Temperature interacts with heat-sensitive physiological mechanisms via multiple pathways to affect health. In the worst cases, these lead to organ failure and death . Excess deaths during extreme heat events occur predominantly in older individuals and are overwhelmingly cardiovascular in origin . A higher occurrence of CVD mortality in association with prolonged period of low temperatures has been well documented globally ; however, there is growing evidence that cardiovascular deaths are more related to heat events than cold spells (Chen et al., 2019; Liu et al., 2015a; Bunker et al.,
IPCC
Climate Change 2022: Impacts, Adaptation and Vulnerability
IPCC Report