{ | |
"significant_genes": { | |
"Variable": [ | |
"HLA-B", | |
"CD36", | |
"KIR2DL3", | |
"CTSW", | |
"CYP2E1", | |
"FAS", | |
"CARD16", | |
"IFNA8", | |
"TXN", | |
"AKT1", | |
"GAB2", | |
"JUN", | |
"ISG15", | |
"IL13RA1", | |
"CARD11", | |
"DNAJC10", | |
"MAF", | |
"MSRA", | |
"LILRA6", | |
"PIK3CB", | |
"CXCL9", | |
"OAS1", | |
"CSF1", | |
"GLB1", | |
"CCR6", | |
"IL36G", | |
"IFNA2", | |
"IL27", | |
"PDCD1LG2", | |
"PANX1", | |
"HLA-DMB", | |
"PIK3C3", | |
"IRF9", | |
"LCP1", | |
"IL2RA", | |
"CCL2", | |
"CD22", | |
"LTB", | |
"HSP90AA1", | |
"CCL28", | |
"NPC2", | |
"IKBKG", | |
"PIK3R5", | |
"MAPK13", | |
"ACKR3", | |
"IL4R", | |
"IL36RN", | |
"CD44", | |
"SELENOS", | |
"IL1B", | |
"CASP5", | |
"CXCL10", | |
"IGFBP7", | |
"ITGB2", | |
"CCR2", | |
"IRF1", | |
"CTSZ", | |
"CD68", | |
"ANPEP", | |
"ULK2", | |
"CD40LG", | |
"IL34", | |
"HLA-DPB1", | |
"EIF2AK3", | |
"CBFB", | |
"BST2", | |
"CCRL2", | |
"IL27RA", | |
"JAK1", | |
"LTA4H", | |
"AKT3", | |
"HLX", | |
"CCL23", | |
"PTK2B", | |
"PSEN1", | |
"BDKRB1", | |
"CD4", | |
"IFNA6", | |
"TCIRG1", | |
"NLRC5", | |
"LTF", | |
"CHUK", | |
"PSMB10", | |
"IL22RA2", | |
"ZAP70", | |
"DEFA4", | |
"MAP3K5", | |
"TGFB3", | |
"BCL2L1", | |
"CXCL12", | |
"CXCL11", | |
"CXCR3", | |
"JUNB", | |
"HLA-A", | |
"TMEM140", | |
"CCL5", | |
"PTGER2", | |
"IFI16", | |
"TLN1", | |
"CX3CR1", | |
"MAP3K8", | |
"RAB31", | |
"MT2A", | |
"BATF", | |
"CCL25", | |
"GSTM4", | |
"IRF7", | |
"IL31", | |
"SMAD4", | |
"APEX1", | |
"CD3D", | |
"IL10RA", | |
"VCAM1", | |
"EIF3F", | |
"PLAU", | |
"ELANE", | |
"TLR3", | |
"ALOX15", | |
"GBA1LP", | |
"ATP6V0D1", | |
"BCR", | |
"IFITM1", | |
"BNIP3", | |
"IKBKB", | |
"OAS2", | |
"IL32", | |
"MVP", | |
"AP1G1", | |
"NOTCH1", | |
"CBL", | |
"IL10RB", | |
"CD84", | |
"LILRA3", | |
"TYROBP", | |
"CD244", | |
"HSP90B1", | |
"TNFSF18", | |
"PRKCQ", | |
"BDKRB2", | |
"HAMP", | |
"IDO1", | |
"ACKR4", | |
"ITK", | |
"GLA", | |
"RACK1", | |
"WIPI1", | |
"CD14", | |
"ALPK1", | |
"EOMES", | |
"BPI", | |
"HERC5", | |
"TYK2", | |
"NAE1", | |
"PXN", | |
"MS4A2", | |
"PLAUR", | |
"CCL22", | |
"IL12B", | |
"KRAS", | |
"CASP10", | |
"AIF1", | |
"IFIH1", | |
"IL20", | |
"LTBR", | |
"SP1", | |
"CRP", | |
"IL36B", | |
"IL17C", | |
"ITGB7", | |
"HPGD", | |
"MAP3K7", | |
"PSAP", | |
"CSF2RA", | |
"PIK3R3", | |
"IFI35", | |
"ATF6", | |
"FCGR2A", | |
"IL7", | |
"MAPK9", | |
"CD80", | |
"IL13", | |
"OASL", | |
"ETS1", | |
"CPA3", | |
"IRF4", | |
"ITGAL", | |
"IFNK", | |
"CXCL1", | |
"HMGB1", | |
"STAT5A", | |
