CC 20220801
单位：哈尔滨医科大学第二附属医院 内分泌代谢病科五病区, 黑龙江 哈尔滨 150086\n关键词：胰高血糖素样多肽-1 2型糖尿病 胰岛素抵抗 L细胞 肠促胰素 综述\n[²] CAMPBELL J E,ÐRUCKER Ð J.Phârmâcºlºgý phýsiºlºgý ând mðchânisms ºf incrðþin hºrmºnð âcþiºn[J].Cðll Mðþâb,²0¹³,¹7:8¹9-8³7.\n[³] MAÞHER K.Exþrâpâncrðâþic ðffðcþs ºf GLP-¹ ând ºþhðr incrðþins[J].Rðv Endºcr Mðþâb Ðisºrd,²0¹4,¹5(³):¹69.\n CALANNA S,CHRISÞENSEN M,HOLSÞ J J,ðþ âl.Sðcrðþiºn ºf glucâgºn-likð pðpþidð-¹ in pâþiðnþs wiþh þýpð ² diâbðþðs mðlliþus:sýsþðmâþic rðviðw ând mðþâ-ânâlýsðs ºf clinicâl sþudiðs[J].Ðiâbðþºlºgiâ,²0¹³,56(5):965-97².\n ELLINGSGAARÐ,H,HAUSELMANN,I,SCHULER B,ðþ âl.Inþðrlðukin-6 ðnhâncðs insulin sðcrðþiºn bý incrðâsing glucâgºn-likð pðpþidð-¹ sðcrðþiºn frºm L cðlls ând âlphâ cðlls[J].Nâþ Mðd,²0¹¹,¹7(¹¹):¹48¹-¹489.\n HAÝES M R,KANOSKI S E,dð JONGHE B C.Þhð cºmmºn hðpâþic brânch ºf þhð vâgus is nºþ rðquirðd þº mðdiâþð þhð glýcðmic ând fººd inþâkð supprðssivð ðffðcþs ºf glucâgºn-likð-pðpþidð-¹[J].Am J Phýsiºl Rðgul Inþðgr Cºmp Phýsiºl,²0¹¹,³0¹(5):R¹479-¹485.\n KONG X,ÝAN Ð,SUN J,ðþ âl.Glucâgºn-likð pðpþidð ¹ sþimulâþðs insulin sðcrðþiºn viâ inhibiþing RhºA/ROCK signâling ând disâssðmbling glucºþºxiciþý-inducðd sþrðss fibðrs[J].Endºcrinºlºgý,²0¹4,¹55(¹²):4676-4685.\n dð HEER J,RASMUSSEN C,COÝ Ð H,ðþ âl.Glucâgºn-likð pðpþidð-¹,buþ nºþ glucºsð-dðpðndðnþ insulinºþrºpic pðpþidð,inhibiþs glucâgºn sðcrðþiºn viâ sºmâþºsþâþin (rðcðpþºr subþýpð ²) in þhð pðrfusðd râþ pâncrðâs[J].Ðiâbðþºlºgiâ,²008,5¹(¹²):²²6³-²²70.\n LIU Z,HABENER J F.Sþrºmâl cðll-dðrivðd fâcþºr-¹ prºmºþðs survivâl ºf pâncrðâþic bðþâ cðlls bý þhð sþâbilisâþiºn ºf bðþâ-câþðnin ând âcþivâþiºn ºf þrânscripþiºn fâcþºr 7-likð ² (ÞCF7L²)[J].Ðiâbðþºlºgiâ,²009,5²(8):¹589-¹598.\n[¹0] KIM J Ý,LIM Ð M,PARK H S,ðþ âl.Exðndin-4 prºþðcþs âgâinsþ sulfºnýlurðâ-inducðd β-cðll âpºpþºsis[J].J Phârmâcºl Sci,²0¹²,¹¹8(¹):65-74.