{
    "significant_genes": {
        "Variable": [
            "HLA-B",
            "CD36",
            "KIR2DL3",
            "CTSW",
            "CYP2E1",
            "FAS",
            "CARD16",
            "IFNA8",
            "TXN",
            "AKT1",
            "JUN",
            "GAB2",
            "ISG15",
            "IL13RA1",
            "CARD11",
            "DNAJC10",
            "LILRA6",
            "CXCL9",
            "MSRA",
            "MAF",
            "PIK3CB",
            "OAS1",
            "CSF1",
            "CCR6",
            "GLB1",
            "IL36G",
            "PANX1",
            "PDCD1LG2",
            "IL27",
            "PIK3C3",
            "HLA-DMB",
            "IRF9",
            "IFNA2",
            "LCP1",
            "IL2RA",
            "CCL2",
            "IKBKG",
            "CD22",
            "IL4R",
            "NPC2",
            "PIK3R5",
            "CCL28",
            "HSP90AA1",
            "MAPK13",
            "ACKR3",
            "LTB",
            "CD44",
            "IL36RN",
            "SELENOS",
            "CCR2",
            "CASP5",
            "IL1B",
            "IRF1",
            "ITGB2",
            "IGFBP7",
            "CXCL10",
            "ULK2",
            "CD68",
            "EIF2AK3",
            "ANPEP",
            "CTSZ",
            "HLA-DPB1",
            "IL34",
            "AKT3",
            "CCRL2",
            "JAK1",
            "HLX",
            "CBFB",
            "BST2",
            "CD40LG",
            "IL27RA",
            "LTA4H",
            "PTK2B",
            "BDKRB1",
            "PSEN1",
            "CCL23",
            "CD4",
            "IL22RA2",
            "TCIRG1",
            "LTF",
            "MAP3K5",
            "PSMB10",
            "CHUK",
            "TGFB3",
            "BCL2L1",
            "IFNA6",
            "NLRC5",
            "DEFA4",
            "ZAP70",
            "CXCL12",
            "TMEM140",
            "JUNB",
            "CXCR3",
            "PTGER2",
            "CXCL11",
            "CX3CR1",
            "HLA-A",
            "IFI16",
            "CCL5",
            "RAB31",
            "TLN1",
            "SMAD4",
            "IL10RA",
            "MAP3K8",
            "MT2A",
            "IRF7",
            "BATF",
            "CCL25",
            "GSTM4",
            "VCAM1",
            "GBA1LP",
            "CD3D",
            "PLAU",
            "IL31",
            "EIF3F",
            "IFITM1",
            "ELANE",
            "BNIP3",
            "APEX1",
            "TLR3",
            "ATP6V0D1",
            "IL32",
            "IL10RB",
            "IKBKB",
            "MVP",
            "ALOX15",
            "OAS2",
            "BCR",
            "CD84",
            "NOTCH1",
            "CBL",
            "AP1G1",
            "HSP90B1",
            "CD244",
            "BDKRB2",
            "PRKCQ",
            "ITK",
            "TNFSF18",
            "TYROBP",
            "ALPK1",
            "IDO1",
            "HAMP",
            "HERC5",
            "CD14",
            "ACKR4",
            "LILRA3",
            "BPI",
            "EOMES",
            "RACK1",
            "CASP10",
            "GLA",
            "NAE1",
            "WIPI1",
            "CRP",
            "CCL22",
            "PXN",
            "KRAS",
            "MAP3K7",
            "AIF1",
            "IL20",
            "MS4A2",
            "LTBR",
            "IL36B",
            "TYK2",
            "HPGD",
            "SP1",
            "IL12B",
            "PLAUR",
            "IFI35",
            "PSAP",
            "PIK3R3",
            "IL7",
            "CSF2RA",
            "IFIH1",
            "CD80",
            "FCGR2A",
            "ITGB7",
            "MAPK9",
            "GNLY",
            "PDCD1",
            "ETS1",
            "IL17C",
            "STAT5A",
            "ITGAL",
            "IRF4",
            "IL16",
            "HMGB1",
            "IL13",
            "IFNK",
            "OASL",
            "CXCL1",
            "MS4A7",
            "CPA3",
            "ATF6",
            "CCL26",
            "LYN",
            "KLRD1",
            "EGLN1",