"MS4A7", | |
"IL16", | |
"GNLY", | |
"KLRD1", | |
"PDCD1", | |
"MAP2K2", | |
"TNFRSF1A", | |
"ACOX1", | |
"EGLN1", | |
"TIGIT", | |
"HLA-E", | |
"LYN", | |
"NCF1", | |
"RELA", | |
"TRAF2", | |
"RNF135", | |
"NTNG2", | |
"CCL26", | |
"PRCP", | |
"FCRL2", | |
"HCST", | |
"FCRL4", | |
"PRKCSH", | |
"IL17F", | |
"IL21R", | |
"CASP8", | |
"TNFRSF10B", | |
"TMPRSS2", | |
"FCAR", | |
"RIGI", | |
"SIRPA", | |
"AGT", | |
"ERN1", | |
"BCL6", | |
"FPR1", | |
"IL23R", | |
"FAM30A", | |
"MGAM", | |
"CRK", | |
"IL17D", | |
"NOD2", | |
"ITGAE", | |
"LCP2", | |
"ULK1", | |
"KDM6B", | |
"NDUFS8", | |
"SOCS3", | |
"CTSL", | |
"IL19", | |
"GZMH", | |
"IL13RA2", | |
"MYD88", | |
"CXCL3", | |
"CCR3", | |
"TNFRSF4", | |
"APOBEC3G", | |
"TRIM33", | |
"CDK4", | |
"CCL13", | |
"NCR3", | |
"TLR4", | |
"CCR5", | |
"TNFSF9", | |
"CR1", | |
"AP1M1", | |
"IFNAR2", | |
"HLA-DQB1", | |
"RASGRP4", | |
"DIABLO", | |
"TNFSF13B", | |
"MEFV", | |
"CD276", | |
"CCL24", | |
"APOL6", | |
"IL6ST", | |
"ITPR3", | |
"IL18RAP", | |
"PDHB", | |
"IL36A", | |
"ATG7", | |
"CXCL2", | |
"UBE2N", | |
"ATG4A", | |
"OS9", | |
"CUL1", | |
"CD3G", | |
"PLEKHA1", | |
"PLCG1", | |
"GUCY1B1", | |
"VRK3", | |
"MKNK1", | |
"HLA-DPA1", | |
"CCL16", | |
"AHR", | |
"CCL27", | |
"CD1E", | |
"C5", | |
"IL12RB1", | |
"HLA-DOB", | |
"MDFIC", | |
"EIF2AK2", | |
"MME", | |
"DDOST", | |
"IL1RN", | |
"IL37", | |
"FOS", | |
"PLAT", | |
"XCR1", | |
"STAT6", | |
"CD38", | |
"ALOX5AP", | |
"GADD45B", | |
"SOD1", | |
"MAP1LC3A", | |
"CCR4", | |
"CD40", | |
"IFITM3", | |
"TOLLIP", | |
"IL9", | |
"PECAM1", | |
"GBP4", | |
"FOXO1", | |
"PTGER4", | |
"CD6", | |
"LCK", | |
"MS4A1", | |
"APBB1IP", | |
"CCL15", | |
"STING1", | |
"IL5RA", | |
"IL9R", | |
"CAP1", | |
"PARP9", | |
"XBP1", | |
"S100A12", | |
"TNFSF4", | |
"PRF1", | |
"WAS", | |
"TXNIP", | |
"FURIN", | |
"CD27", | |
"PIK3CA", | |
"KLRK1", | |
"GK", | |
"IL17RB", | |
"LRG1", | |
"CXCL16", | |
"IL10", | |
"TNFRSF9", | |
"CTLA4", | |
"IL17A", | |
"FPR2", | |
"NFKB1", | |
"CXCL6", | |
"TNFRSF18", | |
"CXCL17", | |
"MAPK8", | |
"IL1RAPL1", | |
"REL", | |
"CDH1", | |
"CGAS", | |
"IL21", | |
"JAK3", | |
"HLA-DMA", | |
"MLKL", | |
"CFLAR", | |
"IL20RB", | |
"FYN", | |
"TRIM22", | |
"CXCL8", | |
"IL15", | |
"IL6", | |
"IFI44", | |
"IL22RA1", | |
"CARD17P", | |
"RUNX3", | |
"DDAH2", | |
"CXCL13", | |
"SUGT1", | |
"IL7R", | |
"IL33", | |
"ATG3", | |
"NFE2L2", | |
"TLR2", | |
"CD79B", | |
"IRAK1", | |
"PLEK", | |
"PLIN4", | |
"NFATC1", | |
"TBK1", | |
"IRF3", | |
"ACSL1", | |
"RAB7A", | |
