aids in quality control by identifying misfolded proteins. The oligosaccharide chains also change the solubility and polarity of the proteins that they are bonded to. For example, if the oligosaccharide chains are negatively charged, with enough density around the protein, they can repulse proteolytic enzymes away from the bonded protein. The diversity in interactions lends itself to different types of glycoproteins with different structures and functions.


title: Glycoprotein

text: One example of glycoproteins found in the body is mucins, which are secreted in the mucus of the respiratory and digestive tracts. The sugars when attached to mucins give them considerable water-holding capacity and also make them resistant to proteolysis by digestive enzymes.


title: Glycoprotein

text: Glycoproteins are important for white blood cell recognition. Examples of glycoproteins in the immune system are:


title: Glycoprotein

text: Variable surface glycoproteins allow the sleeping sickness "Trypanosoma" parasite to escape the immune response of the host.


title: Glycoprotein

text: The viral spike of the human immunodeficiency virus is heavily glycosylated. Approximately half the mass of the spike is glycosylation and the glycans act to limit antibody recognition as the glycans are assembled by the host cell and so are largely 'self'. Over time, some patients can evolve antibodies to recognise the HIV glycans and almost all so-called 'broadly neutralising antibodies (bnAbs) recognise some glycans. This is possible mainly because the unusually high density of glycans hinders normal glycan maturation and they are therefore trapped in the premature, high-mannose, state. This provides a window for immune recognition. In addition, as these glycans are much less variable than the underlying protein, they have emerged as promising targets for vaccine design.


title: Glycoprotein

text: P-glycoproteins are critical for antitumor research due to its ability block the effects of antitumor drugs. P-glycoprotein, or multidrug transporter (MDR1), is a type of ABC transporter that transports compounds out of cells. This transportation of compounds out of cells includes drugs made to be delivered to the cell, causing a decrease in drug effectiveness. Therefore, being able to inhibit this behavior would decrease P-glycoprotein interference in drug delivery, making this an important topic in drug discovery. For example, P-Glycoprotein causes a decrease in anti-cancer drug accumulation within tumor cells, limiting the effectiveness of chemotherapies used to treat cancer.


title: Glycoprotein

text: The glycosylation of proteins has an array of different applications from influencing cell to cell communication to changing the thermal stability and the folding of proteins. Due to the unique abilities of glycoproteins, they can be used in many therapies. By understanding glycoproteins and their synthesis, they can be made to treat cancer, Crohn's Disease, high cholesterol, and more.


title: Glycoprotein

text: The process of glycosylation (binding a carbohydrate to a protein) is a post-translational modification, meaning it happens after the production of the protein. Glycosylation is a process that roughly half of all human proteins undergo and heavily influences the properties and functions of the protein. Within the cell, glycosylation occurs in the endoplasmic reticulum.


title: Glycoprotein

text: There are several techniques for the assembly of glycoproteins. One technique utilizes recombination. The first consideration for this method is the choice of host, as there are many different factors that can influence the success of glycoprotein recombination such as cost, the host environment, the efficacy of the process, and other considerations. Some examples of host cells include E. coli, yeast, plant cells, insect cells, and mammalian cells. Of these options, mammalian cells are the most common because their use does not face the same challenges that other host cells do such as different glycan structures, shorter half life, and potential unwanted immune responses in humans. Of mammalian cells, the most common cell line used for recombinant glycoprotein production is the Chinese hamster ovary line. However, as technologies develop, the most promising cell lines for recombinant glycoprotein production are human cell lines.


title: Glycoprotein

text: The formation of the link between the glycan and the protein is key element of the synthesis of glycoproteins. The most common method of glycosylation of N-linked glycoproteins is through the reaction between a protected glycan and a protected Asparagine. Similarly, an O-linked glycoprotein can be formed through the addition of a glycosyl donor with a protected Serine or Threonine. These two methods are examples of natural linkage. However, there are also methods of unnatural linkages. Some methods include ligation and a reaction between a serine-derived sulfamidate and thiohexoses in water. Once this linkage is complete, the amino acid sequence can be expanded upon using solid-phase peptide synthesis.


title: Pan-Arabism

text: Pan-Arabism ( or ) is an ideology that espouses the unification of the countries of North Africa and Western Asia from the Atlantic Ocean to the Arabian Sea, which is referred to as the Arab world. It is closely connected to Arab nationalism, which asserts the view that the Arabs constitute a single nation. Its popularity reached its height during the 1950s and 1960s. Advocates of pan-Arabism have often espoused socialist principles and strongly opposed Western political involvement in the Arab world. It also sought to empower Arab states against outside forces by forming alliances and, to a lesser extent, economic co-operation.


