article: Interstate 81
links: James Madison University Interstate 86 (east) Interstate 84 (east) Watertown (city), New York Bristol, Tennessee Blacksburg, Virginia Interstate 64 New York (state) Tennessee Interstate 26 Hazleton, Pennsylvania Middletown, VA Bristol, Virginia Pennsylvania Turnpike Harrisburg, Pennsylvania Harrisburg, PA Binghamton, New York Interstate 83 Saint Lawrence River Carlisle, Pennsylvania Tri-Cities, Tennessee Interstate 80 Martinsburg, West Virginia United States Interstate 90 Lexington, Virginia Interstate 88 (east) Ontario Highway 401 Interstate 78 U.S. Route 11 Interstate 70 Interstate 77 Roanoke, Virginia Chambersburg, Pennsylvania Interstate 66 Interstate 40 Hagerstown, Maryland Appalachian Mountains Scranton, Pennsylvania Harrisonburg, Virginia Thousand Islands Bridge Interstate 76 (east) Knoxville, Tennessee Wytheville, Virginia Staunton, Virginia Kingsport, Tennessee Canada–United States border Interstate 74 Wilkes-Barre, Pennsylvania Syracuse, New York Winchester, Virginia