|Title||Genetic heterogeneity in human disease.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||McClellan, J, King, M-C|
|Date Published||2010 Apr 16|
|Keywords||CDCV, fitness effects, heritability, missing heritability, mutation, schizophrenia|
Strong evidence suggests that rare mutations of severe effect are responsible for a substantial portion of complex human disease. Evolutionary forces generate vast genetic heterogeneity in human illness by introducing many new variants in each generation. Current sequencing technologies offer the possibility of finding rare disease-causing mutations and the genes that harbor them.
Genetic heterogeneity in human disease.
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