"PRKCD", | |
"IL17RD", | |
"SELE", | |
"RNF31", | |
"ARRB2", | |
"GPX7", | |
"PLCG2", | |
"TNF", | |
"CCL19", | |
"STAT3", | |
"NRAS", | |
"IL12A", | |
"AP1S2", | |
"OAS3", | |
"PPIA", | |
"MAP2K4", | |
"IL20RA", | |
"PRKCA", | |
"ZBP1", | |
"SLC11A1", | |
"TCF7", | |
"LDHB", | |
"NLRP3", | |
"STT3B", | |
"MAPKAPK2", | |
"CXCR4", | |
"IL31RA", | |
"SPIB", | |
"TRAM1", | |
"RPS6KA3", | |
"KLRC1", | |
"IL6R", | |
"ACVR1", | |
"LIF", | |
"ITGAM", | |
"FCGRT", | |
"CCL18", | |
"PIK3R6", | |
"TAP1", | |
"RIPK1", | |
"TNFRSF25", | |
"IL18BP", | |
"CD86", | |
"HCK", | |
"CASP4", | |
"KIR2DL1", | |
"PYCARD", | |
"AKT2", | |
"CCL8", | |
"CD8A", | |
"ADGRE5", | |
"VSIR", | |
"ATF4", | |
"CXCR5", | |
"IL5", | |
"CSF3R", | |
"CTSA", | |
"GSK3B", | |
"IRAK4", | |
"MAP3K3", | |
"IFNL4", | |
"CTSS", | |
"SSR1", | |
"CXCR6", | |
"IL18R1", | |
"CD3E", | |
"UBE2L6", | |
"SOCS1", | |
"TRIM5", | |
"IL23A", | |
"PNOC", | |
"TCL1A", | |
"PELI2", | |
"HDC", | |
"ICAM3", | |
"CXCR1", | |
"RPS6KB1", | |
"CEBPB", | |
"TLR6", | |
"JAML", | |
"IL1F10", | |
"IL1RAP", | |
"DDX5", | |
"CCR7", | |
"PAK1", | |
"CREBBP", | |
"VEGFA", | |
"LCN2", | |
"ATP6AP2", | |
"IL1RL2", | |
"RASGRP1", | |
"RNF114", | |
"CSF2", | |
"TAB2", | |
"SLC2A3", | |
"IL2RB", | |
"LILRA5", | |
"HAVCR2", | |
"C1QBP", | |
"BCL2", | |
"VWF", | |
"DERL1", | |
"PIK3CG", | |
"CD79A", | |
"NT5E", | |
"VAMP3", | |
"GBP2", | |
"ATM", | |
"TPP1", | |
"CCNC", | |
"TANK", | |
"TBXAS1", | |
"IRAK3", | |
"TLR9", | |
"HMOX1", | |
"NFATC4", | |
"PRDM1", | |
"TAP2", | |
"DTX3L", | |
"GBP5", | |
"NOX1", | |
"CSF2RB", | |
"TRIM56", | |
"TIFA", | |
"IFNGR2", | |
"CD81", | |
"STAT5B", | |
"IL4", | |
"PSTPIP1", | |
"MAFB", | |
"LEF1", | |
"IFNG", | |
"DYSF", | |
"CXCL14", | |
"IFNLR1", | |
"LAMP1", | |
"IL1R1", | |
"GATA3", | |
"RIPK3", | |
"ACSL3", | |
"ALOX5", | |
"RNASEL", | |
"LAMP2", | |
"RAB5C", | |
"C3AR1", | |
"CD274", | |
"EBI3", | |
"MRC1", | |
"TLR1", | |
"TXK", | |
"CCL11", | |
"IL11RA", | |
"IL2RG", | |
"IL12RB2", | |
"YWHAQ", | |
"TNFSF10", | |
"NCR1", | |
"GUCY1A1", | |
"RBCK1", | |
"ADORA2A", | |
"HSD11B1", | |
"SYK", | |
"RHOG", | |
"TGFBR2", | |
"PARP1", | |
"CCR10", | |
"TCN2", | |
"LAT2", | |
"LAG3", | |
"TIMP2", | |
"C5AR1", | |
"LIMK2", | |
"MAVS", | |
"TGFB2", | |
"IFNA5", | |
"IFITM2", | |
"IL3", | |
"HLA-C", | |
"IKBKE", | |
"PTPN4", | |
"CD2", | |
"CEACAM3", | |
"NFAT5", | |
"MX1", | |
"THBS1", | |
"DDIT3", | |
"IL17B", | |
"CSF1R", | |
"IL1R2", | |
"RB1CC1", | |
"NLRP1", | |
"NEO1", | |
"IFIT3", | |
"NFATC2", | |