            "RNF135",
            "NCF1",
            "TIGIT",
            "TNFRSF1A",
            "NTNG2",
            "TRAF2",
            "RELA",
            "PRCP",
            "FCRL4",
            "FCRL2",
            "ERN1",
            "HLA-E",
            "HCST",
            "MAP2K2",
            "IFNAR2",
            "RIGI",
            "IL17F",
            "AGT",
            "IL21R",
            "CASP8",
            "PRKCSH",
            "TMPRSS2",
            "ULK1",
            "BCL6",
            "SIRPA",
            "NOD2",
            "TNFRSF10B",
            "FCAR",
            "FPR1",
            "NDUFS8",
            "FAM30A",
            "IL19",
            "ITGAE",
            "LCP2",
            "IL23R",
            "GZMH",
            "ACOX1",
            "SOCS3",
            "CRK",
            "MYD88",
            "KDM6B",
            "APOBEC3G",
            "CXCL3",
            "TNFRSF4",
            "TNFSF9",
            "IL17D",
            "CCR3",
            "CDK4",
            "CCR5",
            "MGAM",
            "CR1",
            "CTSL",
            "TRIM33",
            "DIABLO",
            "IL6ST",
            "CCL13",
            "TNFSF13B",
            "IL13RA2",
            "CUL1",
            "CD276",
            "ATG7",
            "AP1M1",
            "CXCL2",
            "HLA-DQB1",
            "IL18RAP",
            "TLR4",
            "APOL6",
            "RASGRP4",
            "MEFV",
            "OS9",
            "GUCY1B1",
            "CD3G",
            "IL36A",
            "UBE2N",
            "CD1E",
            "PLEKHA1",
            "NCR3",
            "CCL24",
            "HLA-DPA1",
            "CCL16",
            "VRK3",
            "MKNK1",
            "FOS",
            "PLCG1",
            "GADD45B",
            "PDHB",
            "STAT6",
            "ITPR3",
            "CCR4",
            "IL12RB1",
            "CD6",
            "HLA-DOB",
            "ATG4A",
            "C5",
            "IFITM3",
            "CCL27",
            "IL37",
            "DDOST",
            "CD40",
            "IL9",
            "MDFIC",
            "XCR1",
            "EIF2AK2",
            "IL1RN",
            "PLAT",
            "MS4A1",
            "PECAM1",
            "FOXO1",
            "GBP4",
            "AHR",
            "STING1",
            "ALOX5AP",
            "SOD1",
            "CD38",
            "PTGER4",
            "TOLLIP",
            "CAP1",
            "MAP1LC3A",
            "MME",
            "XBP1",
            "LRG1",
            "CCL15",
            "GK",
            "LCK",
            "TNFSF4",
            "PIK3CA",
            "IL9R",
            "WAS",
            "APBB1IP",
            "PARP9",
            "FURIN",
            "IL17RB",
            "CD27",
            "NFKB1",
            "MAPK8",
            "PRF1",
            "TNFRSF9",
            "S100A12",
            "TXNIP",
            "IL5RA",
            "CTLA4",
            "JAK3",
            "CXCL6",
            "TNFRSF18",
            "KLRK1",
            "CXCL16",
            "CXCL17",
            "FPR2",
            "TRIM22",
            "IL10",
            "IL1RAPL1",
            "ATG3",
            "IL21",
            "REL",
            "IL17A",
            "CXCL8",
            "HLA-DMA",
            "IFI44",
            "IL15",
            "MLKL",
            "CFLAR",
            "FYN",
            "IL20RB",
            "IL33",
            "IL6",
            "SELE",
            "CXCL13",
            "DDAH2",
            "CDH1",
            "CD79B",
            "IL7R",
            "CGAS",
            "IL22RA1",
            "TBK1",
            "SUGT1",
            "PLEK",
            "RUNX3",
            "CARD17P",
            "CCL19",
            "TLR2",
            "IL12A",
            "IL17RD",
            "PRKCD",
            "IRAK1",
            "NFE2L2",
            "GPX7",
            "RAB7A",
            "NRAS",
            "PLCG2",
            "RNF31",
            "AP1S2",
            "OAS3",
            "PPIA",
            "TNF",
            "SLC11A1",
            "NFATC1",
            "LDHB",
            "PRKCA",
            "IRF3",