title: Pan-Arabism

text: The origins of pan-Arabism are often attributed to Jurji Zaydan (1861–1914) and his Nahda (Revival) movement. He was one of the first intellectuals to espouse pan-Arabism as a cultural nationalist force. Zaydan had critical influence on acceptance of a modernized version of the Quranic Arabic language (Modern Standard Arabic) as the universal written and official language throughout the Arab world, instead of adoption of local dialects in the various countries. Zaydan wrote several articles during the early 20th century which emphasized that Arabic-speaking regions stretching from the Maghreb to the Persian Gulf constitute one people with a shared national consciousness and that this linguistic bond trumped religious, racial and specific territorial bonds, inspired in part by his status as a Levantine Christian émigré in 19th century Egypt. He also popularized through his historical novels a secular understanding of Arab history encompassing the pre-Islamic and Islamic periods into a shared history that all Arabs could claim as their own. As a political project, pan-Arabism was first pressed by Sharif Hussein ibn Ali, the Sharif of Mecca, who sought independence for the Mashreq Arabs from the Ottoman Empire, and the establishment of a unified Arab state in the Mashreq. In 1915 and 1916, the Hussein-McMahon Correspondence resulted in an agreement between the United Kingdom and the Sharif that if the Mashreq Arabs revolted successfully against the Ottomans, the United Kingdom would support claims for Mashreq Arab independence. In 1916, however, the Sykes-Picot Agreement between the United Kingdom and France determined that parts of the Mashreq would be divided between those powers rather than forming part of an independent Arab state. When the Ottoman Empire surrendered in 1918, the United Kingdom refused to keep to the letter of its arrangements with Hussein, and the two nations assumed guardianship of Mesopotamia, Lebanon, Palestine and what became modern Syria. Ultimately, Hussein became King of only Hijaz, in the then less strategically valuable south, but lost his Caliphate throne when the kingdom was sacked by the Najdi Ikhwan forces of the Saudites and forcefully incorporated into the newly created Kingdom of Saudi Arabia.


title: Pan-Arabism

text: A more formalized pan-Arab ideology than that of Hussein was first espoused in the 1930s, notably by Syrian thinkers such as Constantin Zureiq, Sati' al-Husri, Zaki al-Arsuzi, and Michel Aflaq. Aflaq and al-Arsuzi were key figures in the establishment of the Arab Ba’ath (Renaissance) Party, and the former was for long its chief ideologist, combining elements of Marxist thought with a nationalism to a considerable extent reminiscent of nineteenth-century European romantic nationalism. It has been said that Arsuzi was fascinated with the Nazi ideology of "racial purity" and impacted Aflaq.


title: Pan-Arabism

text: Abdullah I of Jordan dreamed of uniting Syria, Palestine, and Jordan under his leadership in what he would call Greater Syria. He unsuccessfully proposed a plan to this effect to the United Kingdom, which controlled Palestine at that time. The plan was not popular among the majority of Arabs and fostered distrust among the leaders of the other Middle Eastern countries against Abdallah. The distrust of Abdallah's expansionist aspirations was one of the principal reasons for the founding of the Arab League in 1945. Once Abdallah was assassinated by a Palestinian nationalist in 1951, the vision of Greater Syria was dropped from the Jordanian agenda.


title: Pan-Arabism

text: Although pan-Arabism began at the time of World War I, Egypt (the most populous and arguably most important Arab country) was not interested in pan-Arabism prior to the 1950s. Thus, in the 1930s and 1940s, Egyptian nationalism – not pan-Arabism – was the dominant mode of expression of Egyptian political activists. James Jankowski wrote about Egypt at the time,


title: Pan-Arabism

text: It was not until Gamal Abdel Nasser that Arab nationalism (in addition to Arab socialism) became a state policy and a means with which to define Egypt's position in the Middle East and the world, usually articulated vis-à-vis Zionism in the neighbouring state of Israel.


title: Pan-Arabism

text: There have been several attempts to bring about a pan-Arab state by many well-known Arab leaders, all of which ultimately resulted in failure. British Foreign Minister Anthony Eden called for Arab unity during the 1940s, and was followed by specific proposals from pro-British leaders, including King Abdullah of Transjordan and Prime Minister Nuri al-Said of Iraq, but Egyptian proposals for a broader grouping of independent Arab states prevailed with the establishment of the League of Arab States, a regional international organization, in 1945. In large part representing the popularity Nasser had gained among the masses in the Arab world following the Suez crisis, the United Arab Republic (UAR) in 1958 was the first case of the actual merger of two previously-independent Arab countries. Hastily formed under President Nasser's leadership but on the initiative of Syrian leaders who feared a takeover by communists or "reactionaries" and hoped to lead the new entity, the UAR was a unitary state, not a federal union, with its critics seeing this as hardly more than a small country being annexed by a larger one. It lasted until 1961, when Syrian army officers carried out a coup d'état and withdrew from the union. As politicians felt pressured by the wide public to espouse the idea of unity, Egypt, Syria and Iraq entered into an abortive agreement in 1963 to form the United Arab Republic, which was to be "federal in structure, leaving each member state its identity and institutions." By 1961, Egypt had become the only remaining member but continued to call itself "the UAR" (thereby implying it was open for unification with other Arab countries), but it eventually renamed itself the "Arab Republic of Egypt" in 1973.


title: Pan-Arabism

text: Also in 1958, a Hashemite-led rival, the Arab Federation, was founded between Jordan and Iraq. Tensions with the UAR and the 14 July Revolution made the Arab Federation collapse after only six months. Another attempt, the United Arab States, existed as a confederation between the United Arab Republic and the Mutawakkilite Kingdom of Yemen, but it dissolved in 1961.