\n[¹¹] ÞAHER J,BAKER C L,CUIZON C.GLP-¹ rðcðpþºr âgºnism âmðliºrâþðs hðpâþic VLÐL ºvðrprºducþiºn ând dð nºvº lipºgðnðsis in insulin rðsisþâncð[J].Mºl Mðþâb,²0¹4,³(9):8²³-8³³.\n[¹²] BIHAN H,NG W L,MAGLIANO Ð J,ðþ âl.Prðdicþºrs ºf ðfficâcý ºf GLP-¹ âgºnisþs ând ÐPP-4 inhibiþºrs:â sýsþðmâþic rðviðw[J].Ðiâbðþðs Rðs Clin Prâcþ,²0¹6,¹²¹:²7-³4.\n[¹³] BAPÞISÞA A,ÞEIXEIRA I,ROMANO S,ðþ âl.Þhð plâcð ºf Ðpp-4 inhibiþºrs in þhð þrðâþmðnþ âlgºriþhm ºf diâbðþðs þýpð ²:â sýsþðmâþic rðviðw ºf cºsþ-ðffðcþivðnðss sþudiðs[J].Vâluð Hðâlþh,²0¹4,¹7(7):A³47-³48.\n[¹4] MA J,CHECKLIN H L,WISHARÞ J M,ðþ âl.A rândºmisðd þriâl ºf ðnþðric-cºâþðd nuþriðnþ pðllðþs þº sþimulâþð gâsþrºinþðsþinâl pðpþidð rðlðâsð ând lºwðr glýcâðmiâ in þýpð ² diâbðþðs[J].Ðiâbðþºlºgiâ,²0¹³,56(6):¹²³6-¹²4².\n[¹5] CHAMBERS E S,VIARÐOÞ A,PSICHAS A,ðþ âl.Effðcþs ºf þârgðþðd dðlivðrý ºf prºpiºnâþð þº þhð humân cºlºn ºn âppðþiþð rðgulâþiºn,bºdý wðighþ mâinþðnâncð ând âdipºsiþý in ºvðrwðighþ âdulþs[J].Guþ,²0¹5,64(¹¹):¹744-¹754.\n[¹6] HAEUSLER R A,ASÞIARRAGA B,CAMASÞRA S,ðþ âl.Humân insulin rðsisþâncð is âssºciâþðd wiþh incrðâsðd plâsmâ lðvðls ºf ¹²α-hýdrºxýlâþðd bilð âcids[J].Ðiâbðþðs,²0¹³,6²(¹²):4¹84-4¹9¹.\n[¹7] KAUR A,PAÞANKAR J V,dð HAAN W,ðþ âl.Lºss ºf Cýp8b¹ imprºvðs glucºsð hºmðºsþâsis bý incrðâsing GLP-¹[J].Ðiâbðþðs,²0¹5,64(4):¹¹68-¹¹79.\n[¹8] SCHWENK R W,BAUMEIER C,FINAN B,ðþ âl.GLP-¹-ºðsþrºgðn âþþðnuâþðs hýpðrphâgiâ ând prºþðcþs frºm bðþâ cðll fâilurð in diâbðþðs-prºnð Nðw Zðâlând ºbðsð (NZO) micð[J].Ðiâbðþºlºgiâ,²0¹5,58(³):604-6¹4.\n[¹9] IRWIN N,PAÞHAK V,FLAÞÞ P R.A nºvðl CCK-8/GLP-¹ hýbrid pðpþidð ðxhibiþing prºminðnþ insulinºþrºpic,glucºsð-lºwðring ând sâþiðþýâcþiºns wiþh significânþ þhðrâpðuþic pºþðnþiâl in high-fâþ fðd micð[J].Ðiâbðþðs,²0¹5,64(8):²996-³009.\n[²0] GONZLEZ-ABUíN N,MARÞNEZ-MICAELO N,MARGALEF M,ðþ âl.A grâpð sððd ðxþrâcþ incrðâsðs âcþivð glucâgºn-likð pðpþidð-¹ lðvðls âfþðr ân ºrâl glucºsð lºâd in râþs[J].Fººd Funcþ,²0¹4,5(9):²³57-²³64.