"FBXO6", | |
"SPI1", | |
"CCR8", | |
"ATP6V1B2", | |
"PFKFB3", | |
"TLR7", | |
"BLK", | |
"SIGIRR", | |
"IFNAR1", | |
"HLA-DRA", | |
"EVL", | |
"AIM2", | |
"IL1RAPL2", | |
"ALOX12", | |
"SERPINA1", | |
"IL18", | |
"CCL20", | |
"STAT2", | |
"IL11", | |
"TLR8", | |
"SMAD3", | |
"LILRB2", | |
"PSMB8", | |
"C2", | |
"NCF2", | |
"CTSG", | |
"CXCL5", | |
"SMAD5", | |
"CD28", | |
"SOD2", | |
"ADGRG3", | |
"PTPN6", | |
"SCARB2", | |
"CX3CL1", | |
"IL1RL1", | |
"LAMP3", | |
"CCR9", | |
"SELL", | |
"CCL14", | |
"CCL17", | |
"TRAF6", | |
"ITGAX", | |
"SEM1", | |
"SAMHD1", | |
"CSF3", | |
"CD163", | |
"RGMA", | |
"ATG12", | |
"KPNB1", | |
"NFKB2", | |
"GBP1", | |
"CASP1", | |
"IL22", | |
"CD209", | |
"RSAD2", | |
"JAK2", | |
"RAC2", | |
"IL3RA", | |
"HSP90AB1", | |
"NKG7", | |
"DNAJA2", | |
"IFIT1", | |
"TNFRSF17", | |
"PELI1", | |
"PSMB9", | |
"IL1A", | |
"IL15RA", | |
"IFNW1", | |
"RPS6KA1", | |
"FGR", | |
"TRIM25", | |
"ACE", | |
"HLA-DQA1", | |
"TRAT1", | |
"MARCKS", | |
"NOS2", | |
"GZMB", | |
"NLRC4", | |
"TAB1", | |
"PTGS2", | |
"LANCL1", | |
"NAMPT", | |
"STAT1", | |
"MS4A4A", | |
"FASLG", | |
"IL24", | |
"NFATC3", | |
"NEU1", | |
"FOXP3", | |
"CBLB", | |
"ACKR2", | |
"CXCR2", | |
"MAP2K7", | |
"BECN1", | |
"CD69", | |
"ADAR", | |
"SORT1", | |
"RELB", | |
"THOP1", | |
"PIK3CD", | |
"IL17RE", | |
"CD247", | |
"LRRK2", | |
"MAP2K3", | |
"PLG", | |
"MTOR", | |
"RIPK2", | |
"PIK3R4", | |
"STRAP", | |
"SH2D1A", | |
"MIF", | |
"PTPRC", | |
"CCR1", | |
"XAF1", | |
"EPHX2", | |
"GZMA", | |
"C3", | |
"ACSL4", | |
"CD70", | |
"KLRB1", | |
"CCL1", | |
"STAT4", | |
"IFI27", | |
"IL17RC", | |
"LGALS3", | |
"IL2", | |
"MCL1", | |
"IFNL1", | |
"NGLY1", | |
"CD19", | |
"MAP3K1", | |
"OSM", | |
"TLR5", | |
"ICOS", | |
"LAT", | |
"CCL7", | |
"MAPK1", | |
"LITAF", | |
"SP100", | |
"CD8B", | |
"ENTPD1", | |
"LTC4S", | |
"IFIT2", | |
"P2RX7", | |
"APP", | |
"ICOSLG", | |
"TRAF3", | |
"IL26", | |
"UBA52", | |
"CALM1", | |
"TRIM21", | |
"RBPJ", | |
"IL25", | |
"RAF1", | |
"MYC", | |
"GNS", | |
"NCF4", | |
"ATF2", | |
"F5", | |
"CD59", | |
"GCA", | |
"DHX58", | |
"CASP3", | |
"SIGLEC5", | |
"IFNB1", | |
"ATG13", | |
"HK3", | |
"CCL21", | |
"TGFB1", | |
"TRIM6", | |
"ALPL", | |
"MARCO", | |
"IL17RA", | |
"TBX21", | |
"ATG10", | |
"ITLN1", | |
"HLA-DRB4", | |
"MAPK14", | |
"CYSTM1", | |
"BCL3" | |
], | |
"Coefficient": [ | |
-0.13688915731438064, | |
0.11071803908539456, | |
-0.10262389074740477, | |
0.09747391635970575, | |
-0.09729975462756153, | |
0.09499752786833687, | |