            "STAT3",
            "IL20RA",
            "ARRB2",
            "TCF7",
            "MAP2K4",
            "STT3B",
            "PLIN4",
            "CD86",
            "CCL18",
            "ACVR1",
            "ZBP1",
            "MAPKAPK2",
            "CXCR4",
            "FCGRT",
            "IL6R",
            "NLRP3",
            "KLRC1",
            "SPIB",
            "PIK3R6",
            "RIPK1",
            "AKT2",
            "ITGAM",
            "IL31RA",
            "TRAM1",
            "RPS6KA3",
            "CASP4",
            "TNFRSF25",
            "IL18BP",
            "ACSL1",
            "KIR2DL1",
            "CSF3R",
            "HCK",
            "PYCARD",
            "CXCR5",
            "LIF",
            "VSIR",
            "GSK3B",
            "TAP1",
            "ADGRE5",
            "CD8A",
            "CCL8",
            "ATF4",
            "IL1F10",
            "PELI2",
            "IL5",
            "IRAK4",
            "CTSA",
            "SOCS1",
            "IL18R1",
            "TCL1A",
            "CTSS",
            "VEGFA",
            "PAK1",
            "MAP3K3",
            "CEBPB",
            "CXCR6",
            "TLR6",
            "UBE2L6",
            "PNOC",
            "ATP6AP2",
            "TRIM5",
            "HDC",
            "JAML",
            "SSR1",
            "RPS6KB1",
            "CXCR1",
            "IL23A",
            "IL1RL2",
            "IFNL4",
            "LILRA5",
            "CD3E",
            "VAMP3",
            "GBP5",
            "CSF2",
            "ICAM3",
            "CCR7",
            "IRAK3",
            "DDX5",
            "TAB2",
            "BCL2",
            "RNF114",
            "RASGRP1",
            "IL2RB",
            "CREBBP",
            "CD79A",
            "LCN2",
            "DTX3L",
            "NFATC4",
            "DERL1",
            "IL1RAP",
            "HAVCR2",
            "PIK3CG",
            "TIFA",
            "LAMP1",
            "TANK",
            "GBP2",
            "C1QBP",
            "TBXAS1",
            "TPP1",
            "VWF",
            "CD81",
            "TLR9",
            "IL4",
            "HMOX1",
            "SLC2A3",
            "CSF2RB",
            "CCNC",
            "IL1R1",
            "TRIM56",
            "LEF1",
            "TAP2",
            "ACSL3",
            "NOX1",
            "PRDM1",
            "MRC1",
            "NT5E",
            "CXCL14",
            "STAT5B",
            "IFNLR1",
            "PSTPIP1",
            "ATM",
            "LAMP2",
            "C3AR1",
            "TLR1",
            "RAB5C",
            "HSD11B1",
            "IFNGR2",
            "IL12RB2",
            "NCR1",
            "CD274",
            "RIPK3",
            "MAFB",
            "IL2RG",
            "DYSF",
            "EBI3",
            "ALOX5",
            "IL11RA",
            "IFNG",
            "CCR10",
            "CCL11",
            "RHOG",
            "TNFSF10",
            "YWHAQ",
            "C5AR1",
            "MAVS",
            "GATA3",
            "TXK",
            "PARP1",
            "RNASEL",
            "CEACAM3",
            "GUCY1A1",
            "TCN2",
            "TGFBR2",
            "IFITM2",
            "ADORA2A",
            "SYK",
            "MX1",
            "RBCK1",
            "IL3",
            "LAG3",
            "NFAT5",
            "IL17B",
            "CD2",
            "LIMK2",
            "PTPN4",
            "LAT2",
            "IFNA5",
            "ALOX12",
            "IKBKE",
            "TGFB2",
            "CCR8",
            "THBS1",
            "DDIT3",
            "NEO1",
            "NLRP1",
            "HLA-C",
            "SPI1",
            "IFIT3",
            "PFKFB3",
            "CSF1R",
            "TIMP2",
            "EVL",
            "CCL20",
            "TLR7",
            "IL1RAPL2",
            "AIM2",
            "NFATC2",
            "SCARB2",
            "LILRB2",
            "RB1CC1",
            "FBXO6",
            "SIGIRR",
            "TLR8",
            "IL18",
            "IL1R2",
            "SERPINA1",
            "ADGRG3",
            "STAT2",
            "CCR9",
