This item is in: Food Science > Nestlé functional foods and nutrition series > Nestle nutrition workshop: Pediatric programMicrobial host-interaction: Tolerance versus allergy
Edited by P Brandtzaeg, E Isolauri and S L Prescott
Nestlé Nutrition Workshop Series: Pediatric program Series No. 64
Most indigenous microbes occur in the intestinal tract, and their interactions with the host are largely unknown. Current understanding of host-microbe interactions links early microbial contact to the origin of disease, a theory that has its roots in the hygiene hypothesis. Modern life style appears to deprive the infant of conditions that provide adequate anti-inflammatory or tolerogenic stimuli upon antigen encounter. Thus, maturational signals from the environment and the diet are insufficient to adequately shape the immune system.
Microbial host-interaction deals with the relationship between the gut microbiota as well as altered pattern of early microbial contact and the origin of human disease. New aspects of the original hygiene hypothesis are discussed in relation to disorders spanning from allergy and autoimmunity to obesity.The results presented suggest that all these disorders may be linked to aberrant antigen absorption and immune responses associated with dysfunction of mucosal defense.
Researchers, clinicians and students interested in the interaction of the host with indigenous gut bacteria and the consequences for human health will find this publication of utmost interest.
ISBN 3 8055 9167 5
ISBN-13: 978 3 8055 9167 6
272 pages 234 x 156mm hardback
£165.00 / US$280.00 / €200.00
Usually dispatched within 1–2 weeks
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A paradigm for commensalism: The role of a specific microbial polysaccharide in health and disease; The hygiene hypothesis: Do we still believe in it? ‘ABC’ of mucosal immunology; Innate and adaptive immune pathways to tolerance; Hitting the mucosal road in tolerance induction; Obesity – extending the hygiene hypothesis; Autoimmunity and diet; Eosinophilic esophagitis: Example of an emerging allergic manifestation? Microbial–host interactions in inflammatory bowel diseases and experimental colitis; Development and regulation of immune responses to food antigens in pre- and postnatal life; Novel approaches in treating food allergy using allergens; Allergen avoidance approaches in food allergy management; Role of dietary immunomodulatory factors in the development of immune tolerance; Microbial–host interactions: Selecting the right probiotics and prebiotics for infants; Probiotics and prebiotics: Immunological and clinical effects in allergic disease; Modified proteins in allergy prevention.