In a routine workup of a 59-year-old woman, a smoker of 20 cigarettes/day for 25 years, hypercalcemia of 11.3 mg/dL with a phosphorus of 3.4 mg/dL is detected. It would NOT be efficient at the outset:
Urinary hydroxyproline: Urinary hydroxyproline excretion reflects the degradation of bone collagen, but is also influenced by the metabolism of other tissues (cartilage, skin) and by the absorption of products rich in collagen, such as meat or gelatins. Due to its diverse tissue origin and metabolic pattern, it correlates poorly with bone resorption.
Determine serum PTH levels.
Determine serum vitamin D levels.
Determination of hydroxyprolinuria.
Plain chest X-ray.
Urinary hydroxyproline: Urinary hydroxyproline excretion reflects the degradation of bone collagen, but is also influenced by the metabolism of other tissues (cartilage, skin) and by the absorption of products rich in collagen, such as meat or gelatins.