            "BLK",
            "CTSG",
            "CXCL5",
            "ATP6V1B2",
            "SMAD3",
            "HLA-DRA",
            "CD28",
            "GZMB",
            "CCL17",
            "C2",
            "IL1RL1",
            "SOD2",
            "IL11",
            "PSMB8",
            "NCF2",
            "SMAD5",
            "IFNW1",
            "CX3CL1",
            "SAMHD1",
            "DNAJA2",
            "LAMP3",
            "JAK2",
            "RGMA",
            "IL1A",
            "ATG12",
            "CASP1",
            "RAC2",
            "SELL",
            "IFIT1",
            "IFNAR1",
            "RPS6KA1",
            "PTPN6",
            "PSMB9",
            "TRAF6",
            "CD163",
            "TNFRSF17",
            "IL15RA",
            "CSF3",
            "IL3RA",
            "SEM1",
            "ACE",
            "NFKB2",
            "CCL14",
            "RSAD2",
            "KPNB1",
            "HLA-DQA1",
            "LANCL1",
            "NKG7",
            "HSP90AB1",
            "BECN1",
            "ITGAX",
            "MARCKS",
            "FGR",
            "IL22",
            "TRIM25",
            "PELI1",
            "GBP1",
            "NLRC4",
            "SORT1",
            "MS4A4A",
            "CD209",
            "MIF",
            "NOS2",
            "RELB",
            "TRAT1",
            "NFATC3",
            "IL17RE",
            "MAP2K3",
            "FOXP3",
            "THOP1",
            "PTGS2",
            "NAMPT",
            "CD69",
            "FASLG",
            "CCR1",
            "ADAR",
            "PTPRC",
            "IL24",
            "CD247",
            "CBLB",
            "STAT1",
            "MTOR",
            "SH2D1A",
            "TAB1",
            "ACKR2",
            "XAF1",
            "MAP2K7",
            "PIK3CD",
            "STRAP",
            "IL17RC",
            "PIK3R4",
            "NEU1",
            "RIPK2",
            "CD70",
            "ICOS",
            "STAT4",
            "CCL1",
            "LRRK2",
            "IFI27",
            "NGLY1",
            "IFNL1",
            "CXCR2",
            "KLRB1",
            "IL2",
            "TLR5",
            "OSM",
            "IL25",
            "MAP3K1",
            "LGALS3",
            "LAT",
            "IL26",
            "ACSL4",
            "CD8B",
            "EPHX2",
            "MAPK1",
            "PLG",
            "UBA52",
            "ICOSLG",
            "CCL7",
            "ATF2",
            "C3",
            "CALM1",
            "F5",
            "ATG13",
            "LITAF",
            "CD19",
            "GNS",
            "RAF1",
            "MCL1",
            "GZMA",
            "DHX58",
            "MARCO",
            "APP",
            "ENTPD1",
            "IFIT2",
            "SP100",
            "TRIM21",
            "TRIM6",
            "MYC",
            "TRAF3",
            "TGFB1",
            "RBPJ",
            "IL17RA",
            "LTC4S",
            "NCF4",
            "ATG10",
            "CCL21",
            "CASP3",
            "P2RX7",
            "HLA-DRB4",
            "SIGLEC5",
            "GCA",
            "CD59",
            "BCL3",
            "CYSTM1",
            "TBX21",
            "IFI6",
            "ITLN1",
            "HK3",
            "IFNB1",
            "MAPK14",
            "ALPL"
        ],
        "Coefficient": [
            -0.1378340076771326,
            0.10953301380450559,
            -0.10297606812547141,
            0.09751080944747238,
            -0.09725910612245182,
            0.09591691997394103,
            0.09058571939989725,
            0.0888451344001067,
            0.0866445411906997,
            -0.08578714213914317,
            -0.08451850730363185,
            0.0836717780744679,
            -0.08347948717138597,
            -0.08276687987001813,
            0.07921266685996549,
            0.07682810046565264,
            -0.07486004626643543,
            0.07446214093639246,
            -0.07389930986199948,
            0.07373772003600434,
            0.07362206683979147,
            0.0727999116830842,
            -0.07170082904117264,
