A 55-year-old man, father of a celiac child, with iron-deficiency anemia and a recent increase in the stool rhythm, has been tested negative for HLA-DQ2 and HLA-DQ8 alleles. Which diagnostic test is the most appropriate in this case?
Middle-aged male with iron deficiency anemia and increased number of stools, a colonoscopy should be done to rule out colorectal cancer!!! If the HLA is negative it is very unlikely to be celiac disease (high negative predictive value).
Determination of anti-transglutaminase IgA antibodies.
Upper endoscopy with duodenal biopsies.
D-xylose test.
Evaluate response to gluten-free diet.
Colonoscopy.
If the HLA is negative it is very unlikely to be celiac disease (high negative predictive value).
Middle-aged male with iron deficiency anemia and increased number of stools, a colonoscopy should be done to rule out colorectal cancer!!!