0.08956299764056148, | |
0.08926028598075053, | |
0.08676046432614319, | |
-0.08567540733239426, | |
0.08513207070928744, | |
-0.08411650162308038, | |
-0.08312982498220478, | |
-0.08250790664930231, | |
0.07925408944429155, | |
0.07587548566173188, | |
0.07463735745627825, | |
-0.07444885424109855, | |
-0.07444387865607291, | |
0.07431435645352795, | |
0.07415207553448665, | |
0.07291043710946306, | |
-0.07247804075904725, | |
-0.07109916297058445, | |
-0.07070805574672116, | |
0.0705416547705932, | |
0.07036393631331649, | |
0.07035119213007769, | |
-0.07013944440609789, | |
-0.07001381221057273, | |
-0.06902601395244201, | |
-0.06883624534891986, | |
0.06877697802980647, | |
0.06805557854450331, | |
-0.06796525488692637, | |
-0.06776246388327237, | |
0.06727510981686491, | |
-0.06718428734660127, | |
-0.06705947607511781, | |
-0.06676654275352084, | |
-0.06647738409614148, | |
0.06644196563960328, | |
0.06617032136381595, | |
-0.06599989324753552, | |
0.06572197602029166, | |
0.06557301830517151, | |
-0.06556164664582997, | |
-0.06516738973778767, | |
0.06343482183520828, | |
-0.06318761851514816, | |
-0.06250251302315542, | |
0.06165049489887957, | |
0.06145505500739418, | |
-0.0612785737572831, | |
0.061044945682349215, | |
0.061017730403397766, | |
0.059917063860701426, | |
0.059265402723626945, | |
-0.05894769542566572, | |
0.05890247532084867, | |
0.058745073598989325, | |
-0.0587234029460903, | |
-0.058508410418949414, | |
0.05842278811576971, | |
0.057682376932654385, | |
-0.05761864512797519, | |
0.05755964508192388, | |
0.05730833989006925, | |
0.05721089043146431, | |
-0.057022350631923756, | |
-0.056758037466322485, | |
-0.05664350408968591, | |
-0.05603922997194871, | |
-0.0555357162347081, | |
0.055226780331703765, | |
-0.05506881019640502, | |
-0.05465259578579746, | |
-0.05448500823796212, | |
-0.0542774556631647, | |
-0.054209066866636915, | |
0.05393001557784846, | |
-0.0539155429303289, | |
-0.053867436687860704, | |
0.05370094240313721, | |
-0.053515652243059354, | |
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], | |
"Absolute Coefficient": [ | |
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}, | |
"cv_performance": { | |
"prediction": { | |
"accuracy": 70.66666666666666, | |
"precision": 74.07733937145701, | |
"recall": 75.0157557937444, | |
"f1": 74.51182674536493 | |
}, | |
"selection": { | |
"precision": 10.55687810862905, | |
"recall": 100.0, | |
"f1": 19.09764102388631, | |
"jaccard": 10.55687810862905 | |
} | |
} | |
} |