            -0.07159303045233442,
            -0.07119185230346585,
            0.07099110605419719,
            -0.07051210346868964,
            -0.07050782035786038,
            0.0704799455837806,
            -0.07016944075555019,
            -0.0695976839595904,
            0.06902927741288858,
            0.0687632940028409,
            0.06855822245308586,
            -0.06828571607217569,
            -0.06825544147808979,
            0.06723028382292866,
            0.06706392333406046,
            0.06694675786686546,
            -0.0666930016998399,
            0.0665432776064129,
            -0.06626095438610154,
            -0.06605386482047794,
            -0.06596592243996172,
            0.06583317245644711,
            -0.06562545661555211,
            -0.06561468186019022,
            -0.0651585186447852,
            0.0643000191325259,
            0.0626927205649451,
            -0.06236700151266547,
            -0.062242812888833696,
            0.06094133814647046,
            -0.060512390807962134,
            0.06041393443731243,
            0.0602565718078,
            0.05966644913607488,
            0.05940557970772234,
            0.05925251852876222,
            -0.05891533093753874,
            0.05867043408181381,
            -0.058276280970971574,
            -0.05812605841678553,
            -0.05794693696240923,
            0.05767643969317159,
            0.057357057039637865,
            -0.0572252366877693,
            0.05682613110837405,
            -0.056583827648517736,
            0.05628180490394983,
            0.05627292865261291,
            -0.056247195739150144,
            -0.05606097424741233,
            -0.05593798609674869,
            0.055910310588304486,
            -0.055857578036867084,
            -0.05554397196303693,
            0.05465392314401083,
            -0.05415601115990237,
            0.05407599092576243,
            0.05390706457966059,
            -0.05386513874057031,
            -0.053735541770724884,
            -0.05370963822487609,
            -0.053700612201230714,
            -0.05332741783949584,
            -0.05305567475571268,
            0.05301561022884562,
            -0.052800623751973495,
            -0.052605930985003366,
            0.051072984189461754,
            0.05096339195319184,
            -0.05079729452438766,
            0.05041903675591371,
            0.05028907614411411,
            -0.050262151987401124,
            0.04981927422094893,
            0.04981916991916739,
            0.049761636922874324,
            -0.049318615922247,
            -0.04913525105473762,
            -0.049042398981288975,
            -0.04899273750243758,
            -0.04898983728516517,
            0.04888844149817771,
            -0.04884068621585516,
            -0.048607792458777666,
            0.04849989723504008,
            0.048470750988199,
            -0.04838723972300889,
            -0.048171423626544675,
            0.04811305816166017,
            -0.047594275469036,
            0.04748246349756293,
            -0.047201283981772604,
            0.04716892872298434,
            0.04710520119276819,
            0.04698427881211247,
            -0.04675765877698805,
            0.04663852649391605,
            0.0465807271852497,
            0.04646520717494228,
            0.04642043756155714,
            0.04619869578086588,
            0.04606374416476556,
            -0.04587705229577325,
            -0.0458530968561462,
            -0.04582890481121912,
            -0.045305670476594416,
            0.04525220002613954,
            0.04509588203374473,
            -0.045063184218137826,
            -0.04504320992907867,
            0.0449241016585384,
            0.04486761724961322,
            -0.044754251001298644,
            -0.04455629653338186,
            -0.04438614740145082,
            -0.04426513544133915,
            0.044265080118486906,
            -0.0441593644750097,
            -0.044049980328498745,
            0.04387657080761277,
            0.0433823516286919,
            -0.0432227725503793,
            0.043190307419754805,
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